Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity
Joseph Mercola, William B Grant, Carol L Wagner
Nutrients, doi:10.3390/nu12113361
Vitamin D deficiency co-exists in patients with COVID-19. At this time, dark skin color, increased age, the presence of pre-existing illnesses and vitamin D deficiency are features of severe COVID disease. Of these, only vitamin D deficiency is modifiable. Through its interactions with a multitude of cells, vitamin D may have several ways to reduce the risk of acute respiratory tract infections and COVID-19: reducing the survival and replication of viruses, reducing risk of inflammatory cytokine production, increasing angiotensin-converting enzyme 2 concentrations, and maintaining endothelial integrity. Fourteen observational studies offer evidence that serum 25-hydroxyvitamin D concentrations are inversely correlated with the incidence or severity of COVID-19. The evidence to date generally satisfies Hill's criteria for causality in a biological system, namely, strength of association, consistency, temporality, biological gradient, plausibility (e.g., mechanisms), and coherence, although experimental verification is lacking. Thus, the evidence seems strong enough that people and physicians can use or recommend vitamin D supplements to prevent or treat COVID-19 in light of their safety and wide therapeutic window. In view of public health policy, however, results of large-scale vitamin D randomized controlled trials are required and are currently in progress.
References
Abhimanyu, Coussens, The role of UV radiation and vitamin D in the seasonality and outcomes of infectious disease, Photochem. Photobiol. Sci,
doi:10.1039/C6PP00355AAnnweiler, Hanotte, De L'eprevier, Sabatier, Lafaie et al., Vitamin D and survival in COVID-19 patients: A quasi-experimental study, J. Steroid Biochem. Mol. Biol,
doi:10.1016/j.jsbmb.2020.105771Autier, Mullie, Macacu, Dragomir, Boniol et al., Effect of vitamin D supplementation on non-skeletal disorders: A systematic review of meta-analyses and randomised trials, Lancet Diabetes Endocrinol,
doi:10.1016/S2213-8587(17)30357-1Baktash, Hosack, Patel, Shah, Kandiah et al., Vitamin D status and outcomes for hospitalised older patients with COVID-19, Postgrad. Med. J
Bang, Novovic, Andersen, Fenger, Hansen et al., Variations in Serum 25-Hydroxyvitamin D during Acute Pancreatitis: An Exploratory Longitudinal Study, Endocr. Res,
doi:10.3109/07435800.2011.554937Barlow, Findlay, Currie, Davidson, Antiviral potential of cathelicidins, Futur. Microbiol,
doi:10.2217/fmb.13.135Beard, Bearden, Striker, Vitamin D and the anti-viral state, J. Clin. Virol
Belančić, Kresović, Rački, Potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity, Obes. Med,
doi:10.1016/j.obmed.2020.100259Benne, Kraaijeveld, Van Strijp, Brouwer, Harmsen et al., Interactions of Surfactant Protein a with Influenza A Viruses: Binding and Neutralization, J. Infect. Dis,
doi:10.1093/infdis/171.2.335Bertoldo, Pancheri, Zenari, Boldini, Giovanazzi et al., Serum 25-hydroxyvitamin D levels modulate the acute-phase response associated with the first nitrogen-containing bisphosphonate infusion, J. Bone Miner. Res,
doi:10.1359/jbmr.090819Bhaskar, Sinha, Banach, Mittoo, Weissert et al., Cytokine Storm in COVID-19-Immunopathological Mechanisms, Clinical Considerations, and Therapeutic Approaches: The REPROGRAM Consortium Position Paper, Front. Immunol,
doi:10.3389/fimmu.2020.01648Bombardini, Picano, Angiotensin-Converting Enzyme 2 as the Molecular Bridge between Epidemiologic and Clinical Features of COVID-19, Can. J. Cardiol,
doi:10.1016/j.cjca.2020.03.026Cannell, Vieth, Willett, Zasloff, Hathcock et al., Cod Liver Oil, Vitamin A Toxicity, Frequent Respiratory Infections, and the Vitamin D Deficiency Epidemic, Ann. Otol. Rhinol. Laryngol,
doi:10.1177/000348940811701112Carpagnano, Di Lecce, Quaranta, Zito, Buonamico et al., Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19, J. Endocrinol. Investig,
doi:10.1007/s40618-020-01370-xCaspi, Altman, Dreher, Fulcher, Subhraveti et al., The metacyc database of metabolic pathways and enzymes and the biocyc collection of pathway/genome databases, Nucleic Acids Res,
doi:10.1093/nar/gkr1014Castillo, Costa, Barrios, Díaz, Miranda et al., Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study, J. Steroid Biochem. Mol. Biol,
doi:10.1016/j.jsbmb.2020.105751Chibuzor, Graham-Kalio, Osaji, Meremikwu, Vitamin D, calcium or a combination of vitamin D and calcium for the treatment of nutritional rickets in children, Cochrane Database Syst. Rev,
doi:10.1002/14651858.cd012581.pub2Cook, Kursumovie, Lennane, Exclusive, Deaths of NHS staff from covid-19 analysed, Health Serv. J
Coussens, Timms, Boucher, Venton, Ashcroft et al., 1α,25-dihydroxyvitamin D3inhibits matrix metalloproteinases induced byMycobacterium tuberculosisinfection, Immunology,
doi:10.1111/j.1365-2567.2008.03024.xCrane-Godreau, Clem, Payne, Fiering, Vitamin D Deficiency and Air Pollution Exacerbate COVID-19 through Suppression of Antiviral Peptide LL37, Front. Public Health,
doi:10.3389/fpubh.2020.00232Crowe, Steur, Allen, Appleby, Travis et al., Plasma concentrations of 25-hydroxyvitamin D in meat eaters, fish eaters, vegetarians and vegans: Results from the EPIC-Oxford study, Public Health Nutr,
doi:10.1017/S1368980010002454Cui, Xu, Li, Qiao, Han et al., Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: Role of renin-angiotensin system, Redox Biol
D'avolio, Avataneo, Manca, Cusato, De Nicolo et al., 25-hydroxyvitamin d concentrations are lower in patients with positive pcr for sars-cov-2, Nutrients,
doi:10.3390/nu12051359Davey, Mcauley, O'kane, Matrix metalloproteinases in acute lung injury: Mediators of injury and drivers of repair, Eur. Respir. J,
doi:10.1183/09031936.00032111Dürr, Sudheendra, Ramamoorthy, LL-37, the only human member of the cathelicidin family of antimicrobial peptides, Biochim. Biophys. Acta (BBA) Biomembr,
doi:10.1016/j.bbamem.2006.03.030Fara, Mitrev, Mitrev, Assas, Cytokine storm and COVID-19: A chronicle of pro-inflammatory cytokines, Open Biol,
doi:10.1098/rsob.200160France, Heatmap: Covid-19 Incidence per 100,000 Inhabitants by Age Group
Ganmaa, Uyanga, Zhou, Gantsetseg, Delgerekh et al., Vitamin D Supplements for Prevention of Tuberculosis Infection and Disease, N. Engl. J. Med,
doi:10.1056/NEJMoa1915176Garattini, Jakobsen, Wetterslev, Bertele, Banzi et al., Evidence-based clinical practice: Overview of threats to the validity of evidence and how to minimise them, Eur. J. Intern. Med,
doi:10.1016/j.ejim.2016.03.020Garvin, Alvarez, Miller, Prates, Walker et al., A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm, eLife,
doi:10.7554/eLife.59177Gemmati, Bramanti, Serino, Secchiero, Zauli et al., COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-Chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males?, Int. J. Mol. Sci,
doi:10.3390/ijms21103474Gimenez, Inserra, Ferder, Garcia, Manucha, Vitamin d deficiency in african americans is associated with a high risk of severe disease and mortality by Sars-Cov-2, J. Hum. Hypertens,
doi:10.1038/s41371-020-00398-zGombart, Pierre, Maggini, A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection, Nutrients,
doi:10.3390/nu12010236Goodall, Granados, Luinstra, Pullenayegum, Coleman et al., Vitamin D3and gargling for the prevention of upper respiratory tract infections: A randomized controlled trial, BMC Infect. Dis,
