COVID-19 early treatment: real-time analysis of 5,701 studies
COVID-19 involves the interplay of over 100 viral and host proteins and factors, providing many therapeutic targets.
c19early analyzes over 5,700 studies for 135 treatments—over 17 million hours of research.
US authorities believe only three high-profit early treatments
reduce risk (remdesivir, paxlovid, molnupiravir). In reality, many treatments reduce risk,
and 25 low-cost treatments have been approved across 163 countries.
0.6% of 9,000+ proposed treatments show reduced risk.
Direct treatment to the primary source of initial infection reduces progression and transmission.
Many low-cost agents are widely available.
Exercise, sunlight, a healthy diet, and good sleep all reduce risk.
Vitamins A, C, D, and zinc show reduced risk, as with other viruses.
Methods for increasing internal body temperature reduce risk, comparable to natural fever, enhancing immune system function.
Many systemic agents reduce risk, and may be required when infection progresses beyond the upper respiratory tract.
High-profit systemic agents are also effective, but have greater access and cost barriers.
Highly effective for matching variants but rarely used, with high cost, variant dependence, and IV/subcutaneous administration.
Acetaminophen increases the risk of severe outcomes and mortality.
Antiviral efficacy is offset by serious side effects, resulting in increased mortality with longer followup.
c19early.org
We do not provide medical advice. No treatment is 100% effective, and all may have side effects. Protocols combine multiple treatments. Consult a qualified physician for personalized risk/benefit analysis.
Timeline for when studies showed efficacy - details and limitations.
0.5% of treatments show efficacy.
Top journals that accept positive studies for low cost treatments:
Nutrients,
PLOS ONE,
Frontiers in Medicine,
Cureus,
Journal of Clinical Medicine,
Scientific Reports,
more...
Treatment cost times median NNT - details and limitations.
0.5% of treatments show efficacy.
All clinical results for selected treatments. 0.5% of treatments show efficacy.
| Random effects meta-analysis of all studies (pooled effects, all stages). Treatments with ≤3 studies with distinct authors or with <50 control events are shown in grey. Pooled results across all stages and outcomes depend on the distribution of stages and outcomes tested - for example late stage treatment may be less effective and if the majority of studies are late stage this may obscure the efficacy of early treatment. Please see the specific stage and outcome analyses. Protocols typically combine multiple treatments which may be complementary and synergistic, and the SOC in studies often includes other treatments. 0.5% of proposed treatments show efficacy in clinical studies. | |||||
| Random effects meta-analysis of early treatment studies (pooled effects). Treatments with ≤3 studies with distinct authors or with <50 control events are shown in grey. Pooled results across all outcomes are affected by the distribution of outcomes tested, please see detail pages for specific outcome analysis. Protocols typically combine multiple treatments which may be complementary and synergistic, and the SOC in studies often includes other treatments. 0.5% of proposed treatments show efficacy in clinical studies. | |||||
| Random effects meta-analysis of all mortality results (all stages). Treatments with ≤3 studies with distinct authors or with <25 control events are shown in grey. Pooled results across all stages depend on the distribution of stages tested - for example late stage treatment may be less effective and if the majority of studies are late stage this may obscure the efficacy of early treatment. Please see the specific stage analyses. Protocols typically combine multiple treatments which may be complementary and synergistic, and the SOC in studies often includes other treatments. 0.5% of proposed treatments show efficacy in clinical studies. | |||||
| Random effects meta-analysis of early treatment mortality results. Treatments with ≤3 studies with distinct authors or with <25 control events are shown in grey. Protocols typically combine multiple treatments which may be complementary and synergistic, and the SOC in studies often includes other treatments. 0.5% of proposed treatments show efficacy in clinical studies. | |||||
