Alkalinization
Analgesics..
Antiandrogens..
Bromhexine
Budesonide
Cannabidiol
Colchicine
Conv. Plasma
Curcumin
Ensovibep
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Iota-carragee..
Ivermectin
Lactoferrin
Lifestyle..
Melatonin
Metformin
Molnupiravir
Monoclonals..
Nigella Sativa
Nitazoxanide
Nitric Oxide
Paxlovid
Peg.. Lambda
Povidone-Iod..
Quercetin
Remdesivir
Vitamins..
Zinc

Other
Feedback
Home
Home   COVID-19 treatment studies for Zinc  COVID-19 treatment studies for Zinc  C19 studies: Zinc  Zinc   Select treatmentSelect treatmentTreatmentsTreatments
Alkalinization Meta Lactoferrin Meta
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta Molnupiravir Meta
Cannabidiol Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Nitric Oxide Meta
Ensovibep Meta Paxlovid Meta
Famotidine Meta Peg.. Lambda Meta
Favipiravir Meta Povidone-Iod.. Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Iota-carragee.. Meta
Ivermectin Meta Zinc Meta

Other Treatments Global Adoption
All Studies   Meta Analysis   Recent:  
In Vitro Determination of Inhibitory Effects of Humic Substances Complexing Zn and Se on SARS-CoV-2 Virus Replication
Hajdrik et al., Foods, doi:10.3390/foods11050694 (In Vitro)
Hajdrik et al., In Vitro Determination of Inhibitory Effects of Humic Substances Complexing Zn and Se on SARS-CoV-2 Virus.., Foods, doi:10.3390/foods11050694 (In Vitro)
Feb 2022   Source   PDF  
  Twitter
  Facebook
Share
  All Studies   Meta
In Vitro study of a humic substance containing vitamin C, selemium ions, and zinc ions, showing 50% SARS-CoV-2 inhibition at picomolar concentrations.
2 In Vitro studies support the efficacy of zinc [Hajdrik, Panchariya].
Hajdrik et al., 26 Feb 2022, peer-reviewed, 11 authors.
Contact: domokos.mathe@hcemm.eu (corresponding author), h.polett0809@gmail.com, kovacsnoi@hotmail.com, veres.daniel@med.semmelweis-univ.hu, krisztian.szigeti@gmail.com, hegedus.imre1@med.semmelweis-univ.hu, rkbergmann@web.de, palyi.bernadett@nnk.gov.hu, kis.zoltan@nnk.gov.hu, budfer2@gmail.com, kovacstiborjanos@gmail.com.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperZincAll
Abstract: foods Article In Vitro Determination of Inhibitory Effects of Humic Substances Complexing Zn and Se on SARS-CoV-2 Virus Replication Polett Hajdrik 1,† , Bernadett Pályi 2,† , Zoltán Kis 2,3 , Noémi Kovács 1,4 , Dániel Sándor Veres 1 , Krisztián Szigeti 1 , Ferenc Budán 5,6 , Imre Hegedüs 1 , Tibor Kovács 7 , Ralf Bergmann 1,8 and Domokos Máthé 1,4,9, * 1 2 3 4 5 6 7 8 9   Citation: Hajdrik, P.; Pályi, B.; Kis, Z.; * † Department of Biophysics and Radiation Biology, Semmelweis University, Üllői út 26., H-1085 Budapest, Hungary; h.polett0809@gmail.com (P.H.); kovacsnoi@hotmail.com (N.K.); veres.daniel@med.semmelweis-univ.hu (D.S.V.); krisztian.szigeti@gmail.com (K.S.); hegedus.imre1@med.semmelweis-univ.hu (I.H.); rkbergmann@web.de (R.B.) National Biosafety Laboratory, National Public Health Center, Albert Flórián út 2-6, H-1097 Budapest, Hungary; palyi.bernadett@nnk.gov.hu (B.P.); kis.zoltan@nnk.gov.hu (Z.K.) Department of Microbiology, Semmelweis University, Üllői út 26., H-1085 Budapest, Hungary CROmed Translational Research Ltd., Tűzoltó u. 37-47, H-1094 Budapest, Hungary Institute of Transdisciplinary Discoveries, Medical School, University of Pécs, Ifjúság útja 11, H-7624 Pécs, Hungary; budfer2@gmail.com Institute of Physiology, Medical School, University of Pécs, Szigeti út 12, H-7624 Pécs, Hungary Institute of Radiochemistry and Radioecology, University of Pannonia, Egyetem u. 10., H-8200 Veszprem, Hungary; kovacstiborjanos@gmail.com Helmholtz-Zentrum Dresden Rossendorf, Bautzner Landstraße 400, 01328 Dresden, Germany Hungarian Centre of Excellence for Molecular Medicine, In Vivo Imaging Advanced Core Facility, Semmelweis University Site, Római Blvd. 21, H-6723 Szeged, Hungary Correspondence: domokos.mathe@hcemm.eu These authors contributed equally to this work. Kovács, N.; Veres, D.S.; Szigeti, K.; Budán, F.; Hegedüs, I.; Kovács, T.; Bergmann, R.; et al. In Vitro Determination of Inhibitory Effects of Humic Substances Complexing Zn and Se on SARS-CoV-2 Virus Replication. Foods 2022, 11, 694. https://doi.org/10.3390/ foods11050694 Academic Editors: Maria Luisa Serralheiro and Rita Isabel Pacheco Received: 31 January 2022 Accepted: 23 February 2022 Published: 26 February 2022 Abstract: (1) Background: Humic substances are well-known human nutritional supplement materials and they play an important performance-enhancing role as animal feed additives. For decades, ingredients of humic substances have been proven to carry potent antiviral effects against different viruses. (2) Methods: Here, the antiviral activity of a humic substance containing ascorbic acid, Se− and Zn2+ ions intended as a nutritional supplement material was investigated against SARS-CoV-2 virus B1.1.7 Variant of Concern (“Alpha Variant”) in a VeroE6 cell line. (3) Results: This combination has a significant in vitro antiviral effect at a very low concentration range of its intended active ingredients. (4) Conclusions: Even picomolar concentration ranges of humic substances, Vitamin C and Zn/Se ions in the given composition, were enough to achieve 50% viral replication inhibition in the applied SARS-CoV-2 virus inhibition test. Keywords: SARS-CoV-2; humic acid; fulvic acid; Zn-Se-ascorbic acid complex; antiviral activity; RT-PCR Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affil-
Loading..
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit