Factors Associated with Hospitalization and Disease Severity in a Racially and Ethnically Diverse Population of COVID-19 Patients
et al., medRxiv, doi:10.1101/2020.06.25.20137323 (Preprint)
, Factors Associated with Hospitalization and Disease Severity in a Racially and Ethnically Diverse Population.., medRxiv, doi:10.1101/2020.06.25.20137323 (Preprint)
Retrospective 689 patients showing vitamin D deficiency associated with hospitalization and disease severity.This is the 3rd of 175 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 18 vigintillion).
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risk of death, 7.0% lower, RR 0.93, p = 0.89, high D levels 21 of 600 (3.5%), low D levels 5 of 89 (5.6%), inverted to make RR<1 favor high D levels, odds ratio converted to relative risk.
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risk of death/ICU, 16.7% lower, RR 0.83, p < 0.001, high D levels 68 of 600 (11.3%), low D levels 23 of 89 (25.8%), NNT 6.9, inverted to make RR<1 favor high D levels, odds ratio converted to relative risk.
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risk of ICU admission, 55.3% lower, RR 0.45, p = 0.008, high D levels 47 of 600 (7.8%), low D levels 18 of 89 (20.2%), NNT 8.1, inverted to make RR<1 favor high D levels, odds ratio converted to relative risk.
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risk of hospitalization, 15.1% lower, RR 0.85, p < 0.001, high D levels 171 of 600 (28.5%), low D levels 45 of 89 (50.6%), NNT 4.5, inverted to make RR<1 favor high D levels, odds ratio converted to relative risk.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Mendy et al., 27 Jun 2020, retrospective, USA, preprint, 4 authors.
Factors Associated with Hospitalization and Disease Severity in a Racially and Ethnically Diverse Population of COVID-19 Patients
doi:10.1101/2020.06.25.20137323
Disclosures: Authors declare no relationship with industry or other relevant entities that might pose a conflict of interest in connection with the submitted article. Author Contributions: AM contributed to the study concept and design, analysis and interpretation of data, and writing of the manuscript. SA, AAW, and ALM contributed to the interpretation of data and writing of the manuscript. AM takes full responsibility for the integrity of the dataset and the analysis results.
Abbreviations: IQR, interquartile range COPD, chronic obstructive pulmonary disease; N, number of participants in subgroups. P-values for difference calculated using Wilcoxon rank tests.
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