Conv. Plasma
Nigella Sativa

All vitamin D studies
Meta analysis
study COVID-19 treatment researchVitamin DVitamin D (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 62% Improvement Relative Risk Vitamin D  Reyes Pérez et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 172 patients in Mexico Lower mortality with higher vitamin D levels (p=0.0062) Reyes Pérez et al., Revista de Sanidad.., Apr 2020 Favors vitamin D Favors control

Deficiency of vitamin D is a risk factor of mortality in patients with COVID-19

Reyes Pérez et al., Revista de Sanidad Militar, doi:10.35366/93773
Apr 2020  
  Source   PDF   All   Meta
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments.
Retrospective 172 hospitalized COVID-19 patients in Mexico, reporting a very high prevalence of vitamin D deficiency, and significantly higher mortality with low vitamin D levels in unadjusted results.
This is the 2nd of 196 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 11,637 vigintillion).
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of death, 61.7% lower, RR 0.38, p = 0.006, high D levels (≥8ng/mL) 21 of 137 (15.3%), low D levels (<8ng/mL) 14 of 35 (40.0%), NNT 4.1, inverted to make RR<1 favor high D levels (≥8ng/mL), odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Reyes Pérez et al., 30 Apr 2020, retrospective, Mexico, peer-reviewed, 5 authors. Contact:
This PaperVitamin DAll
La deficiencia de vitamina D es un factor de riesgo de mortalidad en pacientes con COVID-19
Rocío Adriana Reyes Pérez, Ana Victoria Puente Nieto, Adriana Martínez-Cuazitl, Edgardo Alonso Montelongo Mercado, Arturo Rodríguez Tort
Revista de Sanidad Militar, doi:10.35366/93773
Introduction: At this moment COVID-19 disease has no specific treatment and there is no vaccine available. This disease has an elevated morbidity-mortality not only in Mexico but worldwide, and it is the reason why it's essential to study factors that could modulate the course of the disease; the role of vitamin D seems to have a fundamental role in immunity when we talk about respiratory infections. Objective: Determine the association between vitamin D levels and mortality in hospitalized patients with COVID-19 at the Hospital Central Militar México. Material and methods: This study included 172 patients diagnosed with COVID-19 whom serum levels of vitamin 25-(OH)-D were determined. Considering as a case the patients who died from COVID-19 and control patients who survived. Results: Vitamin 25-(OH)-D serum levels in hospitlized patients with COVID-19 were 16.54 ± 7.22 ng/mL. The 95.92% presented vitamin D levels below the ideal range. Patients with vitamin D serum levels bellow 8 ng/mL had 3.68 higher risk of dying from COVID-19. Conclusion: Patients with COVID-19 who require hospitalization were deficient in vitamin D and their serum levels were bellow 8 ng/mL. This is considered a risk factor and therefore increases mortality in the disease caused by COVID-19, reason enough to take several actions such as oral suplementation in order to improve vitamin D serum levels.
Amrein, Scherkl, Hoffmann, Neuwersch, Köstenberger et al., Vitamin D deficiency 2.0: an update on the current status worldwide, Eur J Clin Nutr, doi:10.1038/s41430-020-0558-y
Cannell, Vieth, Umhau, Epidemic influenza and vitamin D, Epidemiol Infect, doi:10.1017/S0950268806007175
Cruz, Cervantes, Juárez, COVID-19, a worldwide public health emergency
Cui, Xu, Li, Qiao, Han et al., Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: Role of renin-angiotensin system, Redox Biol, doi:10.1016/j.redox.2019.101295
Grant, Lahore, Mcdonnell, Baggerly, Francés et al., Evidencia de que la suplementación con vitamina D podría reducir el riesgo de influenza e infecciones y muertes por COVID-19, Nutri
Grant, Lahore, Mcdonnell, Baggerly, French et al., Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients, doi:10.3390/nu12040988
Holick, Medical progress: vitamin D deficiency, N Engl J Med, doi:10.1056/NEJMra070553
Hossein-Nezhad, Holick, Vitamin D for health: a global perspective, Mayo Clin Proc, doi:10.1016/j.mayocp.2013.05.011
Ianevski, Zusinaite, Shtaida, Kallio-Kokko, Valkonen et al., Low temperature and low UV indexes correlated with peaks of influenza virus activity in Northern Europe during 2010-2018, Viruses, doi:10.3390/v11030207
Ilie, Stefanescu, Smith, The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality
Kechichian, Ezzedine, Vitamin D and the skin: an update for dermatologists, Am J Clin Dermatol, doi:10.1007/s40257-017-0323-8
Khan, Fabian, How I treat vitamin d deficiency, J Oncol Pract
Lips, Cashman, Lamberg-Allardt, Bischoff-Ferrari, Obermayer-Pietsch et al., Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European Calcified Tissue Society, Eur J Endocrinol, doi:10.1530/EJE-18-0736
Marik, Kory, Varon, Does vitamin D status impact mortality from SARS-CoV-2 infection?
Raharusun, Priambada, Budiarti, Agung, Budi, Patterns of COVID-19 Mortality and Vitamin D: An Indonesian Study
Rhodes, Subramanian, Laird, Kenny, Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees North supports vitamin D as a factor determining severity, Aliment Pharmacol Ther, doi:10.1111/apt.15777
Rhodes, Webb, Fraser, Kift, Durkin et al., Recommended summer sunlight exposure levels can produce sufficient (> or =20 ng ml(-1)) but not the proposed optimal (> or =32 ng ml(-1))
Richardson, Hirsch, Narasimhan, Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area, JAMA, doi:10.1001/jama.2020.6775
Soler, Lloveras, Batlle, Enzima conversiva de la angiotensina 2 y su papel emergente en la regulación del sistema renina-angiotensina, Medicina Clínica, doi:10.1157/13124619
Sowah, Fan, Dennett, Hagtvedt, Straube, Vitamin D levels and deficiency with different occupations: a systematic review, BMC Public Health, doi:10.1186/s12889-017-4436-z
Spiro, Buttriss, Vitamin D: an overview of vitamin D status and intake in Europe, Nutr Bull, doi:10.1111/nbu.12108
Teymoori-Rad, Shokri, Salimi, Marashi, The interplay between vitamin D and viral infections, Rev Med Virol, doi:10.1002/rmv.2032
Tikellis, Thomas, Angiotensin-converting enzyme 2 (ACE2) is a key modulator of the renin angiotensin system in health and disease, Int J Pept, doi:10.1155/2012/256294
Varsavskya, Rozas, Becerra, Luque, Quesada et al., Recomendaciones de vitamina D para la población general, Endocrinol Diabetes Nutr, doi:10.1016/j.endinu.2016.11.002
Zhou, Yu, Du, Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study [published correction appears, Lancet
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop