Anti-inflammatory and Nutritional Interventions Against SARS-CoV-2: A Comprehensive Review

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L. Li, Database Group. CoVID-19 DashBoard Tsinghua Database Research ' 'Group Qatar Computing Research institute, 30 (2024). ' 'https://ncov.deepeye.tech/.'}, { 'key': '10.1016/j.jafr.2024.101422_bib8', 'doi-asserted-by': 'crossref', 'first-page': '913', 'DOI': '10.1128/JVI.02576-13', 'article-title': 'Inhibition of NF-B-Mediated Inflammation in Severe Acute Respiratory ' 'Syndrome Coronavirus-Infected Mice Increases Survival', 'volume': '88', 'author': 'De Diego', 'year': '2014', 'journal-title': 'Journal of Virology'}, { 'key': '10.1016/j.jafr.2024.101422_bib9', 'first-page': 'e263', 'article-title': 'A recombinant spike-XBB.1.5 protein vaccine induces broad-spectrum ' 'immune responses against XBB.1.5-included Omicron variants of ' 'SARS-CoV-2', 'volume': '26', 'author': 'He', 'year': '2020', 'journal-title': 'MedComm'}, { 'key': '10.1016/j.jafr.2024.101422_bib10', 'doi-asserted-by': 'crossref', 'DOI': '10.1007/s12250-020-00207-4', 'article-title': 'Understanding SARS-CoV-2-Mediated Inflammatory Responses: From ' 'Mechanisms to Potential Therapeutic Tools', 'author': 'Fu', 'year': '2020', 'journal-title': 'Virologica Sinica'}, { 'journal-title': 'Biorxiv preprint', 'article-title': 'Aberrant pathogenic GM-CSF+ T cells and inflammatory CD14+CD16+ 1 ' 'monocytes 2 in severe pulmonary syndrome patients of a new coronavirus', 'year': '2020', 'author': 'Zhou', 'key': '10.1016/j.jafr.2024.101422_bib11'}, { 'key': '10.1016/j.jafr.2024.101422_bib12', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.cell.2020.02.052', 'article-title': 'SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a ' 'clinically proven protease inhibitor', 'author': 'Hoffmann', 'year': '2020', 'journal-title': 'Cell'}, { 'key': '10.1016/j.jafr.2024.101422_bib13', 'doi-asserted-by': 'crossref', 'first-page': '337', 'DOI': '10.1186/s12879-017-2432-7', 'article-title': 'Relative incidence and individual-level severity of seasonal influenza ' 'A H3N2 compared with 2009 pandemic H1N1', 'volume': '1', 'author': 'Kwok', 'year': '2017', 'journal-title': 'BMC Infectious Diseases'}, { 'key': '10.1016/j.jafr.2024.101422_bib14', 'doi-asserted-by': 'crossref', 'DOI': '10.1371/journal.pmed.1000442', 'article-title': 'Epidemiological characteristics of 2009 (H1N1) pandemic influenza based ' 'on paired sera from a longitudinal community cohort study', 'volume': '8', 'author': 'Riley', 'year': '2011', 'journal-title': 'PLoS Medicine'}, { 'key': '10.1016/j.jafr.2024.101422_bib15', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.3390/nu11081933', 'article-title': 'Diet and Immune Function', 'volume': '11', 'author': 'Childs', 'year': '2019', 'journal-title': 'Nutrients'}, { 'key': '10.1016/j.jafr.2024.101422_bib16', 'doi-asserted-by': 'crossref', 'first-page': '115', 'DOI': '10.3390/nu14010115', 'article-title': 'Preventing the Adverse Effects of SARS-CoV-2 Infection and COVID-19 ' 'through Diet, Supplements, and Lifestyle', 'volume': '28', 'author': 'Lordan', 'year': '2021', 'journal-title': 'Nutrients'}, { 'key': '10.1016/j.jafr.2024.101422_bib17', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/nu12061562', 'article-title': 'Strengthening the Immune System and Reducing Inflammation and Oxidative ' 'Stress through Diet and Nutrition: Considerations during the COVID-19 ' 'Crisis', 'volume': '12', 'author': 'Iddir', 'year': '2020', 'journal-title': 'Nutrients'}, { 'key': '10.1016/j.jafr.2024.101422_bib18', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.lfs.2022.120489', 'article-title': 'The effect of polyunsaturated fatty acids on the severity and mortality ' 'of COVID patients: A systematic review', 'volume': '299', 'author': 'Mazidimoradi', 'year': '2022', 'journal-title': 'Life Sci'}, { 'key': '10.1016/j.jafr.2024.101422_bib19', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fphar.2022.755745', 'article-title': 'Riboflavin for COVID-19 Adjuvant Treatment in Patients With Mental ' 'Health Disorders: Observational Study', 'volume': '13', 'author': 'Akasov', 'year': '2022', 'journal-title': 'Front Pharmacol'}, { 'key': '10.1016/j.jafr.2024.101422_bib20', 'doi-asserted-by': 'crossref', 'first-page': '2101', 'DOI': '10.3390/nu11092101', 'article-title': 'Selenium, Selenoproteins and Viral Infection', 'volume': '11', 'author': 'Guillin', 'year': '2019', 'journal-title': 'Nutrients'}, { 'key': '10.1016/j.jafr.2024.101422_bib21', 'doi-asserted-by': 'crossref', 'first-page': '1085', 'DOI': '10.1016/j.dsx.2020.07.001', 'article-title': 'Balanced diet is a major casualty in COVID-19', 'volume': '14', 'author': 'Jayawardena', 'year': '2020', 'journal-title': 'Diabetes Metab Syndr'}, { 'key': '10.1016/j.jafr.2024.101422_bib22', 'doi-asserted-by': 'crossref', 'first-page': '340', 'DOI': '10.3390/nu15020340', 