Inhibitory effect of lactoferrin-coated zinc nanoparticles on SARS-CoV-2 replication and entry along with improvement of lung fibrosis induced in adult male albino rats

DOI record: { "DOI": "10.1016/j.ijbiomac.2023.125552", "ISSN": [ "0141-8130" ], "URL": "http://dx.doi.org/10.1016/j.ijbiomac.2023.125552", "alternative-id": [ "S0141813023024467" ], "article-number": "125552", "assertion": [ { "label": "This article is maintained by", "name": "publisher", "value": "Elsevier" }, { "label": "Article Title", "name": "articletitle", "value": "Inhibitory effect of lactoferrin-coated zinc nanoparticles on SARS-CoV-2 replication and entry along with improvement of lung fibrosis induced in adult male albino rats" }, { "label": "Journal Title", "name": "journaltitle", "value": "International Journal of Biological Macromolecules" }, { "label": "CrossRef DOI link to publisher maintained version", "name": "articlelink", "value": "https://doi.org/10.1016/j.ijbiomac.2023.125552" }, { "label": "Content Type", "name": "content_type", "value": "article" }, { "label": "Copyright", "name": "copyright", "value": "© 2023 Elsevier B.V. All rights reserved." } ], "author": [ { "affiliation": [], "family": "El-Fakharany", "given": "Esmail M.", "sequence": "first" }, { "affiliation": [], "family": "El-Gendi", "given": "Hamada", "sequence": "additional" }, { "affiliation": [], "family": "El-Maradny", "given": "Yousra A.", "sequence": "additional" }, { "affiliation": [], "family": "Abu-Serie", "given": "Marwa M.", "sequence": "additional" }, { "affiliation": [], "family": "Abdel-Wahhab", "given": "Khaled G.", "sequence": "additional" }, { "affiliation": [], "family": "Shaban", "given": "Marwa E.", "sequence": "additional" }, { "affiliation": [], "family": "Ashry", "given": "Mahmoud", "sequence": "additional" } ], "container-title": "International Journal of Biological Macromolecules", "container-title-short": "International Journal of Biological Macromolecules", "content-domain": { "crossmark-restriction": true, "domain": [ "elsevier.com", "sciencedirect.com" ] }, "created": { "date-parts": [ [ 2023, 6, 24 ] ], "date-time": "2023-06-24T16:32:29Z", "timestamp": 1687624349000 }, "deposited": { "date-parts": [ [ 2023, 6, 24 ] ], "date-time": "2023-06-24T16:33:56Z", "timestamp": 1687624436000 }, "indexed": { "date-parts": [ [ 2023, 6, 25 ] ], "date-time": "2023-06-25T04:34:10Z", "timestamp": 1687667650549 }, "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2023, 6 ] ] }, "language": "en", "license": [ { "URL": "https://www.elsevier.com/tdm/userlicense/1.0/", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2023, 6, 1 ] ], "date-time": "2023-06-01T00:00:00Z", "timestamp": 1685577600000 } }, { "URL": "https://doi.org/10.15223/policy-017", "content-version": "stm-asf", "delay-in-days": 0, "start": { "date-parts": [ [ 2023, 6, 1 ] ], "date-time": "2023-06-01T00:00:00Z", "timestamp": 1685577600000 } }, { "URL": "https://doi.org/10.15223/policy-037", "content-version": "stm-asf", "delay-in-days": 0, "start": { "date-parts": [ [ 2023, 6, 1 ] ], "date-time": "2023-06-01T00:00:00Z", "timestamp": 1685577600000 } }, { "URL": "https://doi.org/10.15223/policy-012", "content-version": "stm-asf", "delay-in-days": 0, "start": { "date-parts": [ [ 2023, 6, 1 ] ], "date-time": "2023-06-01T00:00:00Z", "timestamp": 1685577600000 } }, { "URL": "https://doi.org/10.15223/policy-029", "content-version": "stm-asf", "delay-in-days": 0, "start": { "date-parts": [ [ 2023, 6, 1 ] ], "date-time": "2023-06-01T00:00:00Z", "timestamp": 1685577600000 } }, { "URL": "https://doi.org/10.15223/policy-004", "content-version": "stm-asf", "delay-in-days": 0, "start": { "date-parts": [ [ 2023, 6, 1 ] ], "date-time": "2023-06-01T00:00:00Z", "timestamp": 1685577600000 } } ], "link": [ { "URL": "https://api.elsevier.com/content/article/PII:S0141813023024467?httpAccept=text/xml", "content-type": "text/xml", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://api.elsevier.com/content/article/PII:S0141813023024467?httpAccept=text/plain", "content-type": "text/plain", "content-version": "vor", "intended-application": "text-mining" } ], "member": "78", "original-title": [], "page": "125552", "prefix": "10.1016", "published": { "date-parts": [ [ 2023, 6 ] ] }, "published-print": { "date-parts": [ [ 2023, 6 ] ] }, "publisher": "Elsevier BV", "reference": [ { "article-title": "WHO keeps covid-19 a public health emergency of international concern", "author": "McVernon", "journal-title": "BMJ", "key": "10.1016/j.ijbiomac.2023.125552_bb0005", "volume": "380", "year": "2023" }, { "DOI": "10.1001/jama.2022.9655", "article-title": "COVID-19 in 2022—the beginning of the end or the end of the beginning?", "author": "Del Rio", "doi-asserted-by": "crossref", "first-page": "2389", "journal-title": "JAMA", "key": "10.1016/j.ijbiomac.2023.125552_bb0010", "volume": "327", "year": "2022" }, { "DOI": "10.1016/j.cytogfr.2022.02.002", "article-title": "The coronavirus pandemic–2022: viruses, variants & vaccines", "author": "Alexandridi", "doi-asserted-by": "crossref", "journal-title": "Cytokine Growth Factor Rev.", "key": "10.1016/j.ijbiomac.2023.125552_bb0015", "year": "2022" }, { "DOI": "10.3390/diagnostics10121053", "article-title": "Diagnosis and management of acute respiratory distress syndrome in a time of COVID-19", "author": "Kassirian", "doi-asserted-by": "crossref", "first-page": "1053", "journal-title": "Diagnostics", "key": "10.1016/j.ijbiomac.2023.125552_bb0020", "volume": "10", "year": "2020" }, { "DOI": "10.1007/s10787-022-01027-6", "article-title": "Pirfenidone and post-Covid-19 pulmonary fibrosis: invoked again for realistic goals", "author": "Al-kuraishy", "doi-asserted-by": "crossref", "first-page": "2017", "journal-title": "Inflammopharmacology", "key": "10.1016/j.ijbiomac.2023.125552_bb0025", "volume": "30", "year": "2022" }, { "DOI": "10.1016/S2213-2600(18)30502-2", "article-title": "Lung transplantation for idiopathic pulmonary fibrosis", "author": "George", "doi-asserted-by": "crossref", "first-page": "271", "journal-title": "Lancet Respir. Med.", "key": "10.1016/j.ijbiomac.2023.125552_bb0030", "volume": "7", "year": "2019" }, { "DOI": "10.1016/S2213-2600(20)30225-3", "article-title": "Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy", "author": "George", "doi-asserted-by": "crossref", "first-page": "807", "journal-title": "Lancet Respir. Med.", "key": "10.1016/j.ijbiomac.2023.125552_bb0035", "volume": "8", "year": "2020" }, { "DOI": "10.1183/09031936.00077309", "article-title": "Idiopathic pulmonary fibrosis: a disease with similarities and links to cancer biology", "author": "Vancheri", "doi-asserted-by": "crossref", "first-page": "496", "journal-title": "Eur. Respir. J.", "key": "10.1016/j.ijbiomac.2023.125552_bb0040", "volume": "35", "year": "2010" }, { "DOI": "10.1016/S2213-2600(14)70101-8", "article-title": "Idiopathic pulmonary fibrosis in US Medicare beneficiaries aged 65 years and older: incidence, prevalence, and survival, 2001–11", "author": "Raghu", "doi-asserted-by": "crossref", "first-page": "566", "journal-title": "Lancet Respir. Med.", "key": "10.1016/j.ijbiomac.2023.125552_bb0045", "volume": "2", "year": "2014" }, { "DOI": "10.1016/j.jtemb.2022.126956", "article-title": "Zinc and selenium supplementation in COVID-19 prevention and treatment: a systematic review of the experimental studies", "author": "Balboni", "doi-asserted-by": "crossref", "journal-title": "J. Trace Elem. Med. Biol.", "key": "10.1016/j.ijbiomac.2023.125552_bb0050", "volume": "71", "year": "2022" }, { "DOI": "10.1007/s12011-020-02437-9", "article-title": "Zinc and COVID-19: basis of current clinical trials", "author": "Pal", "doi-asserted-by": "crossref", "first-page": "2882", "journal-title": "Biol. Trace Elem. Res.", "key": "10.1016/j.ijbiomac.2023.125552_bb0055", "volume": "199", "year": "2021" }, { "DOI": "10.1016/j.intimp.2021.107571", "article-title": "The potential for Lactoferrin to reduce SARS-CoV-2 induced cytokine storm", "author": "Zimecki", "doi-asserted-by": "crossref", "journal-title": "Int. Immunopharmacol.", "key": "10.1016/j.ijbiomac.2023.125552_bb0060", "volume": "95", "year": "2021" }, { "DOI": "10.1016/j.ijantimicag.2008.07.020", "article-title": "Lactoferrin: structure, function and applications", "author": "González-Chávez", "doi-asserted-by": "crossref", "first-page": "301", "journal-title": "Int. J. Antimicrob. Agents", "key": "10.1016/j.ijbiomac.2023.125552_bb0065", "volume": "33", "year": "2009" }, { "DOI": "10.3390/pharmaceutics15030865", "article-title": "Biomedical