Vitamin A and D deficiencies in the prognosis of respiratory tract infections: A systematic review with perspectives for COVID-19 and a critical analysis on supplementation
Andrade et al.,
Vitamin A and D deficiencies in the prognosis of respiratory tract infections: A systematic review with..,
SciELO preprints, doi:10.1590/SciELOPreprints.839 (Review)
Systematic review showing deficiencies of vitamins A and D negatively affecting the prognosis of respiratory tract infections.
Andrade et al., 24 Jun 2020, peer-reviewed, 6 authors.
Abstract: Vitamin A and D deficiencies in the prognosis of respiratory tract infections: A
systematic review with perspectives for COVID-19 and a critical analysis on
supplementation
Vitamin A and D deficiencies: Perspectives for COVID-19
Maria Izabel Siqueira de Andradea (ORCID: 0000-0003-1087-1320)
Patrícia Fortes Cavalcanti de Macêdob (ORCID: 0000-0002-2728-0431)
Tafnes Laís Pereira Santos de Oliveirac (ORCID: 0000-0002-5904-8557)
Niedja Maria da Silva Limad (ORCID: 0000-0002-5185-1636)
Isabella da Costa Ribeiroc (ORCID: 0000-0002-3817-2073)
Thayná Menezes Santosd (ORCID: 0000-0002-2920-2373)
aFederal
University of Alagoas, Faculty of Nutrition, Brazil, ZIP Code: 57072-900,
author’s email: andrademizabel@gmail.com
bFederal
University of Bahia, Brazil, School of Nutrition, ZIP Code: 40110-907, author’s
email: macedopatriciafortes@gmail.com
cFederal
University of Pernambuco, Health Sciences Center, Brazil, ZIP Code: 50670-
901, author’s email: tafnes_lais@hotmail.com; isabella_ribeiro12@hotmail.com
dFederal
University of Pernambuco, Academic Center of Vitoria, Brazil, ZIP Code:
55608-250, author’s email: niedjanutricionista@gmail.com; thay.meenezes@gmail.com
Correspondence:
Maria Izabel Siqueira de Andrade. Faculty of Nutrition, Department of Nutrition, Campus
A.C. Simões, Lourival Melo Mota Avenue, ZIP Code: 57072-900, Maceió, AL, Brazil.
Email: andrademizabel@gmail.com. Telephone number: +55 81 99894 3348.
Conflict of Interests: The authors report the non-existence of any kind of conflict of
interests.
Financial Support: The authors did not receive any financial support.
Individual Collaboration: Maria Izabel Siqueira de Andrade: study design,
bibliographic search, database construction, data analysis, interpretation of results,
writing, review and approval of the final version of the manuscript. Patrícia Fortes
Cavalcanti de Macêdo: study design, bibliographic search, database construction, data
analysis, interpretation of results, writing, review and approval of the final version of the
manuscript. Tafnes Laís Pereira Santos de Oliveira: study design, bibliographic search,
database construction, data analysis, interpretation of results, writing, review and
approval of the final version of the manuscript. Niedja Maria da Silva Lima: study
design, bibliographic search, database construction, data analysis, review and approval of
the final version. Isabella da Costa Ribeiro: data analysis, writing, review and approval
of the final version of the manuscript. Thayná Menezes Santos: bibliographic search,
data analysis, review and approval of the final version.
ABSTRACT
OBJECTIVE: Considering the rapid spread of COVID-19, the scientific community has
been looking for ways to recognize factors that may interfere with the outcome of viral
infection. Despite the lack of studies with the new coronavirus, it is known that adequate
serum levels of micronutrients are essential for the organic response to infectious
diseases. Thus, we aim to review the effects of vitamin A, D, iron, zinc, or folate
deficiency on the prognosis of patients with respiratory infections with manifestations
similar to COVID-19 and discuss about supplementation of the nutrients analyzed in this
review. METHODS: The search was conducted in the databases PubMed, Lilacs, and
SciELO, including observational studies published between 2010-2020, with results for
individuals with respiratory tract infections with manifestations similar to COVID-19.
RESULTS: Six articles..
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