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0 0.5 1 1.5 2+ Mortality 89% Improvement Relative Risk Annweiler et al. Vitamin D for COVID-19 EARLY Is early treatment with vitamin D beneficial for COVID-19? Retrospective 66 patients in France Lower mortality with vitamin D (p=0.0019) Annweiler et al., The J. Steroid Biochemistry an.., doi:10.1016/j.jsbmb.2020.105771 Favors vitamin D Favors control

Vitamin D and survival in COVID-19 patients: A quasi-experimental study

Annweiler et al., The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2020.105771
Annweiler et al., Vitamin D and survival in COVID-19 patients: A quasi-experimental study, The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2020.105771
Oct 2020   Source   PDF  
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Vitamin D3 supplementation during or just before COVID-19 was associated with 68% lower mortality and less severe COVID-19 in frail elderly.
Retrospective 66 French nursing home residents, mean age 87.7, 9 control patients, and 57 that received an oral bolus of 80,000 IU vitamin D3 either in the week following the suspicion or diagnosis of COVID-19, or during the previous month. 17.5% mortality in the treatment group and 55.6% in the control group.
This is the 4th of 111 COVID-19 controlled studies for vitamin D, which collectively show efficacy with p<0.0000000001 (1 in 49 sextillion). 27 studies are RCTs, which show efficacy with p=0.00002.
risk of death, 89.0% lower, RR 0.11, p = 0.002, treatment 10 of 57 (17.5%), control 5 of 9 (55.6%), NNT 2.6, adjusted per study.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Annweiler et al., 13 Oct 2020, retrospective, France, peer-reviewed, mean age 87.7, 6 authors, dosage 80,000IU single dose, 80,000IU either in the week following the suspicion or diagnosis of COVID-19, or during the previous month.
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This PaperVitamin DAll
Vitamin D and survival in COVID-19 patients: A quasi-experimental study
Cédric Annweiler, Bérangère Hanotte, Claire Grandin De L’eprevier, Jean-Marc Sabatier, Ludovic Lafaie, Thomas Célarier
The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2020.105771
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
Authors contribution -CA has full access to all of the data in the study, takes responsibility for the data, the analyses and interpretation and has the right to publish any and all data, separate and apart from the attitudes of the sponsors. All authors have read and approved the manuscript. Declaration of Competing Interest The authors report no declarations of interest.
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