Cohort study to evaluate the effect of combination Vitamin D, Magnesium and Vitamin B12 (DMB) on progression to severe outcome in older COVID-19 patients

Tan et al., Nutrition, doi:10.1016/j.nut.2020.111017 (date from preprint)

Jun 2020

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Observational study of 43 patients >= 50 years old, with 17 patients receiving vitamin D, magnesium, and vitamin B12 (DMB); and 26 control patients, showing a significantly lower need for oxygen therapy and ICU admission with treatment. DMB OR 0.20 [0.04–0.93] for oxygen therapy and/or intensive care support with multivariate analysis.

This study is excluded in meta analysis: combined treatments may contribute more to the effect seen.

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This study includes vitamin B12 and vitamin D.

risk of oxygen therapy, 80.5% lower, RR 0.20, p = 0.04, treatment 3 of 17 (17.6%), control 16 of 26 (61.5%), NNT 2.3, adjusted per study, multivariate.

risk of ICU admission, 80.9% lower, RR 0.19, p = 0.07, treatment 1 of 17 (5.9%), control 8 of 26 (30.8%), NNT 4.0, no adjusted result available.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Tan et al., 10 Jun 2020, retrospective, Singapore, peer-reviewed, 14 authors, this trial uses multiple treatments in the treatment arm (combined with magnesium and vitamin B12) - results of individual treatments may vary.

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Late treatment
is less effective

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