'article-title': 'Association of Serum Zinc and Inflammatory Markers with the Severity of ' 'COVID-19 Infection in Adult Patients', 'volume': '15', 'author': 'Almasaud', 'year': '2023', 'journal-title': 'Nutrients'}, { 'key': '10.1016/j.jafr.2024.101422_bib23', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1155/2016/5698931', 'article-title': 'Does the Interdependence between Oxidative Stress and Inflammation ' 'Explain the Antioxidant Paradox?', 'volume': '2016', 'author': 'Biswas', 'year': '2016', 'journal-title': 'Oxidative Medicine and Cellular Longevity'}, { 'key': '10.1016/j.jafr.2024.101422_bib24', 'doi-asserted-by': 'crossref', 'first-page': '438', 'DOI': '10.9734/BJMMR/2015/16284', 'article-title': 'Free radicals: health implications and their mitigation by herbals', 'volume': '7', 'author': 'Kumar', 'year': '2015', 'journal-title': 'British Journal of Medicine and Medical Research'}, { 'key': '10.1016/j.jafr.2024.101422_bib25', 'doi-asserted-by': 'crossref', 'first-page': '44', 'DOI': '10.1016/j.cytogfr.2021.11.001', 'article-title': 'SARS-CoV-2 infection and oxidative stress: Pathophysiological insight ' 'into thrombosis and therapeutic opportunities', 'volume': '63', 'author': 'Alam', 'year': '2022', 'journal-title': 'Cytokine Growth Factor Rev'}, { 'key': '10.1016/j.jafr.2024.101422_bib26', 'doi-asserted-by': 'crossref', 'first-page': '153', 'DOI': '10.1016/j.freeradbiomed.2006.09.030', 'article-title': 'Reactive oxygen and nitrogen species as signalling molecules regulating ' 'neutrophil function', 'volume': '42', 'author': 'Fialkow', 'year': '2007', 'journal-title': 'Free Radical Biology and Medicine'}, { 'key': '10.1016/j.jafr.2024.101422_bib27', 'article-title': 'Metabolic Implications of Oxidative Stress and Inflammatory Process in ' 'SARS-CoV-2 Pathogenesis: Therapeutic Potential of Natural Antioxidants', 'volume': '26', 'author': 'Forcados', 'year': '2021', 'journal-title': 'Front Cell Infect Microbiol'}, { 'key': '10.1016/j.jafr.2024.101422_bib28', 'doi-asserted-by': 'crossref', 'first-page': '982', 'DOI': '10.1080/10715762.2021.2005247', 'article-title': 'SARS-CoV-2 induces mitochondrial dysfunction and cell death by ' 'oxidative stress/inflammation in leukocytes of COVID-19 patients', 'volume': '55', 'author': 'De la Cruz-Enríquez', 'year': '2021', 'journal-title': 'Free Radic Res'}, { 'journal-title': 'Preprint at medRxiv', 'article-title': 'Immunopathological characteristics of coronavirus disease 2019 cases in ' 'Guangzhou, China', 'year': '2020', 'author': 'Shi', 'key': '10.1016/j.jafr.2024.101422_bib29'}, { 'key': '10.1016/j.jafr.2024.101422_bib30', 'doi-asserted-by': 'crossref', 'first-page': '479', 'DOI': '10.1002/jmv.25707', 'article-title': 'Potential Interventions for Novel Coronavirus in China: A Systemic ' 'Review', 'volume': '92', 'author': 'Zhang', 'year': '2020', 'journal-title': 'Medical Virology'}, { 'key': '10.1016/j.jafr.2024.101422_bib31', 'doi-asserted-by': 'crossref', 'first-page': '1136', 'DOI': '10.2353/ajpath.2007.061088', 'article-title': 'Pathology and Pathogenesis of Severe Acute Respiratory Syndrome', 'volume': '170', 'author': 'Gu', 'year': '2007', 'journal-title': 'American Journal of Pathology'}, { 'key': '10.1016/j.jafr.2024.101422_bib32', 'first-page': '2', 'article-title': 'COVID-19: immunopathology and its implications for therapy', 'author': 'Cao', 'year': '2020', 'journal-title': 'Nature Reviews'}, { 'key': '10.1016/j.jafr.2024.101422_bib33', 'first-page': '162', 'article-title': 'SARS-CoV-2 variant biology: immune escape, transmission and fitness', 'volume': '21', 'author': 'Carabelli', 'year': '2023', 'journal-title': 'Nat Rev Microbiol'}, { 'key': '10.1016/j.jafr.2024.101422_bib34', 'doi-asserted-by': 'crossref', 'DOI': '10.1172/JCI137647', 'article-title': 'SARS-CoV-2: a storm is raging', 'author': 'Pedersen', 'year': '2020', 'journal-title': 'Journal of Clinical Investigation'}, { 'key': '10.1016/j.jafr.2024.101422_bib35', 'doi-asserted-by': 'crossref', 'first-page': '243', 'DOI': '10.3390/v11030243', 'article-title': 'Viral Infection of Human Natural Killer Cells', 'volume': '11', 'author': 'van-Erp', 'year': '2019', 'journal-title': 'Viruses'}, { 'key': '10.1016/j.jafr.2024.101422_bib36', 'doi-asserted-by': 'crossref', 'first-page': '1708', 'DOI': '10.1056/NEJMoa2002032', 'article-title': 'Clinical characteristics of coronavirus disease 2019 in China', 'volume': '382', 'author': 'Guan', 'year': '2020', 'journal-title': 'New England Journal of Medicine'}, { 'key': '10.1016/j.jafr.2024.101422_bib37', 'first-page': '2012', 'article-title': 'Novel coronavirus 2019-nCoV: prevalence, biological and clinical ' 'characteristics comparison with SARS-CoV and MERS-CoV', 'volume': '24', 'author': 'Meo', 'year': '2020', 'journal-title': 'European Review for Medical and Pharmacological Sciences'}, { 'key': '10.1016/j.jafr.2024.101422_bib38', 'doi-asserted-by': 'crossref', 