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All Studies   Meta Analysis    Recent:   

The Role of Vitamin D in COVID-19 Survival and Prevention: A Meta-analysis

Begum et al., Sudan Journal of Medical Sciences, doi:10.18502/sjms.v19i1.15776
Mar 2024  
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Mortality 57% Improvement Relative Risk Case 48% Vitamin D for COVID-19  Begum et al.  META ANALYSIS c19early.org Favorsvitamin D Favorscontrol 0 0.5 1 1.5 2+
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 98 treatments. c19early.org
Meta analysis of 16 studies including over 5.9 million patients showing significantly lower mortality and cases with vitamin D treatment.
19 meta analyses show significant improvements with vitamin D treatment for mortality1-14, mechanical ventilation1,6,7,12,15,16, ICU admission1,3,6,7,10,12,14-18, hospitalization5,12, severity2,4,6,11,19, and cases8,18,19.
Currently there are 122 vitamin D treatment for COVID-19 studies, showing 36% lower mortality [28‑43%], 19% lower ventilation [-3‑36%], 45% lower ICU admission [28‑58%], 19% lower hospitalization [9‑29%], and 17% fewer cases [9‑24%].
risk of death, 56.7% lower, OR 0.43, p < 0.001, inverted to make OR<1 favor treatment, RR approximated with OR.
risk of case, 47.9% lower, OR 0.52, p = 0.046, inverted to make OR<1 favor treatment, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Begum et al., 29 Mar 2024, peer-reviewed, 2 authors.
This PaperVitamin DAll
The Role of Vitamin D in COVID-19 Survival and Prevention: A Meta-analysis
Shamina Begum, Hyder Osman Mirghani, Prof Elmalaika Nazik, Seid Ahmed Obaid, MD, M.Sc Husain
doi:10.18502/sjms.v19i1.15776
Background: COVID-19 is still ongoing with frequently discovered new strains, although vaccines are highly effective for prevention. Literature on vitamin D supplementation in COVID-19 prevention and its effect on survival is scarce. This meta-analysis assessed the role of vitamin D supplementation in COVID-19 prevention and survival. Methods: Four databases (Web of Science, SCOPUS, PubMed, MEDLINE, and the first 100 articles of Google Scholar) were searched for articles published up to September 2023. The keywords used were COVID-19, mortality, vitamin D supplementation, calcitriol, cholecalciferol, Calcifediol, survival, death, and prevention. Six hundred and seven studies were retrieved, and four hundred and three remained after duplication removal; of them eighty-three full texts were screened, and of them, only sixteen (prospective, randomized controlled trials, and retrospective studies) were included in the final meta-analysis. Results: Sixteen observational studies including 5905,109 patients and 186,500 events were included. Vitamin D supplementation reduced mortality among patients with odd ratio, 2.31, 95% CI,; in addition, supplementation was effective in COVID-19 prevention, odd ratio, 1.92, 95% CI, 1.01-3.64. Conclusion: Vitamin D supplementation prevented COVID-19 and increased survival among patients admitted with moderate/severe COVID-19.
Ethical Considerations The authors did not include any manuscript published by them. Competing Interests None
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