applications of lactoferrin on the ocular surface", "author": "Regueiro", "doi-asserted-by": "crossref", "first-page": "865", "journal-title": "Pharmaceutics", "key": "10.1016/j.ijbiomac.2023.125552_bb0070", "volume": "15", "year": "2023" }, { "DOI": "10.1080/10408398.2021.1900774", "article-title": "Oral fate and stabilization technologies of lactoferrin: a systematic review", "author": "Wei", "doi-asserted-by": "crossref", "first-page": "6341", "journal-title": "Crit. Rev. Food Sci. Nutr.", "key": "10.1016/j.ijbiomac.2023.125552_bb0075", "volume": "62", "year": "2022" }, { "DOI": "10.1007/s00018-005-5368-9", "article-title": "Lactoferrin: molecular structure, binding properties and dynamics of lactoferrin", "author": "Baker", "doi-asserted-by": "crossref", "first-page": "2531", "journal-title": "Cell. Mol. Life Sci.", "key": "10.1016/j.ijbiomac.2023.125552_bb0080", "volume": "62", "year": "2005" }, { "DOI": "10.1016/j.idairyj.2021.105208", "article-title": "Antioxidant, antimicrobial and anticarcinogenic activities of bovine milk proteins and their hydrolysates - a review", "author": "Bielecka", "doi-asserted-by": "crossref", "journal-title": "Int. Dairy J.", "key": "10.1016/j.ijbiomac.2023.125552_bb0085", "volume": "127", "year": "2022" }, { "DOI": "10.1080/22221751.2021.1888660", "article-title": "The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor, Emerg", "author": "Hu", "doi-asserted-by": "crossref", "first-page": "317", "journal-title": "Microbes Infect.", "key": "10.1016/j.ijbiomac.2023.125552_bb0090", "volume": "10", "year": "2021" }, { "DOI": "10.1016/j.virol.2005.01.010", "article-title": "Antiviral activity of human lactoferrin: inhibition of alphavirus interaction with heparan sulfate", "author": "Waarts", "doi-asserted-by": "crossref", "first-page": "284", "journal-title": "Virology", "key": "10.1016/j.ijbiomac.2023.125552_bb0095", "volume": "333", "year": "2005" }, { "DOI": "10.1113/expphysiol.2006.034876", "article-title": "Enteric-formulated lactoferrin was more effectively transported into blood circulation from gastrointestinal tract in adult rats", "author": "Takeuchi", "doi-asserted-by": "crossref", "first-page": "1033", "journal-title": "Exp. Physiol.", "key": "10.1016/j.ijbiomac.2023.125552_bb0100", "volume": "91", "year": "2006" }, { "DOI": "10.1016/j.biomaterials.2020.120355", "article-title": "Lactoferrin, a multi-functional glycoprotein: active therapeutic, drug nanocarrier & targeting ligand", "author": "Elzoghby", "doi-asserted-by": "crossref", "journal-title": "Biomaterials.", "key": "10.1016/j.ijbiomac.2023.125552_bb0105", "volume": "263", "year": "2020" }, { "article-title": "Design and development of lactoferrin conjugated lipid-polymer nano-bio-hybrid for cancer theranostics", "author": "Kumar", "journal-title": "Mater. Today Commun.", "key": "10.1016/j.ijbiomac.2023.125552_bb0110", "volume": "31", "year": "2022" }, { "DOI": "10.1016/j.gene.2023.147355", "article-title": "Evaluation of the effect of nano-encapsulated lactoferrin on the expression of Bak and Bax genes in gastric cancer cell line AGS and study of the molecular docking of lactoferrin with these proteins", "author": "Moradian", "doi-asserted-by": "crossref", "journal-title": "Gene.", "key": "10.1016/j.ijbiomac.2023.125552_bb0115", "volume": "866", "year": "2023" }, { "DOI": "10.1016/j.ejpb.2022.02.010", "article-title": "Lactoferrin-loaded nanostructured lipid carriers (NLCs) as a new formulation for optimized ocular drug delivery", "author": "Varela-Fernández", "doi-asserted-by": "crossref", "first-page": "144", "journal-title": "Eur. J. Pharm. Biopharm.", "key": "10.1016/j.ijbiomac.2023.125552_bb0120", "volume": "172", "year": "2022" }, { "DOI": "10.1007/s42247-021-00335-x", "article-title": "Review on metal nanoparticles as nanocarriers: current challenges and perspectives in drug delivery systems", "author": "Chandrakala", "doi-asserted-by": "crossref", "first-page": "1593", "journal-title": "Emergent Mater.", "key": "10.1016/j.ijbiomac.2023.125552_bb0125", "volume": "5", "year": "2022" }, { "article-title": "Preparation