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All Studies   Meta Analysis    Recent:   

COVID-19 and Vitamin D (Co-VIVID Study): a systematic review and meta-analysis of randomized controlled trials

Varikasuvu et al., Expert Review of Anti-infective Therapy, doi:10.1080/14787210.2022.2035217
Aug 2021  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Meta analysis of 6 vitamin D treatment RCTs, showing statistically significant improvements for pooled outcomes and PCR positivity, and positive but not statistically significant improvements for mortality, mechanical ventilation, ICU admission, and severity.
14 meta analyses show significant improvements with vitamin D treatment for mortality Argano, Begum, D’Ecclesiis, Hariyanto, Hosseini, Jamilian, Nikniaz, Shah, Sobczak, Xie, mechanical ventilation Hariyanto, Meng, Shah, Xie, ICU admission Hariyanto, Hosseini, Meng, Sartini, Shah, Sobczak, Tentolouris, Xie, hospitalization Argano, severity D’Ecclesiis, Nikniaz, Varikasuvu, Xie, and cases Begum, Sartini, Varikasuvu.
Currently there are 120 vitamin D treatment for COVID-19 studies, showing 36% lower mortality [28‑43%], 16% lower ventilation [-7‑34%], 46% lower ICU admission [28‑60%], 19% lower hospitalization [9‑29%], and 17% fewer cases [9‑24%].
Varikasuvu et al., 25 Aug 2021, peer-reviewed, 7 authors.
This PaperVitamin DAll
COVID-19 and Vitamin D (Co-VIVID Study): a systematic review and meta-analysis of randomized controlled trials
Seshadri Reddy Varikasuvu, Balachandar Thangappazham, Hemanth Raj
doi:10.1101/2021.08.22.21262216
Background: Vitamin D levels have been reported to be associated with COVID-19 susceptibility, severity and mortality events.. We performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the use of vitamin D intervention on COVID-19 outcomes. Methods: Literature search was conducted using PubMed, Cochrane library, and ClinicalTrials.gov databases (latest search on August 5, 2021). We included RCTs reporting the use of vitamin D intervention to control/placebo group in COVID-19. Two independent researchers did literature search, abstracted data, and the risk of bias assessment. Results: A total of 6 RCTs with 551 COVID-19 patients were included. The overall collective evidence pooling all the outcomes across all RCTs indicated the beneficial use of vitamin D intervention in COVID-19 (relative risk, RR = 0.60, 95% CI 0.40 to 0.92, Z=2.33, p=0.02, I 2 = 48%). However, no statistical significance was observed for individual outcomes of ICU care (RR = 0.11, 95% CI 0.15 to 1.30, Z=1.48, p=0.14, I 2 = 66%) and mortality (RR = 0.78, 95% CI 0.25 to 2.40, Z=0.66, p=0.02, I 2 = 33%), though decreased rates were noted. The rates of RT-CR positivity was significantly decreased in the intervention group as compared to the non-vitamin D groups (RR = 0.46, 95% CI 0.24 to 0.89, Z=2.31, p=0.02, I 2 = 0%). Conclusion: COVID-19 patients supplemented with vitamin D are more likely to demonstrate fewer rates of ICU admission, mortality events and RT-PCR positivity. However, no statistical significance has been achieved for individual outcomes of ICU and deaths. More RCTs and completion of ongoing trials largely needed to precisely establish the association between vitamin D use and COVID-19.
Funding The costs involved in the conduction of this systematic review and meta-analysis were borne by the authors themselves. Declaration of Competing Interest The authors declare no conflict of interest.
