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0 0.5 1 1.5 2+ Oxygen therapy 80% Improvement Relative Risk ICU admission 81% Tan et al. Vitamin D for COVID-19 LATE TREATMENT Is late treatment with vitamin D+magnesium and vitamin B12 beneficial for COVID-19? Retrospective 43 patients in Singapore Lower need for oxygen therapy with vitamin D+magnesium and vitamin B12 (p=0.04) Tan et al., Nutrition, doi:10.1016/j.nut.2020.111017 Favors vitamin D Favors control
Cohort study to evaluate the effect of combination Vitamin D, Magnesium and Vitamin B12 (DMB) on progression to severe outcome in older COVID-19 patients
Tan et al., Nutrition, doi:10.1016/j.nut.2020.111017 (date from earlier preprint)
Tan et al., Cohort study to evaluate the effect of combination Vitamin D, Magnesium and Vitamin B12 (DMB) on progression.., Nutrition, doi:10.1016/j.nut.2020.111017 (date from earlier preprint)
Jun 2020   Source   PDF  
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Observational study of 43 patients >= 50 years old, with 17 patients receiving vitamin D, magnesium, and vitamin B12 (DMB); and 26 control patients, showing a significantly lower need for oxygen therapy and ICU admission with treatment. DMB OR 0.20 [0.04–0.93] for oxygen therapy and/or intensive care support with multivariate analysis.
risk of oxygen therapy, 80.5% lower, RR 0.20, p = 0.04, treatment 3 of 17 (17.6%), control 16 of 26 (61.5%), NNT 2.3, adjusted per study, multivariate.
risk of ICU admission, 80.9% lower, RR 0.19, p = 0.07, treatment 1 of 17 (5.9%), control 8 of 26 (30.8%), NNT 4.0, no adjusted result available.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Tan et al., 10 Jun 2020, retrospective, Singapore, peer-reviewed, 14 authors, dosage 1,000IU daily, this trial uses multiple treatments in the treatment arm (combined with magnesium and vitamin B12) - results of individual treatments may vary.
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Abstract: Nutrition 79 80 (2020) 111017 Contents lists available at ScienceDirect Nutrition journal homepage: Applied nutritional investigation Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19) Chuen Wen Tan M.R.C.P., F.R.C.Path a,1, Liam Pock Ho F.R.C.P.A. a,b,c,1, Shirin Kalimuddin M.B.B.S., M.R.C.P., M.P.H. d,e, Benjamin Pei Zhi Cherng M.B.B.S., M.R.C.P. d, Yii Ean Teh M.B.B.S., M.R.C.P.(UK) d, Siew Yee Thien M.R.C.P.(UK) d, Hei Man Wong M.R.C.P.(UK), M.Med(NUS) d, Paul Jie Wen Tern M.B B.Chir d, Manju Chandran M.D., F.A.C.P., F.A.C.E., F.A.M.S., C.C.D. f, Jason Wai Mun Chay M.R.C.P., F.R.C.Path(UK) b,c, Chandramouli Nagarajan F.R.C.P.(Edin), F.R.C.Path(UK) a, Rehena Sultana M.Sc. (Statistics), MBA (Systems Management) g, Jenny Guek Hong Low M.R.C.P.(UK), M.P.H.(US) d,e, Heng Joo Ng M.R.C.P.(UK), F.R.C.Path(UK) a,* a Department of Hematology, Singapore General Hospital, Singapore Department of Clinical Pathology, Singapore General Hospital, Singapore c Department of Pathology, Sengkang General Hospital, Singapore d Department of Infectious Diseases, Singapore General Hospital, Singapore e Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore f Department of Endocrinology, Singapore General Hospital, Singapore g Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore b A R T I C L E I N F O Article History: Received 24 June 2020 Received in revised form 25 August 2020 Accepted 1 September 2020 Keywords: Vitamin D Magnesium Vitamin B12 COVID-19 A B S T R A C T Objectives: The aim of this study was to determine clinical outcomes of older patients with coronavirus (COVID-19) who received a combination of vitamin D, magnesium, and vitamin B12 (DMB) compared with those who did not. We hypothesized that fewer patients administered this combination would require oxygen therapy, intensive care support, or a combination of both than those who did not. Methods: This was a cohort observational study of all consecutive hospitalized patients 50 y of age with COVID-19 in a tertiary academic hospital. Before April 6, 2020, no patients received the (DMB) combination. After this date, patients were administered 1000 IU/d oral vitamin D3, 150 mg/d oral magnesium, and 500 mcg/d oral vitamin B12 upon admission if they did not require oxygen therapy. Primary outcome was deterioration leading to any form of oxygen therapy, intensive care support, or both. Results: Between January 15 and April 15, 2020, we identified 43 consecutive patients 50 y of age with COVID-19. Seventeen patients received DMB before onset of primary outcome and 26 patients did not. Baseline demographic characteristics between the two groups were significantly different by age. In univariate analysis, age and hypertension had a significant influence on outcome. After adjusting for age or hypertension separately in a multivariate analysis, the intervention group retained protective significance. Fewer treated patients than controls required initiation of oxygen therapy during hospitalization (17.6 vs 61.5%, P = 0.006). DMB exposure was associated with odds ratios of 0.13 (95% confidence interval [CI], 0.03 0.59) and 0.20 (95% CI, 0.04 0.93) for oxygen therapy, intensive care support, or both on univariate and multivariate analyses, respectively. Conclusions: A vitamin D / magnesium / vitamin B12 combination in..
Late treatment
is less effective
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