doi:10.1186/1471-2334-14-273Grant, Al Anouti, Moukayed, Targeted 25-hydroxyvitamin D concentration measurements and vitamin D3 supplementation can have important patient and public health benefits, Eur. J. Clin. Nutr,
doi:10.1038/s41430-020-0564-0Grant, Boucher, Bhattoa, Lahore, Why vitamin D clinical trials should be based on 25-hydroxyvitamin D concentrations, J. Steroid Biochem. Mol. Biol,
doi:10.1016/j.jsbmb.2017.08.009Grant, Lahore, Mcdonnell, Baggerly, French et al., Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths, Nutrients,
doi:10.3390/nu12040988Grant, Mcdonnell, Statistical error in Vitamin d concentrations and covid-19 infection in UK Biobank, Diabetes Metab. Syndr. Clin. Res. Rev,
doi:10.1016/j.dsx.2020.05.046Haidich, Meta-analysis in medical research, Hippokratia
Hanff, O'harhay, Brown, Cohen, Mohareb, Is There an Association Between COVID-19 Mortality and the Renin-Angiotensin System? A Call for Epidemiologic Investigations, Clin. Infect. Dis,
doi:10.1093/cid/ciaa329Hastie, Mackay, Ho, Celis-Morales, Katikireddi et al., Vitamin D concentrations and COVID-19 infection in UK Biobank, Diabetes Metab. Syndr. Clin. Res. Rev,
doi:10.1016/j.dsx.2020.04.050Heaney, Guidelines for optimizing design and analysis of clinical studies of nutrient effects, Nutr. Rev,
doi:10.1111/nure.12090Henríquez, Romero, Cholecalciferol or Calcifediol in the Management of Vitamin D Deficiency, Nutrients,
doi:10.3390/nu12061617Hill, The Environment and Disease: Association or Causation?, Proc. R. Soc. Med
Ianevski, Zusinaite, Shtaida, Kallio-Kokko, Valkonen et al., Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010-2018, Viruses,
doi:10.3390/v11030207Iddir, Brito, Dingeo, Del Campo, Samouda et al., Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis, Nutrients,
doi:10.3390/nu12061562Ilahi, Armas, Heaney, Pharmacokinetics of a single, large dose of cholecalciferol, Am. J. Clin. Nutr,
doi:10.1093/ajcn/87.3.688Im, Je, Baek, Chung, Kwon et al., Nutritional status of patients with coronavirus disease 2019 (covid-19), Int. J. Infect. Dis,
doi:10.1016/j.ijid.2020.08.018Iwasaki, Saito, Zhao, Sakamoto, Hirota et al., Inflammation triggered by sars-cov-2 and ace2 augment drives multiple organ failure of severe covid-19: Molecular mechanisms and implications, Inflammation,
doi:10.1007/s10753-020-01337-3Jolliffe, Griffiths, Martineau, Vitamin D in the prevention of acute respiratory infection: Systematic review of clinical studies, J. Steroid Biochem. Mol. Biol,
doi:10.1016/j.jsbmb.2012.11.017Junaid, Ejaz, Abdalla, Abosalif, Ullah et al., Effective immune functions of micronutrients against Sars-Cov-2, Nutrients,
doi:10.3390/nu12102992Kanikarla-Marie, Jain, 1,25(OH) 2 D 3 inhibits oxidative stress and monocyte adhesion by mediating the upregulation of GCLC and GSH in endothelial cells treated with acetoacetate (ketosis), J. Steroid Biochem. Mol. Biol,
doi:10.1016/j.jsbmb.2016.03.002Kara, Ekiz, Ricci, Kara, Chang et al., Scientific Strabismus' or two related pandemics: Coronavirus disease and vitamin D deficiency, Br. J. Nutr,
doi:10.1017/S0007114520001749Kaufman, Niles, Kroll, Bi, Holick, SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels, PLoS ONE,
doi:10.1371/journal.pone.0239252Korber, Fischer, Gnanakaran, Yoon, Theiler et al., Tracking changes in sars-cov-2 spike: Evidence that d614g increases infectivity of the covid-19 virus, Cell,
doi:10.1016/j.cell.2020.06.043Kox, Waalders, Kooistra, Gerretsen, Pickkers, Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions, JAMA,
