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Efficacy of “Essential Iodine Drops” against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2)

Köntös, Z., PLOS ONE, doi:10.1371/journal.pone.0254341
Jul 2021  
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In Vitro study showing 99% lower viral titer after 90 seconds with Essential Iodine Drops (EID), a formulation of Iodine-V. Author notes a potential safety advantage compared with PVP-I.
9 preclinical studies support the efficacy of povidone-iodine for COVID-19:
Köntös et al., 9 Jul 2021, Hungary, peer-reviewed, 1 author.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
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Efficacy of “Essential Iodine Drops” against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2)
Zolta ´n Ko ¨nto ¨s
PLOS ONE, doi:10.1371/journal.pone.0254341
Background Aerosolization of respiratory droplets is considered the main route of coronavirus disease 2019 . Therefore, reducing the viral load of Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) shed via respiratory droplets is potentially an ideal strategy to prevent the spread of the pandemic. The in vitro virucidal activity of intranasal Povidone-Iodine (PVP-I) has been demonstrated recently to reduce SARS-CoV-2 viral titres. This study evaluated the virucidal activity of the aqueous solution of Iodine-V (a clathrate complex formed by elemental iodine and fulvic acid) as in Essential Iodine Drops (EID) with 200 μg elemental iodine/ml content against SARS-CoV-2 to ascertain whether it is a better alternative to PVP-I. Methods SARS-CoV-2 (USAWA1/2020 strain) virus stock was prepared by infecting Vero 76 cells (ATCC CRL-1587) until cytopathic effect (CPE). The virucidal activity of EID against SARS-CoV-2 was tested in three dilutions (1:1; 2:1 and 3:1) in triplicates by incubating at room temperature (22 ± 2˚C) for either 60 or 90 seconds. The surviving viruses from each sample were quantified by a standard end-point dilution assay. Results EID (200 μg iodine/ml) after exposure for 60 and 90 seconds was compared to controls. In both cases, the viral titre was reduced by 99% (LRV 2.0). The 1:1 dilution of EID with virus reduced SARS-CoV-2 virus from 31,623 cell culture infectious dose 50% (CCID 50 ) to 316 CCID 50 within 90 seconds. Conclusion Substantial reductions in LRV by Iodine-V in EID confirmed the activity of EID against SARS-CoV-2 in vitro, demonstrating that Iodine-V in EID is effective at inactivating the virus in vitro and therefore suggesting its potential application intranasally to reduce SARS-CoV-2 transmission from known or suspected COVID-19 patients.
Author Contributions Conceptualization: Zolta ´n Ko ¨nto ¨s.
Bidra, Pelletier, Westover, Frank, Brown et al., Rapid In-Vitro Inactivation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Using Povidone-Iodine Oral Antiseptic Rinse, Journal of Prosthodontics, doi:10.1111/jopr.13209
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Pelletier, Tessema, Westover, Frank, Brown et al., Vitro Efficacy of Povidone-Iodine Nasal And Oral Antiseptic Preparations Against, doi:10.1101/2020.05.25.20110239
Reyazulla, Gopinath, Vaibhav, Raut, An unusual complication of late onset allergic contact dermatitis to povidone iodine in oral & maxillofacial surgery-a report of 2 cases, Eur Ann Allergy Clin Immunol
Santarpia, Rivera, Herrera, Morwitzer, Creager et al., Transmission Potential of SARS-CoV-2 in Viral Shedding Observed at the University of Nebraska Medical Center, doi:10.1101/2020.03.23.20039446
Somsen, Van Rijn, Kooij, Bem, Bonn, Small droplet aerosols in poorly ventilated spaces and SARS-CoV-2 transmission, The Lancet Respiratory Medicine, doi:10.1016/S2213-2600%2820%2930245-9
Van Doremalen, Bushmaker, Morris, Holbrook, Gamble et al., Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1, The New England journal of medicine, doi:10.1056/NEJMc2004973
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