| Random effects meta-analysis of prophylaxis studies (pooled effects). Treatments with ≤3 studies with distinct authors or with <50 control events are shown in grey. Pooled results across all outcomes are affected by the distribution of outcomes tested, please see detail pages for specific outcome analysis. Protocols typically combine multiple treatments which may be complementary and synergistic, and the SOC in studies often includes other treatments. 0.5% of proposed treatments show efficacy in clinical studies. | |||||
| Random effects meta-analysis of prophylaxis mortality results. Treatments with ≤3 studies with distinct authors or with <25 control events are shown in grey. Protocols typically combine multiple treatments which may be complementary and synergistic, and the SOC in studies often includes other treatments. 0.5% of proposed treatments show efficacy in clinical studies. | |||||
| Random effects meta-analysis of long covid results. Treatments with ≤3 studies with distinct authors or with <50 control events are shown in grey. Pooled results across all stages and outcomes depend on the distribution of stages and outcomes tested - for example late stage treatment may be less effective and if the majority of studies are late stage this may obscure the efficacy of early treatment. Please see the specific stage and outcome analyses. Protocols typically combine multiple treatments which may be complementary and synergistic, and the SOC in studies often includes other treatments. 0.5% of proposed treatments show efficacy in clinical studies. | |||||
| Random effects meta-analysis of transmission results. Treatments with ≤3 studies with distinct authors or with <50 control events are shown in grey. Pooled results across all stages and outcomes depend on the distribution of stages and outcomes tested - for example late stage treatment may be less effective and if the majority of studies are late stage this may obscure the efficacy of early treatment. Please see the specific stage and outcome analyses. Protocols typically combine multiple treatments which may be complementary and synergistic, and the SOC in studies often includes other treatments. 0.5% of proposed treatments show efficacy in clinical studies. |
| LATE TREATMENT | ||||||
| Physician / Team | Location | Patients | HospitalizationHosp. | MortalityDeath | ||
| Dr. David Uip (*) | Brazil | 2,200 | 38.6% (850) | Ref. | 2.5% (54) | Ref. |
| EARLY TREATMENT - 40 physicians/teams | ||||||
| Physician / Team | Location | Patients | HospitalizationHosp. | ImprovementImp. | MortalityDeath | ImprovementImp. |
| Dr. Roberto Alfonso Accinelli 0/360 deaths for treatment within 3 days |
Peru | 1,265 | 0.6% (7) | 77.5% | ||
| Dr. Mohammed Tarek Alam patients up to 84 years old |
Bangladesh | 100 | 0.0% (0) | 100.0% | ||
| Dr. Oluwagbenga Alonge | Nigeria | 310 | 0.0% (0) | 100.0% | ||
| Dr. Raja Bhattacharya up to 88yo, 81% comorbidities |
India | 148 | 1.4% (2) | 44.9% | ||
| Dr. Flavio Cadegiani | Brazil | 3,450 | 0.1% (4) | 99.7% | 0.0% (0) | 100.0% |
| Dr. Alessandro Capucci | Italy | 350 | 4.6% (16) | 88.2% | ||
| Dr. Shankara Chetty | South Africa | 8,000 | 0.0% (0) | 100.0% | ||
| Dr. Deborah Chisholm | USA | 100 | 0.0% (0) | 100.0% | ||
| Dr. Ryan Cole | USA | 400 | 0.0% (0) | 100.0% | 0.0% (0) | 100.0% |
| Dr. Marco Cosentino vs. 3-3.8% mortality during period; earlier treatment better |
Italy | 392 | 6.4% (25) | 83.5% | 0.3% (1) | 89.6% |
| Dr. Jeff Davis | USA | 6,000 | 0.0% (0) | 100.0% | ||
| Dr. Dhanajay | India | 500 | 0.0% (0) | 100.0% | ||
| Dr. Bryan Tyson & Dr. George Fareed | USA | 20,000 | 0.0% (6) | 99.9% | 0.0% (4) | 99.2% |
| Dr. Raphael Furtado | Brazil | 170 | 0.6% (1) | 98.5% | 0.0% (0) | 100.0% |
| Rabbi Yehoshua Gerzi | Israel | 860 | 0.1% (1) | 99.7% | 0.0% (0) | 100.0% |
| Dr. Heather Gessling | USA | 1,500 | 0.1% (1) | 97.3% | ||
| Dr. Ellen Guimarães | Brazil | 500 | 1.6% (8) | 95.9% | 0.4% (2) | 83.7% |
| Dr. Syed Haider | USA | 4,000 | 0.1% (5) | 99.7% | 0.0% (0) | 100.0% |
| Dr. Mark Hancock | USA | 24 | 0.0% (0) | 100.0% | ||
