Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience
Patrick J Mccullough, Douglas S Lehrer, Jeffrey Amend
The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2018.12.010
Vitamin D3 is a secosteroid hormone produced in the skin in amounts estimated up to 25,000 international units (IUs) a day by the action of UVB radiation on 7-dehydrocholesterol. Vitamin D deficiency is common due to both lack of adequate sun exposure to the skin, and because vitamin D is present in very few food sources. Deficiency is strongly linked to increased risk for a multitude of diseases, several of which have historically been shown to improve dramatically with either adequate UVB exposure to the skin, or to oral or topical supplementation with vitamin D. These diseases include asthma, psoriasis, rheumatoid arthritis, rickets and tuberculosis. All patients in our hospital have been routinely screened on admission for vitamin D deficiency since July 2011, and offered supplementation to either correct or prevent deficiency. During this time, we have admitted over 4700 patients, the vast majority of whom agreed to supplementation with either 5000 or 10,000 IUs/day. Due to disease concerns, a few agreed to larger amounts, ranging from 20,000 to 50,000 IUs/day. There have been no cases of vitamin D3 induced hypercalcemia or any adverse events attributable to vitamin D3 supplementation in any patient. Three patients with psoriasis showed marked clinical improvement in their skin using 20,000 to 50,000 IUs/day. Analysis of 777 recently tested patients (new and long-term) not on D3 revealed 28.7% with 25-hydroxyvitaminD3 (25OHD3) blood levels < 20 ng/ml, 64.1% < 30 ng/ml, a mean 25OHD3 level of 27.1 ng/ ml, with a range from 4.9 to 74.8 ng/ml. Analysis of 418 inpatients on D3 long enough to develop 25OHD3 blood levels > 74.4 ng/ml showed a mean 25OHD3 level of 118.9 ng/ml, with a range from 74.4 to 384.8 ng/ml. The average serum calcium level in these 2 groups was 9.5 (no D3) vs 9.6 (D3), with ranges of 8.4 to 10.7 (no D3) vs 8.6 to 10.7 mg/dl (D3), after excluding patients with other causes of hypercalcemia. The average intact parathyroid hormone levels were 24.2 pg/ml (D3) vs. 30.2 pg/ml (no D3). In summary, long-term supplementation with vitamin D3 in doses ranging from 5000 to 50,000 IUs/day appears to be safe.
Conflicts of Interest The authors have no conflicts of interest to disclose.
References
Aitken, Lupus vulgaris* with special reference to its treatment with the finsenlomholt lamp, Br. Med. J
Aloia, The 2011 report on dietary reference intake for vitamin d: where do we go from Here, J. Clin. Endocrinol. Metab,
doi:10.1210/jc.2011-0090
Araki, Holick, Alfonso, Vitamin d intoxication with severe hypercalcemia due to manufacturing and labeling errors of two dietary supplements made in the United States, J. Clin. Endocrinol. Metab
Barrea, Savanelli, Somma, Napolitano, Megna et al., Vitamin D and its role in psoriasis: an overview of the dermatologist and nutritionist, Rev. Endocr. Metab. Disord,
doi:10.1007/s11154-017-9411-6
Bevans, Taylor, Lesions following the use of Ertron in rheumatoid arthritis, Am. J. Pathol
Biography, Neils Ryberg-Finsen, None
Cannell, Gary Null and Vitamin D Toxicity
Cannon, Ford, Hester, Trump, The incidental use of high-dose vitamin D3 in pancreatic Cancer, Case Rep, Pancreat. Cancer,
doi:10.1089/crpc.2016.0003
Castro, King, Kunselman, for the National Heart, Lung, and Blood Institute's Asthma Net. Effect of Vitamin D 3 on Asthma Treatment Failures in Adults with Symptomatic Asthma and Lower Vitamin D Levels. The VIDA Randomized Clinical Trial, JAMA,
doi:10.1001/jama.2014.5052
Christiansen, Rodbro, Sjö, Anticonvulsant action" of vitamin D in epileptic patients. A controlled pilot study, Br. Med. J
Derex, Trouillas, Reversible parkinsonism, hypophosphoremia, and hypocalcemia under vitamin D therapy, Mov. Disord
Dowling, Prosser Thomas, Lupus vulgaris treated with calciferol, Proc. R. Soc. Med
Dowling, Prosser Thomas, Wallace, Lupus vulgaris treated with calciferol, Proc. R. Soc. Med
Dowling, Prosser, Treatment of lupus vulgaris with calciferol, Lancet
Dreyer, Reed, The treatment of arthritis with massive doses of vitamin D, Arch. Phys. Ther
Dudenkov, Mara, Petterson, Maxson, Thacher, Serum 25-Hydroxyvitamin d values and risk of all cause and cause-specific mortality: a population-based cohort study, Mayo Clin. Proc
Dudenkov, Yawn, Oberelman, Fischer, Singh et al., Changing incidence of serum 25-Hydroxyvitamin d values above 50 ng/ml: a 10-Year population-based study, Mayo Clin. Proc
Ekwaru, Zwicker, Holick, Giovannucci, Veugelers, The importance of body weight for the dose response relationship of oral vitamin d supplementation and serum 25-Hydroxyvitamin d in healthy volunteers, PLoS One,
doi:10.1371/journal.pone.0111265
Evans, Houghton, Schumaker, Brenner, Buras et al., Vitamin D receptor and growth inhibition by 1,25-dihydroxyvitamin D3 in human malignant melanoma cell lines, J. Surg. Res
Fleet, Desmet, Johnson, Vitamin D and cancer: a review of molecular mechanisms, Biochem. J
Garland, French, Baggerly, Heaney, Vitamin d supplement doses and serum 25-Hydroxyvitamin d in the range associated with Cancer prevention, Anticancer Res
Garland, Garland, Do sunlight and vitamin D reduce the likelihood of colon cancer?, Int. J. Epidemiol
Garland, Garland, Gorham, Lipkin, Newmark et al., The role of vitamin d in Cancer prevention, Am. J. Public Health,
doi:10.2105/AJPH.2004.045260
Garland, Kim, Mohr, Gorham, Grant et al., RP meta-analysis of allcause mortality according to serum 25-Hydroxyvitamin d, Am. J. Public Health,