References
Alsafar, Grant, Hijazi, Uddin, Alkaabi et al., COVID-19 disease severity and death in relation to vitamin D status among SARS-CoV-2-positive UAE residents, Nutrients, doi:10.3390/nu13051714
Am, Mj, Mk, Vitamin D Status Is Associated With In-Hospital Mortality and Mechanical Ventilation: A Cohort of COVID-19 Hospitalized Patients, Mayo Clin Proc, doi:10.1016/J.MAYOCP.2021.01.001
Bs, Rapid COVID-19 vaccine development, Science, doi:10.1126/SCIENCE.ABB8923
Da, Ca, Jd, Jf, Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials, Lancet Diabetes Endocrinol, doi:10.1016/S2213-8587(21)00051-6
Dtm, Lhc R, Chdc, Rb S, The possible benefits of vitamin D in COVID-19, Nutrition, doi:10.1016/J.NUT.2021.111356
Ec, Ec, Vb, Ad, Lm, Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study, J Steroid Biochem Mol Biol, doi:10.1016/J.JSBMB.2020.105751
Gv, Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets in Human Cells, Biomedicines, doi:10.3390/BIOMEDICINES8050129
Jac, Mj, Ns, RoB 2: a revised tool for assessing risk of bias in randomised trials, BMJ, doi:10.1136/BMJ.L4898
Kumar, Rathi, Haq, Wimalawansa, Sharma, Putative roles of vitamin D in modulating immune response and immunopathology associated with COVID-19, Virus Res, doi:10.1016/J.VIRUSRES.2020.198235
Lakkireddy, Gadiga, Malathi, Karra, Raju et al., Impact of daily high dose oral vitamin D therapy on the inflammatory markers in patients with COVID 19 disease, Sci Rep, doi:10.1038/s41598-021-90189-4
Lips, Vitamin D to prevent acute respiratory infections, Lancet Diabetes Endocrinol, doi:10.1016/S2213-8587(21)00075-9
Moher, Liberati, Tetzlaff, Altman, Altman et al., Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement, PLoS Med, doi:10.1371/journal.pmed.1000097
Mpw, Vitamin-D levels and intensive care unit outcomes of a cohort of critically ill COVID-19 patients, Clin Chem Lab Med, doi:10.1515/CCLM-2020-1567
Murai, Fernandes, Sales, Pinto, Goessler et al., Effect of a Single High Dose of Vitamin D3on Hospital Length of Stay in Patients with Moderate to Severe COVID-19: A Randomized Clinical Trial, JAMA -J Am Med Assoc, doi:10.1001/jama.2020.26848
Mv, Tv, Ia, Sa, Vp, Low Circulating Vitamin D in Intensive Care Unit-Admitted COVID-19 Patients as a Predictor of Negative Outcomes, J Nutr, doi:10.1093/JN/NXAB107
Oa N, Shedding light on vitamin D: the shared mechanistic and pathophysiological role between hypovitaminosis D and COVID-19 risk factors and complications, Inflammopharmacology, doi:10.1007/S10787-021-00835-6
Phf, Vitamin D and Infectious Diseases: Simple Bystander or Contributing Factor?, Nutrients, doi:10.3390/NU9070651
Pl, Therapeutic and prognostic role of vitamin D for COVID-19 infection: A systematic review and meta-analysis of 43 observational studies, J Steroid Biochem Mol Biol, doi:10.1016/J.JSBMB.2021.105883
Rastogi, Bhansali, Khare, Suri, Yaddanapudi et al., Short term, high-dose vitamin D supplementation for COVID-19 disease: A randomised, placebocontrolled, study (SHADE study), Postgrad Med J, doi:10.1136/postgradmedj-2020-139065
Rj, Vitamin D and coronavirus disease 2019 (COVID-19): rapid evidence review, Aging Clin Exp Res, doi:10.1007/S40520-021-01894-Z
Rm, Mj, Sg, Jp, Predicting the extent of heterogeneity in meta-analysis, using empirical data from the Cochrane Database of Systematic Reviews, Int J Epidemiol, doi:10.1093/IJE/DYS041
Rr, Tl, An update on the association of vitamin D deficiency with common infectious diseases, Can J Physiol Pharmacol, doi:10.1139/CJPP-2014-0352
Sabico, Enani, Sheshah, Aljohani, Aldisi et al., Effects of a 2-week 5000 iu versus 1000 iu vitamin d3 supplementation on recovery of symptoms in patients with mild to moderate covid-19: A randomized clinical trial, Nutrients, doi:10.3390/nu13072170
