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0 0.5 1 1.5 2+ Mortality 57% Improvement Relative Risk Case 48% Vitamin D for COVID-19  Begum et al.  META ANALYSIS Favors vitamin D Favors control

The Role of Vitamin D in COVID-19 Survival and Prevention: A Meta-analysis

Begum et al., Sudan Journal of Medical Sciences, doi:10.18502/sjms.v19i1.15776
Mar 2024  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Meta analysis of 16 studies including over 5.9 million patients showing significantly lower mortality and cases with vitamin D treatment.
12 meta analyses show significant improvements with vitamin D treatment for mortality Argano, Begum, D’Ecclesiis, Hariyanto, Hosseini, Nikniaz, Shah, Xie, mechanical ventilation Hariyanto, Meng, Shah, Xie, ICU admission Hariyanto, Hosseini, Meng, Sartini, Shah, Tentolouris, Xie, hospitalization Argano, severity D’Ecclesiis, Nikniaz, Varikasuvu, Xie, and cases Begum, Sartini, Varikasuvu.
Currently there are 120 vitamin D treatment for COVID-19 studies, showing 36% lower mortality [28‑43%], 16% lower ventilation [-7‑34%], 46% lower ICU admission [28‑60%], 19% lower hospitalization [9‑29%], and 17% fewer cases [9‑24%].
risk of death, 56.7% lower, OR 0.43, p < 0.001, inverted to make OR<1 favor treatment, RR approximated with OR.
risk of case, 47.9% lower, OR 0.52, p = 0.046, inverted to make OR<1 favor treatment, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Begum et al., 29 Mar 2024, peer-reviewed, 2 authors.
This PaperVitamin DAll
The Role of Vitamin D in COVID-19 Survival and Prevention: A Meta-analysis
Shamina Begum, Hyder Osman Mirghani, Prof Elmalaika Nazik, Seid Ahmed Obaid, MD, M.Sc Husain
Background: COVID-19 is still ongoing with frequently discovered new strains, although vaccines are highly effective for prevention. Literature on vitamin D supplementation in COVID-19 prevention and its effect on survival is scarce. This meta-analysis assessed the role of vitamin D supplementation in COVID-19 prevention and survival. Methods: Four databases (Web of Science, SCOPUS, PubMed, MEDLINE, and the first 100 articles of Google Scholar) were searched for articles published up to September 2023. The keywords used were COVID-19, mortality, vitamin D supplementation, calcitriol, cholecalciferol, Calcifediol, survival, death, and prevention. Six hundred and seven studies were retrieved, and four hundred and three remained after duplication removal; of them eighty-three full texts were screened, and of them, only sixteen (prospective, randomized controlled trials, and retrospective studies) were included in the final meta-analysis. Results: Sixteen observational studies including 5905,109 patients and 186,500 events were included. Vitamin D supplementation reduced mortality among patients with odd ratio, 2.31, 95% CI,; in addition, supplementation was effective in COVID-19 prevention, odd ratio, 1.92, 95% CI, 1.01-3.64. Conclusion: Vitamin D supplementation prevented COVID-19 and increased survival among patients admitted with moderate/severe COVID-19.
Ethical Considerations The authors did not include any manuscript published by them. Competing Interests None
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