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Is the shielding effect of cholecalciferol in SARS CoV-2 infection dependable? An evidence based unraveling

Basha et al., Clinical Epidemiology and Global Health, doi:10.1016/j.cegh.2020.10.005
Oct 2020  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Review of vitamin D for COVID-19, concluding that the available evidence is very suggestive of protective and preventive effect of vitamin D.
Authors note that strict lockdown (longer time indoors and home quarantine) may increase the risk of developing vitamin D deficiency. They suggest it is the duty of governments to strengthen recommendations regarding nutritional supplementation (especially vitamin D and C), particularly under quarantine and lockdown times.
Reviews covering vitamin D for COVID-19 include1-24.
Basha et al., 21 Oct 2020, peer-reviewed, 4 authors.
This PaperVitamin DAll
Is the shielding effect of cholecalciferol in SARS CoV-2 infection dependable? An evidence based unraveling
Shaik Lahoor Basha, Sake Suresh, V V Ashok Reddy, S P Surya Teja
Clinical Epidemiology and Global Health, doi:10.1016/j.cegh.2020.10.005
Despite being announced as a global health concern and emergency in January by WHO, designing specific treatment for SARS-CoV-2 is still a summit yet to be conquered. Currently, many drugs are being tested in the clinical scenario and vitamins play a significant role in therapeutic management. Based on the available evidence, we postulate that maintaining normal vitamin D 3 levels may reduce severity, mortality risk of COVID-19. This review elucidates the alarming need for randomized clinical trials to determine the role of vitamin D in patient prognosis in COVID-19 infection and on latitude bases epidemiological outcome.
Declaration of competing interest There are no conflicts of interest to declare.
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