Sk, Aging & COVID-19 susceptibility, disease severity, and clinical outcomes: The role of entangled risk factors, Exp Gerontol, doi:10.1016/J.EXGER.2021.111507
Sm, The interplay between vitamin D and viral infections, Rev Med Virol, doi:10.1002/RMV.2032
Sánchez-Zuno, González-Estevez, Matuz-Flores, Macedo-Ojeda, Hernández-Bello et al., Vitamin D Levels in COVID-19 Outpatients from Western Mexico: Clinical Correlation and Effect of Its Supplementation, J Clin Med, doi:10.3390/jcm10112378
Wb, Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity, Nutrients, doi:10.3390/NU12113361
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WHO Coronavirus (COVID-19) Dashboard | WHO Coronavirus (COVID-19) ' 'Dashboard With Vaccination Data n.d. https://covid19.who.int/ (accessed ' 'August 6, 2021).'}, { 'DOI': '10.1016/j.exger.2021.111507', 'doi-asserted-by': 'crossref', 'key': 'cit0002', 'unstructured': '2. Farshbafnadi M, Kamali Zonouzi S, Sabahi M, Dolatshahi M, Aarabi MH. ' 'Aging & COVID-19 susceptibility, disease severity, and clinical ' 'outcomes: The role of entangled risk factors. Exp Gerontol. ' '2021;154:111507.'}, { 'DOI': '10.1139/cjpp-2014-0352', 'doi-asserted-by': 'crossref', 'key': 'cit0003', 'unstructured': '3. Watkins RR, Lemonovich TL, Salata RA. An update on the association of ' 'vitamin D deficiency with common infectious diseases. Can J Physiol ' 'Pharmacol. 2015;93(5):363-8.'}, { 'DOI': '10.1016/j.nut.2021.111356', 'doi-asserted-by': 'crossref', 'key': 'cit0004', 'unstructured': '4. Brito DTM, Ribeiro LHC, Daltro CHDC, Silva RB. The possible benefits ' 'of vitamin D in COVID-19. Nutrition. 2021;91-92:111356.'}, { 'DOI': '10.3390/biomedicines8050129', 'doi-asserted-by': 'crossref', 'key': 'cit0005', 'unstructured': '5. Glinsky GV. Tripartite Combination of Candidate Pandemic Mitigation ' 'Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of ' 'Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic ' 'Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets in Human Cells. ' 'Biomedicines. 2020;8(5):129.'}, { 'DOI': '10.3390/nu9070651', 'doi-asserted-by': 'crossref', 'key': 'cit0006', 'unstructured': '6. Gois PHF, Ferreira D, Olenski S, Seguro AC. Vitamin D and Infectious ' 'Diseases: Simple Bystander or Contributing Factor? Nutrients. ' '2017;9(7):651.'}, { 'DOI': '10.3390/nu13051714', 'doi-asserted-by': 'crossref', 'key': 'cit0007', 'unstructured': '7. AlSafar H, Grant WB, Hijazi R, Uddin M, Alkaabi N, Tay G, et al. ' 'COVID-19 Disease Severity and Death in Relation to Vitamin D Status ' 'among SARS-CoV-2-Positive UAE Residents. Nutrients. 2021;13(5):1714.'}, { 'DOI': '10.1002/rmv.2119', 'doi-asserted-by': 'crossref', 'key': 'cit0008', 'unstructured': '8. Malek Mahdavi A. A brief review of interplay between vitamin D and ' 'angiotensin-converting enzyme 2: Implications for a potential treatment ' 'for COVID-19. Rev Med Virol. 2020;30(5):e2119.'}, { 'DOI': '10.2217/imt-2020-0349', 'doi-asserted-by': 'crossref', 'key': 'cit0009', 'unstructured': '9. Pinheiro MM, Fabbri A, Infante M. Cytokine storm modulation in ' 'COVID-19: a proposed role for vitamin D and DPP-4 inhibitor combination ' 'therapy (VIDPP-4i). Immunotherapy. 2021;13(9):753-65.'}, { 'DOI': '10.1126/science.abb8923', 'doi-asserted-by': 'crossref', 'key': 'cit0010', 'unstructured': '10. Graham BS. Rapid COVID-19 vaccine development. Science. ' '2020;368(6494):945-6.'}, { 'DOI': '10.1515/cclm-2020-1567', 'doi-asserted-by': 'crossref', 'key': 'cit0011', 'unstructured': '11. Orchard L, Baldry M, Nasim-Mohi M, et al. Vitamin-D levels and ' 'intensive care unit outcomes of a cohort of critically ill COVID-19 ' 'patients. Clin Chem Lab Med. 2021;59(6):1155-63.'}, { 'DOI': '10.1016/j.mayocp.2021.01.001', 'doi-asserted-by': 'crossref', 'key': 'cit0012', 'unstructured': '12. Angelidi AM, Belanger MJ, Lorinsky MK, et al. Vitamin D Status Is ' 'Associated With In-Hospital Mortality and Mechanical Ventilation: A ' 'Cohort of COVID-19 Hospitalized Patients. Mayo Clin Proc. ' '2021;96(4):875-86.'