doi:10.2105/AJPH.2014.302034
Garrett-Mayer, Wagner, Hollis, Kindy, Gattoni-Celli, Vitamin D3 supplementation (4000 IU/d for 1 y) eliminates differences in circulating 25-hydorxyvitamin D between African American and white men, Am J Clin Nutr
Giovannucci, The epidemiology of vitamin D and cancer incidence and mortality: a review (United States), Cancer Causes Control
Gotzsche, Niels Finsen's treatment for lupus vulgaris, J. R. Soc. Med
Grant, An estimate of premature cancer mortality in the US because of inadequate doses of solar ultraviolet-B radiation, Cancer
Haddad, Chyu, Competitive protein-binding radioassay for 25-hydroxycholecalciferol, J. Clin. Endocr
Haghighi, Samimagham, Gahardehi, Calcium and vitamin d supplementation and risk of kidney stone formation in postmenopausal women, IJKD
Hathcock, Shao, Vieth, Heaney, Risk assessment for vitamin D, Am. J. Clin. Nutr
Heaney, Davies, Chen, Holick, Barger-Lux, Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol, Am. J. Clin. Nutr
Hess, Unger, The cure of infantile rickets by sunshine, JAMA
Holick, Binkley, Bischoff-Ferrari, Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline, J. Clin. Endocrinol. Metab
Holick, Environmental factors that influence the cutaneous production of vitamin D, Am. J. Clin. Nutr
Holick, The death D-fying vitamin, Mayo Clin. Proc
Holick, Vitamin d deficiency, New Engl. J. Med
Holick, Vitamin d is not as toxic as was once thought: a historical and an up-to date perspective, Mayo Clin. Proc
Hollis, Circulating 25-hydroxyvitamin d levels indicative of vitamin d sufficiency: implications for establishing a new effective dietary intake. Recommendation for vitamin D, J. Nutr
Holló, Clemens, Kamondi, Lakatos, Szűcs, Correction of vitamin D deficiency improves seizure control in epilepsy: a pilot study, Epilepsy Behav,
doi:10.1016/j.yebeh.2012.03.011
Hossein-Nezhad, Holick, Vitamin d for health; a global perspective, Mayo Clin. Proc
Howard, Meyer, Intoxication with vitamin D, J. Clin. Endocrinol
Huckins, Felson, Holick, Treatment of psoriatic arthritis with oral 1,25-dihydroxyvitamin D3: a pilot study, Arthritis Rheum
Jones, Pharmacokinectics of vitamin D toxicity, Am. J. Clin. Nutr
Kimball, Mirhosseini, Holick, Evaluation of vitamin D3 intakes up to 15,000 international units/day and serum 25-hydroxyvitamin D concentrations up to 300 nmol/L on calcium metabolism in a community setting, Dermato-Endocrinology,
doi:10.1080/19381980.2017.1300213
Krafka, A simple treatment for psoriasis, J. Clin. Lab. Med
Lappe, Travers-Gustafson, Davies, Recker, Heaney, Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial, Am. J. Clin. Nutr
Leake, Vitamin d toxicity, Cal. West. Med
Liu, Stenger, Li, Toll-like receptor triggering of a vitamin D-Mediated human antimicrobial response, Science
Luxwolda, Kuipers, Kema, Van Der Veer, Dijck-Brouwer et al., Vitamin D status indicators in indigenous populations in East Africa, Eur. J. Nutr,
doi:10.1007/s00394-012-0421-6
Madden, Murphy, Zgaga, Bennett, De novo vitamin D supplement use post-diagnosis is associated with breast cancer survival, Breast Cancer Res. Treat,
doi:10.1007/s10549-018-4896-6
Marshall, Savage, Garrett-Mayer, Vitamin D3 supplementation at 4000 international units per day for one year results in a decrease of positive cores at repeat biopsy in subjects with low-risk prostate Cancer under active surveillance, J. Clin. Endocrinol. Metab
Masten, Good climate -an asset in the treatment of tuberculosis, Chest
Masten, Tuberculosis of the Lungs (A Booklet for the Patient), Colorado State Board of Health Bulletin
Mccullough, Amend, Results of daily oral dosing with up to 60,000 international units (iu) of vitamin D3 for 2 to 6 years in 3 adult males, J. Steroid Biochem. Mol. Biol,
doi:10.1016/j.jsbmb.2016.12.009
Mccullough, Arnold-Long, Marked Improvement in Psoriasis Skin Lesions Within 5 Months in Two Patients After Treatment With Oral Vitamin D3 in Doses Ranging From
Mccullough, Heaney, Correction of vitamin D deficiency using sublingually administered vitamin D2 in a Crohn's disease patient with mal-absorption and a new ileostomy, J. Ster. Biochem. Mol. Biol
Mccullough, Lehrer, Vitamin D, cod liver oil, sunshine and phototherapy: safe, effective and forgotten tools for treating and curing tuberculosis infections -a comprehensive review, J. Steroid Biochem. Mol. Biol
Mcdonnell, Baggerly, Baggerly, Aliano, French, Maternal 25(OH)D concentrations ≥40 ng/mL associated with 60% lower preterm birth risk among general obstetrical patients at an urban medical center, PLoS One,
doi:10.1371/journal.pone.0180483
Mcdonnell, Baggerly, French, Baggerly, Garland et al., Breast cancer risk markedly lower with serum 25-hydroxyvitamin D concentrations > 60 vs < 20ng/ml (150 vs 50 nmol/L): pooled analysis of two randomized trials and a prospective cohort, PLoS One,
doi:10.1371/journal.pone.0199265
Menter, Korman, Elmets, Guidelines of care for the management of psoriasis and psoriatic arthritis. Section 5. Guidelines of care for the treatment of psoriasis with phototherapy and photochemotherapy, J. Am. Acad. Dermatol
Michelson, Steves, Treatment of cutaneous tuberculosis with large doses of vitamin D, Arch. Derm. Syphilol
Morimoto, Yoshikawa, Kozuka, An open study of vitamin D3 treatment in psoriasis vulgaris, Br. J. Dermatol
Morner, Nobel Prize for Physiology or Medicine Award Ceremony Speech
Newmark, Newmark, Vitamin d and Parkinson's disease-a hypothesis, Mov. Disord
