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25-hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2

D'Avolio et al., Nutrients, 12:5, 1–7, doi:10.3390/nu12051359
May 2020  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Retrospective 107 patients in Switzerland showing lower vitamin D levels (11.1 ng/mL) in PCR positive patients compared with negative patients (24.6 ng/mL), p = 0.004.
D'Avolio et al., 9 May 2020, peer-reviewed, 8 authors.
This PaperVitamin DAll
25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2
Antonio D’avolio, Valeria Avataneo, Alessandra Manca, Jessica Cusato, Amedeo De Nicolò, Renzo Lucchini, Franco Keller, Marco Cantù
Nutrients, doi:10.3390/nu12051359
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), with a clinical outcome ranging from mild to severe, including death. To date, it is unclear why some patients develop severe symptoms. Many authors have suggested the involvement of vitamin D in reducing the risk of infections; thus, we retrospectively investigated the 25-hydroxyvitamin D (25(OH)D) concentrations in plasma obtained from a cohort of patients from Switzerland. In this cohort, significantly lower 25(OH)D levels (p = 0.004) were found in PCR-positive for SARS-CoV-2 (median value 11.1 ng/mL) patients compared with negative patients (24.6 ng/mL); this was also confirmed by stratifying patients according to age >70 years. On the basis of this preliminary observation, vitamin D supplementation might be a useful measure to reduce the risk of infection. Randomized controlled trials and large population studies should be conducted to evaluate these recommendations and to confirm our preliminary observation.
Conflicts of Interest: The authors declare that they have no conflict of interest and no competing financial interests. Disclaimer: PHASE I AIFA, UNI EN ISO 9001 and 13485 Certificate Laboratory; Certificate No. IT-64386 and DM/17/154/S; Certification for: "Design, development and application of determination methods for clinical analytes and drugs, also with reference to in vitro dyagnostics. pharmacogenetic analyses." and "Design and development and application of quantification and detection methods of clinical analytes and drugs, finalized to the production of in vitro diagnostics" www.tdm-torino.org.
References
Arihiro, Nakashima, Matsuoka, Suto, Uchiyama et al., Randomized Trial of Vitamin D Supplementation to Prevent Seasonal Influenza and Upper Respiratory Infection in Patients With Inflammatory Bowel Disease, Inflamm. Bowel Dis, doi:10.1093/ibd/izy346
Fu, Wang, Yuan, Chen, Ao et al., Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis, J. Infect, doi:10.1016/j.jinf.2020.03.041
Grant, Lahore, Mcdonnell, Baggerly, French et al., Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths, Nutrients, doi:10.3390/nu12040988
Kakodkar, Kaka, Baig, A Comprehensive Literature Review on the Clinical Presentation, and Management of the Pandemic Coronavirus Disease 2019 (COVID-19), Cureus, doi:10.7759/cureus.7560
Mccartney, Byrne, Optimisation of Vitamin D Status for Enhanced Immuno-protection Against Covid-19, Ir. Med. J
Molloy, Murphy, Vitamin, Covid-19 and Children, Ir. Med. J
Panarese, Shahini, Letter: Covid-19, and vitamin D, Aliment. Pharmacol. Ther, doi:10.1111/apt.15752
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