AR12 for COVID-19
c19early.org
COVID-19 Treatment Clinical Evidence
COVID-19 involves the interplay of 400+ viral and host proteins and factors, providing many therapeutic targets.
c19early analyzes 6,000+ studies for 210+ treatments—over 17 million hours of research.
Only three high-profit early treatments are approved in the US.
In reality, many treatments reduce risk,
with 25 low-cost treatments approved across 163 countries.
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Naso/
oropharyngeal treatment Effective Treatment directly to the primary source of initial infection. -
Healthy lifestyles Protective Exercise, sunlight, a healthy diet, and good sleep all reduce risk.
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Immune support Effective Vitamins A, C, D, and zinc show reduced risk, as with other viruses.
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Thermotherapy Effective Methods for increasing internal body temperature, enhancing immune system function.
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Systemic agents Effective Many systemic agents reduce risk, and may be required when infection progresses.
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High-profit systemic agents Conditional Effective, but with greater access and cost barriers.
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Monoclonal antibodies Limited Utility Effective but rarely used—high cost, variant dependence, IV/SC admin.
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Acetaminophen Harmful Increased risk of severe outcomes and mortality.
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Remdesivir Harmful Increased mortality with longer followup. Increased kidney and liver injury, cardiac disorders.
AR12 may be beneficial for
COVID-19 according to the study below.
COVID-19 involves the interplay of 400+ viral and host proteins and factors providing many therapeutic targets.
Scientists have proposed 11,000+ potential treatments.
c19early.org analyzes
210+ treatments.
We have not reviewed AR12 in detail.
, Nature’s cryptographic codebreaker: in silico decoding of apigenin’s triple defense against SARS-CoV-2, Frontiers in Microbiology, doi:10.3389/fmicb.2025.1708660
Introduction The coronavirus disease 2019 (COVID-19) pandemic underscored the urgent need for broad-spectrum antiviral agents capable of targeting both viral proteins and host factors to mitigate disease severity. Apigenin has antiviral and anti-inflammatory properties. However, the potential of apigenin against SARS-CoV-2 remains insufficiently explored. Methods In this study, the potential role of apigenin in the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the underlying mechanism were explored using matrix factorization, deep learning, multiscale molecular modeling and network pharmacology. Results The graph-based integrated Gaussian kernel similarity (GiGs) model predicted that apigenin might be a drug against SARS-CoV-2. The prediction of drug-target affinity using a convolution model with self-attention (CSatDTA) model revealed the potential binding affinity of apigenin with glucose-regulated protein 78 (GRP78) and heparan sulfate proteoglycan (HSPG). Molecular docking further validated strong binding to GRP78 (–8.198 kcal/mol) and moderate binding to HSPG (–5.6 kcal/mol), mediated by van der Waals forces and hydrogen bonds. Multiscale molecular modeling revealed that apigenin could bind to Non-structural protein 15 (Nsp15). Further, the network pharmacology analysis implied that apigenin might modulate the host inflammatory responses by potentially regulating the PI3K-Akt and HIF-1 signaling pathways and binding directly to protein kinase B (AKT1) and prostaglandin endoperoxide synthase 2 (PTGS2). Discussion Computational profiling suggests apigenin exerts a multi-target mechanism against SARS-CoV-2, potentially disrupting viral entry, replication, and host inflammatory responses. The findings of this research outline a promising strategy and provide a rationale for developing novel natural product-based treatment methods for SARS-CoV-2.