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Interaction between age and vitamin D deficiency in severe COVID-19 infection

Macaya et al., Nutr. Hosp., doi:10.20960/nh.03193
Oct 2020  
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Severe case 55% Improvement Relative Risk Vitamin D for COVID-19  Macaya et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 80 patients in Spain Lower severe cases with higher vitamin D levels (not stat. sig., p=0.07) c19early.org Macaya et al., Nutr. Hosp., October 2020 Favorsvitamin D Favorscontrol 0 0.5 1 1.5 2+
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020, now with p < 0.00000000001 from 125 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments.
5,300+ studies for 116 treatments. c19early.org
Retrospective 80 hospitalized patients in Spain showing higher risk of severe COVID-19 with vitamin D deficiency.
This is the 21st of 214 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 4,225,339,384 vigintillion).
risk of severe case, 55.0% lower, RR 0.45, p = 0.07, high D levels 11 of 35 (31.4%), low D levels 20 of 45 (44.4%), NNT 7.7, inverted to make RR<1 favor high D levels, odds ratio converted to relative risk, >20ng/mL.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Macaya et al., 21 Oct 2020, retrospective, Spain, peer-reviewed, 8 authors.
This PaperVitamin DAll
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Aging and the Immune System: the Impact of Immunosenescence on Viral Infection, Immunity and Vaccine Immunogenicity. Immune Network [Internet] 2019 [cited 2020 Apr 26]. Available from: https://synapse.koreamed.org/DOIx.php?id=10.4110/in.2019.19.e37" }, { "DOI": "10.1016/j.endinu.2016.11.002", "doi-asserted-by": "crossref", "key": "ref20", "unstructured": "Varsavsky M, Rozas Moreno P, Becerra Fernández A, Luque Fernández I, Quesada Gómez JM, Ávila Rubio V, et al. Recomendaciones de vitamina D para la población general. Endocrinología, Diabetes y Nutrición 2017;64:7-14." } ], "reference-count": 20, "references-count": 20, "relation": {}, "resource": { "primary": { "URL": "https://www.nutricionhospitalaria.org/articles/03193/show" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [ "Nutrition and Dietetics", "Medicine (miscellaneous)" ], "subtitle": [], "title": "Interaction between age and vitamin D deficiency in severe COVID-19 infection", "type": "journal-article" }
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