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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 79% Improvement Relative Risk Severe case 71% Vitamin D for COVID-19  Karonova et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 80 patients in Russia Lower severe cases with higher vitamin D levels (p=0.05) c19early.org Karonova et al., Infectology, December 2020 Favors vitamin D Favors control

Serum 25(oH)D level in patients with CoVID-19

Karonova et al., Infectology, doi:10.22625/2072-6732-2020-12-3-21-27
Dec 2020  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Retrospective 80 COVID-19 patients showing low vitamin D levels associated with severity and mortality.
This is the 35th of 196 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 11,637 vigintillion).
risk of death, 79.4% lower, RR 0.21, p = 0.11, high D levels 1 of 23 (4.3%), low D levels 12 of 57 (21.1%), NNT 6.0, inverted to make RR<1 favor high D levels, odds ratio converted to relative risk, >20ng/ml.
risk of severe case, 71.1% lower, RR 0.29, p = 0.05, high D levels 3 of 23 (13.0%), low D levels 22 of 57 (38.6%), NNT 3.9, inverted to make RR<1 favor high D levels, odds ratio converted to relative risk, >20ng/ml.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Karonova et al., 31 Dec 2020, retrospective, Russia, peer-reviewed, 3 authors.
This PaperVitamin DAll
serum 25(oH)D level in patients with CoVID-19
T L Karonova, А Т Andreeva, М А Vashukova
Journal Infectology, doi:10.22625/2072-6732-2020-12-3-21-27
Введение Единичные исследования, проведенные с момента начала пандемии COVID-19, продемонстрировали, что дефицит витамина D может быть одним из факторов, повышающих заболеваемость и ухудшающих течение респираторной вирусной инфекции (ОРВИ), вызванной SARS-CoV-2 [1]. Иммуномодулирующие эффекты витамина D хорошо изучены и связаны во многом с экспрессией фермента CYP27B1 в клетках иммунной систе-
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Diabetes mellitus and ' 'cardiovascular diseases occurred with the same frequency, regardless of the severity of the ' 'disease. Analysis of the outcomes of coronavirus infection in these patients showed mortality ' 'in 52,0% of cases in severe patients. Serum 25(OH)D level ranged from 3,0 to 88,8 ng / ml ' '(16,7 ± 12,7 ng / ml). It was found that in patients with severe course, the level of 25(OH)D ' 'blood was significantly lower (11.9 ± 6.4 ng / ml) and vitamin D deficiency was more common ' 'than in patients with moderate to severe course of the disease (18,5 ± 14,0 ng / ml, p = ' '0,027). The same pattern was revealed in patients with a fatal outcome, where the level of ' '25(OH)D was 10,8 ± 6,1 ng / ml, compared with this indicator in patients discharged from the ' 'hospital (17,8 ± 13,4 ng / ml) (p = 0,02).<jats:bold>Conclusions.</jats:bold>Vitamin D ' 'deficiency and obesity have been found to increase the risk of severe course and death of ' 'coronavirus infection.</jats:p>', 'author': [ { 'affiliation': [{'name': 'National Medical Research Centre named after V.A. Almazov'}], 'family': 'Karonova', 'given': 'T. L.', 'sequence': 'first'}, { 'affiliation': [{'name': 'National Medical Research Centre named after V.A. Almazov'}], 'family': 'Andreeva', 'given': 'А. Т.', 'sequence': 'additional'}, { 'affiliation': [{'name': 'Clinical Infectious Hospital named after S.P. Botkin'}], 'family': 'Vashukova', 'given': 'М. 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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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