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All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Oxygen therapy 80% Improvement Relative Risk ICU admission 81% Vitamin B12 for COVID-19  Tan et al.  LATE TREATMENT Is late treatment with vitamin B12 + combined treatments beneficial for COVID-19? Retrospective 43 patients in Singapore Lower need for oxygen therapy with vitamin B12 + combined treatments (p=0.04) c19early.org Tan et al., Nutrition, June 2020 Favors vitamin B12 Favors control

Cohort study to evaluate the effect of combination Vitamin D, Magnesium and Vitamin B12 (DMB) on progression to severe outcome in older COVID-19 patients

Tan et al., Nutrition, doi:10.1016/j.nut.2020.111017 (date from preprint)
Jun 2020  
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Observational study of 43 patients >= 50 years old, with 17 patients receiving vitamin D, magnesium, and vitamin B12 (DMB); and 26 control patients, showing a significantly lower need for oxygen therapy and ICU admission with treatment. DMB OR 0.20 [0.04–0.93] for oxygen therapy and/or intensive care support with multivariate analysis.
This study is excluded in meta analysis: combined treatments may contribute more to the effect seen.
This study includes vitamin B12 and vitamin D.
risk of oxygen therapy, 80.5% lower, RR 0.20, p = 0.04, treatment 3 of 17 (17.6%), control 16 of 26 (61.5%), NNT 2.3, adjusted per study, multivariate.
risk of ICU admission, 80.9% lower, RR 0.19, p = 0.07, treatment 1 of 17 (5.9%), control 8 of 26 (30.8%), NNT 4.0, no adjusted result available.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Tan et al., 10 Jun 2020, retrospective, Singapore, peer-reviewed, 14 authors, this trial uses multiple treatments in the treatment arm (combined with magnesium and vitamin B12) - results of individual treatments may vary.
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Late treatment
is less effective
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