doi:10.1001/jama.2020.17052Krishnan, Ochola, Mundy, Jones, Kruger et al., Acute fluid shifts influence the assessment of serum vitamin D status in critically ill patients, Crit. Care,
doi:10.1186/cc9341Krishnan, Trump, Johnson, Feldman, The role of vitamin D in cancer prevention and treatment, Endocrinol. Metab. Clin. N. Am,
doi:10.1016/j.ecl.2010.02.011Kroll, Bi, Garber, Kaufman, Liu et al., Temporal Relationship between Vitamin D Status and Parathyroid Hormone in the United States, PLoS ONE,
doi:10.1371/journal.pone.0118108Kumar, Gupta, Banerjee, Letter: Does vitamin d have a potential role against Covid-19?, Aliment. Pharmacol. Ther,
doi:10.1111/apt.15801Laaksi, Ruohola, Tuohimaa, Auvinen, Haataja et al., An association of serum vitamin D concentrations < 40 nmol/L with acute respiratory tract infection in young Finnish men, Am. J. Clin. Nutr,
doi:10.1093/ajcn/86.3.714Lahore, Covid-19 Intervention Trial Summary
Leikina, Delanoe-Ayari, Melikov, Cho, Chen et al., Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins, Nat. Immunol,
doi:10.1038/ni1248Levine, Whitsett, Hartshorn, Crouch, Korfhagen, Surfactant Protein D Enhances Clearance of Influenza A Virus from the Lung In Vivo, J. Immunol,
doi:10.4049/jimmunol.167.10.5868Li, Qiao, Uskokovic, Xiang, Zheng et al., A negative endocrine regulator of the renin-angiotensin system and blood pressure, J. Steroid Biochem. Mol. Biol,
doi:10.1016/j.jsbmb.2004.03.004Li, Reeves, Wang, Bassat, Brooks et al., Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: A systematic analysis, Lancet Glob. Health
Li, Wang, Nair, Global Seasonality of Human Seasonal Coronaviruses: A Clue for Postpandemic Circulating Season of Severe Acute Respiratory Syndrome Coronavirus 2?, J. Infect. Dis
Lin, Zhao, Zhou, Zhou, Xu, Coronavirus disease 2019 (COVID-19): Cytokine storms, hyper-inflammatory phenotypes, and acute respiratory distress syndrome, Genes Dis,
doi:10.1016/j.gendis.2020.06.009Macaya, Paeres, Valls, Fernández-Ortiz, Del Castillo et al., Interaction between age and vitamin D deficiency in severe COVID-19 infection, Nutrición Hospitalaria,
doi:10.20960/nh.03193Mahdavi, A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19, Rev. Med. Virol,
doi:10.1002/rmv.2119Manson, Cook, Lee, Christen, Bassuk et al., Vitamin d supplements and prevention of cancer and cardiovascular disease, N. Engl. J. Med,
doi:10.1056/NEJMoa1809944Manson, Crooks, Naja, Ledlie, Goulden et al., COVID-19-associated hyperinflammation and escalation of patient care: A retrospective longitudinal cohort study, Lancet Rheumatol,
doi:10.1016/S2665-9913(20)30275-7Martineau, Jolliffe, Demaret, Vitamin D and Tuberculosis, Vitamin D
Martineau, Jolliffe, Greenberg, Aloia, Bergman et al., Vitamin D supplementation to prevent acute respiratory infections: Individual participant data meta-analysis, Health Technol. Assess,
doi:10.3310/hta23020Mcelvaney, Mcevoy, Mcelvaney, Carroll, Murphy et al., Characterization of the Inflammatory Response to Severe COVID-19
Meftahi, Jangravi, Sahraei, Bahari, The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: The contribution of "inflame-aging, Inflamm. Res,
doi:10.1007/s00011-020-01372-8Meltzer, Best, Zhang, Vokes, Arora et al., Association of Vitamin D Status and Other Clinical Characteristics with COVID-19 Test Results, JAMA Netw. Open,
doi:10.1001/jamanetworkopen.2020.19722Merad, Martin, Pathological inflammation in patients with COVID-19: A key role for monocytes and macrophages, Nat. Rev. Immunol,
doi:10.1038/s41577-020-0331-4Merzon, Tworowski, Gorohovski, Vinker, Cohen et al., Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: An Israeli population-based study, FEBS J,
doi:10.1111/febs.15495Morris, Bortolasci, Puri, Olive, Marx et al., The pathophysiology of sars-cov-2: A suggested model and therapeutic approach, Life Sci,
