Tenecteplase for COVID-19: real-time analysis

c19early.org

Tenecteplase for COVID-19

1 study with 13 patients

Serious outcome risk

Tenecteplase

Control

No significant improvements are seen in meta-analysis to date.

COVID-19 Tenecteplase studies · November 2026

Outcome (studies)

Improvement

Relative risk · 95% CI

All studies (1)−25%

Mortality (1)−25%

Hospitalization (1)15%

RCTs (1)−25%

Late (1)−25%

00.511.5+

← Tenecteplase
reduces riskIncreased
risk →

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Tenecteplase is a recombinant tissue plasminogen activator (tPA) and fibrinolytic agent that dissolves blood clots by converting plasminogen to plasmin.


Feb 16 2024	Poor et al., Cureus, doi:10.7759/cureus.54298	Tenecteplase With Concomitant Anticoagulation for Acute Respiratory Failure in Patients With COVID-19: A Randomized Controlled Trial
Feb 16 2024	25% higher mortality (p=1), 38% lower progression (p=0.59), and 15% shorter hospitalization (p=0.82). RCT 13 hospitalized COVID-19 patients with acute respiratory failure showing no significant difference in mortality or respiratory outcomes with tenecteplase plus heparin versus placebo plus heparin. At 28 days, 63% of tenecteplase patien..

Most accessed treatments

Antiviral effects

Vitamins & Minerals

Host endosomal entry / trafficking

Dual-action mAbs

RdRp

Nasal & Oral Sprays / Rinses

Analgesics

Antiandrogens

Host targets and pathways

Inflammatory and immune modulation

Mpro (Gen 1)

Oxidative stress and cytoprotection

Lifestyles

TMPRSS2

Spike neutralization

Replication inhibition (target unresolved)

COVID-19 mAbs

Pleiotropic modulation

Attachment / entry inhibition

Mpro (Gen 2)

H1RAs

Nutrients and microbiome support

Host mAbs

IL-6 / IL-6R blockade

Physical and extracorporeal interventions

Natural products and extracts

Symptom management

Unconfirmed antiviral rationale

Lifestyle, behaviors, and exposure prevention

Other complication management

Mpro / 3CLpro

Host pyrimidine synthesis

Direct viral inactivation

Endothelial / vascular protection

Direct respiratory tract treatments

Other antibodies, proteins, peptides, cells, and RNA therapies

Secondary infection and coinfection management

Tenecteplase for COVID-19: real-time analysis