Nguyen, Baggerly, French, Heaney, Gorham et al., 25Hydroxyvitamin D in the range of 20 to 100 ng/ml and Incidence of Kidney Stones, Am. J. Public Health
Norman, Bouillon, Vitamin D nutritional policy needs a vision for the future, Exp. Biol. Med
Norman, Minireview: vitamin d receptor: new assignments for an already busy receptor, Endocrinology
Nygaad, Frandsen, Brandi, Effects of high doses of cholecalciferol in normal subjects: a randomized double-blinded, placebo-controlled trial, PLoS One
Osmancevic, Landin-Wilhelmsen, Larko, Krogstad, Vitamin D status in psoriasis patients during different treatments with phototherapy, J. Photochem. Photobiol. B: Biol
Parks, The therapy of rickets, JAMA
Penniston, Jones, Nakada, Hansen, Vitamin D repletion does not alter urinary calcium excretion in healthy postmenopausal women, BJU Int
Perez, Raab, Chen, Turner, Holick, Safety and efficacy of oral calcitriol (1,25-dihydorxyvitamin D3) for the treatment of psoriasis, Br. J. Dermatol
Pipili, Oreopoulos, Vitamin d status in patients with recurrent kidney stones, Nephron Clin. Pract
Raab, Vitamin D -its bactericidal action, Chest
Rajakumar, Vitamin d, cod-liver oil, sunlight, and rickets: a historical perspective, Pediatrics
Ramagopalan, Heger, Berlanga, A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution, Genome Res
Rappaport, Reed, Hathaway, Struck, The treatment of hay fever and Asthma with viosterol of high potency, J. Allergy
Reed, Symptoms of viosterol overdosage in human subjects, JAMA
Ryan, Moran, Mckenna, The effect of narrowband UV-B treatment for psoriasis on vitamin d status during wintertime in Ireland, Arch. Dermatol
Shabahang, Buffan, Nolla, Schumaker, Brenner et al., The effect of 1, 25-dihydroxyvitamin D3 on the growth of soft-tissue sarcoma cells as mediated by the vitamin D receptor, Ann. Surg. Oncol
Shabahang, Buras, Davoodi, Schumaker, Nauta et al., 1,25-Dihydroxyvitamin D3 receptor as a marker of human colon carcinoma cell line differentiation and growth inhibition, Cancer Res
Shabahang, Buras, Davoodi, Schumaker, Nauta et al., Growth inhibition of HT-29 human colon cancer cells by analogues of 1,25-dihydroxyvitamin D3, Cancer Res
Smith, Pincus, Donovan, Holick, A novel approach for the evaluation and treatment of psoriasis, J. Am. Acad. Dermatol
Stamp, Haddad, Twigg, Comparison of oral 25-hydroxycholecalciferol, vitamin D, and ultraviolet light as determinants of circulating 25-hydroxyvitamin D, Lancet
Szabo, Vitamin, the Sunshine Supplement, has Shadowy Money Behind It
Tang, Mcfann, Chonchol, Association between serum 25-hydroxyvitamin d and nephrolithiasis: the national health and nutrition examination survey III, 1988-94, Nephrol. Dial. Transplant
Tavera-Mendoza, White, Cell defenses and the sunshine vitamin, Sci. Am
Tomlinson, Calcium content of skin in lupus vulgaris treated with Calciferol, Lancet
Uhmann, Niemann, Lammering, Antitumoral effects of calcitriol in basal cell carcinomas involve inhibition of hedgehog signaling and induction of vitamin d receptor signaling and differentiation, Mol. Cancer Ther
Van Lugt, Rottier, Finsen therapy and vitamin D, Acta Dermato-Venerologica
Vieth, Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety, Am. J. Clin. Nutr
Williams, On the use and administration of cod-liver oil in pulmonary consumption, Lond. J. Med
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'series-title': 'Tuberculosis of the Lungs (A Booklet for the Patient)',
'first-page': '1',
'author': 'Masten',
'year': '1936'},
{ 'issue': '7',
'key': '10.1016/j.jsbmb.2018.12.010_bib0045',
'first-page': '20',
'article-title': 'Good climate – an asset in the treatment of tuberculosis',
'volume': '3',
'author': 'Masten',
'year': '1937',
'journal-title': 'Chest'},
{ 'issue': 'January',
'key': '10.1016/j.jsbmb.2018.12.010_bib0050',
'doi-asserted-by': 'crossref',
'first-page': '160',
'DOI': '10.1136/bmj.1.3968.160',
'article-title': 'Lupus vulgaris* with special reference to its treatment with the '
'finsen-lomholt lamp',
'volume': '23',
'author': 'Aitken',
'year': '1937',
'journal-title': 'Br. Med. J.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0055',
'first-page': '264',
'article-title': 'Finsen therapy and vitamin D',
'volume': '38',
'author': 'Van Der Lugt',
'year': '1958',
'journal-title': 'Acta Dermato-Venerologica'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0060',
'doi-asserted-by': 'crossref',
'first-page': '41',
'DOI': '10.1258/jrsm.2010.10k066',
'article-title': 'Niels Finsen’s treatment for lupus vulgaris',
'volume': '104',
'author': 'Gotzsche',
'year': '2011',
'journal-title': 'J. R. Soc. Med.'},
{ 'issue': '1',
'key': '10.1016/j.jsbmb.2018.12.010_bib0065',
'doi-asserted-by': 'crossref',
'first-page': '39',
'DOI': '10.1001/jama.1921.02630270037013',
'article-title': 'The cure of infantile rickets by sunshine',
'volume': '77',
'author': 'Hess',
'year': '1921',
'journal-title': 'JAMA'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0070',
'first-page': '1147',
'article-title': 'A simple treatment for psoriasis',
'volume': '21',
'author': 'Krafka',
'year': '1936',
'journal-title': 'J. Clin. Lab. Med.'},
{ 'issue': 'September (6)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0075',
'doi-asserted-by': 'crossref',
'first-page': '541',
'DOI': '10.1016/S0021-8707(34)90130-1',
'article-title': 'The treatment of hay fever and Asthma with viosterol of high potency',
'volume': '5',
'author': 'Rappaport',
'year': '1934',
'journal-title': 'J. Allergy'},
{ 'issue': 'September',
'key': '10.1016/j.jsbmb.2018.12.010_bib0080',
'first-page': '537',
