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c19early.org COVID-19 treatment researchAER002AER002 (more..)
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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ outSMART-LC Peluso (DB RCT) -6% 1.06 [0.96-1.18] PASC 24 (n) 12 (n) Improvement, RR [CI] Treatment Control Tau​2 = 0.00, I​2 = 0.0%, p = 0.25 Late treatment -6% 1.06 [0.96-1.18] 24 (n) 12 (n) 6% higher risk All studies -6% 1.06 [0.96-1.18] 24 (n) 12 (n) 6% higher risk 1 AER002 COVID-19 study c19early.org October 2025 Tau​2 = 0.00, I​2 = 0.0%, p = 0.25 Effect extraction pre-specified(most serious outcome) Favors AER002 Favors control
Oct 28
Peluso et al., NCT05877508 An Exploratory, Randomized, Double-Blind Placebo-Controlled Study to Assess the Safety of an Anti-SARS-CoV-2 Monoclonal Antibody and Response to Treatment in Individuals With Long COVID (outSMART-LC)
6% higher PASC (p=0.25). RCT 36 patients showing no improvement in long COVID with AER002.
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