Zinc and SARS‑CoV‑2: A molecular modeling study of Zn interactions with RNA‑dependent RNA‑polymerase and 3C‑like proteinase enzymes
et al., International Journal of Molecular Medicine,
In Silico analysis supporting the hypothesis that Zn would bind and regulate the enzymatic activities of 3CLpro and RdRp of SARS‑CoV-2 and therefore inhibit viral replication. Since Zn has established immune health benefits, is readily available, inexpensive and safe, the authors propose that Zn could help ameliorate COVID-19.
Pormohammad et al., 18 Nov 2020, peer-reviewed, 3 authors.
In Silico studies are an important part of preclinical research, however results may be very different in vivo.