and characterization of amine-functionalized mupirocin-loaded zinc oxide nanoparticles: a potent drug delivery agent in targeting human epidermoid carcinoma (A431) cells", "author": "Chelladurai", "journal-title": "J. Drug Deliv. Sci. Technol.", "key": "10.1016/j.ijbiomac.2023.125552_bb0130", "volume": "70", "year": "2022" }, { "DOI": "10.1016/j.ijbiomac.2020.09.235", "article-title": "Nanoformulation of lactoferrin potentiates its activity and enhances novel biotechnological applications", "author": "El-Fakharany", "doi-asserted-by": "crossref", "first-page": "970", "journal-title": "Int. J. Biol. Macromol.", "key": "10.1016/j.ijbiomac.2023.125552_bb0135", "volume": "165", "year": "2020" }, { "DOI": "10.1021/acs.bioconjchem.6b00575", "article-title": "Size-dependent protein–nanoparticle interactions in citrate-stabilized gold nanoparticles: the emergence of the protein corona", "author": "Piella", "doi-asserted-by": "crossref", "first-page": "88", "journal-title": "Bioconjug. Chem.", "key": "10.1016/j.ijbiomac.2023.125552_bb0140", "volume": "28", "year": "2017" }, { "DOI": "10.1007/s11947-012-0797-6", "article-title": "Zinc oxide nanoparticles: synthesis, antimicrobial activity and food packaging applications", "author": "Espitia", "doi-asserted-by": "crossref", "first-page": "1447", "journal-title": "Food Bioprocess Technol.", "key": "10.1016/j.ijbiomac.2023.125552_bb0145", "volume": "5", "year": "2012" }, { "DOI": "10.1039/C9RA07630A", "article-title": "Green synthesis of zinc oxide nanostructures and investigation of their photocatalytic and bactericidal applications", "author": "Kahsay", "doi-asserted-by": "crossref", "first-page": "36967", "journal-title": "RSC Adv.", "key": "10.1016/j.ijbiomac.2023.125552_bb0150", "volume": "9", "year": "2019" }, { "DOI": "10.1038/s41598-022-12648-w", "article-title": "Assessment of antimicrobial, cytotoxicity, and antiviral impact of a green zinc oxide/activated carbon nanocomposite", "author": "Hassan", "doi-asserted-by": "crossref", "first-page": "8774", "journal-title": "Sci. Rep.", "key": "10.1016/j.ijbiomac.2023.125552_bb0155", "volume": "12", "year": "2022" }, { "DOI": "10.3390/nano11051312", "article-title": "Antiviral activity of silver, copper oxide and zinc oxide nanoparticle coatings against SARS-CoV-2", "author": "Merkl", "doi-asserted-by": "crossref", "first-page": "1312", "journal-title": "Nanomaterials", "key": "10.1016/j.ijbiomac.2023.125552_bb0160", "volume": "11", "year": "2021" }, { "DOI": "10.3389/fmicb.2022.881595", "article-title": "Antiviral activity of zinc oxide nanoparticles and tetrapods against the hepatitis E and hepatitis C viruses", "author": "Gupta", "doi-asserted-by": "crossref", "journal-title": "Front. Microbiol.", "key": "10.1016/j.ijbiomac.2023.125552_bb0165", "volume": "13", "year": "2022" }, { "DOI": "10.1186/s12929-019-0563-4", "article-title": "Inhibition of H1N1 influenza virus infection by zinc oxide nanoparticles: another emerging application of nanomedicine", "author": "Ghaffari", "doi-asserted-by": "crossref", "first-page": "1", "journal-title": "J. Biomed. Sci.", "key": "10.1016/j.ijbiomac.2023.125552_bb0170", "volume": "26", "year": "2019" }, { "DOI": "10.1039/D0BM01086C", "article-title": "The investigation of the parameters affecting the ZnO nanoparticle cytotoxicity behaviour: a tutorial review", "author": "Canta", "doi-asserted-by": "crossref", "first-page": "6157", "journal-title": "Biomater. Sci.", "key": "10.1016/j.ijbiomac.2023.125552_bb0175", "volume": "8", "year": "2020" }, { "DOI": "10.5812/kowsar.1735143X.1367", "article-title": "Examination of the activity of camel milk casein against hepatitis C virus (genotype-4a) and its apoptotic potential in hepatoma and hela cell lines", "author": "Almahdy", "doi-asserted-by": "crossref", "first-page": "724", "journal-title": "Hepat. Mon.", "key": "10.1016/j.ijbiomac.2023.125552_bb0180", "volume": "11", "year": "2011" }, { "article-title": "Potential activity of camel milk-amylase and lactoferrin against hepatitis C virus infectivity in HepG2 and lymphocytes", "author": "El-Fakharany", "first-page": "101", "journal-title": "Hepat. Mon.", "key": "10.1016/j.ijbiomac.2023.125552_bb0185", "volume": "8", "year": "2008" }, { "DOI": "10.1186/1743-422X-10-199", "article-title": "Effectiveness