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Vitamin D and COVID‐19: How much more evidence do we need?

Kow et al., Nutrition in Clinical Practice, doi:10.1002/ncp.11349, Jul 2025
https://c19early.org/kow11.html
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020, now with p < 0.00000000001 from 126 studies, recognized in 18 countries.
No treatment is 100% effective. Protocols combine treatments.
5,900+ studies for 173 treatments. c19early.org
Discussion of clinical evidence supporting vitamin D treatment for COVID‑19. Authors highlight Vasconcelos et al. showing reduced all‑cause mortality, and cite their own systematic review and meta‑analysis of 19 RCTs that found a significant mortality reduction2. They argue that RCT findings, along with vitamin D’s immunomodulatory and anti‑inflammatory actions, render further confirmatory trials unnecessary and expose an ethical inconsistency in delaying adoption when costlier, risk‑laden COVID‑19 therapies entered practice on slimmer evidence. Emphasising vitamin D’s safety, affordability, and the high prevalence of deficiency, authors call on clinicians and policymakers to integrate treatment as a standard adjunctive therapy while future work fine‑tunes dosing and administration.
Reviews covering vitamin D for COVID-19 include3-41.
Kow et al., 6 Jul 2025, peer-reviewed, 3 authors.
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High‐dose vitamin D supplementation in patients with severe acute respiratory syndrome coronavirus 2 pneumonia hospitalized in a polyvalent intensive care unit: a retrospective cohort study [published online ahead of print Published online February 19] 2025.Nutr Clin Pract.doi:10.1002/ncp.11277" }, { "DOI": "10.1007/s10787-024-01564-2", "article-title": "The impact of vitamin D administration on mortality in COVID‐19 patients: a systematic review and meta‐analysis of randomized controlled trials", "author": "Kow CS", "doi-asserted-by": "crossref", "first-page": "3205", "issue": "5", "journal-title": "Inflammopharmacology", "key": "e_1_2_1_5_3_1", "volume": "32", "year": "2024" }, { "DOI": "10.3390/nu12061626", "article-title": "Vitamin D supplementation in influenza and COVID‐19 infections comment on: “Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID‐19 Infections and Deaths” nutrients 2020, 12(4), 988", "author": "Kow CS", "doi-asserted-by": "crossref", "first-page": "1626", "issue": "6", "journal-title": "Nutrients", "key": "e_1_2_1_5_4_1", "volume": "12", "year": "2020" }, { "DOI": "10.1002/jmv.26832", "article-title": "Vitamin D deficiency is associated with COVID‐19 positivity and severity of the disease", "author": "Demir M", "doi-asserted-by": "crossref", "first-page": "2992", "issue": "5", "journal-title": "J Med Virol", "key": "e_1_2_1_5_5_1", "volume": "93", "year": "2021" }, { "DOI": "10.1093/jac/dkad275", "article-title": "Is molnupiravir a wise investment? Reassessing COVID‐19 treatment strategies", "author": "Kow CS", "doi-asserted-by": "crossref", "first-page": "2779", "issue": "11", "journal-title": "J Antimicrob Chemother", "key": "e_1_2_1_5_6_1", "volume": "78", "year": "2023" } ], "reference-count": 5, "references-count": 5, "relation": {}, "resource": { "primary": { "URL": "https://aspenjournals.onlinelibrary.wiley.com/doi/10.1002/ncp.11349" } }, "score": 1, "short-container-title": [ "Nut in Clin Prac" ], "short-title": [], "source": "Crossref", "subject": [], "subtitle": [], "title": [ "Vitamin D and COVID‐19: How much more evidence do we need?" ], "type": "journal-article", "update-policy": "https://doi.org/10.1002/crossmark_policy" }
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