'article-title': 'The treatment of arthritis with massive doses of vitamin D',
'volume': '16',
'author': 'Dreyer',
'year': '1935',
'journal-title': 'Arch. Phys. Ther.'},
{ 'issue': '11',
'key': '10.1016/j.jsbmb.2018.12.010_bib0085',
'doi-asserted-by': 'crossref',
'first-page': '895',
'DOI': '10.1210/jcem-8-11-895',
'article-title': 'Intoxication with vitamin D',
'volume': '8',
'author': 'Howard',
'year': '1948',
'journal-title': 'J. Clin. Endocrinol.'},
{ 'issue': '5',
'key': '10.1016/j.jsbmb.2018.12.010_bib0090',
'doi-asserted-by': 'crossref',
'first-page': '370',
'DOI': '10.1001/jama.1940.72810310011009a',
'article-title': 'The therapy of rickets',
'volume': '115',
'author': 'Parks',
'year': '1940',
'journal-title': 'JAMA'},
{ 'issue': 'December',
'key': '10.1016/j.jsbmb.2018.12.010_bib0095',
'first-page': '96',
'article-title': 'Lupus vulgaris treated with calciferol',
'volume': '39',
'author': 'Dowling',
'year': '1945',
'journal-title': 'Proc. R. Soc. Med.'},
{ 'issue': 'March',
'key': '10.1016/j.jsbmb.2018.12.010_bib0100',
'first-page': '225',
'article-title': 'Lupus vulgaris treated with calciferol',
'volume': '39',
'author': 'Dowling',
'year': '1946',
'journal-title': 'Proc. R. Soc. Med.'},
{ 'issue': '3',
'key': '10.1016/j.jsbmb.2018.12.010_bib0105',
'doi-asserted-by': 'crossref',
'first-page': '317',
'DOI': '10.1001/archderm.1947.01520090037004',
'article-title': 'Treatment of cutaneous tuberculosis with large doses of vitamin D',
'volume': '56',
'author': 'Michelson',
'year': '1947',
'journal-title': 'Arch. Derm. Syphilol.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0110',
'doi-asserted-by': 'crossref',
'first-page': '327',
'DOI': '10.1016/S0140-6736(48)92091-1',
'article-title': 'Calcium content of skin in lupus vulgaris treated with Calciferol',
'volume': '251',
'author': 'Tomlinson',
'year': '1948',
'journal-title': 'Lancet'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0115',
'first-page': '409',
'article-title': 'Vitamin D – its bactericidal action',
'volume': '12',
'author': 'Raab',
'year': '1946',
'journal-title': 'Chest'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0120',
'doi-asserted-by': 'crossref',
'first-page': '21',
'DOI': '10.1016/j.jsbmb.2017.07.027',
'article-title': 'Vitamin D, cod liver oil, sunshine and phototherapy: safe, effective '
'and forgotten tools for treating and curing tuberculosis infections – a '
'comprehensive review',
'volume': '177',
'author': 'McCullough',
'year': '2018',
'journal-title': 'J. Steroid Biochem. Mol. Biol.'},
{ 'issue': 'June',
'key': '10.1016/j.jsbmb.2018.12.010_bib0125',
'doi-asserted-by': 'crossref',
'first-page': '1341',
'DOI': '10.1016/S0140-6736(77)92553-3',
'article-title': 'Comparison of oral 25-hydroxycholecalciferol, vitamin D, and '
'ultraviolet light as determinants of circulating 25-hydroxyvitamin D',
'author': 'Stamp',
'year': '1977',
'journal-title': 'Lancet'},
{ 'issue': 'suppl',
'key': '10.1016/j.jsbmb.2018.12.010_bib0130',
'article-title': 'Environmental factors that influence the cutaneous production of '
'vitamin D',
'volume': '61',
'author': 'Holick',
'year': '1995',
'journal-title': 'Am. J. Clin. Nutr.'},
{ 'issue': 'July (7)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0135',
'doi-asserted-by': 'crossref',
'first-page': '1911',
'DOI': '10.1210/jc.2011-0385',
'article-title': 'Evaluation, treatment, and prevention of vitamin D deficiency: an '
'endocrine society clinical practice guideline',
'volume': '96',
'author': 'Holick',
'year': '2011',
'journal-title': 'J. Clin. Endocrinol. Metab.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0140',
'doi-asserted-by': 'crossref',
'first-page': '266',
'DOI': '10.1056/NEJMra070553',
'article-title': 'Vitamin d deficiency',
'volume': '357',
'author': 'Holick',
'year': '2007',
'journal-title': 'New Engl. J. Med.'},
{ 'issue': 'May (21)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0145',
'doi-asserted-by': 'crossref',
'first-page': '1745',
'DOI': '10.1001/jama.1934.02750210017005',
'article-title': 'Symptoms of viosterol overdosage in human subjects',
'volume': '102',
'author': 'Reed',
'year': '1934',
'journal-title': 'JAMA'},
{ 'issue': 'March (3)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0150',
'first-page': '149',
'article-title': 'Vitamin d toxicity',
'volume': '44',
'author': 'Leake',
'year': '1936',
'journal-title': 'Cal. West. Med.'},
{ 'issue': 'May (3)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0155',
'first-page': '367',
'article-title': 'Lesions following the use of Ertron in rheumatoid arthritis',
'volume': '23',
'author': 'Bevans',
'year': '1947',
'journal-title': 'Am. J. Pathol.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0160',
'series-title': 'Gary Null and Vitamin D Toxicity',
'author': 'Cannell',
'year': '2010'},
{ 'issue': 'December (12)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0165',
'doi-asserted-by': 'crossref',
'first-page': '3603',
'DOI': '10.1210/jc.2011-1443',
'article-title': 'Vitamin d intoxication with severe hypercalcemia due to manufacturing '
'and labeling errors of two dietary supplements made in the United '
'States',
'volume': '96',
'author': 'Araki',
'year': '2011',
'journal-title': 'J. Clin. Endocrinol. Metab.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0170',
'doi-asserted-by': 'crossref',
'first-page': '1352',
'DOI': '10.1101/gr.107920.110',
'article-title': 'A ChIP-seq defined genome-wide map of vitamin D receptor binding: '
'associations with disease and evolution',
'volume': '20',
'author': 'Ramagopalan',
'year': '2010',
'journal-title': 'Genome Res.'},
{ 'issue': 'July (7)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0175',
'doi-asserted-by': 'crossref',
'first-page': '720',
'DOI': '10.1016/j.mayocp.2013.05.011',
'article-title': 'Vitamin d for health; a global perspective',
'volume': '88',
'author': 'Hossein-nezhad',
'year': '2013',
'journal-title': 'Mayo Clin. Proc.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0180',
'doi-asserted-by': 'crossref',
'first-page': '842',
'DOI': '10.1093/ajcn/69.5.842',
'article-title': 'Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and '
'safety',
'volume': '69',
'author': 'Vieth',
'year': '1999',
'journal-title': 'Am. J. Clin. Nutr.'},
{ 'issue': '77',
'key': '10.1016/j.jsbmb.2018.12.010_bib0185',
'doi-asserted-by': 'crossref',
'first-page': '204',
'DOI': '10.1093/ajcn/77.1.204',
'article-title': 'Human serum 25-hydroxycholecalciferol response to extended oral dosing '
'with cholecalciferol',
'author': 'Heaney',
'year': '2003',
'journal-title': 'Am. J. Clin. Nutr.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0190',
'doi-asserted-by': 'crossref',
'first-page': '317',
'DOI': '10.1093/jn/135.2.317',
'article-title': 'Circulating 25-hydroxyvitamin d levels indicative of vitamin d '
'sufficiency: implications for establishing a new effective dietary '
'intake. Recommendation for vitamin D',
'volume': '135',
'author': 'Hollis',
'year': '2005',
'journal-title': 'J. Nutr.'},
{ 'issue': 'S2',
'key': '10.1016/j.jsbmb.2018.12.010_bib0195',
'doi-asserted-by': 'crossref',
'first-page': 'V64',
'DOI': '10.1359/jbmr.07s221',
'article-title': 'Vitamin D toxicity, policy, and science',
'volume': '22',
'author': 'Vieth',
'year': '2007',
'journal-title': 'J. Bone Miner. Res.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0200',
'doi-asserted-by': 'crossref',
'first-page': '6',
'DOI': '10.1093/ajcn/85.1.6',
'article-title': 'Risk assessment for vitamin D',
'volume': '85',
'author': 'Hathcock',
'year': '2007',
'journal-title': 'Am. J. Clin. Nutr.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0205',
'doi-asserted-by': 'crossref',
'first-page': '992',
'DOI': '10.1210/jcem-33-6-992',
'article-title': 'Competitive protein-binding radioassay for 25-hydroxycholecalciferol',
'volume': '33',
'author': 'Haddad',
'year': '1971',
'journal-title': 'J. Clin. Endocr.'},
{ 'issue': 'suppl',
'key': '10.1016/j.jsbmb.2018.12.010_bib0210',
'article-title': 'Pharmacokinectics of vitamin D toxicity',
'volume': '88',
'author': 'Jones',
'year': '2008',
'journal-title': 'Am. J. Clin. Nutr.'},
{ 'issue': '8',
'key': '10.1016/j.jsbmb.2018.12.010_bib0215',
'doi-asserted-by': 'crossref',
'first-page': '836',
'DOI': '10.1001/archdermatol.2010.195',
'article-title': 'The effect of narrowband UV-B treatment for psoriasis on vitamin d '
'status during wintertime in Ireland',
'volume': '146',
'author': 'Ryan',
'year': '2010',
'journal-title': 'Arch. Dermatol.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0220',
'first-page': '617',
'article-title': 'Vitamin d supplement doses and serum 25-Hydroxyvitamin d in the range '
'associated with Cancer prevention',
'volume': '31',
'author': 'Garland',
'year': '2011',
'journal-title': 'Anticancer Res.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0225',
'doi-asserted-by': 'crossref',
'unstructured': 'Garrett-Mayer E, Wagner CL, Hollis BW, Kindy MS, Gattoni-Celli S. '
'Vitamin D3 supplementation (4000 IU/d for 1 y) eliminates differences in '
'circulating 25-hydorxyvitamin D between African American and white men. '
'Am J Clin Nutr doi: 10.3945/ajcn.112.034256.',
'DOI': '10.3945/ajcn.112.034256'},
{ 'issue': 'July (7)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0230',
'doi-asserted-by': 'crossref',
'first-page': '2315',
'DOI': '10.1210/jc.2012-1451',
'article-title': 'Vitamin D3 supplementation at 4000 international units per day for one '
'year results in a decrease of positive cores at repeat biopsy in '
'subjects with low-risk prostate Cancer under active surveillance',
'volume': '97',
'author': 'Marshall',
'year': '2012',
'journal-title': 'J. Clin. Endocrinol. Metab.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0235',
'series-title': 'Dietary Reference Intakes for Calcium and Vitamin D. Report Brief',
'year': '2010'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0240',
'series-title': 'Dietary Reference Intakes for Calcium and Vitamin D',
'author': 'IOM (Institute of Medicine)',
'year': '2011'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0245',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.jsbmb.2016.12.009',
'article-title': 'Results of daily oral dosing with up to 60,000 international units (iu) '
'of vitamin D3 for 2 to 6 years in 3 adult males',
'author': 'McCullough',
'year': '2017',
'journal-title': 'J. Steroid Biochem. Mol. Biol.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0250',
'doi-asserted-by': 'crossref',
'first-page': '211',
'DOI': '10.1016/j.jsbmb.2016.12.021',
'article-title': 'Correction of vitamin D deficiency using sublingually administered '
'vitamin D2 in a Crohn’s disease patient with mal-absorption and a new '
'ileostomy',
'volume': '173',
'author': 'McCullough',
'year': '2017',
'journal-title': 'J. Ster. Biochem. Mol. Biol.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0255',
'doi-asserted-by': 'crossref',
'first-page': '117',
'DOI': '10.1016/j.jphotobiol.2010.05.008',
'article-title': 'Vitamin D status in psoriasis patients during different treatments with '
'phototherapy',
'volume': '101',
'author': 'Osmancevic',
'year': '2010',