}, { 'DOI': '10.1093/jn/nxab107', 'doi-asserted-by': 'crossref', 'key': 'cit0013', 'unstructured': '13. Bychinin MV, Klypa TV, Mandel IA, et al. Low Circulating Vitamin D ' 'in Intensive Care Unit-Admitted COVID-19 Patients as a Predictor of ' 'Negative Outcomes. J Nutr. 2021;151(8):2199-205.'}, { 'DOI': '10.1080/07315724.2021.1877580', 'doi-asserted-by': 'crossref', 'key': 'cit0014', 'unstructured': '14. Infante M, Buoso A, Pieri M, et al. Low Vitamin D Status at ' 'Admission as a Risk Factor for Poor Survival in Hospitalized Patients ' 'With COVID-19: An Italian Retrospective Study. J Am Coll Nutr. 2021. ' 'doi: 10.1080/07315724.2021.1877580.'}, { 'key': 'cit0015', 'unstructured': '15. Infante M, Pieri M, Lupisella S, et al. Low testosterone levels and ' 'high estradiol to testosterone ratio are associated with ' 'hyperinflammatory state and mortality in hospitalized men with COVID-19. ' 'Eur Rev Med Pharmacol Sci. 2021;25(19):5889-903.'}, { 'DOI': '10.1186/s12879-021-06281-7', 'doi-asserted-by': 'crossref', 'key': 'cit0016', 'unstructured': '16. Campi I, Gennari L, Merlotti D, et al. Vitamin D and COVID-19 ' 'severity and related mortality: a prospective study in Italy. BMC Infect ' 'Dis. 2021;21(1):566.'}, { 'DOI': '10.3390/nu12113361', 'doi-asserted-by': 'crossref', 'key': 'cit0017', 'unstructured': '17. Mercola J, Grant WB, Wagner CL. Evidence Regarding Vitamin D and ' 'Risk of COVID-19 and Its Severity. Nutrients. 2020;12(11):3361.'}, { 'DOI': '10.1016/j.jsbmb.2021.105883', 'doi-asserted-by': 'crossref', 'key': 'cit0018', 'unstructured': '18. Petrelli F, Luciani A, Perego G, Dognini G, Colombelli PL, Ghidini ' 'A. Therapeutic and prognostic role of vitamin D for COVID-19 infection: ' 'A systematic review and meta-analysis of 43 observational studies. J ' 'Steroid Biochem Mol Biol. 2021;211:105883.'}, { 'key': 'cit0019', 'unstructured': '19. Velikova T, Fabbri A, Infante M. The role of vitamin D as a ' 'potential adjuvant for COVID-19 vaccines. Eur Rev Med Pharmacol Sci. ' '2021;25(17):5323-7.'}, { 'DOI': '10.3390/ijms22168988', 'doi-asserted-by': 'crossref', 'key': 'cit0020', 'unstructured': '20. Chiu SK, Tsai KW, Wu CC, et al. Putative Role of Vitamin D for ' 'COVID-19 Vaccination. Int J Mol Sci. 2021;22(16):8988.'}, { 'DOI': '10.1016/j.jsbmb.2020.105751', 'doi-asserted-by': 'crossref', 'key': 'cit0021', 'unstructured': '21. Castillo EM, Entrenas Costa LM, Vaquero Barrios JM, et al. “Effect ' 'of calcifediol treatment and best available therapy versus best ' 'available therapy on intensive care unit admission and mortality among ' 'patients hospitalized for COVID-19: A pilot randomized clinical study”. ' 'J Steroid Biochem Mol Biol. 2020;203:105751.'}, { 'DOI': '10.1038/s41598-021-90189-4', 'doi-asserted-by': 'crossref', 'key': 'cit0022', 'unstructured': '22. Lakkireddy M, Gadiga SG, Malathi RD, et al. Impact of daily high ' 'dose oral vitamin D therapy on the inflammatory markers in patients with ' 'COVID 19 disease. Sci Rep. 2021;11(1):10641.'}, { 'DOI': '10.1001/jama.2020.26848', 'doi-asserted-by': 'crossref', 'key': 'cit0023', 'unstructured': '23. Murai IH, Fernandes AL, Sales LP, et al. Effect of a Single High ' 'Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate ' 'to Severe COVID-19: A Randomized Clinical Trial. JAMA. ' '2021;325(11):1053-1060.'}, { 'DOI': '10.1136/postgradmedj-2020-139065', 'doi-asserted-by': 'crossref', 'key': 'cit0024', 'unstructured': '24. Rastogi A, Bhansali A, Khare N, et al. Short term, high-dose vitamin ' 'D supplementation for COVID-19 disease: a randomised, ' 'placebo-controlled, study (SHADE study). Postgrad Med J. ' '2020:postgradmedj-2020-139065. doi: 10.1136/postgradmedj-2020-139065.25. ' 'Sabico S, Enani MA, Sheshah E, et al. Effects of a 2-Week 5000 IU versus ' '1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients ' 'with Mild to Moderate Covid-19: A Randomized Clinical Trial. Nutrients. ' '2021;13(7):2170.'