of human, camel, bovine and sheep lactoferrin on the hepatitis C virus cellular infectivity: comparison study", "author": "El-Fakharany", "doi-asserted-by": "crossref", "first-page": "1", "journal-title": "Virol. J.", "key": "10.1016/j.ijbiomac.2023.125552_bb0190", "volume": "10", "year": "2013" }, { "DOI": "10.1128/AAC.01688-08", "article-title": "Inhibitory effects of lactoferrin on growth and biofilm formation of Porphyromonas gingivalis and Prevotella intermedia", "author": "Wakabayashi", "doi-asserted-by": "crossref", "first-page": "3308", "journal-title": "Antimicrob. Agents Chemother.", "key": "10.1016/j.ijbiomac.2023.125552_bb0195", "volume": "53", "year": "2009" }, { "DOI": "10.1016/0003-2697(76)90527-3", "article-title": "A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding", "author": "Bradford", "doi-asserted-by": "crossref", "first-page": "248", "journal-title": "Anal. Biochem.", "key": "10.1016/j.ijbiomac.2023.125552_bb0200", "volume": "72", "year": "1976" }, { "DOI": "10.1038/227680a0", "article-title": "Cleavage of structural proteins during the assembly of the head of bacteriophage T4", "author": "Laemmli", "doi-asserted-by": "crossref", "first-page": "680", "journal-title": "Nature.", "key": "10.1016/j.ijbiomac.2023.125552_bb0205", "volume": "227", "year": "1970" }, { "article-title": "Effect of ascorbic acid on structural properties of ZnO nanoparticles prepared by precipitation process", "author": "Chaithanatkun", "first-page": "145", "key": "10.1016/j.ijbiomac.2023.125552_bb0210", "series-title": "10th IEEE Int. Conf. Nano/Micro Eng. Mol. Syst", "year": "2015" }, { "DOI": "10.1023/A:1009221616623", "article-title": "Metal complexes of lactoferrin and their effect on the intracellular multiplication of Legionella pneumophila", "author": "Goldoni", "doi-asserted-by": "crossref", "first-page": "15", "journal-title": "Biometals.", "key": "10.1016/j.ijbiomac.2023.125552_bb0215", "volume": "13", "year": "2000" }, { "DOI": "10.1016/j.cej.2018.12.084", "article-title": "Lactoferrin adsorption onto silver nanoparticle interface: implications of corona on protein conformation, nanoparticle cytotoxicity and the formulation adjuvanticity", "author": "Nayak", "doi-asserted-by": "crossref", "first-page": "470", "journal-title": "Chem. Eng. J.", "key": "10.1016/j.ijbiomac.2023.125552_bb0220", "volume": "361", "year": "2019" }, { "DOI": "10.3389/fchem.2020.572885", "article-title": "Hijacking SARS-CoV-2/ACE2 receptor interaction by natural and semi-synthetic steroidal agents acting on functional pockets on the receptor binding domain", "author": "Carino", "doi-asserted-by": "crossref", "journal-title": "Front. Chem.", "key": "10.1016/j.ijbiomac.2023.125552_bb0225", "volume": "8", "year": "2020" }, { "DOI": "10.1007/s10753-012-9491-0", "article-title": "Effect of resveratrol on treatment of bleomycin-induced pulmonary fibrosis in rats", "author": "Akgedik", "doi-asserted-by": "crossref", "first-page": "1732", "journal-title": "Inflammation", "key": "10.1016/j.ijbiomac.2023.125552_bb0230", "volume": "35", "year": "2012" }, { "article-title": "The role of nanotechnology in the treatment of viral infections", "author": "Singh", "first-page": "105", "journal-title": "Ther. Adv. Infect. Dis.", "key": "10.1016/j.ijbiomac.2023.125552_bb0235", "volume": "4", "year": "2017" }, { "DOI": "10.1016/j.cbpb.2008.02.005", "article-title": "Isolation of lactoferrin from milk of different species: calorimetric and antimicrobial studies", "author": "Conesa", "doi-asserted-by": "crossref", "first-page": "131", "journal-title": "Comp. Biochem. Physiol. Part B Biochem. Mol. Biol.", "key": "10.1016/j.ijbiomac.2023.125552_bb0240", "volume": "150", "year": "2008" }, { "DOI": "10.1371/journal.pone.0268537", "article-title": "Characterization of proteolytic degradation products of vaginally administered bovine lactoferrin", "author": "Hopp", "doi-asserted-by": "crossref", "journal-title": "PLoS One", "key": "10.1016/j.ijbiomac.2023.125552_bb0245", "volume": "17", "year": "2022" }, { "DOI": "10.1080/01904167.2020.1724305", "article-title": "Effects of green synthesized zinc and copper nano-fertilizers on the morphological and biochemical attributes of basil plant", "author": "Abbasifar", "doi-asserted-by": "crossref", "first-page": "1104", "journal-title": "J. Plant Nutr.", "key": "10.1016/j.ijbiomac.2023.125552_bb0250", "volume": "43", "year": "2020" }, { "DOI": "10.1016/j.ceramint.2021.12.228", "article-title": "Green and cost-effective synthesis of zinc oxide thin films by L-ascorbic acid (AA) and their potential for electronics and antibacterial applications", "author": "Taşdemir", "doi-asserted-by": "crossref", "first-page": "10164", "journal-title": "Ceram. Int.", "key": "10.1016/j.ijbiomac.2023.125552_bb0255", "volume": "48", "year": "2022" }, { "DOI": "10.1016/j.ijpharm.2022.121458", "article-title": "The impact of protein corona on the biological behavior of targeting nanomedicines", "author": "Farshbaf", "doi-asserted-by": "crossref", "journal-title": "Int. J. Pharm.", "key": "10.1016/j.ijbiomac.2023.125552_bb0260", "volume": "614", "year": "2022" }, { "DOI": "10.1016/j.jconrel.2022.05.055", "article-title": "Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy", "author": "Khan", "doi-asserted-by": "crossref", "first-page": "127", "journal-title": "J. Control. Release", "key": "10.1016/j.ijbiomac.2023.125552_bb0265", "volume": "348", "year": "2022" }, { "DOI": "10.1021/nl060860z", "article-title": "The importance of an endotoxin-free environment during the production of nanoparticles used in medical applications", "author": "Vallhov", "doi-asserted-by": "crossref", "first-page": "1682", "journal-title": "Nano Lett.", "key": "10.1016/j.ijbiomac.2023.125552_bb0270", "volume": "6", "year": "2006" }, { "DOI": "10.1002/jat.4133", "article-title": "Cytotoxicity of zinc oxide nanoparticles to innate and adaptive human immune cells", "author": "Czyżowska", "doi-asserted-by": "crossref", "first-page": "1425", "journal-title": "J. Appl. Toxicol.", "key": "10.1016/j.ijbiomac.2023.125552_bb0275", "volume": "41", "year": "2021" }, { "DOI": "10.1021/nn901372t", "article-title": "Time evolution of the nanoparticle protein corona", "author": "Casals", "doi-asserted-by": "crossref", "first-page": "3623", "journal-title": "ACS Nano", "key": "10.1016/j.ijbiomac.2023.125552_bb0280", "volume": "4", "year": "2010" }, { "article-title": "Oral administration of encapsulated bovine lactoferrin protein nanocapsules against intracellular parasite Toxoplasma gondii", "author": "Anand", "first-page": "6355", "journal-title": "Int. J. Nanomedicine", "key": "10.1016/j.ijbiomac.2023.125552_bb0285", "volume": "10", "year": "2015" }, { "DOI": "10.1007/s41061-021-00353-7", "article-title": "The repurposed ACE2 inhibitors: SARS-CoV-2 entry blockers of Covid-19", "author": "Ahmad", "doi-asserted-by": "crossref", "first-page": "40", "journal-title": "Top. Curr. Chem.", "key": "10.1016/j.ijbiomac.2023.125552_bb0290", "volume": "379", "year": "2021" }, { "DOI": "10.1096/fasebj.28.1_supplement.1067.4", "article-title": "Concentration-dependent effects of zinc on angiotensin-converting enzyme-2 activity (1067.4)", "author": "Speth", "doi-asserted-by": "crossref", "first-page": "1064", "journal-title": "FASEB J.", "key": "10.1016/j.ijbiomac.2023.125552_bb0295", "volume": "28", "year": "2014" }, { "DOI": "10.1007/s10989-022-10373-6", "article-title": "Modeling substrate coordination to Zn-bound angiotensin converting enzyme 2", "author": "Fatouros", "doi-asserted-by": "crossref", "first-page": "65", "journal-title": "Int. J. Pept. Res. Ther.", "key": "10.1016/j.ijbiomac.2023.125552_bb0300", "volume": "28", "year": "2022" }, { "article-title": "Lactoferrin for the treatment of COVID-19", "author": "Wang", "first-page": "1", "journal-title": "Exp. Ther. Med.", "key": "10.1016/j.ijbiomac.2023.125552_bb0305", "volume": "20", "year": "2020" }, { "DOI": "10.3389/fphar.2021.666600", "article-title": "Lactoferrin against SARS-CoV-2: in vitro and in silico evidences", "author": "Campione", "doi-asserted-by": "crossref", "first-page": "1", "journal-title": "Front. Pharmacol.", "key": "10.1016/j.ijbiomac.2023.125552_bb0310", "volume": "12", "year": "2021" }, { "DOI": "10.1016/j.pharmthera.2020.107587", "article-title": "Cathepsin