'first-page': '130', 'DOI': '10.1111/resp.13196', 'article-title': 'MERS, SARS and other coronaviruses as causes of pneumonia', 'volume': '3', 'author': 'Yin', 'year': '2018', 'journal-title': 'Respirology'}, { 'key': '10.1016/j.jafr.2024.101422_bib39', 'doi-asserted-by': 'crossref', 'unstructured': 'W. Wang, Y. Xu, R. Gao, et al., Detection of SARS-CoV-2 in different ' 'types of clinical specimens, Journal of American Medical Association ' '2020 (2020). https://doi.org/10.1001/jama.2020.3786.', 'DOI': '10.1001/jama.2020.3786'}, { 'key': '10.1016/j.jafr.2024.101422_bib40', 'doi-asserted-by': 'crossref', 'unstructured': 'Z. Wu, J. M. McGoogan, Characteristics of and Important Lessons from the ' 'Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a ' 'Report of 72314 Cases from the Chinese Center for Disease Control and ' 'Prevention, Journal of the American Medical Association (2020) E1-E4. ' 'https://doi.org/10.1001/jama.2020.2648.', 'DOI': '10.1001/jama.2020.2648'}, { 'key': '10.1016/j.jafr.2024.101422_bib41', 'doi-asserted-by': 'crossref', 'first-page': '502', 'DOI': '10.1038/s41591-020-0817-4', 'article-title': 'Characteristics of pediatric SARS-CoV-2 infection and potential ' 'evidence for persistent faecal viral shedding', 'volume': '26', 'author': 'Xu', 'year': '2020', 'journal-title': 'Nature Medicals'}, { 'key': '10.1016/j.jafr.2024.101422_bib42', 'unstructured': 'M. Cascella, M. Rajnik, A. Cuomo, et al., Features, Evaluation and ' 'Treatment Coronavirus (COVID-19), Treasure Island (2020). ' 'https://www.ncbi.nlm.nih.gov/books/NBK554776/.'}, { 'key': '10.1016/j.jafr.2024.101422_bib43', 'doi-asserted-by': 'crossref', 'first-page': '1199', 'DOI': '10.1056/NEJMoa2001316', 'article-title': 'Early Transmission Dynamics in Wuhan, China, of Novel ' 'Coronavirus-Infected Pneumonia', 'volume': '382', 'author': 'Li', 'year': '2020', 'journal-title': 'New England Journal of Medicine'}, { 'key': '10.1016/j.jafr.2024.101422_bib44', 'doi-asserted-by': 'crossref', 'first-page': '970', 'DOI': '10.1056/NEJMc2001468', 'article-title': 'Transmission of 2019-nCoV infection from an asymptomatic contact in ' 'Germany', 'volume': '382', 'author': 'Rothe', 'year': '2020', 'journal-title': 'New England Journal of Medicine'}, { 'key': '10.1016/j.jafr.2024.101422_bib45', 'article-title': 'Airflow Dynamics of Human Jets: Sneezing and Breathing - Potential ' 'Sources of Infectious Aerosols', 'volume': '8', 'author': 'Tang', 'year': '2013', 'journal-title': 'PloS One'}, { 'key': '10.1016/j.jafr.2024.101422_bib46', 'doi-asserted-by': 'crossref', 'first-page': '1054', 'DOI': '10.1016/S0140-6736(20)30566-3', 'article-title': 'Clinical course and risk factors for mortality of adult inpatients with ' 'COVID-19 in Wuhan, China: a retrospective cohort study', 'volume': '395', 'author': 'Zhou', 'year': '2020', 'journal-title': 'Lancet'}, { 'key': '10.1016/j.jafr.2024.101422_bib47', 'doi-asserted-by': 'crossref', 'first-page': '693', 'DOI': '10.1016/S0140-6736(22)00982-5', 'article-title': 'Influenza', 'volume': '27', 'author': 'Uyeki', 'year': '2022', 'journal-title': 'Lancet'}, { 'key': '10.1016/j.jafr.2024.101422_bib48', 'doi-asserted-by': 'crossref', 'first-page': '1036', 'DOI': '10.1016/j.cell.2020.04.026', 'article-title': 'Imbalanced host response to SARS-CoV-2 drives the development of ' 'COVID-19', 'volume': '181', 'author': 'Blanco-Melo', 'year': '2020', 'journal-title': 'Cell'}, { 'key': '10.1016/j.jafr.2024.101422_bib49', 'first-page': '420', 'article-title': 'Pathological findings of Covid-19 associated with acute respiratory ' 'distress syndrome', 'volume': '8', 'author': 'Xu', 'year': '2020', 'journal-title': 'Lancet'}, { 'key': '10.1016/j.jafr.2024.101422_bib50', 'doi-asserted-by': 'crossref', 'first-page': '93', 'DOI': '10.1016/bs.aivir.2019.08.002', 'article-title': 'Structural insights into coronavirus entry', 'volume': '105', 'author': 'Tortorici', 'year': '2019', 'journal-title': 'Advance Virus Research'}, { 'key': '10.1016/j.jafr.2024.101422_bib51', 'doi-asserted-by': 'crossref', 'first-page': '290', 'DOI': '10.1038/s41586-020-2349-y', 'article-title': 'Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV ' 'antibody', 'volume': '583', 'author': 'Pinto', 'year': '2020', 'journal-title': 'Nature'}, { 'key': '10.1016/j.jafr.2024.101422_bib52', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1186/s40779-020-00240-0', 'article-title': 'The origin, transmission and clinical therapies on 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'Cell'}, { 'key': '10.1016/j.jafr.2024.101422_bib56', 'doi-asserted-by': 'crossref', 'DOI': '10.1172/JCI137244', 'article-title': 'Clinical and immunological features of severe and moderate coronavirus ' 'disease-2019', 'author': 'Chen', 'year': '2020', 'journal-title': 'Journal of Clinical Investigation'}, { 'key': '10.1016/j.jafr.2024.101422_bib57', 'doi-asserted-by': 'crossref', 'first-page': 