Momordica charantia for COVID-19

The emergence of SARS-CoV-2, the etiological agent of COVID-19, has resulted in widespread global infection and millions of deaths. Viral entry is initiated by the interaction between the viral spike (S) protein and the host cell receptor ACE2, followed by TMPRSS2-mediated proteolytic activation that facilitates membrane fusion. Bitter melon (Momordica charantia L., MC), a traditional medicinal and edible plant widely used in tropical Asia, possesses notable anti-inflammatory, antioxidant, antitumor, and hypoglycemic properties. In this study, the ethanol extract of bitter melon (EMC) markedly downregulated ACE2 and TMPRSS2 expression in both in vitro and in vivo models without inducing cytotoxicity. Furthermore, phytochemicals isolated from EMC—including p-coumaric acid, rutin, and quercetin—exhibited comparable inhibitory effects. These results indicate that EMC and its bioactive constituents may interfere with SARS-CoV-2 entry by modulating the ACE2/TMPRSS2 axis, highlighting their potential as natural adjuncts for COVID-19 prevention or management.

This cross‐sectional study investigated nonconventional therapies for COVID‐19 in Trinidad, emphasizing the need for documentation supporting future pharmaceutical research. The survey, conducted from June 20 to July 19, 2022, garnered responses from 57 participants aged 18 and above, with 82.46% vaccinated. The majority (81%) utilized both conventional and nonconventional therapies, revealing insights for potential alternatives to traditional treatments. Conventional treatments, including antibiotics, Ivermectin, anti‐inflammatories, analgesics, bronchodilators, and cough/flu syrups, were frequently reported. Nonconventional therapies encompassed vitamins, minerals, supplements, and various plant and animal products. When participants used conventional therapies, either alone or in combination with nonconventional ones, 13.21% reported side effects. These included severe thirst, headache, nausea, drowsiness, and one case of weight gain. Conversely, those exclusively using nonconventional treatments reported no side effects. Encouragingly, nonconventional therapies demonstrated promising effects in managing COVID‐19, emphasizing the need for meticulous selection, research, and development of their bioactive compounds as potential alternatives to conventional therapies.

Coronavirus Disease 2019 (COVID-19) is a transmittable disease caused by severe acute respiratory coronavirus 2 (SARS-CoV-2). The outbreak of the disease has affected the world in a negative manner. The development and on-going vaccination efforts has reduced the mortality rate in people with existing comorbidities and lowered virus transmission rate. However, there are still the needs for prescribed medicines that can be consumed by COVID-19 infected persons. Momordica charantia L. has been used in traditional medicines to treat various diseases including anti-diabetic and cancer. Pharmacological studies on Momordica charantia L. revealed that the plant stored many useful phytoconstituents that might be exploited for producing drug compounds to treat COVID-19. Nowadays, computational-aided drug methods are widely used in drug discovery process as it requires minimal compound design and improve the development pipeline. In this study, molecular docking of five phytochemicals from Momordica charantia L. were carried out against SARS-CoV-2 main protease (Mpro). The results obtained revealed that some of the phytochemicals showed a better dock score compared to the drug molnupiravir. Based on the dock score and the medicinal properties of each compound, it is suggested that these compounds can be further studied for potential drugs against COVID-19.