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Mediterranean Diet and SARS-COV-2 Infection: Is There Any Association? A Proof-of-Concept Study

Ponzo et al., Nutrients, doi:10.3390/nu13051721
May 2021  
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Diet for COVID-19
23rd treatment shown to reduce risk in June 2021, now with p < 0.00000000001 from 29 studies.
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5,100+ studies for 112 treatments. c19early.org
Retrospective 1,206 healthcare professionals in Italy, showing the risk of COVID-19 infection inversely associated with adherence to the Mediterranean diet.
Ponzo et al., 19 May 2021, retrospective, Italy, peer-reviewed, survey, 9 authors.
This PaperDietAll
Mediterranean Diet and SARS-COV-2 Infection: Is There Any Association? A Proof-of-Concept Study
Valentina Ponzo, Marianna Pellegrini, Chiara D’eusebio, Fabio Bioletto, Ilaria Goitre, Silvio Buscemi, Simone Frea, Ezio Ghigo, Simona Bo
Nutrients, doi:10.3390/nu13051721
The aim of this observational study was investigating the possible correlation between adherence to the Mediterranean diet (MeD) and SARS-COV-2 infection rates and severity among healthcare professionals (HCPs). An online self-administrated questionnaire (evaluating both MeD adherence and dietary habits) was filled out by HCPs working in Piedmont (Northern Italy) from 15 January to 28 February 2021. Out of the 1206 questionnaires collected, 900 were considered reliable and analyzed. Individuals who reported the SARS-COV-2 infection (n = 148) showed a significantly lower MeD score, with a lower adherence in fruit, vegetables, cereals, and olive oil consumption. In a logistic regression model, the risk of infection was inversely associated with the MeD score (OR = 0.88; 95% CI 0.81-0.97) and the consumption of cereals (OR = 0.64; 0.45-0.90). Asymptomatic individuals with SARS-COV-2 infection reported a lower intake of saturated fats than symptomatic; individuals requiring hospitalization were significantly older and reported worse dietary habits than both asymptomatic and symptomatic individuals. After combining all symptomatic individuals together, age (OR = 1.05; 1.01-1.09) and saturated fats intake (OR = 1.09; 1.01-1.17) were associated with the infection severity. HCPs who reported a SARS-COV-2 infection showed a significantly lower MeD score and cereal consumption. The infection severity was directly associated with higher age and saturated fat intake.
Conflicts of Interest: The authors declare no conflict of interest.
References
Angelidi, Kokkinos, Katechaki, Ros, Mantzoros, Mediterranean diet as a nutritional approach for COVID-19, Metabolism, doi:10.1016/j.metabol.2020.154407
Annweiler, Corvaisier, Gautier, Dubée, Legrand et al., Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study, Nutrients, doi:10.3390/nu12113377
Antonopoulou, Fragopoulou, Karantonis, Mitsou, Sitara et al., Effect of Traditional Greek Mediterranean Meals on Platelet Aggregation in Normal Subjects and in Patients with Type 2 Diabetes Mellitus, J. Med. Food, doi:10.1089/jmf.2006.9.356
Asselta, Paraboschi, Mantovani, Duga, ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy, Aging, doi:10.18632/aging.103415
Aune, Keum, Giovannucci, Fadnes, Boffetta et al., Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: Systematic review and dose-response meta-analysis of prospective studies, BMJ, doi:10.1136/bmj.i2716
Aune, Norat, Romundstad, Vatten, Whole grain and refined grain consumption and the risk of type 2 diabetes: A systematic review and dose-response meta-analysis of cohort studies, Eur. J. Epidemiol, doi:10.1007/s10654-013-9852-5
Bach-Faig, Berry, Lairon, Reguant, Trichopoulou et al., Mediterranean diet pyramid today. Science and cultural updates, Public Health Nutr, doi:10.1017/S1368980011002515