'S3', 'DOI': '10.1016/j.jaci.2009.12.980', 'article-title': 'Overview of the Immune Response', 'volume': '125', 'author': 'Chaplin', 'year': '2010', 'journal-title': 'Journal of Allergy and Clinical Immunology'}, { 'journal-title': 'medRxiv', 'article-title': 'Reduction and functional exhaustion of T cells in patients with ' 'coronavirus disease 2019 (COVID-19)', 'year': '2020', 'author': 'Diao', 'key': '10.1016/j.jafr.2024.101422_bib58'}, { 'key': '10.1016/j.jafr.2024.101422_bib59', 'doi-asserted-by': 'crossref', 'first-page': '1891', 'DOI': '10.3389/fmicb.2018.01891', 'article-title': 'Increased virulence of an epidemic strain of vesicular stomatitis virus ' 'is associated with interference of the innate response in pigs', 'volume': '9', 'author': 'Velazquez-Salinas', 'year': '2018', 'journal-title': 'Frontiers in Microbiology'}, { 'key': '10.1016/j.jafr.2024.101422_bib60', 'doi-asserted-by': 'crossref', 'first-page': '174', 'DOI': '10.4049/jimmunol.0903548', 'article-title': 'Expression of Costimulatory TNFR2 Induces Resistance of CD4+FoxP3- ' 'Conventional T Cells to Suppression by CD4+FoxP3+ Regulatory T Cells', 'volume': '185', 'author': 'Chen', 'year': '2010', 'journal-title': 'Journal of Immunology'}, { 'key': '10.1016/j.jafr.2024.101422_bib61', 'doi-asserted-by': 'crossref', 'first-page': '181', 'DOI': '10.1016/j.chom.2016.01.007', 'article-title': 'Dysregulated type I interferon and inflammatory monocyte-macrophage ' 'responses cause lethal pneumonia in SARS-CoV-infected Mice', 'volume': '19', 'author': 'Channappanavar', 'year': '2016', 'journal-title': 'Cell Host and Microbe'}, { 'key': '10.1016/j.jafr.2024.101422_bib62', 'doi-asserted-by': 'crossref', 'first-page': '881', 'DOI': '10.1016/j.cell.2022.01.014', 'article-title': 'Multiple early factors anticipate post-acute COVID-19 sequelae', 'volume': '185', 'author': 'Su', 'year': '2022', 'journal-title': 'Cell'}, { 'key': '10.1016/j.jafr.2024.101422_bib63', 'unstructured': 'WHO, Report of the WHO–China Joint Mission on coronavirus disease 2019 ' '(COVID-19), (2020). ' 'https://www.who.int/publications-detail/report-of-the-who-china-joint-mission-on-coronavirus-disease-2019-(COVID-19).'}, { 'key': '10.1016/j.jafr.2024.101422_bib64', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1186/s12933-017-0604-9', 'article-title': 'Oxidative stress and inflammation as central mediators of atrial ' 'fibrillation in obesity and diabetes', 'volume': '16', 'author': 'Karam', 'year': '2017', 'journal-title': 'Cardiovascular Diabetology'}, { 'key': '10.1016/j.jafr.2024.101422_bib65', 'doi-asserted-by': 'crossref', 'first-page': '369', 'DOI': '10.1016/j.autrev.2010.12.006', 'article-title': 'Inflammation as “common soil” of the multifactorial diseases', 'volume': '10', 'author': 'Scrivo', 'year': '2011', 'journal-title': 'Autoimmune Review'}, { 'key': '10.1016/j.jafr.2024.101422_bib66', 'doi-asserted-by': 'crossref', 'first-page': '424', 'DOI': '10.1002/jmv.25685', 'article-title': 'Coronavirus Infections and Immune Responses', 'volume': '92', 'author': 'Li', 'year': '2020', 'journal-title': 'Journal of Medical Virology'}, { 'key': '10.1016/j.jafr.2024.101422_bib67', 'doi-asserted-by': 'crossref', 'first-page': 'e692', 'DOI': '10.1016/S2666-5247(23)00171-4', 'article-title': 'Dynamics of inflammatory responses after SARS-CoV-2 infection by ' 'vaccination status in the USA: a prospective cohort study', 'volume': '4', 'author': 'Zhu', 'year': '2023', 'journal-title': 'Lancet Microbe'}, { 'key': '10.1016/j.jafr.2024.101422_bib68', 'first-page': '370', 'article-title': 'Acute respiratory distress revealing anti-synthetase syndrome', 'volume': '73', 'author': 'Maloir', 'year': '2018', 'journal-title': 'Revue Medicale de Liege'}, { 'key': '10.1016/j.jafr.2024.101422_bib69', 'doi-asserted-by': 'crossref', 'DOI': '10.1155/2019/6491738', 'article-title': 'Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Infection, ' 'Immunological Response, and Vaccine Development', 'volume': '2019', 'author': 'Mubarak', 'year': '2019', 'journal-title': 'Journal of Immunology Research'}, { 'key': '10.1016/j.jafr.2024.101422_bib70', 'doi-asserted-by': 'crossref', 'first-page': '135', 'DOI': '10.1042/BJ20050698', 'article-title': 'Bcl-xL inhibits T-cell apoptosis induced by expression of SARS ' 'coronavirus E protein in the absence of growth factors', 'volume': '392', 'author': 'Yang', 'year': '2005', 'journal-title': 'The Biochemical Journal'}, { 'key': '10.1016/j.jafr.2024.101422_bib71', 'doi-asserted-by': 'crossref', 'unstructured': 'C. Qin, L. Zhou, Z. Hu, et al., Dysregulation of immune responses in ' 'patients with COVID-19 in Wuhan, China, Clinical Infectious Disease ' '(2020). https://doi.org/10.1093/cid/ciaa248.', 'DOI': '10.1093/cid/ciaa248'}, { 'key': '10.1016/j.jafr.2024.101422_bib72', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.biopha.2020.110195', 'article-title': 'New understanding of the damage of SARS-CoV-2 infection outside the ' 'respiratory system', 'volume': '127', 'author': 'Zhang', 'year': '2020', 'journal-title': 'Biomedicine and Pharmacotherapy'}, { 'key': '10.1016/j.jafr.2024.101422_bib73', 'doi-asserted-by': 'crossref', 'first-page': '533', 'DOI': '10.1038/s41423-020-0402-2', 'article-title': 'Functional exhaustion of antiviral lymphocytes in COVID-19 patients', 'volume': '17', 'author': 'Zheng', 'year': '2020', 'journal-title': 'Cellular and Molecular Immunology'}, { 'key': '10.1016/j.jafr.2024.101422_bib74', 'doi-asserted-by': 'crossref', 'first-page': 'e692', 'DOI': '10.1016/S2666-5247(23)00171-4', 'article-title': 'Dynamics of inflammatory responses after SARS-CoV-2 infection by ' 'vaccination status in the USA: a prospective cohort study', 'volume': '4', 'author': 'Zhu', 'year': '2023', 'journal-title': 'Lancet Microbe'}, { 'journal-title': 'The Lancet', 'article-title': 'Clinical course and outcomes of critically ill patients with SARS-CoV-2 ' 'pneumonia in Wuhan, China: a single-centre, retrospective, ' 'observational study', 'year': '2020', 'author': 'Yang', 'key': '10.1016/j.jafr.2024.101422_bib75'}, { 'key': '10.1016/j.jafr.2024.101422_bib76', 'doi-asserted-by': 'crossref', 'first-page': '201', 'DOI': '10.1016/j.jshs.2018.09.009', 'article-title': "The compelling link between physical activity and the body's defence " 'system', 'volume': '8', 'author': 'Nieman', 'year': '2019', 'journal-title': 'Journal of Sport Health Science'}, { 'key': '10.1016/j.jafr.2024.101422_bib77', 'doi-asserted-by': 'crossref', 'first-page': '484', 'DOI': '10.1038/s41577-021-00646-4', 'article-title': 'Immune ageing at single-cell resolution', 'volume': '22', 'author': 'Mogilenko', 'year': '2022', 'journal-title': 'Nat Rev Immunol'}, { 'key': '10.1016/j.jafr.2024.101422_bib78', 'doi-asserted-by': 'crossref', 'first-page': '496', 'DOI': '10.1016/S0140-6736(12)61266-5', 'article-title': 'Acute pneumonia and the cardiovascular system', 'volume': '381', 'author': 'Corrales-Medina', 'year': '2013', 'journal-title': 'Lancet'}, { 'key': '10.1016/j.jafr.2024.101422_bib79', 'first-page': '372', 'article-title': 'Severe covid-19 pneumonia: pathogenesis and clinical management', 'volume': '10', 'author': 'Attaway', 'year': '2021', 'journal-title': 'BMJ'}, { 'key': '10.1016/j.jafr.2024.101422_bib80', 'doi-asserted-by': 'crossref', 'first-page': '96', 'DOI': '10.1186/s13073-022-01100-3', 'article-title': 'Clinical implications of host genetic variation and susceptibility to ' 'severe or critical COVID-19', 'volume': '14', 'author': 'van der Made', 'year': '2022', 'journal-title': 'Genome Med'}, { 'key': '10.1016/j.jafr.2024.101422_bib81', 'doi-asserted-by': 'crossref', 'first-page': '138', 'DOI': '10.1016/j.bbi.2021.02.021', 'article-title': 'Persistent psychopathology and neurocognitive impairment in COVID-19 ' 'survivors: Effect of inflammatory biomarkers at three-month follow-up', 'volume': '94', 'author': 'Mazza', 'year': '2021', 'journal-title': 'Brain Behav Immun'}, { 'key': '10.1016/j.jafr.2024.101422_bib82', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/S1473-3099(20)30243-7', 'article-title': 'Estimates of the severity of coronavirus disease 2019: a model-based ' 'analysis', 'author': 'Verity', 'year': '2020', 'journal-title': 'The Lancet Infectious Disease'}, { 'key': '10.1016/j.jafr.2024.101422_bib83', 'doi-asserted-by': 'crossref', 'first-page': '715', 'DOI': '10.7326/0003-4819-139-9-200311040-00005', 'article-title': 'Outcomes and prognostic factors in 267 patients with severe acute ' 'respiratory syndrome in Hong Kong', 'volume': '139', 'author': 'Choi', 'year': '2003', 'journal-title': 'Annals of Internal Medicine'}, { 'key': '10.1016/j.jafr.2024.101422_bib84', 'doi-asserted-by': 'crossref', 'first-page': '286', 'DOI': '10.1136/thoraxjnl-2016-209313', 'article-title': 'Predictors of mortality in the Middle East respiratory syndrome (MERS)', 'volume': '73', 'author': 'Hong', 'year': '2018', 'journal-title': 'Thorax'}, { 'key': '10.1016/j.jafr.2024.101422_bib85', 'doi-asserted-by': 'crossref', 'first-page': '75', 'DOI': '10.1038/s41577-022-00751-y', 'article-title': 'DNA damage and repair in age-related inflammation', 'volume': '23', 'author': 'Zhao', 'year': '2023', 'journal-title': 'Nat Rev Immunol'}, { 'key': '10.1016/j.jafr.2024.101422_bib86', 'doi-asserted-by': 'crossref', 'first-page': '576', 'DOI': '10.1038/s41574-018-0059-4', 'article-title': 'Inflammaging: a new immune-metabolic viewpoint for age-related diseases', 'volume': '14', 'author': 'Franceschi', 'year': '2018', 'journal-title': 'Nat Rev Endocrinol'}, { 'key': '10.1016/j.jafr.2024.101422_bib87', 'doi-asserted-by': 'crossref', 'DOI': '10.1080/19490976.2023.2290320', 'article-title': 'Disentangling the age-related manner in the associations between gut ' "microbiome and women's health: a multi-cohort microbiome study", 'volume': '15', 'author': 'Dong', 'year': '2023', 'journal-title': 'Gut Microbes'}, { 'key': '10.1016/j.jafr.2024.101422_bib88', 'doi-asserted-by': 'crossref', 'first-page': '171', 'DOI': '10.1126/scitranslmed.3004794', 'article-title': 'Lineage structure of the human antibody repertoire in response to ' 'influenza vaccination', 'volume': '5', 'author': 'Jiang', 'year': '2013', 'journal-title': 'Science Translational Medicine'}, { 'key': '10.1016/j.jafr.2024.101422_bib89', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.arr.2020.101205', 'article-title': 'Aging in COVID-19: Vulnerability, immunity and intervention', 'volume': '65', 'author': 'Chen', 'year': '2021', 'journal-title': 'Ageing Res Rev'}, { 'key': '10.1016/j.jafr.2024.101422_bib90', 'doi-asserted-by': 'crossref', 'first-page': '2801', 'DOI': '10.1001/jama.289.21.JOC30885', 'article-title': 'Clinical features and short-term outcomes of 144 patients with SARS in ' 'the greater Toronto area', 'volume': '289', 'author': 'Booth', 'year': '2003', 'journal-title': 'Journal of American Medical Association'}, { 'key': '10.1016/j.jafr.2024.101422_bib91', 'doi-asserted-by': 'crossref', 'first-page': '686', 'DOI': '10.1136/thorax.58.8.686', 'article-title': 'Short term outcome and risk factors for adverse clinical outcomes in ' 'adults with severe acute respiratory syndrome (SARS)', 'volume': '58', 'author': 'Chan', 'year': '2003', 'journal-title': 'Thorax'}, { 'key': '10.1016/j.jafr.2024.101422_bib92', 'doi-asserted-by': 'crossref', 'first-page': '243', 'DOI': '10.1016/j.cell.2022.11.001', 'article-title': 'Hallmarks of aging: An expanding universe', 'volume': '186', 'author': 'López-Otín', 'year': '2023', 'journal-title': 'Cell'}, { 'journal-title': 'Preprint at medRxiv', 'article-title': 'Restoration of leukomonocyte counts is associated with viral clearance ' 'in COVID-19 hospitalized patients', 'year': '2020', 'author': 'Chen', 'key': '10.1016/j.jafr.2024.101422_bib93'}, { 'key': '10.1016/j.jafr.2024.101422_bib94', 'doi-asserted-by': 'crossref', 'first-page': '33', 'DOI': '10.1016/S2213-2600(20)30417-3', 'article-title': 'Age-sex specific pulmonary embolism-related mortality in the USA and ' 'Canada, 2000-18: an analysis of the WHO Mortality Database and of the ' 'CDC Multiple Cause of Death database', 'volume': '9', 'author': 'Barco', 'year': '2021', 'journal-title': 'Lancet Respir Med'}, { 'key': '10.1016/j.jafr.2024.101422_bib95', 'doi-asserted-by': 'crossref', 'first-page': '709', 'DOI': '10.1016/S2213-2600(23)00159-5', 'article-title': 'Respiratory sequelae of COVID-19: pulmonary and extrapulmonary origins, ' 'and approaches to clinical care and rehabilitation', 'volume': '11', 'author': 'Singh', 'year': '2023', 'journal-title': 'Lancet Respir Med'}, { 'key': '10.1016/j.jafr.2024.101422_bib96', 'first-page': '1', 'article-title': 'Coronavirus infections: Epidemiological, clinical and immunological ' 'features and hypotheses', 'author': 'Raoult', 'year': '2020', 'journal-title': 'Cell Stress'}, { 'key': '10.1016/j.jafr.2024.101422_bib97', 'doi-asserted-by': 'crossref', 'first-page': '973', 'DOI': '10.1136/gutjnl-2020-321195', 'article-title': 'COVID-19 and the gastrointestinal tract: more than meets the eye', 'volume': '69', 'author': 'Ng', 'year': '2020', 'journal-title': 'Gut'}, { 'key': '10.1016/j.jafr.2024.101422_bib98', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.arr.2021.101541', 'article-title': 'Rebalancing the unbalanced aged immune system - A special focus on zinc', 'volume': '74', 'author': 'Baarz', 'year': '2022', 'journal-title': 'Ageing Res Rev'}, { 'key': '10.1016/j.jafr.2024.101422_bib99', 'doi-asserted-by': 'crossref', 'first-page': '340', 'DOI': '10.3390/nu15020340', 'article-title': 'Association of Serum Zinc and Inflammatory Markers with the Severity of ' 'COVID-19 Infection in Adult Patients', 'volume': '15', 'author': 'Almasaud', 'year': '2023', 'journal-title': 'Nutrients'}, { 'key': '10.1016/j.jafr.2024.101422_bib100', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1017/S0029665123004792', 'article-title': 'Nutrition and immunity: lessons from coronavirus disease-2019', 'volume': '27', 'author': 'Calder', 'year': '2023', 'journal-title': 'Proc Nutr Soc'}, { 'key': '10.1016/j.jafr.2024.101422_bib101', 'doi-asserted-by': 'crossref', 'DOI': '10.1080/07853890.2023.2265298', 'article-title': 'Approach to COVID-19 in older adults and indications for improving the ' 'outcomes', 'volume': '55', 'author': 'Tana', 'year': '2023', 'journal-title': 'Ann Med'}, { 'key': '10.1016/j.jafr.2024.101422_bib102', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.3390/nu12041181', 'article-title': 'Optimal Nutritional Status for a Well-Functioning Immune System is an ' 'Important Factor to Protect Against Viral Infections', 'volume': '12', 'author': 'Calder', 'year': '2020', 'journal-title': 'Nutrients'}, { 'key': '10.1016/j.jafr.2024.101422_bib103', 