Serum 25(oH)D level in patients with CoVID-19

{ 'indexed': {'date-parts': [[2024, 2, 14]], 'date-time': '2024-02-14T10:01:03Z', 'timestamp': 1707904863880}, 'reference-count': 37, 'publisher': 'SPRIDA', 'issue': '3', 'license': [ { 'start': { 'date-parts': [[2020, 8, 2]], 'date-time': '2020-08-02T00:00:00Z', 'timestamp': 1596326400000}, 'content-version': 'unspecified', 'delay-in-days': 0, 'URL': 'https://journal.niidi.ru/jofin/about/editorialPolicies#openAccessPolicy'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p>Recently, vitamin D deficiency is considered as a risk factor for the incidence and ' 'severity of new coronavirus infection.<jats:bold>The aim</jats:bold>of this work was to ' 'evaluate the vitamin D level of patients with COVID-19 hospitalized with communityacquired ' 'pneumonia and compare the value of 25(OH)D in blood serum with the clinical manifestations of ' 'the disease.<jats:bold>Results.</jats:bold>Included are 80 patients aged 18 to 94 years (mean ' 'age 53,2 ± 15,7 years), 43 (53,8%) men; with severe course – in 25 (31,3%) patients (12 ' 'males), and moderate – in 55 people (68,7%) (31 males). Half of the severely ill patients ' 'were obese, and among the deceased patients, the number of obese people was 61,5%, which was ' 'significantly higher than the discharged ones – 14,9% (p&lt;0,001). Diabetes mellitus and ' 'cardiovascular diseases occurred with the same frequency, regardless of the severity of the ' 'disease. Analysis of the outcomes of coronavirus infection in these patients showed mortality ' 'in 52,0% of cases in severe patients. Serum 25(OH)D level ranged from 3,0 to 88,8 ng / ml ' '(16,7 ± 12,7 ng / ml). It was found that in patients with severe course, the level of 25(OH)D ' 'blood was significantly lower (11.9 ± 6.4 ng / ml) and vitamin D deficiency was more common ' 'than in patients with moderate to severe course of the disease (18,5 ± 14,0 ng / ml, p = ' '0,027). The same pattern was revealed in patients with a fatal outcome, where the level of ' '25(OH)D was 10,8 ± 6,1 ng / ml, compared with this indicator in patients discharged from the ' 'hospital (17,8 ± 13,4 ng / ml) (p = 0,02).<jats:bold>Conclusions.</jats:bold>Vitamin D ' 'deficiency and obesity have been found to increase the risk of severe course and death of ' 'coronavirus infection.</jats:p>', 'DOI': '10.22625/2072-6732-2020-12-3-21-27', 'type': 'journal-article', 'created': {'date-parts': [[2020, 8, 2]], 'date-time': '2020-08-02T12:24:07Z', 'timestamp': 1596371047000}, 'page': '21-27', 'source': 'Crossref', 'is-referenced-by-count': 20, 'title': 'serum 25(oH)D level in patients with CoVID-19', 'prefix': '10.22625', 'volume': '12', 'author': [ { 'given': 'T. L.', 'family': 'Karonova', 'sequence': 'first', 'affiliation': [{'name': 'National Medical Research Centre named after V.A. Almazov'}]}, { 'given': 'А. Т.', 'family': 'Andreeva', 'sequence': 'additional', 'affiliation': [{'name': 'National Medical Research Centre named after V.A. Almazov'}]}, { 'given': 'М. А.', 'family': 'Vashukova', 'sequence': 'additional', 'affiliation': [{'name': 'Clinical Infectious Hospital named after S.P. Botkin'}]}], 'member': '9914', 'published-online': {'date-parts': [[2020, 8, 2]]}, 'reference': [ { 'key': 'ref1', 'doi-asserted-by': 'crossref', 'unstructured': 'Karonova, T.L. Vitamin D as a factor in increasing immunity and reducing ' 'the risk of acute respiratory viral infections and COVID-19 / Т.L. ' 'Karonova, М.А. Vashukova, D.А. Gusev i dr. // Arterial hypertension. – ' '2020. – Vol. 26, № 3. – S.295- 303.', 'DOI': '10.18705/1607-419X-2020-26-3-295-303'}, { 'key': 'ref2', 'doi-asserted-by': 'crossref', 'unstructured': 'Baeke, F. Human T lymphocytes are direct targets of ' '1,25-dihydroxyvitamin D3 in the immune system / F. Baeke, H. Korf, L. 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