Chemical and spectroscopic characterization of (Artemisinin/Quercetin/ Zinc) novel mixed ligand complex with assessment of its potent high antiviral activity against SARS-CoV-2 and antioxidant capacity against toxicity induced by acrylamide in male rats

{ 'indexed': {'date-parts': [[2024, 1, 3]], 'date-time': '2024-01-03T00:57:38Z', 'timestamp': 1704243458534}, 'reference-count': 82, 'publisher': 'PeerJ', 'license': [ { 'start': { 'date-parts': [[2024, 1, 2]], 'date-time': '2024-01-02T00:00:00Z', 'timestamp': 1704153600000}, 'content-version': 'unspecified', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'funder': [{'name': 'The Deanship of Scientific Research, Taif University'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p>A novel Artemisinin/Quercetin/Zinc (Art/Q/Zn) mixed ligand complex was synthesized, ' 'tested for its antiviral activity against coronavirus (SARS-CoV-2), and investigated for its ' 'effect against toxicity and oxidative stress induced by acrylamide (Acy), which develops upon ' 'cooking starchy foods at high temperatures. The synthesized complex was chemically ' 'characterized by performing elemental analysis, conductance measurements, FT-IR, UV, magnetic ' 'measurements, and XRD. The morphological surface of the complex Art/Q/Zn was investigated ' 'using scanning and transmission electron microscopy (SEM and TEM) and energy dispersive X-ray ' 'analysis (XRD). The <jats:italic>in vitro</jats:italic> antiviral activity of the complex ' 'Art/Q/Zn against SARS-CoV-2 and its <jats:italic>in vivo</jats:italic> activity against ' 'Acy-induced toxicity in hepatic and pulmonary tissues were analyzed. An experimental model ' 'was used to evaluate the beneficial effects of the novel Art/Q/Zn novel complex on lung and ' 'liver toxicities of Acy. Forty male rats were randomly divided into four groups: control, Acy ' '(500 mg/Kg), Art/Q/Zn (30 mg/kg), and a combination of Acy and Art/Q/Zn. The complex was ' 'orally administered for 30 days. Hepatic function and inflammation marker (CRP), tumor ' 'necrosis factor, interleukin-6 (IL-6), antioxidant enzyme (CAT, SOD, and GPx), marker of ' 'oxidative stress (MDA), and blood pressure levels were investigated. Histological and ' 'ultrastructure alterations and caspase-3 variations (immunological marker) were also ' 'investigated. FT-IR spectra revealed that Zn (II) is able to chelate through C=O and C-OH ' '(Ring II) which are the carbonyl oxygen atoms of the quercetin ligand and carbonyl oxygen ' 'atom C=O of the Art ligand, forming Art/Q/Zn complex with the chemical formula ' '[Zn(Q)(Art)(Cl)(H<jats:sub>2</jats:sub>O)<jats:sub>2</jats:sub>]⋅3H<jats:sub>2</jats:sub>O. ' 'The novel complex exhibited a potent anti-SARS-CoV-2 activity even at a low concentration ' '(IC<jats:sub>50</jats:sub> = 10.14 µg/ml) and was not cytotoxic to the cellular host ' '(CC<jats:sub>50</jats:sub> = 208.5 µg/ml). Art/Q/Zn may inhibit the viral replication and ' 'binding to the angiotensin-converting enzyme-2 (ACE2) receptor and the main protease ' 'inhibitor (M<jats:sup>Pro</jats:sup>), thereby inhibiting the activity of SARS-CoV-2 and this ' 'proved by the molecular dynamics simulation. It alleviated Acy hepatic and pulmonary toxicity ' 'by improving all biochemical markers. Therefore, it can be concluded that the novel formula ' 'Art/Q/Zn complex is an effective antioxidant agent against the oxidative stress series, and ' 'it has high inhibitory effect against SARS-CoV-2.</jats:p>', 'DOI': '10.7717/peerj.15638', 'type': 'journal-article', 'created': {'date-parts': [[2024, 1, 2]], 'date-time': '2024-01-02T12:29:50Z', 'timestamp': 1704198590000}, 'page': 'e15638', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Chemical and spectroscopic characterization of (Artemisinin/Querctin/ Zinc) novel mixed ligand ' 'complex with assessment of its potent high antiviral activity against SARS-CoV-2 and antioxidant ' 'capacity against toxicity induced by acrylamide in male rats', 'prefix': '10.7717', 'volume': '12', 'author': [ { 'given': 'Samy M.', 'family': 'El-Megharbel', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Chemistry, College of Sciences, Taif University, ' 'Taif, Saudi Arabia'}]}, { 'given': 'Safa H.', 'family': 'Qahl', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Biology, College of Science, University of Jeddah, ' 'Jeddah, Saudi Arabia'}]}, { 'given': 'Bander', 'family': 'Albogami', 'sequence': 'additional', 'affiliation': [ { 'name': 'Biology Department, College of Sciences, Taif University, Taif, ' 'Saudi Arabia'}]}, { 'given': 'Reham Z.', 'family': 'Hamza', 'sequence': 'additional', 'affiliation': [ { 'name': 'Biology Department, College of Sciences, Taif University, Taif, ' 'Saudi Arabia'}]}], 'member': '4443', 'published-online': {'date-parts': [[2024, 1, 2]]}, 'reference': [ { 'issue': '20', 'key': '10.7717/peerj.15638/ref-1', 'doi-asserted-by': 'publisher', 'first-page': '12235', 'DOI': '10.3390/ijms232012235', 'article-title': 'Anticoagulants as potential SARS-CoV-2 Mpro inhibitors for COVID-19 ' 'patients: in vitro, molecular docking, molecular dynamics, DFT, and SAR ' 'studies', 'volume': '23', 'author': 'Abo\xa0Elmaaty', 'year': '2022', 'journal-title': 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