L-selective inhibitors: a potentially promising treatment for COVID-19 patients", "author": "Liu", "doi-asserted-by": "crossref", "journal-title": "Pharmacol. Ther.", "key": "10.1016/j.ijbiomac.2023.125552_bb0315", "volume": "213", "year": "2020" }, { "DOI": "10.1371/journal.ppat.1009013", "article-title": "The role of cysteine peptidases in coronavirus cell entry and replication: the therapeutic potential of cathepsin inhibitors", "author": "Pišlar", "doi-asserted-by": "crossref", "journal-title": "PLoS Pathog.", "key": "10.1016/j.ijbiomac.2023.125552_bb0320", "volume": "16", "year": "2020" }, { "DOI": "10.1016/j.idairyj.2022.105488", "article-title": "Hydrolysis improves the inhibition efficacy of bovine lactoferrin against infection by SARS-CoV-2 pseudovirus", "author": "Patil", "doi-asserted-by": "crossref", "journal-title": "Int. Dairy J.", "key": "10.1016/j.ijbiomac.2023.125552_bb0325", "volume": "137", "year": "2023" }, { "DOI": "10.1016/j.ejphar.2020.173499", "article-title": "Food proteins are a potential resource for mining cathepsin L inhibitory drugs to combat SARS-CoV-2", "author": "Madadlou", "doi-asserted-by": "crossref", "journal-title": "Eur. J. Pharmacol.", "key": "10.1016/j.ijbiomac.2023.125552_bb0330", "volume": "885", "year": "2020" }, { "DOI": "10.3390/cells10051052", "article-title": "Remdesivir and ledipasvir among the FDA-approved antiviral drugs have potential to inhibit SARS-CoV-2 replication", "author": "Pirzada", "doi-asserted-by": "crossref", "first-page": "1052", "journal-title": "Cells.", "key": "10.1016/j.ijbiomac.2023.125552_bb0335", "volume": "10", "year": "2021" }, { "DOI": "10.1186/s12931-020-01590-y", "article-title": "Can biomarkers of extracellular matrix remodelling and wound healing be used to identify high risk patients infected with SARS-CoV-2?: lessons learned from pulmonary fibrosis", "author": "Leeming", "doi-asserted-by": "crossref", "first-page": "38", "journal-title": "Respir. Res.", "key": "10.1016/j.ijbiomac.2023.125552_bb0340", "volume": "22", "year": "2021" }, { "DOI": "10.1177/2040622315624276", "article-title": "New perspectives on management of idiopathic pulmonary fibrosis", "author": "Puglisi", "doi-asserted-by": "crossref", "first-page": "108", "journal-title": "Ther. Adv. Chronic Dis.", "key": "10.1016/j.ijbiomac.2023.125552_bb0345", "volume": "7", "year": "2016" }, { "DOI": "10.1007/s13770-020-00294-0", "article-title": "Histological and physiological studies of the effect of bone marrow-derived mesenchymal stem cells on bleomycin induced lung fibrosis in adult albino rats", "author": "Zakaria", "doi-asserted-by": "crossref", "first-page": "127", "journal-title": "Tissue Eng. Regen. Med.", "key": "10.1016/j.ijbiomac.2023.125552_bb0350", "volume": "18", "year": "2021" }, { "author": "Maimonaparveen", "key": "10.1016/j.ijbiomac.2023.125552_bb0355", "series-title": "Effect of Bleomycin (BLM) Induced Toxicity on Body Weights and Hematological Parameters and Protective Role of Whole Pomegranate Juice in Rats", "year": "2021" }, { "DOI": "10.1016/j.cotox.2018.08.001", "article-title": "Oxidative toxicology of bleomycin: role of the extracellular redox environment", "author": "Allawzi", "doi-asserted-by": "crossref", "first-page": "68", "journal-title": "Curr. Opin. Toxicol.", "key": "10.1016/j.ijbiomac.2023.125552_bb0360", "volume": "13", "year": "2019" }, { "DOI": "10.1139/o01-228", "article-title": "Characterization of mammalian receptors for lactoferrin", "author": "Suzuki", "doi-asserted-by": "crossref", "first-page": "75", "journal-title": "Biochem. Cell Biol.", "key": "10.1016/j.ijbiomac.2023.125552_bb0365", "volume": "80", "year": "2002" }, { "author": "Mehdizadeh", "journal-title": "Mater. Sci. Eng. A", "key": "10.1016/j.ijbiomac.2023.125552_bb0370", "year": "2022" }, { "article-title": "Interstitial fibrosis and growth factors", "author": "Lasky", "first-page": "751", "journal-title": "Environ. Health Perspect.", "key": "10.1016/j.ijbiomac.2023.125552_bb0375", "volume": "108", "year": "2000" }, { "article-title": "Investigating the relationship between health literacy and Covid-19 preventive behaviors: a cross-sectional study in Hormozgan, Iran", "author": "Shahabi", "journal-title": "J. Heal. Lit.", "key": "10.1016/j.ijbiomac.2023.125552_bb0380", "year": "2023" }, { "DOI": "10.1097/MCC.0b013e32801162cb", "article-title": "Hyperoxia in the intensive care unit: why more is not always better", "author": "Altemeier", "doi-asserted-by": "crossref", "first-page": "73", "journal-title": "Curr. Opin. Crit. Care", "key": "10.1016/j.ijbiomac.2023.125552_bb0385", "volume": "13", "year": "2007" }, { "DOI": "10.4049/jimmunol.171.2.955", "article-title": "Sublethal hyperoxia impairs pulmonary innate immunity", "author": "Baleeiro", "doi-asserted-by": "crossref", "first-page": "955", "journal-title": "J. Immunol.", "key": "10.1016/j.ijbiomac.2023.125552_bb0390", "volume": "171", "year": "2003" }, { "DOI": "10.1016/j.lfs.2008.03.018", "article-title": "Diallyl sulfide attenuates bleomycin-induced pulmonary fibrosis: critical role of iNOS, NF-κB, TNF-α and IL-1β", "author": "Kalayarasan", "doi-asserted-by": "crossref", "first-page": "1142", "journal-title": "Life Sci.", "key": "10.1016/j.ijbiomac.2023.125552_bb0395", "volume": "82", "year": "2008" }, { "DOI": "10.1016/j.hepres.2006.06.005", "article-title": "Lactoferrin inhibits lipid peroxidation in patients with chronic hepatitis C", "author": "Konishi", "doi-asserted-by": "crossref", "first-page": "27", "journal-title": "Hepatol. Res.", "key": "10.1016/j.ijbiomac.2023.125552_bb0400", "volume": "36", "year": "2006" }, { "DOI": "10.1016/j.biochi.2008.05.021", "article-title": "Twenty-five years of research on bovine lactoferrin applications", "author": "Tomita", "doi-asserted-by": "crossref", "first-page": "52", "journal-title": "Biochimie.", "key": "10.1016/j.ijbiomac.2023.125552_bb0405", "volume": "91", "year": "2009" }, { "DOI": "10.1089/ars.2011.4271", "article-title": "Mammalian iron homeostasis in health and disease: uptake, storage, transport, and molecular mechanisms of action", "author": "Lawen", "doi-asserted-by": "crossref", "first-page": "2473", "journal-title": "Antioxid. Redox Signal.", "key": "10.1016/j.ijbiomac.2023.125552_bb0410", "volume": "18", "year": "2013" }, { "article-title": "Lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine imbalance", "author": "Togawa", "first-page": "G187", "journal-title": "Am. J. Physiol. Liver Physiol.", "key": "10.1016/j.ijbiomac.2023.125552_bb0415", "volume": "283", "year": "2002" }, { "DOI": "10.3389/fimmu.2017.00705", "article-title": "Lactoferrin efficiently counteracts the inflammation-induced changes of the iron homeostasis system in macrophages", "author": "Cutone", "doi-asserted-by": "crossref", "first-page": "705", "journal-title": "Front. Immunol.", "key": "10.1016/j.ijbiomac.2023.125552_bb0420", "volume": "8", "year": "2017" }, { "DOI": "10.2174/138161209788453202", "article-title": "Lactoferrin as a natural immune modulator", "author": "Actor", "doi-asserted-by": "crossref", "first-page": "1956", "journal-title": "Curr. Pharm. Des.", "key": "10.1016/j.ijbiomac.2023.125552_bb0425", "volume": "15", "year": "2009" }, { "DOI": "10.1038/aps.2013.200", "article-title": "Immunomodulatory effects of lactoferrin", "author": "Siqueiros-Cendón", "doi-asserted-by": "crossref", "first-page": "557", "journal-title": "Acta Pharmacol. Sin.", "key": "10.1016/j.ijbiomac.2023.125552_bb0430", "volume": "35", "year": "2014" }, { "DOI": "10.1007/978-3-319-63245-2_8", "article-title": "ROS signaling in the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)", "author": "Kellner", "doi-asserted-by": "crossref", "first-page": "105", "journal-title": "Pulm. Vasc. Redox Signal. Heal. Dis.", "key": "10.1016/j.ijbiomac.2023.125552_bb0435", "year": "2017" } ], "reference-count": 87, "references-count": 87, "relation": {}, "resource": { "primary": { "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0141813023024467" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [ "Molecular Biology", "General Medicine", "Biochemistry", "Structural Biology" ], "subtitle": [], "title": "Inhibitory effect of lactoferrin-coated zinc nanoparticles on SARS-CoV-2 replication and entry along with improvement of lung fibrosis induced in adult male albino rats", "type": "journal-article", "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy" }