'journal-title': 'J. Photochem. Photobiol. B: Biol.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0260',
'unstructured': 'Light Therapy. National Psoriasis Foundation. '
'http://www.psoriasis.org/about-psoriasis/treatments/phototherapy.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0265',
'doi-asserted-by': 'crossref',
'first-page': '114',
'DOI': '10.1016/j.jaad.2009.08.026',
'article-title': 'Guidelines of care for the management of psoriasis and psoriatic '
'arthritis. Section 5. Guidelines of care for the treatment of psoriasis '
'with phototherapy and photochemotherapy',
'volume': '62',
'author': 'Menter',
'year': '2010',
'journal-title': 'J. Am. Acad. Dermatol.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0270',
'doi-asserted-by': 'crossref',
'first-page': '421',
'DOI': '10.1111/j.1365-2133.1986.tb06236.x',
'article-title': 'An open study of vitamin D3 treatment in psoriasis vulgaris',
'volume': '115',
'author': 'Morimoto',
'year': '1986',
'journal-title': 'Br. J. Dermatol.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0275',
'doi-asserted-by': 'crossref',
'first-page': '516',
'DOI': '10.1016/S0190-9622(88)70207-8',
'article-title': 'A novel approach for the evaluation and treatment of psoriasis',
'volume': '19',
'author': 'Smith',
'year': '1988',
'journal-title': 'J. Am. Acad. Dermatol.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0280',
'doi-asserted-by': 'crossref',
'first-page': '1070',
'DOI': '10.1111/j.1365-2133.1996.tb07945.x',
'article-title': 'Safety and efficacy of oral calcitriol (1,25-dihydorxyvitamin D3) for '
'the treatment of psoriasis',
'volume': '134',
'author': 'Perez',
'year': '1996',
'journal-title': 'Br. J. Dermatol.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0285',
'series-title': 'Marked Improvement in Psoriasis Skin Lesions Within 5 Months in Two '
'Patients After Treatment With Oral Vitamin D3 in Doses Ranging From '
'10,000 International Units (IU’s) to 40,000 IUs Daily. Poster '
'Presentation',
'author': 'McCullough',
'year': '2012'},
{ 'issue': 'November (11)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0290',
'article-title': 'Treatment of psoriatic arthritis with oral 1,25-dihydroxyvitamin D3: a '
'pilot study',
'volume': '33',
'author': 'Huckins',
'year': '1990',
'journal-title': 'Arthritis Rheum.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0295',
'doi-asserted-by': 'crossref',
'first-page': '195',
'DOI': '10.1007/s11154-017-9411-6',
'article-title': 'Vitamin D and its role in psoriasis: an overview of the dermatologist '
'and nutritionist',
'volume': '18',
'author': 'Barrea',
'year': '2017',
'journal-title': 'Rev. Endocr. Metab. Disord.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0300',
'doi-asserted-by': 'crossref',
'first-page': '1770',
'DOI': '10.1126/science.1123933',
'article-title': 'Toll-like receptor triggering of a vitamin D-Mediated human '
'antimicrobial response',
'volume': '311',
'author': 'Liu',
'year': '2006',
'journal-title': 'Science'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0305',
'doi-asserted-by': 'crossref',
'first-page': '227',
'DOI': '10.1093/ije/9.3.227',
'article-title': 'Do sunlight and vitamin D reduce the likelihood of colon cancer?',
'volume': '9',
'author': 'Garland',
'year': '1980',
'journal-title': 'Int. J. Epidemiol.'},
{ 'issue': '6',
'key': '10.1016/j.jsbmb.2018.12.010_bib0310',
'doi-asserted-by': 'crossref',
'first-page': '1867',
'DOI': '10.1002/cncr.10427',
'article-title': 'An estimate of premature cancer mortality in the US because of '
'inadequate doses of solar ultraviolet-B radiation',
'volume': '94',
'author': 'Grant',
'year': '2002',
'journal-title': 'Cancer'},
{ 'issue': 'March (2)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0315',
'doi-asserted-by': 'crossref',
'first-page': '83',
'DOI': '10.1007/s10552-004-1661-4',
'article-title': 'The epidemiology of vitamin D and cancer incidence and mortality: a '
'review (United States)',
'volume': '16',
'author': 'Giovannucci',
'year': '2005',
'journal-title': 'Cancer Causes Control'},
{ 'issue': 'February (2)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0320',
'doi-asserted-by': 'crossref',
'first-page': '252',
'DOI': '10.2105/AJPH.2004.045260',
'article-title': 'The role of vitamin d in Cancer prevention',
'volume': '96',
'author': 'Garland',
'year': '2006',
'journal-title': 'Am. J. Public Health'},
{ 'issue': 'June (6)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0325',
'article-title': 'Breast cancer risk markedly lower with serum 25-hydroxyvitamin D '
'concentrations >60 vs <20ng/ml (150 vs 50 nmol/L): pooled analysis of '
'two randomized trials and a prospective cohort',
'volume': '13',
'author': 'McDonnell',
'year': '2018',
'journal-title': 'PLoS One'},
{ 'issue': 'August (16)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0330',
'first-page': '3712',
'article-title': '1,25-Dihydroxyvitamin D3 receptor as a marker of human colon carcinoma '
'cell line differentiation and growth inhibition',
'volume': '53',
'author': 'Shabahang',
'year': '1993',
'journal-title': 'Cancer Res.'},
{ 'issue': 'August (15)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0335',
'first-page': '4057',
'article-title': 'Growth inhibition of HT-29 human colon cancer cells by analogues of '
'1,25-dihydroxyvitamin D3',
'volume': '54',
'author': 'Shabahang',
'year': '1994',
'journal-title': 'Cancer Res.'},
{ 'issue': 'March (2)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0340',
'doi-asserted-by': 'crossref',
'first-page': '144',
'DOI': '10.1007/BF02305793',
'article-title': 'The effect of 1, 25-dihydroxyvitamin D3 on the growth of soft-tissue '