| Dr. Sabine Hazan | USA | 1,000 | 0.0% (0) | 100.0% | ||
| Dr. Mollie James | USA | 3,500 | 1.1% (40) | 97.0% | 0.0% (1) | 98.8% |
| Dr. Roberta Lacerda | Brazil | 550 | 1.5% (8) | 96.2% | 0.4% (2) | 85.2% |
| Dr. Katarina Lindley | USA | 100 | 5.0% (5) | 87.1% | 0.0% (0) | 100.0% |
| Dr. Ben Marble | USA | 150,000 | 0.0% (4) | 99.9% | ||
| Dr. Edimilson Migowski | Brazil | 2,000 | 0.3% (7) | 99.1% | 0.1% (2) | 95.9% |
| Dr. Abdulrahman Mohana | Saudi Arabia | 2,733 | 0.0% (0) | 100.0% | ||
| Dr. Carlos Nigro | Brazil | 5,000 | 0.9% (45) | 97.7% | 0.5% (23) | 81.3% |
| Dr. Benoit Ochs | Luxembourg | 800 | 0.0% (0) | 100.0% | ||
| Dr. Ortore | Italy | 240 | 1.2% (3) | 96.8% | 0.0% (0) | 100.0% |
| Dr. Valerio Pascua one death for a patient presenting on the 5th day in need of supplemental oxygen |
Honduras | 415 | 6.3% (26) | 83.8% | 0.2% (1) | 90.2% |
| Dr. Sebastian Pop | Romania | 300 | 0.0% (0) | 100.0% | ||
| Dr. Brian Proctor | USA | 869 | 2.3% (20) | 94.0% | 0.2% (2) | 90.6% |
| Dr. Anastacio Queiroz | Brazil | 700 | 0.0% (0) | 100.0% | ||
| Dr. Didier Raoult | France | 8,315 | 2.6% (214) | 93.3% | 0.1% (5) | 97.6% |
| Dr. Karin Ried up to 99yo, 73% comorbidities, av. age 63 |
Turkey | 237 | 0.4% (1) | 82.8% | ||
| Dr. Roman Rozencwaig patients up to 86 years old |
Canada | 80 | 0.0% (0) | 100.0% | ||
| Dr. Vipul Shah | India | 8,000 | 0.1% (5) | 97.5% | ||
| Dr. Silvestre Sobrinho | Brazil | 116 | 8.6% (10) | 77.7% | 0.0% (0) | 100.0% |
| Dr. Unknown | Brazil | 957 | 1.7% (16) | 95.7% | 0.2% (2) | 91.5% |
| Dr. Vladimir Zelenko | USA | 2,200 | 0.5% (12) | 98.6% | 0.1% (2) | 96.3% |
| Mean improvement with early treatment protocols | 238,381 | HospitalizationHosp. | 94.4% | MortalityDeath | 94.9% | |
Physician results with early treatment protocols compared to
no early treatment. These results are subject to selection and ascertainment
bias and more accurate analysis requires details of the patient populations
and followup, however results are consistently better across many teams, and consistent
with the extensive controlled trial evidence that shows a significant
reduction in risk with many early treatments, and improved results with the
use of multiple treatments in combination.
| Muthusamy | In Silico study identifying 32 anti-parisitic compounds effectively inhibiting the RBD of the SARS-CoV-2 spike protein, showing ivermectin and.. |
| Pickard | In Vitro studying identifying 35 compounds that inhibit SARS-CoV-2 in Vero cells and hepatocytes when treated prior to infection, and several.. |
| Bess | In Silico study showing potential benefit of mebendazole and zinc against SARS-CoV-2 according to an AI platform, eVir, designed to identify.. |
| Agamah | In Silico study identifying potential drugs beneficial for COVID-19 by integrating transcriptomics, proteomics, metabolomics, lipidomics, and drug.. |
| El-Tanani | RCT 69 outpatients in Jordan, showing improved viral clearance and CRP with mebendazole. Authors note that mebendazole, like ivermectin, has been.. |
| Hamdan | In Silico study showing that H1RA antihistamines, including bilastine, fexofenadine, mizolastine, rupatadine, terfenadine, and the leukotriene.. |
| Vukosavljević | Cross-sectional observational study of 175 adults in Serbia showing high prevalence (73%) of self-medication during the COVID-19 pandemic, primarily.. |
| Yang | Bioinformatic study analyzing gene expression data from COVID-19 patients to identify six programmed cell death (PCD) related biomarkers (CCNB1,.. |
| Htet | Systematic review and meta-analysis of 16 RCTs with 19,797 COVID-19 patients, showing a statistically significant increased risk of hepatotoxicity.. |
| Lundrigan | In Vitro study showing that site-specific fluorescent labeling of SARS-CoV-2 Nsp13 helicase enables monitoring of its binding activity with nucleic.. |
| Sanchez | In Vitro study showing that tyrosine kinase receptor (RTK) inhibitors lapatinib and GW441756 significantly reduce SARS-CoV-2 replication in human.. |
| Xue | Multi-omics and rat model study identifying the VCL/ICAM-1 pathway as a key driver of lung inflammatory damage in SARS-CoV-2 Omicron infection... |
