SIR1-365 for COVID-19
1 study with 42 patients
No significant improvements are seen in meta analysis to date.
COVID-19 SIR1-365 studies. Dec 2025. c19early.org
0 0.5 1 1.5+ All studies -88% RCTs -88% Late -88% FavorsSIR1-365 Favorscontrol
SIR1-365 is an oral small-molecule RIPK1 kinase inhibitor with anti-inflammatory and immunomodulatory activity.
Nov 27
2021
Qu et al., NCT04622332 A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Study to Assess Safety and Efficacy of SIR1-365 in Patients With Severe COVID-19
88% worse recovery (p=0.44). Pilot RCT 42 hospitalized COVID-19 patients showing no significant differences with SIR1-365 treatment. foo