Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All povidone‑iodine studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchPVP-IPovidone-Iod.. (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Povidone iodine gargle and mouthwash

Hassandarvish et al., British Dental Journal volume, doi:10.1038/s41415-020-1794-1
Jun 2020  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
PVP-I for COVID-19
12th treatment shown to reduce risk in February 2021
 
*, now known with p = 0.000000004 from 21 studies.
Lower risk for mortality, cases, and viral clearance.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
In Vitro study showing undiluted PVP-I (1% w/v) achieved >5 log10 reduction in SARS-CoV-2 virus titres at 15, 30 and 60 seconds treatment exposure under both clean and dirty conditions. In contrast, when PVP-I was tested at 1:2 dilution a >4 log10 kill at 15 seconds and >5 log10 kill at 30 and 60 seconds in comparison to control was seen in both clean and dirty conditions.
9 preclinical studies support the efficacy of povidone-iodine for COVID-19:
Hassandarvish et al., 26 Jun 2020, peer-reviewed, 8 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
This PaperPovidone-Iod..All
Special care and new environments
S Carr, P Hassandarvish, V Tiong, Malaya, Malaysia A B Sazaly, N A Mohamed, Kuala Lumpur, H Arumugam, A Ananthanarayanan, M Qasuri, Singapore Y Hadjiat
British Dental Journal, doi:10.1038/s41415-020-1786-1
30 and 60 seconds treatment exposure under both clean and dirty conditions. In contrast, when PVP-I was tested at 1:2 dilution a >4 log10 kill at 15 seconds and >5 log10 kill at 30 and 60 seconds in comparison to control was seen in both clean and dirty. Dental practice poses a potential risk of COVID-19 cross-infection among patients, dentists and their assistants through direct exposure to saliva and indirect contact through contaminated instruments. 3 Several associations, including the Australian Dental Association, have recommended using a preprocedural mouthwash with products such as povidone iodine. 4 In our study, we present direct evidence of the virucidal activity of PVP-I gargle and against SARS-CoV-2 in just 15 seconds. In today's scenario, PVP-I gargle and mouthwash could be an adjuvant to PPEs in reducing the risk of COVID-19 transmission in healthcare practices, especially when oral interventions are warranted, such as in dental practice.
References
Challacombe, Kirk-Bayley, Sunkaraneni, Combes, Povidone iodine, Br Dent J
Fallahi H R, Keyhan S O, Zandian, Kim, Cheshmi, Being a front-line dentist during the Covid-19 pandemic: a literature review, Maxillofac Plast Reconstr Surg
Janssen, Eickmann, Zorn, In vitro bactericidal and virucidal efficacy of povidone-iodine gargle/mouthwash against respiratory and oral tract pathogens, Infect Dis Ther
{ 'indexed': {'date-parts': [[2024, 5, 1]], 'date-time': '2024-05-01T13:23:22Z', 'timestamp': 1714569802524}, 'reference-count': 4, 'publisher': 'Springer Science and Business Media LLC', 'issue': '12', 'license': [ { 'start': { 'date-parts': [[2020, 6, 1]], 'date-time': '2020-06-01T00:00:00Z', 'timestamp': 1590969600000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.springer.com/tdm'}, { 'start': { 'date-parts': [[2020, 6, 1]], 'date-time': '2020-06-01T00:00:00Z', 'timestamp': 1590969600000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://www.springer.com/tdm'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2020, 6]]}, 'DOI': '10.1038/s41415-020-1794-1', 'type': 'journal-article', 'created': {'date-parts': [[2020, 6, 26]], 'date-time': '2020-06-26T18:16:26Z', 'timestamp': 1593195386000}, 'page': '900-900', 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 15, 'title': 'Povidone iodine gargle and mouthwash', 'prefix': '10.1038', 'volume': '228', 'author': [ {'given': 'P.', 'family': 'Hassandarvish', 'sequence': 'first', 'affiliation': []}, {'given': 'V.', 'family': 'Tiong', 'sequence': 'additional', 'affiliation': []}, {'given': 'A. B.', 'family': 'Sazaly', 'sequence': 'additional', 'affiliation': []}, {'given': 'N. A.', 'family': 'Mohamed', 'sequence': 'additional', 'affiliation': []}, {'given': 'H.', 'family': 'Arumugam', 'sequence': 'additional', 'affiliation': []}, {'given': 'A.', 'family': 'Ananthanarayanan', 'sequence': 'additional', 'affiliation': []}, {'given': 'M.', 'family': 'Qasuri', 'sequence': 'additional', 'affiliation': []}, {'given': 'Y.', 'family': 'Hadjiat', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2020, 6, 26]]}, 'reference': [ { 'key': '1794_CR22642', 'doi-asserted-by': 'crossref', 'unstructured': 'Challacombe S J, Kirk-Bayley J, Sunkaraneni V S, Combes J. Povidone ' 'iodine. Br Dent J 2020; 228: 656-657.', 'DOI': '10.1038/s41415-020-1589-4'}, { 'key': '1794_CR22644', 'doi-asserted-by': 'crossref', 'unstructured': 'M, Koburger-Janssen T, Eickmann M, Zorn J. In vitro bactericidal and ' 'virucidal efficacy of povidone-iodine gargle/mouthwash against ' 'respiratory and oral tract pathogens. Infect Dis Ther 2018; 7: 249-259.', 'DOI': '10.1007/s40121-018-0200-7'}, { 'key': '1794_CR22646', 'doi-asserted-by': 'crossref', 'unstructured': 'Fallahi H R, Keyhan S O, Zandian D, Kim S-G, Cheshmi B. Being a ' 'front-line dentist during the Covid-19 pandemic: a literature review. ' 'Maxillofac Plast Reconstr Surg 2020; 42: 12.', 'DOI': '10.1186/s40902-020-00256-5'}, { 'key': '1794_CR22649', 'unstructured': 'Australian Dental Association. Managing COVID-19 guidelines. Available ' 'at: ' 'https://www.ada.org.au/Campaign/COVID-19/Guide-to-Managing-COVID-19/ADA-Managing-COVID-19-Guide-v-2.aspx ' '(accessed 3 June 2020).'}], 'container-title': 'British Dental Journal', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'http://www.nature.com/articles/s41415-020-1794-1.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'http://www.nature.com/articles/s41415-020-1794-1', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'http://www.nature.com/articles/s41415-020-1794-1.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 5, 20]], 'date-time': '2023-05-20T21:42:37Z', 'timestamp': 1684618957000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.nature.com/articles/s41415-020-1794-1'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2020, 6]]}, 'references-count': 4, 'journal-issue': {'issue': '12', 'published-print': {'date-parts': [[2020, 6]]}}, 'alternative-id': ['1794'], 'URL': 'http://dx.doi.org/10.1038/s41415-020-1794-1', 'relation': {}, 'ISSN': ['0007-0610', '1476-5373'], 'subject': [], 'container-title-short': 'Br Dent J', 'published': {'date-parts': [[2020, 6]]}, 'assertion': [ { 'value': '26 June 2020', 'order': 1, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '24 July 2020', 'order': 2, 'name': 'change_date', 'label': 'Change Date', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': 'Correction', 'order': 3, 'name': 'change_type', 'label': 'Change Type', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': "Author's correction note: Letter 2020; 900. When published an author's name " 'was misspelt. M. Hadjiat should have read Y. Hadjiat. The original article has ' 'been corrected.', 'order': 4, 'name': 'change_details', 'label': 'Change Details', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': 'This content has been made available to all.', 'name': 'free', 'label': 'Free to read'}]}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit