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c19early.org COVID-19 treatment researchApilimodApilimod (more..)
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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Young (DB RCT) -199% 2.99 [0.12-72.1] death 1/71 0/70 Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.51 Early treatment -199% 2.99 [0.12-72.1] 1/71 0/70 199% higher risk All studies -199% 2.99 [0.12-72.1] 1/71 0/70 199% higher risk 1 apilimod COVID-19 study c19early.org November 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.51 Effect extraction pre-specified(most serious outcome) Favors apilimod Favors control
Apilimod is an oral, small molecule drug that inhibits the human PIKfyve kinase.
Apr 19
2021
Young et al., NCT04446377 A Phase II Randomized, Double-Blind, Placebo-Controlled Study of LAM-002A for the Prevention of Progression of COVID-19
199% higher mortality (p=1), 100% higher combined mortality/hospitalization (p=1), and 109% worse recovery (p=0.43). RCT 142 COVID-19 patients showing no significant differences with apilimod treatment.
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