Becker, Foley, Shelley, Gibney, Energy under-reporting in Swedish and Irish dietary surveys: Implications for food-based dietary guidelines, Br. J. Nutr, doi:10.1017/S0007114599000975
Bonaccio, Di Castelnuovo, Bonanni, Costanzo, De Lucia et al., Decline of the Mediterranean diet at a time of economic crisis. Results from the Moli-sani study, Nutr. Metab. Cardiovasc. Dis, doi:10.1016/j.numecd.2014.02.014
Bousquet, Anto, Czarlewski, Haahtela, Fonseca et al., Cabbage and fermented vegetables: From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19, Allergy, doi:10.1111/all.14549
Bousquet, Anto, Iaccarino, Czarlewski, Haahtela et al., Is diet partly responsible for differences in COVID-19 death rates between and within countries?, Clin. Transl. Allergy, doi:10.1186/s13601-020-00323-0
Bracale, Vaccaro, Coletta, Cricelli, Gamaleri et al., Nutrition behaviour and compliance with the Mediterranean diet pyramid recommendations: An Italian survey-based study, Eat. Weight. Disord. Stud. Anorex. Bulim. Obes, doi:10.1007/s40519-019-00807-4
Brassard, Laramée, Robitaille, Lemieux, Lamarche, Differences in Population-Based Dietary Intake Estimates Obtained From an Interviewer-Administered and a Self-Administered Web-Based 24-h Recall, Front. Nutr, doi:10.3389/fnut.2020.00137
Buscemi, Buscemi, Batsis, There is a relationship between obesity and coronavirus disease 2019 but more information is needed, Obesity, doi:10.1002/oby.22883
Buscemi, Rosafio, Vasto, Massenti, Grosso et al., Validation of a food frequency questionnaire for use in Italian adults living in Sicily, Int. J. Food Sci. Nutr
Calatayud, Calatayud, Gallego, González-Martín, Alguacil, Effects of Mediterranean diet in patients with recurring colds and frequent complications, Allergol. Immunopathol, doi:10.1016/j.aller.2016.08.006
Calder, Ahluwalia, Brouns, Buetler, Clement et al., Dietary factors and low-grade inflammation in relation to overweight and obesity, Br. J. Nutr, doi:10.1017/S0007114511005460
Calder, Nutrition, immunity and COVID-19, BMJ Nutr. Prev. Health, doi:10.1136/bmjnph-2020-000085
Cani, Amar, Iglesias, Poggi, Knauf et al., Metabolic Endotoxemia Initiates Obesity and Insulin Resistance, Diabetes, doi:10.2337/db06-1491
Castillo, Costa, Barrios, Díaz, Miranda et al., Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study, J. Steroid Biochem. Mol. Biol, doi:10.1016/j.jsbmb.2020.105751
Chen, Tong, Xu, Han, Wan et al., Whole-grain intake and total, cardiovascular, and cancer mortality: A systematic review and meta-analysis of prospective studies, Am. J. Clin. Nutr, doi:10.3945/ajcn.115.122432
Colaneri, Novelli, Cutti, Muzzi, Resani et al., The experience of the health care workers of a severely hit SARS-CoV-2 referral Hospital in Italy: Incidence, clinical course and modifiable risk factors for COVID-19 infection, J. Public Health, doi:10.1093/pubmed/fdaa195
Crowley, O'callaghan, O'brien, The Immunomodulatory Potential of Cereal Grains, Curr. Nutr. Food Sci, doi:10.2174/1573401313666170517163116
Cândido, Valente, Grześkowiak, Moreira, Rocha et al., Impact of dietary fat on gut microbiota and low-grade systemic inflammation: Mechanisms and clinical implications on obesity, Int. J. Food Sci. Nutr, doi:10.1080/09637486.2017.1343286
De Punder, Pruimboom, The Dietary Intake of Wheat and other Cereal Grains and Their Role in Inflammation, Nutrients, doi:10.3390/nu5030771
Detopoulou, Demopoulos, Antonopoulou, Micronutrients, Phytochemicals and Mediterranean Diet: A Potential Protective Role against COVID-19 through Modulation of PAF Actions and Metabolism, Nutrients, doi:10.3390/nu13020462
Di Renzo, Gualtieri, Pivari, Soldati, Attinà et al., Eating habits and lifestyle changes during COVID-19 lockdown: An Italian survey, J. Transl. Med, doi:10.1186/s12967-020-02399-5
