All Studies Meta Analysis

Povidone iodine gargle and mouthwash

Hassandarvish et al., British Dental Journal volume, doi:10.1038/s41415-020-1794-1

Jun 2020

Post
Facebook

Source PDF All Studies Meta AnalysisMeta

PVP-I for COVID-19

13th treatment shown to reduce risk in February 2021, now with p = 0.0000000011 from 21 studies.

Lower risk for mortality, hospitalization, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine treatments.

5,500+ studies for 119 treatments. c19early.org

In Vitro study showing undiluted PVP-I (1% w/v) achieved >5 log10 reduction in SARS-CoV-2 virus titres at 15, 30 and 60 seconds treatment exposure under both clean and dirty conditions. In contrast, when PVP-I was tested at 1:2 dilution a >4 log10 kill at 15 seconds and >5 log10 kill at 30 and 60 seconds in comparison to control was seen in both clean and dirty conditions.

9 preclinical studies support the efficacy of povidone-iodine for COVID-19:

8 In Vitro studies1-8

1 In Vivo animal study9

Important missing comments or errors? Let us know.

1. Xu et al., Differential Effects of Antiseptic Mouth Rinses on SARS-CoV-2 Infectivity In Vitro, Pathogens, doi:10.3390/pathogens10030272.mdpi.com, doi.org.

2. Tucker et al., In vitro inactivation of SARS-CoV-2 with 0.5% povidone iodine nasal spray (Nasodine) at clinically relevant concentrations and timeframes using tissue culture and PCR based assays, bioRxiv, doi:10.1101/2021.01.31.426979.biorxiv.org, doi.org.

3. Pelletier et al., Efficacy of Povidone-Iodine Nasal and Oral Antiseptic Preparations Against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2), Ear, Nose & Throat Journal, doi:10.1177/0145561320957237.sagepub.com, doi.org.

4. Frank et al., In Vitro Efficacy of a Povidone-Iodine Nasal Antiseptic for Rapid Inactivation of SARS-CoV-2, JAMA Otolaryngol Head Neck Surg, doi:10.1001/jamaoto.2020.3053.jamanetwork.com, doi.org.

5. Meister et al., Virucidal Efficacy of Different Oral Rinses Against Severe Acute Respiratory Syndrome Coronavirus 2, The Journal of Infectious Diseases, doi:10.1093/infdis/jiaa471.oup.com, doi.org.

6. Anderson et al., Povidone-Iodine Demonstrates Rapid In Vitro Virucidal Activity Against SARS-CoV-2, The Virus Causing COVID-19 Disease, Infectious Diseases and Therapy, doi:10.1007/s40121-020-00316-3.springer.com, doi.org.

7. Hassandarvish et al., Povidone iodine gargle and mouthwash, British Dental Journal volume, doi:10.1038/s41415-020-1794-1.nature.com, doi.org.

8. Bidra et al., Rapid In-Vitro Inactivation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Using Povidone-Iodine Oral Antiseptic Rinse, Journal of Prosthodontics, doi:10.1111/jopr.13209.wiley.com, doi.org.

9. Gaaloul ben Hnia et al., Intranasal antisepsis to reduce influenza virus transmission in an animal model, Influenza and Other Respiratory Viruses, doi:10.1111/irv.13035.wiley.com, doi.org.

Hassandarvish et al., 26 Jun 2020, peer-reviewed, 8 authors.

In Vitro studies are an important part of preclinical research, however results may be very different in vivo.

This Paper Povidone-Iod..All

Special care and new environments

S Carr, P Hassandarvish, V Tiong, Malaya, Malaysia A B Sazaly, N A Mohamed, Kuala Lumpur, H Arumugam, A Ananthanarayanan, M Qasuri, Singapore Y Hadjiat

British Dental Journal, doi:10.1038/s41415-020-1786-1

30 and 60 seconds treatment exposure under both clean and dirty conditions. In contrast, when PVP-I was tested at 1:2 dilution a >4 log10 kill at 15 seconds and >5 log10 kill at 30 and 60 seconds in comparison to control was seen in both clean and dirty. Dental practice poses a potential risk of COVID-19 cross-infection among patients, dentists and their assistants through direct exposure to saliva and indirect contact through contaminated instruments. 3 Several associations, including the Australian Dental Association, have recommended using a preprocedural mouthwash with products such as povidone iodine. 4 In our study, we present direct evidence of the virucidal activity of PVP-I gargle and against SARS-CoV-2 in just 15 seconds. In today's scenario, PVP-I gargle and mouthwash could be an adjuvant to PPEs in reducing the risk of COVID-19 transmission in healthcare practices, especially when oral interventions are warranted, such as in dental practice.

