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Zinc and SARS-CoV-2: A molecular modeling study of Zn interactions with RNA-dependent RNA-polymerase and 3C-like proteinase enzymes

Pormohammad et al., International Journal of Molecular Medicine, doi:10.3892/ijmm.2020.4790
Nov 2020  
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Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020
*, now with p = 0.0000013 from 44 studies, recognized in 17 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments.
In Silico analysis supporting the hypothesis that Zn would bind and regulate the enzymatic activities of 3CLpro and RdRp of SARS-CoV-2 and therefore inhibit viral replication. Since Zn has established immune health benefits, is readily available, inexpensive and safe, the authors propose that Zn could help ameliorate COVID-19.
10 preclinical studies support the efficacy of zinc for COVID-19:
Pormohammad et al., 18 Nov 2020, peer-reviewed, 3 authors.
In Silico studies are an important part of preclinical research, however results may be very different in vivo.
This PaperZincAll
Zinc and SARS‑CoV‑2: A molecular modeling study of Zn interactions with RNA‑dependent RNA‑polymerase and 3C‑like proteinase enzymes
Ali Pormohammad, Nadia K Monych, Professor Raymond J Turner
International Journal of Molecular Medicine, doi:10.3892/ijmm.2020.4790
RNA-dependent RNA-polymerase (RdRp) and 3c-like proteinase (3cL pro ) are two main enzymes that play a key role in the replication of SARS-coV-2. Zinc (Zn) has strong immunogenic properties and is known to bind to a number of proteins, modulating their activities. Zn also has a history of use in viral infection control. Thus, the present study models potential Zn binding to RdRp and the 3cL pro . Through molecular modeling, the Zn binding sites in the aforementioned two important enzymes of viral replication were found to be conserved between severe acute respiratory syndrome (SARS)-coronavirus (coV) and SARS-coV-2. The location of these sites may influence the enzymatic activity of 3cL pro and RdRp in coronavirus disease 2019 . Since Zn has established immune health benefits, is readily available, non-expensive and a safe food supplement, with the comparisons presented here between SARS-coV and cOVId-19, the present study proposes that Zn could help ameliorate the disease process of cOVId-19 infection.
Authors' contributions AP and RJT conceived and designed the study; NKM and AP performed comprehensive research; AP and NKM analyzed the data; AP, NKM and RJT wrote and revised the paper; AP, NKM and RJT participated in data analysis and manuscript editing. All authors read and approved the final manuscript. Ethics approval and consent to participate Not applicable. Patient consent for publication Not applicable. Competing interests The authors declare that they have no competing interests.
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