Di Santo, Franchini, Filiputti, Martone, Sannino, The Effects of COVID-19 and Quarantine Measures on the Lifestyles and Mental Health of People Over 60 at Increased Risk of Dementia, Front. Psychiatry, doi:10.3389/fpsyt.2020.578628
Dinu, Pagliai, Angelino, Rosi, Dall'asta et al., Effects of Popular Diets on Anthropometric and Cardiometabolic Parameters: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials, Adv. Nutr, doi:10.1093/advances/nmaa006
Dinu, Pagliai, Casini, Sofi, Mediterranean diet and multiple health outcomes: An umbrella review of meta-analyses of observational studies and randomised trials, Eur. J. Clin. Nutr, doi:10.1038/ejcn.2017.58
Dinu, Pagliai, Giangrandi, Colombini, Toniolo et al., Adherence to the Mediterranean diet among Italian adults: Results from the web-based Medi-Lite questionnaire, Int. J. Food Sci. Nutr, doi:10.1080/09637486.2020.1793306
Epicentro, Sorveglianza Integrata COVID-19: I Principali Dati Nazionali
Esposito, Marfella, Ciotola, Di Palo, Giugliano et al., Effect of a Mediterranean-style Diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: A randomized trial, JAMA, doi:10.1001/jama.292.12.1440
Esposito, Pontillo, Di Palo, Giugliano, Masella et al., Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: A randomized trial, JAMA, doi:10.1001/jama.289.14.1799
Fardet, New hypotheses for the health-protective mechanisms of whole-grain cereals: What is beyond fibre?, Nutr. Res. Rev, doi:10.1017/S0954422410000041
Franzke, Bechmann, Zimmer, Ess, Internet Research: Ethical Guidelines
Fuke, Nagata, Suganuma, Ota, Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors, Nutrients, doi:10.3390/nu11102277
Garriguet, Accounting for misreporting when comparing energy intake across time in Canada, Public Health Rep
Garzaro, Clari, Ciocan, Grillo, Mansour et al., COVID-19 Infection and Diffusion Among the Healthcare Workforce in a Large University-Hospital in Northwest Italy, SSRN Electron. J, doi:10.2139/ssrn.3578806
Giannini, Passeri, Tripepi, Sella, Fusaro et al., Effectiveness of In-Hospital Cholecalciferol Use on Clinical Outcomes in Comorbid COVID-19 Patients: A Hypothesis-Generating Study, Nutrients, doi:10.3390/nu13010219
Godos, Rapisarda, Marventano, Galvano, Mistretta et al., Association between polyphenol intake and adherence to the Mediterranean diet in Sicily, southern Italy, NFS J, doi:10.1016/j.nfs.2017.06.001
Goumenou, Sarigiannis, Tsatsakis, Anesti, Docea et al., COVID-19 in Northern Italy: An integrative overview of factors possibly influencing the sharp increase of the outbreak (Review), Mol. Med. Rep, doi:10.3892/mmr.2020.11079
Gray, Wang, Martin, Donnelly, Gutiérrez et al., Adherence to Mediterranean-style diet and risk of sepsis in the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort, Br. J. Nutr, doi:10.1017/S0007114518002866
Greene, Roberts, Frugé, Negative Association between Mediterranean Diet Adherence and COVID-19 Cases and Related Deaths in Spain and 23 OECD Countries: An Ecological Study, Front. Nutr, doi:10.3389/fnut.2021.591964
Hajihashemi, Haghighatdoost, Effects of Whole-Grain Consumption on Selected Biomarkers of Systematic Inflammation: A Systematic Review and Meta-analysis of Randomized Controlled Trials, J. Am. Coll. Nutr, doi:10.1080/07315724.2018.1490935
Han, Baruah, Cox, Vanrompay, Bossier, Structure-Functional Activity Relationship of β-Glucans From the Perspective of Immunomodulation: A Mini-Review, Front. Immunol, doi:10.3389/fimmu.2020.00658
He, Li, Guo, Zhong, Tang, Food groups and the likelihood of non-alcoholic fatty liver disease: A systematic review and meta-analysis, Br. J. Nutr, doi:10.1017/S0007114520000914
Hemilä, Chalker, Reanalysis of the Effect of Vitamin C on Mortality in the CITRIS-ALI Trial: Important Findings Dismissed in the Trial Report, Front. Med, doi:10.3389/fmed.2020.590853