doi:10.1016/j.lfs.2020.118166Murthi, Davies-Tuck, Lappas, Singh, Mockler et al., Maternal 25-hydroxyvitamin D is inversely correlated with foetal serotonin, Clin. Endocrinol,
doi:10.1111/cen.13281Newens, Filteau, Tomkins, Plasma 25-hydroxyvitamin D does not vary over the course of a malarial infection, Trans. R. Soc. Trop. Med. Hyg,
doi:10.1016/j.trstmh.2005.06.022Panagiotou, Tee, Ihsan, Athar, Marchitelli et al., Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalised with COVID-19 are associated with greater disease severity: Results of a local audit of practice, Clin. Endocrinol,
doi:10.1111/cen.14276Panfili, Roversi, D'argenio, Rossi, Cappa et al., Possible role of vitamin D in Covid-19 infection in pediatric population, J. Endocrinol. Investig,
doi:10.1007/s40618-020-01327-0Park, Kwon, Choi, Kang, Choe et al., Virus isolation from the first patient with sars-cov-2 in korea, J. Korean Med. Sci
Parlak, Ertürk, Ça G, Sebin, Gümüşdere, The effect of inflammatory cytokines and the level of vitamin D on prognosis in Crimean-Congo hemorrhagic fever, Int. J. Clin. Exp. Med
Phillips, Park, Robinson, Jones, The Perfect Storm: COVID-19 Health Disparities in US Blacks, J. Racial Ethn. Health Disparities,
doi:10.1007/s40615-020-00871-yPhokela, Peleg, Moya, Alcorn, Regulation of human pulmonary surfactant protein gene expression by 1α,25-dihydroxyvitamin D3, Am. J. Physiol. Cell. Mol. Physiol
Pittas, Dawson-Hughes, Sheehan, Ware, Knowler et al., Vitamin D Supplementation and Prevention of Type 2 Diabetes, N. Engl. J. Med,
doi:10.1056/NEJMoa1900906Pizzini, Aichner, Sahanic, Böhm, Egger et al., Impact of Vitamin D Deficiency on COVID-19-A Prospective Analysis from the CovILD Registry, Nutrients,
doi:10.3390/nu12092775Pérez, Nieto, Martínez-Cuazitl, Mercado, Tort, La deficiencia de vitamina D es un factor de riesgo de mortalidad en pacientes con COVID-19, Rev. Sanid. Mil,
doi:10.35366/93773Qin, Zhou, Hu, Zhang, Yang et al., Dysregulation of Immune Response in Patients with Coronavirus 2019 (COVID-19) in Wuhan, China, Clin. Infect. Dis,
doi:10.1093/cid/ciaa248Quesada-Gomez, Castillo, Bouillon, Vitamin d receptor stimulation to reduce acute respiratory distress syndrome (ards) in patients with Coronavirus sars-cov-2 infections: Revised ms sbmb 2020_166, J. Steroid Biochem. Mol. Biol,
doi:10.1016/j.jsbmb.2020.105719Radujkovic, Hippchen, Tiwari-Heckler, Dreher, Boxberger et al., Vitamin D Deficiency and Outcome of COVID-19 Patients, Nutrients,
doi:10.3390/nu12092757Reid, Toole, Knox, Talwar, Harten et al., The relation between acute changes in the systemic inflammatory response and plasma 25-hydroxyvitamin D concentrations after elective knee arthroplasty, Am. J. Clin. Nutr
Rejnmark, Bislev, Cashman, Eiríksdottir, Gaksch et al., Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data, PLoS ONE,
doi:10.1371/journal.pone.0180512Rondanelli, Miccono, Lamburghini, Avanzato, Riva et al., Self-Care for Common Colds: The Pivotal Role of Vitamin D, Vitamin C, Zinc, and Echinacea in Three Main Immune Interactive Clusters (Physical Barriers, Innate and Adaptive Immunity) Involved during an Episode of Common Colds-Practical Advice on Dosages and on the Time to Take These Nutrients/Botanicals in order to Prevent or Treat Common Colds, Evid.-Based Complement. Altern. Med,
doi:10.1155/2018/5813095Ross, Manson, Abrams, Aloia, Brannon et al., Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know, J. Clin. Endocrinol. Metab,
doi:10.1210/jc.2010-2704Ross, Manson, Abrams, Aloia, Brannon et al., The 2011 dietary reference intakes for calcium and vitamin d: What dietetics practitioners need to know, J. Am. Diet. Assoc,