}, { 'DOI': '10.3390/jcm10112378', 'doi-asserted-by': 'crossref', 'key': 'cit0025', 'unstructured': '26. Sánchez-Zuno GA, González-Estevez G, Matuz-Flores MG, et al. Vitamin ' 'D Levels in COVID-19 Outpatients from Western Mexico: Clinical ' 'Correlation and Effect of Its Supplementation. J Clin Med. ' '2021;10:2378.'}, { 'DOI': '10.1371/journal.pmed.1000097', 'doi-asserted-by': 'crossref', 'key': 'cit0026', 'unstructured': '27. Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred ' 'reporting items for systematic reviews and meta-analyses: the PRISMA ' 'statement. PLoS Med. 2009;6(7):e1000097.'}, { 'DOI': '10.1136/bmj.l4898', 'doi-asserted-by': 'crossref', 'key': 'cit0027', 'unstructured': '28. Sterne JAC, Savović J, Page MJ, et al. RoB 2: a revised tool for ' 'assessing risk of bias in randomised trials. BMJ. 2019;366:l4898.'}, { 'DOI': '10.1093/ije/dys041', 'doi-asserted-by': 'crossref', 'key': 'cit0028', 'unstructured': '29. Turner RM, Davey J, Clarke MJ, Thompson SG, Higgins JP. Predicting ' 'the extent of heterogeneity in meta-analysis, using empirical data from ' 'the Cochrane Database of Systematic Reviews. Int J Epidemiol. ' '2012;41(3):818-27.'}, { 'DOI': '10.1002/rmv.2032', 'doi-asserted-by': 'crossref', 'key': 'cit0029', 'unstructured': '30. Teymoori-Rad M, Shokri F, Salimi V, Marashi SM. The interplay ' 'between vitamin D and viral infections. Rev Med Virol. ' '2019;29(2):e2032.'}, { 'DOI': '10.1136/thorax-2020-BTSabstracts.105', 'doi-asserted-by': 'crossref', 'key': 'cit0030', 'unstructured': '31. Jolliffe DA, Camargo CA Jr, Sluyter JD, et al. Vitamin D ' 'supplementation to prevent acute respiratory infections: a systematic ' 'review and meta-analysis of aggregate data from randomised controlled ' 'trials. Lancet Diabetes Endocrinol. 2021;9(5):276-292.'}, { 'DOI': '10.1016/S2213-8587(21)00075-9', 'doi-asserted-by': 'crossref', 'key': 'cit0031', 'unstructured': '32. Lips P. Vitamin D to prevent acute respiratory infections. Lancet ' 'Diabetes Endocrinol. 2021;9(5):249-251.'}, { 'DOI': '10.1007/s10787-021-00835-6', 'doi-asserted-by': 'crossref', 'key': 'cit0032', 'unstructured': '33. Menshawey E, Menshawey R, Nabeh OA. Shedding light on vitamin D: the ' 'shared mechanistic and pathophysiological role between hypovitaminosis D ' 'and COVID-19 risk factors and complications. Inflammopharmacology. ' '2021;29(4):1017-1031.'}, { 'DOI': '10.1016/j.virusres.2020.198235', 'doi-asserted-by': 'crossref', 'key': 'cit0033', 'unstructured': '34. Kumar R, Rathi H, Haq A, Wimalawansa SJ, Sharma A. Putative roles of ' 'vitamin D in modulating immune response and immunopathology associated ' 'with COVID-19. Virus Res. 2021;292:198235.'}, { 'DOI': '10.1007/s40520-021-01894-z', 'doi-asserted-by': 'crossref', 'key': 'cit0034', 'unstructured': '35. Raisi-Estabragh Z, Martineau AR, Curtis EM, et al. Vitamin D and ' 'coronavirus disease 2019 (COVID-19): rapid evidence review. Aging Clin ' 'Exp Res. 2021;33(7):2031-41.'}], 'reference-count': 34, 'references-count': 34, 'relation': {}, 'score': 1, 'short-container-title': ['Expert Review of Anti-infective Therapy'], 'short-title': [], 'source': 'Crossref', 'subject': ['Virology', 'Infectious Diseases', 'Microbiology (medical)', 'Microbiology'], 'subtitle': [], 'title': [ 'COVID-19 and Vitamin D (Co-VIVID Study): a systematic review and meta-analysis of randomized ' 'controlled trials'], 'type': 'journal-article', 'update-policy': 'http://dx.doi.org/10.1080/tandf_crossmark_01'}
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