(+)-ovatodiolide for COVID-19

(+)-ovatodiolide has been reported as potentially beneficial for COVID-19 in the following study.

COVID-19 involves the interplay of 350+ viral and host proteins and factors providing many therapeutic targets. Scientists have proposed 10,000+ potential treatments. c19early.org analyzes 200+ treatments. We have not reviewed (+)-ovatodiolide in detail.

Study suggesting benefit with (+)-ovatodiolide

Yu et al., Identification and Semisynthesis of (−)-Anisomelic Acid as Oral Agent against SARS-CoV-2 in Mice, National Science Review, doi:10.1093/nsr/nwac176

Abstract (−)-Anisomelic acid (AA), isolated from Anisomeles indica (L.) Kuntze (Labiatae) leaves, is a macrocyclic cembranolide with a trans-fused α-methylene-γ-lactone motif. AA effectively inhibits SARS-CoV-2 replication and viral-induced cytopathic effect (CPE) with an EC50 of 1.1 and 4.3 μM, respectively. Challenge studies of SARS-CoV-2-infected K18-hACE2 mice showed that oral administration of AA and subcutaneous dosing of remdesivir can both reduce the viral titers in the lung tissue at the same level. To facilitate drug discovery, we used a semisynthetic approach to shorten the project timelines. The enantioselective semisynthesis of AA from the naturally enriched and commercially available starting material (+)-costunolide was achieved in five steps with a 27% overall yield. The developed chemistry provides opportunities for developing AA-based novel ligands for selectively targeting proteins involved in viral infections.