'doi-asserted-by': 'crossref', 'DOI': '10.1371/journal.pmed.1003999', 'article-title': 'High-dose versus standard-dose vitamin D supplementation in older ' 'adults with COVID-19 (COVIT-TRIAL): A multicenter, open-label, ' 'randomized controlled superiority trial', 'volume': '19', 'author': 'Annweiler', 'year': '2022', 'journal-title': 'PLoS Med'}, { 'key': '10.1016/j.jafr.2024.101422_bib104', 'doi-asserted-by': 'crossref', 'first-page': '300', 'DOI': '10.1186/s13054-017-1891-y', 'article-title': 'Hypovitaminosis C and vitamin C deficiency in critically ill patients ' 'despite recommended enteral and parenteral intakes', 'volume': '21', 'author': 'Carr', 'year': '2017', 'journal-title': 'Critical Care'}, { 'key': '10.1016/j.jafr.2024.101422_bib105', 'doi-asserted-by': 'crossref', 'first-page': '1745', 'DOI': '10.1001/jama.2023.21407', 'article-title': 'Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two ' 'Harmonized Randomized Clinical Trials', 'volume': '330', 'author': 'Adhikari', 'year': '2023', 'journal-title': 'JAMA'}, { 'key': '10.1016/j.jafr.2024.101422_bib106', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/S2213-8587(20)30183-2', 'article-title': 'Vitamin-D and COVID-19: do deficient risk a poorer outcome?', 'author': 'Mitchell', 'year': '2020', 'journal-title': 'Lancet Diabetes and Endocrinology'}, { 'journal-title': 'med Rxiv', 'article-title': 'Vitamin C for the treatment of COVID-19: A living systematic review ' 'protocol', 'year': '2020', 'author': 'Baladia', 'key': '10.1016/j.jafr.2024.101422_bib107'}, { 'key': '10.1016/j.jafr.2024.101422_bib108', 'doi-asserted-by': 'crossref', 'first-page': '1261', 'DOI': '10.1001/jama.2019.11825', 'article-title': 'Effect of vitamin C infusion on organ failure and biomarkers of ' 'inflammation and vascular injury in patients with sepsis and severe ' 'acute respiratory failure: the CITRIS-ALI randomized clinical trial', 'volume': '322', 'author': 'Fowler', 'year': '2019', 'journal-title': 'Journal of American Medical Association'}, { 'key': '10.1016/j.jafr.2024.101422_bib109', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.3389/fimmu.2018.03160', 'article-title': 'Nutritional Modulation of Immune Function: Analysis of Evidence, ' 'Mechanisms, and Clinical Relevance', 'volume': '9', 'author': 'Wu', 'year': '2019', 'journal-title': 'Frontiers in Immunology'}, { 'key': '10.1016/j.jafr.2024.101422_bib110', 'doi-asserted-by': 'crossref', 'first-page': '367', 'DOI': '10.1016/j.dsx.2020.04.015', 'article-title': 'Enhancing immunity in viral infections, with special emphasis on ' 'COVID-19: A review', 'volume': '14', 'author': 'Jayawardena', 'year': '2020', 'journal-title': 'Diabetes & Metabolic Syndrome: Clinical Research & Reviews'}, { 'key': '10.1016/j.jafr.2024.101422_bib111', 'doi-asserted-by': 'crossref', 'first-page': '2245', 'DOI': '10.18632/aging.101319', 'article-title': 'Towards natural mimetics of metformin and rapamycin', 'volume': '9', 'author': 'Aliper', 'year': '2017', 'journal-title': 'Aging'}, { 'key': '10.1016/j.jafr.2024.101422_bib112', 'doi-asserted-by': 'crossref', 'first-page': '45010', 'DOI': '10.18632/oncotarget.6878', 'article-title': 'Inhibitors of mTOR in ageing and cancer', 'volume': '6', 'author': 'Zhavoronkov', 'year': '2015', 'journal-title': 'Oncotarget'}, { 'key': '10.1016/j.jafr.2024.101422_bib113', 'doi-asserted-by': 'crossref', 'first-page': '23238', 'DOI': '10.18632/oncotarget.4836', 'article-title': 'Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a ' 'senescence program)', 'volume': '6', 'author': 'Leontieva', 'year': '2015', 'journal-title': 'Oncotarget'}, { 'key': '10.1016/j.jafr.2024.101422_bib114', 'doi-asserted-by': 'crossref', 'first-page': '19405', 'DOI': '10.18632/oncotarget.3740', 'article-title': 'Rejuvenating immunity: anti-ageing drug today eight years later', 'volume': '6', 'author': 'Blagosklonny', 'year': '2015', 'journal-title': 'Oncotarget'}, { 'key': '10.1016/j.jafr.2024.101422_bib115', 'doi-asserted-by': 'crossref', 'first-page': '62', 'DOI': '10.1038/s41421-022-00428-9', 'article-title': 'A trifunctional peptide broadly inhibits SARS-CoV-2 Delta and Omicron ' 'variants in hamsters', 'volume': '8', 'author': 'Zhao', 'year': '2022', 'journal-title': 'Cell Discov'}, { 'key': '10.1016/j.jafr.2024.101422_bib116', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.foodchem.2020.128366', 'article-title': 'Identification of tuna protein-derived peptides as potent SARS-CoV-2 ' 'inhibitors via molecular docking and molecular dynamic simulation', 'volume': '342', 'author': 'Yu', 'year': '2021', 'journal-title': 'Food Chem'}, { 'key': '10.1016/j.jafr.2024.101422_bib117', 'doi-asserted-by': 'crossref', 'DOI': '10.1002/anie.202301147', 'article-title': 'Precise Epitope Organization with Self-adjuvant Framework Nucleic Acid ' 'for Efficient COVID-19 Peptide Vaccine Construction', 'volume': '62', 'author': 'Shen', 'year': '2023', 'journal-title': 'Angew Chem Int Ed Engl'}, { 'key': '10.1016/j.jafr.2024.101422_bib118', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.arr.2021.101422', 'article-title': 'Immunosenescence and inflammaging in the aging process: age-related ' 'diseases or longevity?', 'volume': '71', 'author': 'Santoro', 'year': '2021', 'journal-title': 'Ageing Res Rev'}, { 'key': '10.1016/j.jafr.2024.101422_bib119', 'doi-asserted-by': 'crossref', 'unstructured': 'X. Wang, X. Fang, Z. Cai, et al., Comorbid Chronic Diseases and Acute ' 'Organ Injuries Are Strongly Correlated with Disease Severity and ' 'Mortality among COVID-19 Patients: A Systemic Review and Meta-Analysis, ' 'Research 2020 (2020) 1-17. https://doi.org/10.34133/2020/2402961.', 'DOI': '10.34133/2020/2402961'}, { 'key': '10.1016/j.jafr.2024.101422_bib120', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.metabol.2020.154407', 'article-title': 'Mediterranean diet as a nutritional approach for COVID-19', 'volume': '114', 'author': 'Angelidi', 'year': '2021', 'journal-title': 'Metabolism'}, { 'key': '10.1016/j.jafr.2024.101422_bib121', 'doi-asserted-by': 'crossref', 'first-page': '1721', 'DOI': '10.3390/nu13051721', 'article-title': 'Mediterranean Diet and SARS-COV-2 Infection: Is There Any Association? ' 'A Proof-of-Concept Study', 'volume': '13', 'author': 'Ponzo', 'year': '2021', 'journal-title': 'Nutrients'}, { 'key': '10.1016/j.jafr.2024.101422_bib122', 'doi-asserted-by': 'crossref', 'first-page': '1596', 'DOI': '10.1016/j.advnut.2023.09.006', 'article-title': 'Diet Quality and Risk of SARS-CoV-2 Infection or COVID-19: A Systematic ' 'Review of Observational Studies', 'volume': '14', 'author': 'Sharma', 'year': '2023', 'journal-title': 'Adv Nutr'}, { 'key': '10.1016/j.jafr.2024.101422_bib123', 'doi-asserted-by': 'crossref', 'DOI': '10.1080/19490976.2023.2229938', 'article-title': 'Limosilactobacillus reuteri DSM 17938 supplementation and SARS-CoV-2 ' 'specific antibody response in healthy adults: a randomized, ' 'triple-blinded, placebo-controlled trial', 'volume': '15', 'author': 'Forsgård', 'year': '2023', 'journal-title': 'Gut Microbes'}, { 'key': '10.1016/j.jafr.2024.101422_bib124', 'doi-asserted-by': 'crossref', 'DOI': '10.1080/19490976.2021.2018899', 'article-title': 'Probiotic improves symptomatic and viral clearance in Covid19 ' 'outpatients: a randomized, quadruple-blinded, placebo-controlled trial', 'volume': '14', 'author': 'Gutiérrez-Castrellón', 'year': '2022', 'journal-title': 'Gut Microbes'}, { 'key': '10.1016/j.jafr.2024.101422_bib125', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1002/rmv.2204', 'article-title': 'Mega doses of retinol: A possible immunomodulation in Covid-19 illness ' 'in resource-limited settings', 'volume': '31', 'author': 'Midha', 'year': '2021', 'journal-title': 'Rev Med Virol'}, { 'key': '10.1016/j.jafr.2024.101422_bib126', 'doi-asserted-by': 'crossref', 'first-page': '1509', 'DOI': '10.3390/vaccines11091509', 'article-title': 'Exploring the Effects of Vitamin D and Vitamin A Levels on the Response ' 'to COVID-19 Vaccine', 'volume': '11', 'author': 'Kofahi', 'year': '2023', 'journal-title': 'Vaccines (Basel)'}, { 'key': '10.1016/j.jafr.2024.101422_bib127', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.molstruc.2021.131394', 'article-title': 'Molecular docking and dynamics studies of Nicotinamide Riboside as a ' 'potential multi-target nutraceutical against SARS-CoV-2 entry, ' 'replication, and transcription: A new insight', 'volume': '1247', 'author': 'Esam', 'year': '2022', 'journal-title': 'J Mol Struct'}, { 'key': '10.1016/j.jafr.2024.101422_bib128', 'doi-asserted-by': 'crossref', 'first-page': '2777', 'DOI': '10.3390/microorganisms11112777', 'article-title': 'Potent Antiviral Activity of Vitamin B12 against Severe Acute ' 'Respiratory Syndrome Coronavirus 2, Middle East Respiratory Syndrome ' 'Coronavirus, and Human Coronavirus 229E', 'volume': '11', 'author': 'Moatasim', 'year': '2023', 'journal-title': 'Microorganisms'}, { 'key': '10.1016/j.jafr.2024.101422_bib129', 'doi-asserted-by': 'crossref', 'first-page': '1172', 'DOI': '10.3390/nu13041172', 'article-title': 'Vitamin C in the Treatment of COVID-19', 'volume': '13', 'author': 'Milani', 'year': '2021', 'journal-title': 'Nutrients'}, { 'key': '10.1016/j.jafr.2024.101422_bib130', 'doi-asserted-by': 'crossref', 'first-page': '3252', 'DOI': '10.3390/nu14163252', 'article-title': 'Vitamin D Status and Mortality from SARS CoV-2: A Prospective Study of ' 'Unvaccinated Caucasian Adults', 'volume': '14', 'author': 'Barrett', 'year': '2022', 'journal-title': 'Nutrients'}, { 'key': '10.1016/j.jafr.2024.101422_bib131', 'doi-asserted-by': 'crossref', 'first-page': '194', 'DOI': '10.1016/j.freeradbiomed.2023.06.026', 'article-title': 'Do the oxidative stress biomarkers predict COVID-19 outcome? 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