| Najimi | In Vitro and In Silico study showing that l-tartaric acid, l-ascorbic acid, and Curcuma longa extract (curcumin, demethoxycurcumin,.. |
| Najimi | In Vitro and In Silico study showing that l-tartaric acid, l-ascorbic acid, and Curcuma longa extract (curcumin, demethoxycurcumin,.. |
| Kroon | Crossover study of 9 healthy males comparing curcumin bioavailability from three commercial formulations (AOV, Longvida, NovaSOL). None of the three.. |
| Htet | Systematic review and meta-analysis of 16 RCTs with 19,797 COVID-19 patients, showing a statistically significant increased risk of hepatotoxicity.. |
| Kocas | In Vitro study showing enhanced intracellular uptake of ivermectin through liposomal encapsulation in Vero E6 cells with reduced cytotoxicity. While.. |
| Sarhan | 108 patient late treatment RCT: 35% higher mortality (p=0.39) and 35% lower hospital discharge (p=0.39) |
| Tanriverdi | 178 patients sufficiency: 60% lower mortality (p=0.07) |
| Baby | Review of TMPRSS2 as a drug target to combat influenza and coronavirus infections. Authors highlight that TMPRSS2, a transmembrane serine protease.. |
| Gómez-Zorrilla | 69 patient late treatment RCT: 76% lower progression (p=0.05) and 40% improved recovery (p=0.08) |
| Muniz | Non-COVID-19 specific RCT with 150 participants in Brazil showing reduced frequency (21.5% lower) and severity (11% lower) of upper respiratory.. |
| Muniz | Non-COVID-19 specific RCT with 150 participants in Brazil showing reduced frequency (21.5% lower) and severity (11% lower) of upper respiratory.. |
Recent studies (see the individual treatment pages for all studies):
May 7 |
et al., American Journal of Respiratory and Critical Care Medicine, doi:10.1164/ajrccm.2025.211.Abstracts.A3027 | Early and Delayed Administration of Azvudine on Mortality of Adult Patients With COVID-19: A Retrospective Study |
| PSM retrospective 604 hospitalized COVID-19 patients showing lower mortality with azvudine. Detailed results are only provided for the subgroup of non-mild patients. | ||
May 3 |
et al., iScience, doi:10.1016/j.isci.2025.112575 | A pharmacokinetic study and critical reappraisal of curcumin formulations enhancing bioavailability |
| Crossover study of 9 healthy males comparing curcumin bioavailability from three commercial formulations (AOV, Longvida, NovaSOL). None of the three products tested contained the claimed amount of curcumin. Results showed plasma levels of.. | ||
May 2 |
et al., AAPS PharmSciTech, doi:10.1208/s12249-025-03113-8 | Enhancing Intracellular Uptake of Ivermectin through Liposomal Encapsulation |
| In Vitro study showing enhanced intracellular uptake of ivermectin through liposomal encapsulation in Vero E6 cells with reduced cytotoxicity. While free ivermectin showed a half-maximal cytotoxic concentration (CC50) of 10 μM, liposomal .. | ||
May 2 |
et al., medRxiv, doi:10.1101/2025.05.01.25326797 | A randomised-controlled Phase I de-escalation trial of Molnupiravir and Nirmatrelvir/Ritonavir combination for mild-moderate SARS-CoV-2 infection |
| 1% worse viral clearance (p=0.94). Randomized open-label phase I trial of 24 outpatients with mild-moderate COVID-19 showing safety and tolerability of combined molnupiravir and paxlovid therapy. The paper reports that the control group received standard of care and ".. | ||
Apr 30 |
et al., Health Technology Assessment, doi:10.3310/MTRS8833 | Lessons from the PROTECT-CH COVID-19 platform trial in care homes |
| Discussion of a planned COVID-19 platform trial (PROTECT-CH) in care homes that failed to start recruitment. The trial was designed to test prophylactic antiviral interventions (initially ciclesonide and niclosamide) to reduce SARS-CoV-2 .. | ||
Apr 30 |
et al., International Journal of Tokat Medical Sciences, 17:18-25 | COVİD-19 Pnömonisi Gelişen Hastalarda Vitamin D Düzeylerinin Hastane Yatış Süresi ve Mortalite ile İlişkisinin Değerlendirilmesi: Retrospektif Analiz |
| 60% lower mortality (p=0.07). Retrospective 178 hospitalized COVID-19 pneumonia patients showing higher mortality with lower vitamin D levels. | ||
Apr 28 |
et al., ChemistrySelect, doi:10.1002/slct.202406035 | Phytochemical Inhibitors of SARS‐CoV‐2 Entry: Targeting the ACE2‐RBD Interaction with l‐Tartaric Acid, l‐Ascorbic Acid, and Curcuma longa Extract |
