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Possible Link between Gut Microbiota, Diet, and COVID-19 Infection

Fazli et al., Journal of Medical Bacteriology, 12:4
Nov 2024  
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Vitamin D for COVID-19
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Review of the relationship between gut microbiota, diet, and COVID-19 infection. Authors analyze how SARS-CoV-2 infection affects gut microbiota composition and how dietary factors may influence disease outcomes. Studies show COVID-19 patients experience significant changes in gut microbiome composition, with decreased abundance of beneficial bacteria, while showing increases in potentially harmful bacteria. These alterations correlate with disease severity and inflammatory cytokine levels. Authors discuss how dietary interventions, particularly probiotics and prebiotics, may help combat COVID-19 by modulating the gut-lung axis and immune responses. Authors also examine the role of micronutrients, finding that vitamin D deficiency correlates with increased COVID-19 severity, while vitamin C supplementation may help prevent cytokine storm. Zinc deficiency is associated with worse outcomes, and selenium status may influence mortality rates. Authors call for further research to better understand the complex interactions between diet, gut health, and COVID-19 pathogenesis.
Reviews covering vitamin D for COVID-19 include1-35.
Review covers probiotics, selenium, vitamin C, vitamin D, and zinc.
Fazli et al., 11 Nov 2024, peer-reviewed, 9 authors.
This PaperVitamin DAll
Possible Link between Gut Microbiota, Diet, and COVID-19 Infection
Mohammad Ghodratie, Fatemeh Sameni, Paria Fazli, Shima Saberifard, Mahla Azimi, Zahra Miri Kordkandi, Bita Zandi, Fatemeh Roozbahani, Yalda Malekzadegan
Background: Coronavirus disease 2019 (COVID-19) is a concern for world health since it may impact both the upper (nose, throat, sinuses) and lower (trachea, lungs) respiratory tracts. Death (at a rate of 10%), respiratory failure, multi-organ failure, and acute respiratory distress syndrome (ARDS) are among the problems that might arise. Recent years have seen a global spread of zoonotic coronaviruses, which have caused human epidemics such as MERS and SARS. Various clinical symptoms may be seen in this sickness because to the numerous changes in intestinal homeostasis caused by SARS-CoV-2. Because of the beneficial impact that probiotics have on the host immune system, gastrointestinal disorders may now be effectively treated. This article discusses the close relationship between what we eat, the bacteria in our gut, and the risk of contracting the COV-19 virus. Conclusion: The relationship between gut microbiota, dietary factors, and COVID-19 severity indicates that the microbiome may influence immune regulation. Imbalances in microbial communities and reduced diversity can intensify inflammation, potentially worsening COVID-19 outcomes. Strategies such as probiotics, prebiotics, and dietary changes might provide therapeutic benefits by improving gut health and strengthening immune defenses. However, further research is required to clarify these mechanisms and establish effective interventions.
Ethics approval and consent to participate Not applicable for this section. Conflict of interest The authors have declared that no competing interests exists.
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