Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes
Chiodini et al.,
Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes,
Frontiers in Public Health, doi:10.3389/fpubh.2021.736665
Meta analysis concluding that "patients with low vitamin D levels present an increased risk of ARDS requiring admission to intensive care unit (ICU) or mortality due to SARS-CoV-2 infection and a higher susceptibility to SARS-CoV-2 infection and related hospitalization".
Currently there are
107 vitamin D studies and meta analysis shows:
Chiodini et al., 22 Dec 2021, peer-reviewed, 13 authors.
Abstract: SYSTEMATIC REVIEW
published: 22 December 2021
doi: 10.3389/fpubh.2021.736665
Vitamin D Status and SARS-CoV-2
Infection and COVID-19 Clinical
Outcomes
Iacopo Chiodini 1,2*† , Davide Gatti 3† , Davide Soranna 4 , Daniela Merlotti 5 ,
Christian Mingiano 5 , Angelo Fassio 3 , Giovanni Adami 3 , Alberto Falchetti 6 ,
Cristina Eller-Vainicher 7 , Maurizio Rossini 3 , Luca Persani 1,2 , Antonella Zambon 4,8 and
Luigi Gennari 5
1
Department of Endocrine and Metabolic Diseases, Istituto di Ricovero e Cura a Caratttere Scientifico (IRCCS), Istituto
Auxologico Italiano, Milan, Italy, 2 Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan,
Italy, 3 Rheumatology Unit, University of Verona, Verona, Italy, 4 Biostatistic Unit, Istituto di Ricovero e Cura a Caratttere
Scientifico (IRCCS), Istituto Auxologico Italiano, Milan, Italy, 5 Department of Medicine, Surgery and Neurosciences, University
of Siena, Siena, Italy, 6 Unit of Rehabilitation Medicine, San Giuseppe Hospital, Istituto di Ricovero e Cura a Caratttere
Scientifico (IRCCS), Istituto Auxologico Italiano, Piancavallo, Italy, 7 Unit of Endocrinology, Fondazione Istituto di Ricovero e
Cura a Caratttere Scientifico (IRCCS) Cà Granda, Milan, Italy, 8 Department of Statistics and Quantitative Methods, Università
di Milano-Bicocca, Milan, Italy
Edited by:
Yoav Keynan,
University of Manitoba, Canada
Reviewed by:
Naveen Kumar Devanga Ragupathi,
The University of Sheffield,
United Kingdom
William B. Grant,
Sunlight Nutrition and Health
Research Center, United States
*Correspondence:
Iacopo Chiodini
iacopo.chiodini@unimi.it
† These
authors have contributed
equally to this work
Specialty section:
This article was submitted to
Infectious Diseases - Surveillance,
Prevention and Treatment,
a section of the journal
Frontiers in Public Health
Received: 27 July 2021
Accepted: 11 November 2021
Published: 22 December 2021
Citation:
Chiodini I, Gatti D, Soranna D,
Merlotti D, Mingiano C, Fassio A,
Adami G, Falchetti A, Eller-Vainicher C,
Rossini M, Persani L, Zambon A and
Gennari L (2021) Vitamin D Status and
SARS-CoV-2 Infection and COVID-19
Clinical Outcomes.
Front. Public Health 9:736665.
doi: 10.3389/fpubh.2021.736665
Background: Several studies suggest an association between serum 25-hydroxyvitamin
D (25OHD) and the outcomes of Severe Acute Respiratory Syndrome Corona-Virus-2
(SARS-CoV-2) infection, in particular Coronavirus Disease-2019 (COVID-19) related
severity and mortality. The aim of the present meta-analysis was to investigate
whether vitamin D status is associated with the COVID-19 severity, defined as
ARDS requiring admission to intensive care unit (ICU) or mortality (primary endpoints)
and with the susceptibility to SARS-CoV-2 and COVID-19-related hospitalization
(secondary endpoints).
Methods: A search in PubMed, ScienceDirect, Web of Science, Google Scholar,
Scopus, and preprints repositories was performed until March 31th 2021 to identify
all original observational studies reporting association measures, or enough data to
calculate them, between Vitamin D status (insufficiency <75, deficiency <50, or severe
deficiency <25 nmol/L) and risk of SARS-CoV-2 infection, COVID-19 hospitalization, ICU
admission, or death during COVID-19 hospitalization.
Findings: Fifty-four studies (49 as fully-printed and 5 as pre-print publications) were
included for a total of 1,403,715 individuals. The association between vitamin D
status and SARS-CoV2 infection, COVID-19..
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