| In Vitro and In Silico study showing that l-tartaric acid, l-ascorbic acid, and Curcuma longa extract (curcumin, demethoxycurcumin, bisdemethoxycurcumin) inhibit the SARS-CoV-2 spike RBD interaction with human ACE2. Authors demonstrate by.. | ||
Apr 25 |
et al., Communications Medicine, doi:10.1038/s43856-025-00844-4 | Dissecting clinical features of COVID-19 in a cohort of 21,312 acute care patients |
| Retrospective 21,312 acute care COVID-19 patients in the USA showing that low albumin levels were one of the best predictors of disease severity, with hypoalbuminemia associated with higher rates of severe/critical disease trajectories an.. | ||
Apr 24 |
et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofaf246 | Aerosolized dornase alfa (DNase I) for the treatment of severe respiratory failure in COVID-19: a randomized controlled trial |
| 11% higher mortality (p=1) and 2% worse recovery (p=0.94). RCT 76 hospitalized COVID-19 patients showing no significant difference with inhaled dornase alfa (DNase I) for resolution of hypoxia or other clinical outcomes. | ||
Apr 22 |
et al., Authorea Inc., doi:10.22541/au.174532324.40343996/v1 | Zinc adjuvant treatment in SARS-CoV-2: a randomized clinical trial |
| 76% lower progression (p=0.05) and 40% improved recovery (p=0.08). RCT 71 hospitalized COVID-19 patients showing reduced disease progression with zinc treatment. In this open-label trial, patients were randomized to receive standard of care alone or with zinc acetate (90 mg/day) for 14 days. Disease prog.. | ||
Apr 21 |
et al., Cureus, doi:10.7759/cureus.82736 | Intranasal Chlorpheniramine for Early Symptomatic Treatment of COVID-19 and the Impact on Long-COVID |
| Review of intranasal chlorpheniramine maleate (iCPM) as a therapy for COVID-19 and long COVID. Authors explore how iCPM combines antihistamine activity via H1 receptor antagonism with bitter taste receptor (T2R) activation to address both.. | ||
Apr 18 |
et al., iScience, doi:10.1016/j.isci.2025.112105 | M-Motif, a potential non-conventional NLS in YAP/TAZ and other cellular and viral proteins that inhibits classic protein import |
| In Vitro study showing that TAZ/YAP proteins contain an M-motif, a novel type of nuclear localization signal that can inhibit classic protein import and may play a role in viral immune evasion. Authors identified that this M-motif consist.. | ||
Apr 18 |
et al., Journal of Drug Delivery Science and Technology, doi:10.1016/j.jddst.2025.106941 | Development and Optimization of Lyophilized Dry Emulsion Tablet for Improved Oral Delivery of Ivermectin |
| In Vitro and rabbit study showing that rapidly disintegrating lyophilized dry‑emulsion tablets (IVM‑LDET) markedly improve oral ivermectin delivery. Authors applied a quality‑by‑design approach to oil‑in‑water emulsions.. | ||
Apr 16 |
et al., Italian Journal of Pediatrics, doi:10.1186/s13052-025-01961-5 | Role of nutrient supplements in children with post-COVID condition: a retrospective preliminary observation and narrative review |
| Retrospective 1,243 children with COVID-19 showing lower risk of long COVID at 6 months when treated with a Multi-Element Product (MEP) containing antioxidants and anti-inflammatory compounds (magnesium 200 mg, quercetin 150 mg, curcumin .. | ||
Apr 11 |
et al., NCT04590547 | Safety, Tolerability and Efficacy and Dose Response of GLS-1027 in the Prevention of Severe Pneumonitis Caused by SARS-CoV-2 Infection |
| 200% higher mortality (p=0.34), 1% worse recovery (p=0.99), and 1% shorter hospitalization (p=0.87). RCT 132 hospitalized COVID-19 patients showing no significant difference in outcomes with zenuzolac (GLS-1027) treatment. | ||
Apr 11 |
et al., JMIR Formative Research, doi:10.2196/66509 | Oxidative Stress Markers and Prediction of Severity With a Machine Learning Approach in Hospitalized Patients With COVID-19 and Severe Lung Disease: Observational, Retrospective, Single-Center Feasibility Study |
| Retrospective 28 hospitalized COVID-19 patients showing an association between oxidative stress biomarkers and disease severity. Lower zinc and thiol levels, higher Cu/Zn ratios, and increased high-sensitivity C-reactive protein (hs-CRP) .. | ||
Apr 11 |
et al., Journal of Clinical and Translational Science, doi:10.1017/cts.2024.1162 | Is PHASTR faster? A target trial emulation case study in the N3C |
| 53% lower PASC (p=0.02). N3C target trial emulation study with 9,660 adult COVID-19 patients, showing metformin associated with lower risk of long COVID or death. | ||
Apr 9 |
et al., VIEW, doi:10.1002/VIW.20240075 | The effectiveness and safety of azvudine treatment in COVID‐19 patients with kidney disease based on a multicenter retrospective cohort study |
| 38% lower mortality (p<0.0001) and 21% lower progression (p=0.03). PSM retrospective 4,192 hospitalized COVID-19 patients with kidney disease showing significantly reduced all-cause mortality and disease progression with azvudine. | ||
Apr 9 |
et al., mBio, doi:10.1128/mbio.04015-24 | SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx |
| In Vitro study showing that certain gut bacteria can modulate SARS-CoV-2 infection by degrading heparan sulfate (HS) on cell surfaces. Authors found that the abundance of HS-modifying bacteria inversely correlates with age, sex, and COVID.. | ||
Apr 8 |
et al., Cell Reports, doi:10.1016/j.celrep.2025.115543 | Antibody evasiveness of SARS-CoV-2 subvariants KP.3.1.1 and XEC |
| In Vitro study showing that VYD222 (pemivibart) shows reduced efficacy against emerging SARS-CoV-2 variants KP.3.1.1 and XEC due to mutations that affect RBD conformation and antibody binding. | ||
Apr 8 |
et al., Clinical and Translational Medicine, doi:10.1002/ctm2.70275 | Severe SARS‐CoV‐2 infection in diabetes was rescued in mice supplemented with metformin and/or αKG, and patients taking metformin, via HIF1α‐IFN axis |
| In Vitro and mouse study showing that metformin and/or alpha-ketoglutarate (αKG) supplementation reduces SARS-CoV-2 infection severity in diabetic mice by modulating the HIF1α–interferon axis. Diabetic mice exhibited elevated viral loads,.. | ||
Apr 7 |
et al., Frontiers in Nutrition, doi:10.3389/fnut.2025.1476622 | Low vitamin K status is a potential risk factor for COVID-19 infected patients: a systematic review and meta-analysis |
| Meta-analysis of 6 studies examining vitamin K status in COVID-19 patients showing that infected patients have significantly higher levels of dephosphorylated-uncarboxylated Matrix Gla Protein (dp-ucMGP), indicating lower vitamin K status.. | ||
Apr 7 |
et al., Scientific Reports, doi:10.1038/s41598-025-92242-y | Antiviral effect of Bromelain combined with acetylcysteine against SARS-CoV-2 Omicron variant |
| In Vitro and Ex Vivo study showing that BromAc (bromelain and N-acetylcysteine) exhibits antiviral activity against SARS-CoV-2 Omicron variant. Authors demonstrate that BromAc at 250 μg/mL significantly reduces infectious viral particles .. | ||
We aim to cover the most promising early treatments for
COVID-19. We use pre-specified effect extraction criteria that prioritizes
more serious outcomes, for details see methods. For specific
outcomes and different treatment stages see the individual pages. Not all
treatments are covered here, effectiveness has been reported for many other treatments in studies.
Of the 5,701 studies,
2,687 present results comparing with a control group,
2,470 are treatment studies, and
217 analyze outcomes based on serum levels. There are
109 animal studies,
216 in silico studies,
405 in vitro studies,
449 reviews,
and 238 meta analyses.
Please send us corrections, updates, or comments.
c19early involves the extraction of 100,000+ datapoints from
thousands of papers. Community updates
help ensure high accuracy.
Treatments and other interventions are complementary.
All practical, effective, and safe
means should be used based on risk/benefit analysis.
No treatment or intervention is 100% available and effective for all current
and future variants.
We do not provide medical advice. Before taking any medication,
consult a qualified physician who can provide personalized advice and details
of risks and benefits based on your medical history and situation. IMA and WCH
provide treatment protocols.
Thanks for your feedback! Please search before submitting papers and note
that studies are listed under the date they were first available, which may be
the date of an earlier preprint.