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0 0.5 1 1.5 2+ Mortality 7% Improvement Relative Risk Death/ICU 17% ICU admission 55% Hospitalization 15% Vitamin D for COVID-19  Mendy et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 689 patients in the USA Lower death/ICU (p=0.001) and ICU admission (p=0.008) Mendy et al., medRxiv, June 2020 Favors vitamin D Favors control

Factors Associated with Hospitalization and Disease Severity in a Racially and Ethnically Diverse Population of COVID-19 Patients

Mendy et al., medRxiv, doi:10.1101/2020.06.25.20137323
Jun 2020  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Retrospective 689 patients showing vitamin D deficiency associated with hospitalization and disease severity.
This is the 3rd of 196 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 11,637 vigintillion).
risk of death, 7.0% lower, RR 0.93, p = 0.89, high D levels 21 of 600 (3.5%), low D levels 5 of 89 (5.6%), inverted to make RR<1 favor high D levels, odds ratio converted to relative risk.
risk of death/ICU, 16.7% lower, RR 0.83, p < 0.001, high D levels 68 of 600 (11.3%), low D levels 23 of 89 (25.8%), NNT 6.9, inverted to make RR<1 favor high D levels, odds ratio converted to relative risk.
risk of ICU admission, 55.3% lower, RR 0.45, p = 0.008, high D levels 47 of 600 (7.8%), low D levels 18 of 89 (20.2%), NNT 8.1, inverted to make RR<1 favor high D levels, odds ratio converted to relative risk.
risk of hospitalization, 15.1% lower, RR 0.85, p < 0.001, high D levels 171 of 600 (28.5%), low D levels 45 of 89 (50.6%), NNT 4.5, inverted to make RR<1 favor high D levels, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mendy et al., 27 Jun 2020, retrospective, USA, preprint, 4 authors.
This PaperVitamin DAll
Factors Associated with Hospitalization and Disease Severity in a Racially and Ethnically Diverse Population of COVID-19 Patients
MD Angelico Mendy, Senu Apewokin, Anjanette A Wells, Ardythe L Morrow
Disclosures: Authors declare no relationship with industry or other relevant entities that might pose a conflict of interest in connection with the submitted article. Author Contributions: AM contributed to the study concept and design, analysis and interpretation of data, and writing of the manuscript. SA, AAW, and ALM contributed to the interpretation of data and writing of the manuscript. AM takes full responsibility for the integrity of the dataset and the analysis results.
Abbreviations: IQR, interquartile range COPD, chronic obstructive pulmonary disease; N, number of participants in subgroups. P-values for difference calculated using Wilcoxon rank tests.
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