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Intranasal antisepsis to reduce influenza virus transmission in an animal model

Gaaloul ben Hnia et al., Influenza and Other Respiratory Viruses, doi:10.1111/irv.13035
Oct 2022  
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PVP-I for COVID-19
13th treatment shown to reduce risk in February 2021
 
*, now with p = 0.000000004 from 21 studies.
Lower risk for mortality, cases, and viral clearance.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
Animal study showing povidone-iodine effective in reducing influenza A transmission.
9 preclinical studies support the efficacy of povidone-iodine for COVID-19:
Gaaloul ben Hnia et al., 12 Oct 2022, peer-reviewed, 6 authors. Contact: nicole.bouvier@mountsinai.org.
This PaperPovidone-Iod..All
Intranasal antisepsis to reduce influenza virus transmission in an animal model
Nassima Gaaloul Ben Hnia, Mathew Kipkemboi Komen, Katie F Wlaschin, Ranjani V Parthasarathy, Kevin D Landgrebe, Nicole M Bouvier
Influenza and Other Respiratory Viruses, doi:10.1111/irv.13035
Background: Seasonal influenza annually causes significant morbidity and mortality, and unpredictable respiratory virus zoonoses, such as the current COVID-19 pandemic, can threaten the health and lives of millions more. Molecular iodine (I 2 ) is a broad-spectrum, pathogen-nonspecific antiseptic agent that has demonstrated antimicrobial activity against a wide range of bacteria, virus, and fungi. Methods: We investigated a commercially available antiseptic, a non-irritating formulation of iodine (5% povidone-iodine) with a film-forming agent that extends the duration of the iodine's antimicrobial activity, for its ability to prevent influenza virus transmission between infected and susceptible animals in the guinea pig model of influenza virus transmission. Results: We observed that a once-daily topical application of this long-lasting antiseptic to the nares of either the infected virus-donor guinea pig or the susceptible virus-recipient guinea pig, or to the nares of both animals, prior to virus inoculation effectively reduced transmission of a highly transmissible influenza A virus, even when the donor and recipient guinea pigs shared the same cage. Daily treatment of the recipient guinea pig starting 1 day after initial exposure to an infected donor guinea pig in the same cage was similarly effective in preventing detectable influenza virus infection in the recipient animal. Conclusions: We conclude that a daily application of this antiseptic formulation is efficacious in reducing the transmission of influenza A virus in the guinea pig model, and further study in this and other preclinical models is warranted.
PEER REVIEW The peer review history for this article is available at https://publons. com/publon/10.1111/irv.13035. SUPPORTING INFORMATION Additional supporting information can be found online in the Supporting Information section at the end of this article.
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Current Topics in ' 'Microbiology and Immunology', 'author': 'Lowen AC', 'year': '2014'}, {'key': 'e_1_2_8_53_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41564‐019‐0447‐0'}, {'key': 'e_1_2_8_54_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jhin.2011.05.002'}, { 'key': 'e_1_2_8_55_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S1473‐3099(04)00938‐7'}, { 'key': 'e_1_2_8_56_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/0002‐9610(86)90477‐0'}], 'container-title': 'Influenza and Other Respiratory Viruses', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://onlinelibrary.wiley.com/doi/pdf/10.1111/irv.13035', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://onlinelibrary.wiley.com/doi/full-xml/10.1111/irv.13035', 'content-type': 'application/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://onlinelibrary.wiley.com/doi/pdf/10.1111/irv.13035', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 10, 13]], 'date-time': '2022-10-13T05:40:02Z', 'timestamp': 1665639602000}, 'score': 1, 'resource': {'primary': {'URL': 'https://onlinelibrary.wiley.com/doi/10.1111/irv.13035'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 10, 12]]}, 'references-count': 55, 'alternative-id': ['10.1111/irv.13035'], 'URL': 'http://dx.doi.org/10.1111/irv.13035', 'relation': {}, 'ISSN': ['1750-2640', '1750-2659'], 'subject': [ 'Infectious Diseases', 'Public Health, Environmental and Occupational Health', 'Pulmonary and Respiratory Medicine', 'Epidemiology'], 'container-title-short': 'Influenza Resp Viruses', 'published': {'date-parts': [[2022, 10, 12]]}, 'assertion': [ { 'value': '2022-04-26', 'order': 0, 'name': 'received', 'label': 'Received', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2022-07-10', 'order': 1, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2022-10-12', 'order': 2, 'name': 'published', 'label': 'Published', 'group': {'name': 'publication_history', 'label': 'Publication History'}}]}
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