Hollaender, Ross, Kristensen, Whole-grain and blood lipid changes in apparently healthy adults: A systematic review and meta-analysis of randomized controlled studies1-3, Am. J. Clin. Nutr, doi:10.3945/ajcn.115.109165
Hooper, Littman, Macpherson, Interactions between the Microbiota and the Immune System, Science, doi:10.1126/science.1223490
Iddir, Brito, Dingeo, Fernandez Del Campo, Samouda et al., Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis, Nutrients, doi:10.3390/nu12061562
Ilie, Stefanescu, Smith, The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality, Aging Clin. Exp. Res, doi:10.1007/s40520-020-01570-8
Jovic, Ali, Ibrahim, Jessop, Tarassoli et al., Could Vitamins Help in the Fight Against COVID-19?, Nutrients, doi:10.3390/nu12092550
Kamyari, Soltanian, Mahjub, Moghimbeigi, Diet, Nutrition, Obesity, and Their Implications for COVID-19 Mortality: Development of a Marginalized Two-Part Model for Semicontinuous Data, JMIR Public Health Surveill, doi:10.2196/22717
Karantonis, Fragopoulou, Antonopoulou, Rementzis, Phenekos et al., Effect of fast-food Mediterranean-type diet on type 2 diabetics and healthy human subjects' platelet aggregation, Diabetes Res. Clin. Pract, doi:10.1016/j.diabres.2005.09.003
Kennedy, Martinez, Chuang, Lapoint, Mcintosh, Saturated Fatty Acid-Mediated Inflammation and Insulin Resistance in Adipose Tissue: Mechanisms of Action and Implications, J. Nutr, doi:10.3945/jn.108.098269
Krajmalnik-Brown, Ilhan, Kang, Dibaise, Effects of Gut Microbes on Nutrient Absorption and Energy Regulation, Nutr. Clin. Pract, doi:10.1177/0884533611436116
Leone, Battezzati, De Amicis, De Carlo, Bertoli, Trends of Adherence to the Mediterranean Dietary Pattern in Northern Italy from 2010 to 2016, Nutrients, doi:10.3390/nu9070734
Li, Leung, Chan, Yiu, Tang, A global perspective on the crosstalk between saturated fatty acids and Toll-like receptor 4 in the etiology of inflammation and insulin resistance, Prog. Lipid Res, doi:10.1016/j.plipres.2019.101020
Ling, Broad, Murphy, Pappachan, Pardesi-Newton et al., High-Dose Cholecalciferol Booster Therapy is Associated with a Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational Study, Nutrients, doi:10.3390/nu12123799
Liu, Mao, Liang, Yang, Lu et al., Association between age and clinical characteristics and outcomes of COVID-19, Eur. Respir. J, doi:10.1183/13993003.01112-2020
Lordan, Tsoupras, Zabetakis, Demopoulos, Forty Years Since the Structural Elucidation of Platelet-Activating Factor (PAF): Historical, Current, and Future Research Perspectives, Molecules, doi:10.3390/molecules24234414
Luukkonen, Sädevirta, Zhou, Kayser, Ali et al., Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars, Diabetes Care, doi:10.2337/dc18-0071
Maiorino, Bellastella, Longo, Caruso, Esposito, Mediterranean Diet and COVID-19: Hypothesizing Potential Benefits in People with Diabetes, Front. Endocrinol, doi:10.3389/fendo.2020.574315
Marhl, Grubelnik, Magdič, Markovič, Diabetes and metabolic syndrome as risk factors for COVID-19, Diabetes Metab. Syndr. Clin. Res. Rev, doi:10.1016/j.dsx.2020.05.013
Marventano, Godos, Platania, Galvano, Mistretta et al., Mediterranean diet adherence in the Mediterranean healthy eating, aging and lifestyle (MEAL) study cohort, Int. J. Food Sci. Nutr, doi:10.1080/09637486.2017.1332170
Maugeri, Castrogiovanni, Battaglia, Pippi, D'agata et al., The impact of physical activity on psychological health during Covid-19 pandemic in Italy, Heliyon, doi:10.1016/j.heliyon.2020.e04315
Mazidi, Heidari-Bakavoli, Khayyatzadeh, Azarpazhooh, Nematy et al., Serum hs-CRP varies with dietary cholesterol, but not dietary fatty acid intake in individuals free of any history of cardiovascular disease, Eur. J. Clin. Nutr, doi:10.1038/ejcn.2016.92
Mazzocchi, Leone, Agostoni, Pali-Schöll, The Secrets of the Mediterranean Diet. Does [Only] Olive Oil Matter?, Nutrients, doi:10.3390/nu11122941
