Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All povidone‑iodine studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchPVP-IPovidone-Iod.. (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Intranasal antisepsis to reduce influenza virus transmission in an animal model

Gaaloul ben Hnia et al., Influenza and Other Respiratory Viruses, doi:10.1111/irv.13035
Oct 2022  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
PVP-I for COVID-19
13th treatment shown to reduce risk in February 2021
 
*, now known with p = 0.000000037 from 20 studies.
Lower risk for mortality, cases, and viral clearance.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,900+ studies for 60+ treatments. c19early.org
Animal study showing povidone-iodine effective in reducing influenza A transmission.
9 preclinical studies support the efficacy of povidone-iodine for COVID-19:
Gaaloul ben Hnia et al., 12 Oct 2022, peer-reviewed, 6 authors. Contact: nicole.bouvier@mountsinai.org.
This PaperPovidone-Iod..All
Intranasal antisepsis to reduce influenza virus transmission in an animal model
Nassima Gaaloul Ben Hnia, Mathew Kipkemboi Komen, Katie F Wlaschin, Ranjani V Parthasarathy, Kevin D Landgrebe, Nicole M Bouvier
Influenza and Other Respiratory Viruses, doi:10.1111/irv.13035
Background: Seasonal influenza annually causes significant morbidity and mortality, and unpredictable respiratory virus zoonoses, such as the current COVID-19 pandemic, can threaten the health and lives of millions more. Molecular iodine (I 2 ) is a broad-spectrum, pathogen-nonspecific antiseptic agent that has demonstrated antimicrobial activity against a wide range of bacteria, virus, and fungi. Methods: We investigated a commercially available antiseptic, a non-irritating formulation of iodine (5% povidone-iodine) with a film-forming agent that extends the duration of the iodine's antimicrobial activity, for its ability to prevent influenza virus transmission between infected and susceptible animals in the guinea pig model of influenza virus transmission. Results: We observed that a once-daily topical application of this long-lasting antiseptic to the nares of either the infected virus-donor guinea pig or the susceptible virus-recipient guinea pig, or to the nares of both animals, prior to virus inoculation effectively reduced transmission of a highly transmissible influenza A virus, even when the donor and recipient guinea pigs shared the same cage. Daily treatment of the recipient guinea pig starting 1 day after initial exposure to an infected donor guinea pig in the same cage was similarly effective in preventing detectable influenza virus infection in the recipient animal. Conclusions: We conclude that a daily application of this antiseptic formulation is efficacious in reducing the transmission of influenza A virus in the guinea pig model, and further study in this and other preclinical models is warranted.
PEER REVIEW The peer review history for this article is available at https://publons. com/publon/10.1111/irv.13035. SUPPORTING INFORMATION Additional supporting information can be found online in the Supporting Information section at the end of this article.
References
Ai, Zheng, Chu, Zhang, Effects of Xingbi gel on leukotriene E4 and immunoglobulin E production and nasal eosinophilia in a guinea pig model for allergic rhinitis, Asian Pac J Allergy Immunol
Anderson, David, Scholz, Efficacy of skin and nasal povidone-iodine preparation against mupirocin-resistant methicillinresistant Staphylococcus aureus and S. aureus within the anterior nares, Antimicrob Agents Chemother
Bahekar, Shah, Ayer, Mandhane, Thennati, Validation of guinea pig model of allergic rhinitis by oral and topical drugs, Int Immunopharmacol, doi:info:doi/10.1016/j.intimp.2008.06.010
Beamish, Iodine in the prophylaxis of influenza, BMJ Military Health
Bidra, Pelletier, Westover, Frank, Brown et al., Rapid in-vitro inactivation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using povidone-iodine oral antiseptic rinse, J Prosthodont, doi:info:doi/10.1111/jopr.13209
Bigliardi, Alsagoff, El-Kafrawi, Pyon, Wa et al., Povidone iodine in wound healing: a review of current concepts and practices, Int J Surg, doi:info:doi/10.1016/j.ijsu.2017.06.073
Bogaert, De Groot, Hermans, Streptococcus pneumoniae colonisation: the key to pneumococcal disease, Lancet Infect Dis, doi:info:doi/10.1016/S1473-3099(04)00938-7
Bouvier, Lowen, Animal models for influenza virus pathogenesis and transmission, Viruses, doi:info:doi/10.3390/v20801530
