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Perspective: Vitamin D supplementation prevents rickets and acute respiratory infections when given as daily maintenance but not as intermittent bolus: implications for COVID-19

Griffin et al., Clinical Medicine, doi:10.7861/clinmed.2021-0035
Mar 2021  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Review of evidence showing that low-dose daily vitamin D supplementation is more effective than intermittent high-dose bolus for preventing various conditions, with a plausible biological mechanism. Bolus treatment may be less effective than daily treatment because high-dose bolus vitamin D may induce a long-lasting increase in the catabolizing enzyme 24-hydroxylase and in fibroblast growth factor 23 (FGF23), both of which have vitamin D inactivating effects. 24-hydroxylase activity can remain elevated for several weeks after bolus dosing, paradoxically leading to reduced levels of activated vitamin D. FGF23 increases progressively for at least 3 months after a large bolus dose and suppresses activation of vitamin D.
Griffin et al., 31 Mar 2021, peer-reviewed, 8 authors.
This PaperVitamin DAll
Perspective: Vitamin D supplementation prevents rickets and acute respiratory infections when given as daily maintenance but not as intermittent bolus: implications for COVID-19
George Griffin, Martin Hewison, Julian Hopkin, Rose Anne Kenny, Richard Quinton, Jonathan Rhodes, Sreedhar Subramanian, David Thickett
Clinical Medicine, doi:10.7861/clinmed.2021-0035
The value of vitamin D supplementation in the treatment or prevention of various conditions is often viewed with scepticism as a result of contradictory results of randomised trials. It is now becoming apparent that there is a pattern to these inconsistencies. A recent large trial has shown that high-dose intermittent bolus vitamin D therapy is ineffective at preventing rickets -the condition that is most unequivocally caused by vitamin D deficiency. There is a plausible biological explanation since high-dose bolus replacement induces long-term expression of the catabolic enzyme 24-hydroxylase and fibroblast growth factor 23, both of which have vitamin D inactivating effects. Meta-analyses of vitamin D supplementation in prevention of acute respiratory infection and trials in tuberculosis and other conditions also support efficacy of low dose daily maintenance rather than intermittent bolus dosing. This is particularly relevant during the current COVID-19 pandemic given the well-documented associations between COVID-19 risk and vitamin D deficiency. We would urge that clinicians take note of these findings and give strong support to widespread use of daily vitamin D supplementation.
Conflicts of interest Martin Hewison and David Thickett have received speaking honoraria from Thornton Ross.
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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