doi:10.1016/j.jada.2011.01.004Roy, Matson, Herlekar, Response to 'vitamin d concentrations and covid-19 infection in uk biobank, Diabetes Metab. Syndr,
doi:10.1016/j.dsx.2020.05.049Rusciano, Bagnoli, Galeazzi, The fight against covid-19: The role of drugs and food supplements, J. Pharm. Pharm. Res
Speeckaert, Delanghe, Association between low vitamin D and COVID-19: Don't forget the vitamin D binding protein, Aging Clin. Exp. Res,
doi:10.1007/s40520-020-01607-yStrickland, Powell-Young, Reyes-Miranda, Alzaghari, Giger, African-americans have a higher propensity for death from covid-19: Rationale and causation, J. Natl. Black Nurses Assoc
Swaminathan, Magnesium Metabolism and its Disorders, Clin. Biochem. Rev
Timms, Mannan, Hitman, Noonan, Mills et al., Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: Mechanisms for inflammatory damage in chronic disorders?, QJM Int. J. Med,
doi:10.1093/qjmed/95.12.787Ueland, Holter, Holten, Müller, Lind et al., Distinct and early increase in circulating MMP-9 in COVID-19 patients with respiratory failure, J. Infect,
doi:10.1016/j.jinf.2020.06.061Urashima, Segawa, Okazaki, Kurihara, Wada et al., Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren, Am. J. Clin. Nutr,
doi:10.3945/ajcn.2009.29094Uwitonze, Razzaque, Role of Magnesium in Vitamin D Activation and Function, J. Am. Osteopat. Assoc,
doi:10.7556/jaoa.2018.037Valcour, Blocki, Hawkins, Rao, Effects of Age and Serum 25-OH-Vitamin D on Serum Parathyroid Hormone Levels, J. Clin. Endocrinol. Metab,
doi:10.1210/jc.2012-2276Webb, Peltan, Jensen, Hoda, Hunter et al., Clinical criteria for covid-19-associated hyperinflammaotry syndrome: A cohort study, Lancet Rheumatol,
doi:10.1016/S2665-9913(20)30343-XXu, Yang, Chen, Luo, Zhang et al., Vitamin D alleviates lipopolysaccharide-induced acute lung injury via regulation of the renin-angiotensin system, Mol. Med. Rep,
doi:10.3892/mmr.2017.7546Ye, Tang, Liao, Shaw, Deng et al., Does Serum Vitamin D Level Affect COVID-19 Infection and Its Severity?-A Case-Control Study, J. Am. Coll. Nutr,
doi:10.1080/07315724.2020.1826005Yehia, Winegar, Fogel, Fakih, Ottenbacher et al., Association of Race With Mortality Among Patients Hospitalized With Coronavirus Disease 2019 (COVID-19) at 92 US Hospitals, JAMA Netw. Open,
doi:10.1001/jamanetworkopen.2020.18039Zhang, Mccullough, Tecson, Vitamin D deficiency in association with endothelial dysfunction: Implications for patients withCOVID-19, Rev. Cardiovasc. Med,
doi:10.31083/j.rcm.2020.03.131Zhang, Niu, Meta-analysis of randomized controlled trials on vitamin D supplement and cancer incidence and mortality, Biosci. Rep,
doi:10.1042/BSR20190369Zhang, Tecson, Mccullough, Endothelial dysfunction contributes to COVID-19-associated vascular inflammation and coagulopathy, Rev. Cardiovasc. Med,
doi:10.31083/j.rcm.2020.03.126Zheng, Yang, Hu, Li, Wang et al., Vitamin d attenuates lung injury via stimulating epithelial repair, reducing epithelial cell apoptosis and inhibits tgf-beta induced epithelial to mesenchymal transition, Biochem. Pharmacol
Zhou, Yang, Chi, Dong, Lv et al., Comorbidities and the risk of severe or fatal outcomes associated with coronavirus disease 2019: A systematic review and meta-analysis, Int. J. Infect. Dis,
doi:10.1016/j.ijid.2020.07.029Zisi, Challa, Makis, The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood, Hormones,
doi:10.1007/s42000-019-00155-zZittermann, Ernst, Birschmann, Dittrich, Effect of Vitamin D or Activated Vitamin D on Circulating 1,25-Dihydroxyvitamin D Concentrations: A Systematic Review and Metaanalysis of Randomized Controlled Trials, Clin. Chem,
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