Miossec, Understanding the cytokine storm during COVID-19: Contribution of preexisting chronic inflammation, Eur. J. Rheumatol, doi:10.5152/eurjrheum.2020.2062
Morze, Danielewicz, Przybyłowicz, Zeng, Hoffmann et al., An updated systematic review and meta-analysis on adherence to mediterranean diet and risk of cancer, Eur. J. Nutr, doi:10.1007/s00394-020-02346-6
Noale, Nardi, Limongi, Siviero, Caregaro et al., Adolescents in Southern regions of Italy adhere to the Mediterranean Diet more than those in the Northern regions, Nutr. Res, doi:10.1016/j.nutres.2014.08.001
Nomikos, Fragopoulou, Antonopoulou, Panagiotakos, Mediterranean diet and platelet-activating factor; a systematic review, Clin. Biochem, doi:10.1016/j.clinbiochem.2018.08.004
Ogundijo, Tas, Onarinde, Exploring the Impact of COVID-19 Pandemic on Eating and Purchasing Behaviours of People Living in England, Nutrients, doi:10.3390/nu13051499
Pan, Sze, Minhas, Bangash, Pareek et al., The impact of ethnicity on clinical outcomes in COVID-19: A systematic review, EClinicalMedicine, doi:10.1016/j.eclinm.2020.100404
Papadaki, Nolen-Doerr, Mantzoros, The Effect of the Mediterranean Diet on Metabolic Health: A Systematic Review and Meta-Analysis of Controlled Trials in Adults, Nutrients, doi:10.3390/nu12113342
Pellegrini, Ponzo, Rosato, Scumaci, Goitre et al., Changes in Weight and Nutritional Habits in Adults with Obesity during the "Lockdown" Period Caused by the COVID-19 Virus Emergency, Nutrients, doi:10.3390/nu12072016
Pennington, Kompaniyets, Summers, Danielson, Goodman et al., Risk of Clinical Severity by Age and Race/Ethnicity Among Adults Hospitalized for COVID-19-United States, Open Forum Infect. Dis, doi:10.1093/ofid/ofaa638
Pietrobon, Teixeira, Sato, I mmunosenescence and Inflammaging: Risk Factors of Severe COVID-19 in Older People, Front. Immunol, doi:10.3389/fimmu.2020.579220
Poslusna, Ruprich, De Vries, Jakubikova, Van't Veer, Misreporting of energy and micronutrient intake estimated by food records and 24 hour recalls, control and adjustment methods in practice, Br. J. Nutr, doi:10.1017/S0007114509990602
Predieri, Sinesio, Monteleone, Spinelli, Cianciabella et al., Age, Geographical Area, Food Neophobia and Their Relationships with the Adherence to the Mediterranean Diet: New Insights from a Large Population Cross-Sectional Study, Nutrients, doi:10.3390/nu12061778
Rastogi, Bhansali, Khare, Suri, Yaddanapudi et al., Short term, high-dose vitamin D supplementation for COVID-19 disease: A randomised, placebo-controlled, study (SHADE study), Postgrad. Med. J, doi:10.1136/postgradmedj-2020-139065
Ruggiero, Di Castelnuovo, Costanzo, Persichillo, Bracone et al., Socioeconomic and psychosocial determinants of adherence to the Mediterranean diet in a general adult Italian population, Eur. J. Public Health, doi:10.1093/eurpub/cky127
Santos, Oliveira, Casal, Lopes, Saturated fatty acids intake in relation to C-reactive protein, adiponectin, and leptin: A population-based study, Nutrition, doi:10.1016/j.nut.2013.01.009
Scarmozzino, Visioli, Covid-19 and the Subsequent Lockdown Modified Dietary Habits of Almost Half the Population in an Italian Sample, Foods, doi:10.3390/foods9050675
Schlesinger, Neuenschwander, Schwedhelm, Hoffmann, Bechthold et al., Food Groups and Risk of Overweight, Obesity, and Weight Gain: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies, Adv. Nutr, doi:10.1093/advances/nmy092
Schwartz, Zhang, Karnik, Borwege, Anand et al., Nutrient modification of the innate immune response: A novel mechanism by which saturated fatty acids greatly amplify monocyte inflammation, Arterioscler. Thromb. Vasc. Biol, doi:10.1161/ATVBAHA.109.201681