References

Challacombe, Kirk-Bayley, Sunkaraneni, Combes, Povidone iodine, Br Dent J

Fallahi H R, Keyhan S O, Zandian, Kim, Cheshmi, Being a front-line dentist during the Covid-19 pandemic: a literature review, Maxillofac Plast Reconstr Surg

Janssen, Eickmann, Zorn, In vitro bactericidal and virucidal efficacy of povidone-iodine gargle/mouthwash against respiratory and oral tract pathogens, Infect Dis Ther

DOI record: { "DOI": "10.1038/s41415-020-1794-1", "ISSN": [ "0007-0610", "1476-5373" ], "URL": "http://dx.doi.org/10.1038/s41415-020-1794-1", "alternative-id": [ "1794" ], "assertion": [ { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "First Online", "name": "first_online", "order": 1, "value": "26 June 2020" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Change Date", "name": "change_date", "order": 2, "value": "24 July 2020" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Change Type", "name": "change_type", "order": 3, "value": "Correction" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Change Details", "name": "change_details", "order": 4, "value": "Author's correction note: Letter 2020; 900. When published an author's name was misspelt. M. Hadjiat should have read Y. Hadjiat. The original article has been corrected." }, { "label": "Free to read", "name": "free", "value": "This content has been made available to all." } ], "author": [ { "affiliation": [], "family": "Hassandarvish", "given": "P.", "sequence": "first" }, { "affiliation": [], "family": "Tiong", "given": "V.", "sequence": "additional" }, { "affiliation": [], "family": "Sazaly", "given": "A. B.", "sequence": "additional" }, { "affiliation": [], "family": "Mohamed", "given": "N. A.", "sequence": "additional" }, { "affiliation": [], "family": "Arumugam", "given": "H.", "sequence": "additional" }, { "affiliation": [], "family": "Ananthanarayanan", "given": "A.", "sequence": "additional" }, { "affiliation": [], "family": "Qasuri", "given": "M.", "sequence": "additional" }, { "affiliation": [], "family": "Hadjiat", "given": "Y.", "sequence": "additional" } ], "container-title": "British Dental Journal", "container-title-short": "Br Dent J", "content-domain": { "crossmark-restriction": false, "domain": [ "link.springer.com" ] }, "created": { "date-parts": [ [ 2020, 6, 26 ] ], "date-time": "2020-06-26T18:16:26Z", "timestamp": 1593195386000 }, "deposited": { "date-parts": [ [ 2023, 5, 20 ] ], "date-time": "2023-05-20T21:42:37Z", "timestamp": 1684618957000 }, "indexed": { "date-parts": [ [ 2024, 5, 1 ] ], "date-time": "2024-05-01T13:23:22Z", "timestamp": 1714569802524 }, "is-referenced-by-count": 15, "issue": "12", "issued": { "date-parts": [ [ 2020, 6 ] ] }, "journal-issue": { "issue": "12", "published-print": { "date-parts": [ [ 2020, 6 ] ] } }, "language": "en", "license": [ { "URL": "https://www.springer.com/tdm", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2020, 6, 1 ] ], "date-time": "2020-06-01T00:00:00Z", "timestamp": 1590969600000 } }, { "URL": "https://www.springer.com/tdm", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2020, 6, 1 ] ], "date-time": "2020-06-01T00:00:00Z", "timestamp": 1590969600000 } } ], "link": [ { "URL": "http://www.nature.com/articles/s41415-020-1794-1.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "http://www.nature.com/articles/s41415-020-1794-1", "content-type": "text/html", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "http://www.nature.com/articles/s41415-020-1794-1.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "297", "original-title": [], "page": "900-900", "prefix": "10.1038", "published": { "date-parts": [ [ 2020, 6 ] ] }, "published-online": { "date-parts": [ [ 2020, 6, 26 ] ] }, "published-print": { "date-parts": [ [ 2020, 6 ] ] }, "publisher": "Springer Science and Business Media LLC", "reference": [ { "DOI": "10.1038/s41415-020-1589-4", "doi-asserted-by": "crossref", "key": "1794_CR22642", "unstructured": "Challacombe S J, Kirk-Bayley J, Sunkaraneni V S, Combes J. Povidone iodine. Br Dent J 2020; 228: 656-657." }, { "DOI": "10.1007/s40121-018-0200-7", "doi-asserted-by": "crossref", "key": "1794_CR22644", "unstructured": "M, Koburger-Janssen T, Eickmann M, Zorn J. In vitro bactericidal and virucidal efficacy of povidone-iodine gargle/mouthwash against respiratory and oral tract pathogens. Infect Dis Ther 2018; 7: 249-259." }, { "DOI": "10.1186/s40902-020-00256-5", "doi-asserted-by": "crossref", "key": "1794_CR22646", "unstructured": "Fallahi H R, Keyhan S O, Zandian D, Kim S-G, Cheshmi B. Being a front-line dentist during the Covid-19 pandemic: a literature review. Maxillofac Plast Reconstr Surg 2020; 42: 12." }, { "key": "1794_CR22649", "unstructured": "Australian Dental Association. Managing COVID-19 guidelines. Available at: https://www.ada.org.au/Campaign/COVID-19/Guide-to-Managing-COVID-19/ADA-Managing-COVID-19-Guide-v-2.aspx (accessed 3 June 2020)." } ], "reference-count": 4, "references-count": 4, "relation": {}, "resource": { "primary": { "URL": "https://www.nature.com/articles/s41415-020-1794-1" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [], "subtitle": [], "title": "Povidone iodine gargle and mouthwash", "type": "journal-article", "update-policy": "http://dx.doi.org/10.1007/springer_crossmark_policy", "volume": "228" }

Download Image

Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

Submit

Post

@CovidAnalysis

FAQ

Public domain CC0 1.0