Abstract: Journal of Steroid Biochemistry and Molecular Biology 203 (2020) 105751
Contents lists available at ScienceDirect
Journal of Steroid Biochemistry and Molecular Biology
journal homepage: www.elsevier.com/locate/jsbmb
“Effect of calcifediol treatment and best available therapy versus best
available therapy on intensive care unit admission and mortality among
patients hospitalized for COVID-19: A pilot randomized clinical study”
Marta Entrenas Castillo a, Luis Manuel Entrenas Costa a, *, José Manuel Vaquero Barrios a,
Juan Francisco Alcalá Díaz b, José López Miranda b, Roger Bouillon c,
José Manuel Quesada Gomez d
a
UGC de Neumología, Instituto Maimónides de Investigación Biomédica de Córdoba 9 (IMIBIC). Hospital Universitario Reina Sofía, Universidad de Córdoba, Avda.
Menéndez 10 Pidal s/n, 14004 11, Córdoba, Spain
b
Departamento de Medicina Interna. IMIBIC, CIBER de Fisiopatología de la Obesidad y la Nutrición. Hospital Universitario Reina Sofía, Universidad de Córdoba,
Fundación Progreso y Salud. Avda. Menéndez Pidal s/n, 14004 14, Córdoba, Spain
c
Department of Chronic Diseases, Metabolism and Ageing, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Herestraat, ON1/902, 3000, Leuven,
Belgium
d
IMIBIC. CIBER de Fragilidad y Envejecimiento Saludable. Hospital Universitario Reina Sofía, Universidad de Córdoba, Fundación Progreso y Salud. Avda. Menéndez
Pidal s/n, 18 14004, Córdoba, Spain
A R T I C L E I N F O
A B S T R A C T
Keywords:
COVID-19
SARS-CoV-2
Vitamin D
Vitamin D3 or cholecalciferol
Calcifediol or 25-hydroxyvitamin D3
1α, 25(OH)2D or 1α, 25-dihydroxyvitamin D or
calcitriol
Acute respiratory distress syndrome (ARDS)
Cytokine/Chemokine storm
Renin-angiotensin system
Hypercoagulability
Hydroxychloroquine
Chloroquine
Covidiol
Neutrophil activity
Vitamin D endocrine system
Cuboidal alveolar coating cells type II
Cathelicidin peptide
Defensins
TLR co-receptor CD14
Vitamin D receptor
Objective: The vitamin D endocrine system may have a variety of actions on cells and tissues involved in COVID19 progression especially by decreasing the Acute Respiratory Distress Syndrome. Calcifediol can rapidly in
crease serum 25OHD concentration. We therefore evaluated the effect of calcifediol treatment, on Intensive Care
Unit Admission and Mortality rate among Spanish patients hospitalized for COVID-19.
Design: Parallel pilot randomized open label, double-masked clinical trial.
Setting: University hospital setting (Reina Sofia University Hospital, Córdoba Spain.)
Participants: 76 consecutive patients hospitalized with COVID-19 infection, clinical picture of acute respiratory
infection, confirmed by a radiographic pattern of viral pneumonia and by a positive SARS-CoV-2 PCR with
CURB65 severity scale (recommending hospital admission in case of total score > 1).
Procedures: All hospitalized patients received as best available therapy the same standard care, (per hospital
protocol), of a combination of hydroxychloroquine (400 mg every 12 h on the first day, and 200 mg every 12 h for
the following 5 days), azithromycin (500 mg orally for 5 days. Eligible patients were allocated at a 2 calcifediol:1
no calcifediol ratio through electronic randomization on the day of admission to take oral calcifediol (0.532 mg), or
not. Patients in the calcifediol treatment group continued with oral calcifediol (0.266 mg) on day 3 and 7, and then
weekly until discharge or ICU admission. Outcomes of effectiveness included..
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