Schwingshackl, Hoffmann, Lampousi, Knüppel, Iqbal et al., Food groups and risk of type 2 diabetes mellitus: A systematic review and meta-analysis of prospective studies, Eur. J. Epidemiol, doi:10.1007/s10654-017-0246-y
Schwingshackl, Hoffmann, Mediterranean dietary pattern, inflammation and endothelial function: A systematic review and meta-analysis of intervention trials, Nutr. Metab. Cardiovasc. Dis, doi:10.1016/j.numecd.2014.03.003
Schwingshackl, Schwedhelm, Hoffmann, Lampousi, Knüppel et al., Food groups and risk of all-cause mortality: A systematic review and meta-analysis of prospective studies, Am. J. Clin. Nutr, doi:10.3945/ajcn.117.153148
Seidu, Gillies, Zaccardi, Kunutsor, Hartmann-Boyce et al., The impact of obesity on severe disease and mortality in people with SARS-CoV-2: A systematic review and meta-analysis, Endocrinol. Diabetes Metab, doi:10.1002/edm2.176
Sergi, Morris, Kahn, Mclean, Hay et al., Palmitic acid triggers inflammatory responses in N42 cultured hypothalamic cells partially via ceramide synthesis but not via TLR4, Nutr. Neurosci, doi:10.1080/1028415X.2018.1501533
Shakoor, Feehan, Apostolopoulos, Platat, Al Dhaheri et al., Immunomodulatory Effects of Dietary Polyphenols, Nutrients, doi:10.3390/nu13030728
Sofi, Abbate, Gensini, Casini, Accruing evidence on benefits of adherence to the Mediterranean diet on health: An updated systematic review and meta-analysis, Am. J. Clin. Nutr, doi:10.3945/ajcn.2010.29673
Sofi, Dinu, Pagliai, Marcucci, Casini, Validation of a literature-based adherence score to Mediterranean diet: The MEDI-LITE score, Int. J. Food Sci. Nutr, doi:10.1080/09637486.2017.1287884
Sofi, Macchi, Abbate, Gensini, Casini, Mediterranean diet and health status: An updated meta-analysis and a proposal for a literature-based adherence score, Public Health Nutr, doi:10.1017/S1368980013003169
Soltani, Jayedi, Shab-Bidar, Becerra-Tomás, Salas-Salvadó, Adherence to the Mediterranean Diet in Relation to All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Adv. Nutr, doi:10.1093/advances/nmz041
Tan, Ho, Kalimuddin, Cherng, Teh et al., Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19), Nutrition, doi:10.1016/j.nut.2020.111017
Verde, Mulè, Zappalà, Privitera, Maugeri et al., Higher adherence to the Mediterranean diet is inversely associated with having hypertension: Is low salt intake a mediating factor?, Int. J. Food Sci. Nutr, doi:10.1080/09637486.2017.1350941
Veronese, Notarnicola, Cisternino, Inguaggiato, Guerra et al., Trends in adherence to the Mediterranean diet in South Italy: A cross sectional study, Nutr. Metab. Cardiovasc. Dis, doi:10.1016/j.numecd.2019.11.003
Vitaglione, Mennella, Ferracane, Rivellese, Giacco et al., Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: Role of polyphenols bound to cereal dietary fiber, Am. J. Clin. Nutr, doi:10.3945/ajcn.114.088120
Weill, Plissonneau, Legrand, Rioux, Thibault, May omega-3 fatty acid dietary supplementation help reduce severe complications in Covid-19 patients?, Biochimie, doi:10.1016/j.biochi.2020.09.003
Wu, Guan, Lv, Wang, Li, No Evidence of Increased Risk of Stroke with Consumption of Refined Grains: A Meta-analysis of Prospective Cohort Studies, J. Stroke Cerebrovasc. Dis, doi:10.1016/j.jstrokecerebrovasdis.2015.08.004
Yamazaki, Murray, Kita, Innate immunomodulatory effects of cereal grains through induction of IL-10, J. Allergy Clin. Immunol, doi:10.1016/j.jaci.2007.08.031
Yang, Liang, Balakrishnan, Belobrajdic, Feng et al., Role of Dietary Nutrients in the Modulation of Gut Microbiota: A Narrative Review, Nutrients, doi:10.3390/nu12020381
Zhang, Taylor, Bennett, Saad, Rayman, Association between regional selenium status and reported outcome of COVID-19 cases in China, Am. J. Clin. Nutr, doi:10.1093/ajcn/nqaa095
Zheng, Peng, Xu, Zhao, Liu et al., Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis, J. Infect, doi:10.1016/j.jinf.2020.04.021
Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study, Lancet
Zong, Gao, Hu, Sun, Whole Grain Intake and Mortality From All Causes, Cardiovascular Disease, and Cancer, Circulation, doi:10.1161/CIRCULATIONAHA.115.021101
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Out of the 1206 questionnaires collected, 900 ' 'were considered reliable and analyzed. Individuals who reported the SARS-COV-2 infection (n = ' '148) showed a significantly lower MeD score, with a lower adherence in fruit, vegetables, ' 'cereals, and olive oil consumption. In a logistic regression model, the risk of infection was ' 'inversely associated with the MeD score (OR = 0.88; 95% CI 0.81–0.97) and the consumption of ' 'cereals (OR = 0.64; 0.45–0.90). Asymptomatic individuals with SARS-COV-2 infection reported a ' 'lower intake of saturated fats than symptomatic; individuals requiring hospitalization were ' 'significantly older and reported worse dietary habits than both asymptomatic and symptomatic ' 'individuals. After combining all symptomatic individuals together, age (OR = 1.05; 1.01–1.09) ' 'and saturated fats intake (OR = 1.09; 1.01–1.17) were associated with the infection severity. ' 'HCPs who reported a SARS-COV-2 infection showed a significantly lower MeD score and cereal ' 'consumption. The infection severity was directly associated with higher age and saturated fat ' 'intake.</jats:p>', 'DOI': '10.3390/nu13051721', 'type': 'journal-article', 'created': {'date-parts': [[2021, 5, 20]], 'date-time': '2021-05-20T01:49:21Z', 'timestamp': 1621475361000}, 'page': '1721', 'source': 'Crossref', 'is-referenced-by-count': 6, 'title': [ 'Mediterranean Diet and SARS-COV-2 Infection: Is There Any Association? A Proof-of-Concept ' 'Study'], 'prefix': '10.3390', 'volume': '13', 'author': [ {'given': 'Valentina', 'family': 'Ponzo', 'sequence': 'first', 'affiliation': []}, {'given': 'Marianna', 'family': 'Pellegrini', 'sequence': 'additional', 'affiliation': []}, {'given': 'Chiara', 'family': 'D’Eusebio', 'sequence': 'additional', 'affiliation': []}, {'given': 'Fabio', 'family': 'Bioletto', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ilaria', 'family': 'Goitre', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-0730-7649', 'authenticated-orcid': False, 'given': 'Silvio', 'family': 'Buscemi', 'sequence': 'additional', 'affiliation': []}, {'given': 'Simone', 'family': 'Frea', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ezio', 'family': 'Ghigo', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0001-6862-8628', 'authenticated-orcid': False, 'given': 'Simona', 'family': 'Bo', 'sequence': 'additional', 'affiliation': []}], 'member': '1968', 'published-online': {'date-parts': [[2021, 5, 19]]}, 'reference': [ { 'key': 'ref1', 'unstructured': 'Coronavirus Disease ' '(COVID-19)https://www.who.int/emergencies/diseases/novel-coronavirus-2019'}, {'key': 'ref2', 'unstructured': 'COVID-19 Maphttps://coronavirus.jhu.edu/map.html'}, { 'key': 'ref3', 'unstructured': 'Sorveglianza Integrata COVID-19: I Principali Dati ' 'Nazionalihttps://www.epicentro.iss.it/coronavirus/sars-cov-2-sorveglianza-dati'}, {'key': 'ref4', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/oby.22883'}, {'key': 'ref5', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.eclinm.2020.100404'}, {'key': 'ref6', 'doi-asserted-by': 'publisher', 'DOI': '10.3892/mmr.2020.11079'}, {'key': 'ref7', 'doi-asserted-by': 'publisher', 'DOI': '10.18632/aging.103415'}, {'key': 'ref8', 'doi-asserted-by': 'publisher', 'DOI': '10.1186/s13601-020-00323-0'}, {'key': 'ref9', 'doi-asserted-by': 'publisher', 'DOI': '10.2196/22717'}, {'key': 'ref10', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/all.14549'}, {'key': 'ref11', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s40520-020-01570-8'}, {'key': 'ref12', 'doi-asserted-by': 'publisher', 'DOI': '10.1093/ajcn/nqaa095'}, {'key': 'ref13', 'doi-asserted-by': 'publisher', 'DOI': '10.3389/fmed.2020.590853'}, {'key': 'ref14', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/nu12113377'}, {'key': 'ref15', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jsbmb.2020.105751'}, {'key': 'ref16', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/nu12123799'}, {'key': 'ref17', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.nut.2020.111017'}, {'key': 'ref18', 'doi-asserted-by': 'publisher', 'DOI': '10.1136/postgradmedj-2020-139065'}, {'key': 'ref19', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/nu13010219'}, {'key': 'ref20', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/nu12072016'}, {'key': 'ref21', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/foods9050675'}, {'key': 'ref22', 'doi-asserted-by': 'publisher', 'DOI': '10.1186/s12967-020-02399-5'}, {'key': 'ref23', 'doi-asserted-by': 'publisher', 'DOI': '10.3389/fpsyt.2020.578628'}, {'key': 'ref24', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.heliyon.2020.e04315'}, {'key': 'ref25', 'doi-asserted-by': 'publisher', 'DOI': '10.1017/S1368980011002515'}, {'key': 'ref26', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/nu11122941'}, {'key': 'ref27', 'doi-asserted-by': 'publisher', 'DOI': '10.1017/S0007114511005460'}, {'key': 'ref28', 'doi-asserted-by': 'publisher', 'DOI': '10.3945/ajcn.2010.29673'}, {'key': 'ref29', 'doi-asserted-by': 'publisher', 'DOI': '10.1093/advances/nmz041'}, {'key': 'ref30', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/ejcn.2017.58'}, {'key': 'ref31', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/nu12113342'}, {'key': 'ref32', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s00394-020-02346-6'}, {'key': 'ref33', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.numecd.2014.03.003'}, {'key': 'ref34', 'doi-asserted-by': 'publisher', 'DOI': '10.1001/jama.292.12.1440'}, {'key': 'ref35', 'doi-asserted-by': 'publisher', 'DOI': '10.1001/jama.289.14.1799'}, {'key': 'ref36', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.aller.2016.08.006'}, {'key': 'ref37', 'doi-asserted-by': 'publisher', 'DOI': '10.1017/S0007114518002866'}, {'key': 'ref38', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.metabol.2020.154407'}, {'key': 'ref39', 'doi-asserted-by': 'publisher', 'DOI': '10.3389/fendo.2020.574315'}, {'key': 'ref40', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/nu13020462'}, {'key': 'ref41', 'doi-asserted-by': 'publisher', 'DOI': '10.1093/pubmed/fdaa195'}, {'key': 'ref42', 'doi-asserted-by': 'publisher', 'DOI': '10.2139/ssrn.3578806'}, { 'key': 'ref43', 'unstructured': 'Internet Research: Ethical Guidelines. 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when comparing energy intake across time in ' 'Canada', 'volume': '29', 'author': 'Garriguet', 'year': '2018', 'journal-title': 'Public Health Rep.'}, {'key': 'ref52', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/09637486.2020.1793306'}, {'key': 'ref53', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/09637486.2017.1332170'}, {'key': 'ref54', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/09637486.2017.1350941'}, {'key': 'ref55', 'doi-asserted-by': 'publisher', 'DOI': '10.1093/eurpub/cky127'}, {'key': 'ref56', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/nu12061778'}, {'key': 'ref57', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.nutres.2014.08.001'}, {'key': 'ref58', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.numecd.2014.02.014'}, {'key': 'ref59', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/nu9070734'}, {'key': 'ref60', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.numecd.2019.11.003'}, {'key': 'ref61', 'doi-asserted-by': 'publisher', 'DOI': 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