PSiNP-NH2[Nic] for COVID-19
c19early.org
COVID-19 Treatment Clinical Evidence
COVID-19 involves the interplay of 400+ viral and host proteins and factors, providing many therapeutic targets.
c19early analyzes 6,000+ studies for 210+ treatments—over 17 million hours of research.
Only three high-profit early treatments are approved in the US.
In reality, many treatments reduce risk,
with 24 low-cost treatments approved across 163 countries.
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Naso/
oropharyngeal treatment Effective Treatment directly to the primary source of initial infection. -
Healthy lifestyles Protective Exercise, sunlight, a healthy diet, and good sleep all reduce risk.
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Immune support Effective Vitamins A, C, D, and zinc show reduced risk, as with other viruses.
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Thermotherapy Effective Methods for increasing internal body temperature, enhancing immune system function.
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Systemic agents Effective Many systemic agents reduce risk, and may be required when infection progresses.
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High-profit systemic agents Conditional Effective, but with greater access and cost barriers.
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Monoclonal antibodies Limited Utility Effective but rarely used—high cost, variant dependence, IV/SC admin.
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Acetaminophen Harmful Increased risk of severe outcomes and mortality.
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Remdesivir Harmful Increased mortality with longer followup. Increased kidney and liver injury, cardiac disorders.
PSiNP-NH2[Nic] may be beneficial for
COVID-19 according to the study below.
COVID-19 involves the interplay of 400+ viral and host proteins and factors providing many therapeutic targets.
Scientists have proposed 11,000+ potential treatments.
c19early.org analyzes
210+ treatments.
We have not reviewed pSiNP-NH2[Nic] in detail.
, Development of niclosamide-based COVID-19 therapeutic agent using porous silicon nanoparticles, Nanotechnology, doi:10.1088/1361-6528/ae5301
Abstract This study explores the potential of porous silicon nanoparticles (pSiNPs) as advanced nanocarriers to enhance the therapeutic efficacy and reduce the cytotoxicity of niclosamide for COVID-19 treatment. Niclosamide, an FDA-approved drug used to treat tapeworm infections, has been suggensted as a potential treatment for COVID-19. However, its clinical application is limited by its significant cytotoxicity and low bioavailability. To address these challenges, three types of pSiNPs-pSiNP-H, pSiNP-COOH, and pSiNP-NH 2 -were synthesized. Niclosamide was successfully loaded onto each type of pSiNPs, achieving a loading efficiency over 30%. Among them, the antiviral activity of niclosamide-loaded pSiNP-NH 2 was assessed against the Delta variant of SARS-CoV-2 in Vero E6 cells using plaque assays and real-time PCR. Results demonstrated that niclosamide-loaded pSiNP-NH 2 significantly suppressed viral replication more efficiently than free niclosamide at equivalent doses, while minimizing host cell cytotoxicity. These findings suggest that pSiNP-NH 2 could serve as a potent drug delivery platform, improving the therapeutic index of niclosamide for COVID-19 treatment.