'sarcoma cells as mediated by the vitamin D receptor',
'volume': '3',
'author': 'Shabahang',
'year': '1996',
'journal-title': 'Ann. Surg. Oncol.'},
{ 'issue': 'February (1)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0345',
'doi-asserted-by': 'crossref',
'first-page': '127',
'DOI': '10.1006/jsre.1996.0092',
'article-title': 'Vitamin D receptor and growth inhibition by 1,25-dihydroxyvitamin D3 in '
'human malignant melanoma cell lines',
'volume': '61',
'author': 'Evans',
'year': '1996',
'journal-title': 'J. Surg. Res.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0350',
'doi-asserted-by': 'crossref',
'first-page': '2179',
'DOI': '10.1158/1535-7163.MCT-11-0422',
'article-title': 'Antitumoral effects of calcitriol in basal cell carcinomas involve '
'inhibition of hedgehog signaling and induction of vitamin d receptor '
'signaling and differentiation',
'volume': '10',
'author': 'Uhmann',
'year': '2011',
'journal-title': 'Mol. Cancer Ther.'},
{ 'issue': 'December (6)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0355',
'doi-asserted-by': 'crossref',
'first-page': '388',
'DOI': '10.1016/j.mam.2008.07.003',
'article-title': 'Molecular actions of vitamin D contributing to cancer prevention',
'volume': '29',
'author': 'Fleet',
'year': '2008',
'journal-title': 'Mol. Aspects Med.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0360',
'doi-asserted-by': 'crossref',
'first-page': '61',
'DOI': '10.1042/BJ20110744',
'article-title': 'Vitamin D and cancer: a review of molecular mechanisms',
'volume': '441',
'author': 'Fleet',
'year': '2012',
'journal-title': 'Biochem. J.'},
{ 'issue': 'June (6)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0365',
'doi-asserted-by': 'crossref',
'first-page': '1586',
'DOI': '10.1093/ajcn/85.6.1586',
'article-title': 'Vitamin D and calcium supplementation reduces cancer risk: results of a '
'randomized trial',
'volume': '85',
'author': 'Lappe',
'year': '2007',
'journal-title': 'Am. J. Clin. Nutr.'},
{ 'issue': '1',
'key': '10.1016/j.jsbmb.2018.12.010_bib0370',
'article-title': 'The incidental use of high-dose vitamin D3 in pancreatic Cancer',
'volume': '2',
'author': 'Cannon',
'year': '2016',
'journal-title': 'Case Rep. Pancreat. Cancer'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0375',
'doi-asserted-by': 'crossref',
'DOI': '10.1007/s10549-018-4896-6',
'article-title': 'De novo vitamin D supplement use post-diagnosis is associated with '
'breast cancer survival',
'author': 'Madden',
'year': '2018',
'journal-title': 'Breast Cancer Res. Treat.'},
{ 'issue': '20',
'key': '10.1016/j.jsbmb.2018.12.010_bib0380',
'doi-asserted-by': 'crossref',
'first-page': '2083',
'DOI': '10.1001/jama.2014.5052',
'article-title': 'for the National Heart, Lung, and Blood Institute’s Asthma Net. Effect '
'of Vitamin D3on Asthma Treatment Failures in Adults with Symptomatic '
'Asthma and Lower Vitamin D Levels. The VIDA Randomized Clinical Trial',
'volume': '311',
'author': 'Castro',
'year': '2014',
'journal-title': 'JAMA'},
{ 'issue': 'October (10)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0385',
'first-page': '2987',
'article-title': 'The 2011 report on dietary reference intake for vitamin d: where do we '
'go from Here? John F. Aloia',
'volume': '96',
'year': '2011',
'journal-title': 'J. Clin. Endocrinol. Metab.'},
{ 'issue': 'July (4)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0390',
'doi-asserted-by': 'crossref',
'first-page': '612',
'DOI': '10.1002/mds.870120424',
'article-title': 'Reversible parkinsonism, hypophosphoremia, and hypocalcemia under '
'vitamin D therapy',
'volume': '12',
'author': 'Derex',
'year': '1997',
'journal-title': 'Mov. Disord.'},
{ 'issue': 'June',
'key': '10.1016/j.jsbmb.2018.12.010_bib0395',
'doi-asserted-by': 'crossref',
'first-page': '919',
'DOI': '10.1016/S0140-6736(46)90616-2',
'article-title': 'Treatment of lupus vulgaris with calciferol',
'volume': '22',
'author': 'Dowling',
'year': '1946',
'journal-title': 'Lancet'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0400',
'doi-asserted-by': 'crossref',
'first-page': '258',
'DOI': '10.1136/bmj.2.5913.258',
'article-title': '“Anticonvulsant action” of vitamin D in epileptic patients. A '
'controlled pilot study',
'volume': '2',
'author': 'Christiansen',
'year': '1974',
'journal-title': 'Br. Med. J.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0405',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.yebeh.2012.03.011',
'article-title': 'Correction of vitamin D deficiency improves seizure control in '
'epilepsy: a pilot study',
'author': 'Holló',
'year': '2012',
'journal-title': 'Epilepsy Behav.'},
{ 'issue': '4',
'key': '10.1016/j.jsbmb.2018.12.010_bib0410',
'doi-asserted-by': 'crossref',
'DOI': '10.1002/mds.21317',
'article-title': 'Vitamin d and Parkinson’s disease—a hypothesis',
'volume': '22',
'author': 'Newmark',
'year': '2007',
'journal-title': 'Mov. Disord.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0415',
'unstructured': 'L. Szabo. Vitamin D, the Sunshine Supplement, has Shadowy Money Behind '
'It. '
'https://www.nytimes.com/2018/08/18/business/vitamin-d-michael-holick.html.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0420',
'series-title': 'Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, '
'and Fluoride',
'year': '1997'},
{ 'issue': 'April (3)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0425',
'doi-asserted-by': 'crossref',
'first-page': '1115',
'DOI': '10.1007/s00394-012-0421-6',
'article-title': 'Vitamin D status indicators in indigenous populations in East Africa',
'volume': '52',
'author': 'Luxwolda',
'year': '2013',
'journal-title': 'Eur. J. Nutr.'},
{ 'issue': '11',
'key': '10.1016/j.jsbmb.2018.12.010_bib0430',
'doi-asserted-by': 'crossref',
'DOI': '10.1371/journal.pone.0111265',
'article-title': 'The importance of body weight for the dose response relationship of '
'oral vitamin d supplementation and serum 25-Hydroxyvitamin d in healthy '
'volunteers',
'volume': '9',
'author': 'Ekwaru',
'year': '2014',
'journal-title': 'PLoS One'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0435',
'doi-asserted-by': 'crossref',
'first-page': 'e43',
'DOI': '10.2105/AJPH.2014.302034',
'article-title': 'RP meta-analysis of all-cause mortality according to serum '
'25-Hydroxyvitamin d',
'volume': '104',
'author': 'Garland',
'year': '2014',
'journal-title': 'Am. J. Public Health'},
{ 'issue': 'May (5)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0440',
'doi-asserted-by': 'crossref',
'first-page': '577',
'DOI': '10.1016/j.mayocp.2015.02.012',
'article-title': 'Changing incidence of serum 25-Hydroxyvitamin d values above 50 ng/ml: '
'a 10-Year population-based study',
'volume': '90',
'author': 'Dudenkov',
'year': '2015',
'journal-title': 'Mayo Clin. Proc.'},
{ 'issue': 'May (5)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0445',
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'first-page': '561',
'DOI': '10.1016/j.mayocp.2015.03.015',
'article-title': 'Vitamin d is not as toxic as was once thought: a historical and an '
'up-to date perspective',
'volume': '90',
'author': 'Holick',
'year': '2015',
'journal-title': 'Mayo Clin. Proc.'},
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'key': '10.1016/j.jsbmb.2018.12.010_bib0450',
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'first-page': '721',
'DOI': '10.1016/j.mayocp.2018.03.006',
'article-title': 'Serum 25-Hydroxyvitamin d values and risk of all cause and '
'cause-specific mortality: a population-based cohort study',
'volume': '93',
'author': 'Dudenkov',
'year': '2018',
'journal-title': 'Mayo Clin. Proc.'},
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'doi-asserted-by': 'crossref',
'first-page': '679',
'DOI': '10.1016/j.mayocp.2018.04.014',
'article-title': 'The death D-fying vitamin',
'volume': '93',
'author': 'Holick',
'year': '2018',
'journal-title': 'Mayo Clin. Proc.'},
{ 'issue': '1',
'key': '10.1016/j.jsbmb.2018.12.010_bib0460',
'doi-asserted-by': 'crossref',
'DOI': '10.1080/19381980.2017.1300213',
'article-title': 'Evaluation of vitamin D3 intakes up to 15,000 international units/day '
'and serum 25-hydroxyvitamin D concentrations up to 300 nmol/L on '
'calcium metabolism in a community setting',
'volume': '9',
'author': 'Kimball',
'year': '2017',
'journal-title': 'Dermato-Endocrinology'},
{ 'issue': '7',
'key': '10.1016/j.jsbmb.2018.12.010_bib0465',
'doi-asserted-by': 'crossref',
'DOI': '10.1371/journal.pone.0180483',
'article-title': 'Maternal 25(OH)D concentrations ≥40 ng/mL associated with 60% lower '
'preterm birth risk among general obstetrical patients at an urban '
'medical center',
'volume': '12',
'author': 'McDonnell',
'year': '2017',
'journal-title': 'PLoS One'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0470',
'doi-asserted-by': 'crossref',
'DOI': '10.2105/AJPH.2013.301368',
'article-title': '25Hydroxyvitamin D in the range of 20 to 100 ng/ml and Incidence of '
'Kidney Stones',
'volume': '104',
'author': 'Nguyen',
'year': '2014',
'journal-title': 'Am. J. Public Health'},
{ 'issue': '8',
'key': '10.1016/j.jsbmb.2018.12.010_bib0475',
'doi-asserted-by': 'crossref',
'first-page': 'e102965',
'DOI': '10.1371/journal.pone.0102965',
'article-title': 'Effects of high doses of cholecalciferol in normal subjects: a '
'randomized double-blinded, placebo-controlled trial',
'volume': '9',
'author': 'Nygaad',
'year': '2014',
'journal-title': 'PLoS One'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0480',
'first-page': '210',
'article-title': 'Calcium and vitamin d supplementation and risk of kidney stone '
'formation in postmenopausal women',
'volume': '7',
'author': 'Haghighi',
'year': '2013',
'journal-title': 'IJKD'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0485',
'doi-asserted-by': 'crossref',
'first-page': '134',
'DOI': '10.1159/000351377',
'article-title': 'Vitamin d status in patients with recurrent kidney stones',
'volume': '122',
'author': 'Pipili',
'year': '2012',
'journal-title': 'Nephron Clin. Pract.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0490',
'doi-asserted-by': 'crossref',
'first-page': '4385',
'DOI': '10.1093/ndt/gfs297',
'article-title': 'Association between serum 25-hydroxyvitamin d and nephrolithiasis: the '
'national health and nutrition examination survey III, 1988-94',
'volume': '27',
'author': 'Tang',
'year': '2012',
'journal-title': 'Nephrol. Dial. Transplant.'},
{ 'key': '10.1016/j.jsbmb.2018.12.010_bib0495',
'doi-asserted-by': 'crossref',
'first-page': '1512',
'DOI': '10.1111/j.1464-410X.2009.08559.x',
'article-title': 'Vitamin D repletion does not alter urinary calcium excretion in healthy '
'postmenopausal women',
'volume': '104',
'author': 'Penniston',
'year': '2009',
'journal-title': 'BJU Int.'},
{ 'issue': 'February (2)',
'key': '10.1016/j.jsbmb.2018.12.010_bib0500',
'doi-asserted-by': 'crossref',
'first-page': '405',
'DOI': '10.1016/j.juro.2016.08.084',
'article-title': 'Vitamin d intake and the risk of incident kidney stones',
'volume': '197',
'author': 'Ferraro',
'year': '2017',
'journal-title': 'J. Urol.'}],
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