Bouvier, Lowen, Palese, Oseltamivir-resistant influenza A viruses are transmitted efficiently among guinea pigs by direct contact but not by aerosol, J Virol, doi:info:doi/10.1128/JVI.01226-08
Bundgaard, Bundgaard, Raaschou-Pedersen, Effectiveness of adding a mask recommendation to other public health measures to prevent SARS-CoV-2 infection in Danish mask wearers, Ann Intern Med, doi:info:doi/10.7326/M20-6817
Cdc, Burden of influenza
Changani, Hotee, Campbell, Effect of the TRPV1 antagonist SB-705498 on the nasal parasympathetic reflex response in the ovalbumin sensitized guinea pig, Br J Pharmacol, doi:info:doi/10.1111/bph.12145
Core, R: A Language and Environment for Statistical Computing, Version 3.6.2
Cowling, Zhou, Ip, Leung, Aiello, Face masks to prevent transmission of influenza virus: a systematic review, Epidemiol Infect, doi:info:doi/10.1017/S0950268809991658
Danzy, Lowen, Steel, Quantitative approach to assess influenza a virus fitness and transmission in guinea pigs, J Virol, doi:info:doi/10.1128/JVI.02320-20
De Araujo, Guariza-Filho, Gonçalves, Front lines of the COVID-19 pandemic: what is the effectiveness of using personal protective equipment in health service environments?-A systematic review, Int Arch Occup Environ Health October, doi:info:doi/10.1007/s00420-021-01775-y
Eggers, Koburger-Janssen, Eickmann, Zorn, In vitro bactericidal and virucidal efficacy of povidone-iodine gargle/mouthwash against respiratory and oral tract pathogens, Infect Dis Ther, doi:info:doi/10.1007/s40121-018-0200-7
Gottardi, The uptake and release of molecular iodine by the skin: chemical and bactericidal evidence of residual effects caused by povidone-iodine preparations, J Hosp Infect, doi:info:doi/10.1016/0195-6701(95)90289-9
Huang, Wood, Jelley, Impact of the COVID-19 nonpharmaceutical interventions on influenza and other respiratory viral infections in New Zealand, Nat Commun, doi:info:doi/10.1038/s41467-021-21157-9
Jamil, Ly, Morey, Love, Marsman et al., Default "Gunel and Dickey" Bayes factors for contingency tables, Behav Res Methods, doi:info:doi/10.3758/s13428-016-0739-8
Jefferson, Mar, Dooley, Physical interventions to interrupt or reduce the spread of respiratory viruses, Cochrane Database Syst Rev, doi:info:doi/10.1002/14651858.CD006207.pub5
Kelly, Iodine in medicine and pharmacy since its discovery-1811-1961, Proc R Soc Med, doi:info:doi/10.1177/003591576105401001
Koburger, Hübner, Braun, Siebert, Kramer, Standardized comparison of antiseptic efficacy of triclosan, PVP-iodine, octenidine dihydrochloride, polyhexanide and chlorhexidine digluconate, J Antimicrob Chemother, doi:info:doi/10.1093/jac/dkq212
Krammer, Smith, Fouchier, Influenza Nat, Rev Dis Primers, doi:info:doi/10.1038/s41572-018-0002-y
Lepelletier, Maillard, Pozzetto, Simon, Povidone iodine: properties, mechanisms of action, and role in infection control and Staphylococcus aureus decolonization, Antimicrob Agents Chemother, doi:info:doi/10.1128/AAC.00682-20
Lowen, Bouvier, Steel, Transmission in the guinea pig model
Lowen, Mubareka, Tumpey, García-Sastre, Palese, The guinea pig as a transmission model for human influenza viruses, Proc Natl Acad Sci, doi:info:doi/10.1073/pnas.0604157103
Markel, Lipman, Navarro, Nonpharmaceutical interventions implemented by US cities during the 1918-1919 influenza pandemic, JAMA, doi:info:doi/10.1001/jama.298.6.644
Martius, Schmitz, Lipschitz, Einzelreferate und Buchbesprechungen, Klin Wochenschr, doi:info:doi/10.1007/BF01703719
Matrosovich, Matrosovich, Carr, Roberts, Klenk, Overexpression of the α-2,6-sialyltransferase in MDCK cells increases influenza virus sensitivity to neuraminidase inhibitors, J Virol, doi:info:doi/10.1128/JVI.77.15.8418-8425.2003
Matrosovich, Matrosovich, Garten, Klenk, New lowviscosity overlay medium for viral plaque assays, Virol J, doi:info:doi/10.1186/1743-422X-3-63
Mcdonnell, Burke, Disinfection: is it time to reconsider Spaulding?, J Hosp Infect, doi:info:doi/10.1016/j.jhin.2011.05.002
Menon, The 1957 pandemic of influenza in India, Bull World Health Organ
Molinari, Ortega-Sanchez, Messonnier, The annual impact of seasonal influenza in the US: measuring disease burden and costs, Vaccine, doi:info:doi/10.1016/j.vaccine.2007.03.046
Morey, BayesFactor: computation of Bayes factors for common designs
Morey, Odds and probabilities using BayesFactor
Murray, A Dissertation on the Influence of Heat and Humidity: With Practical Observations on the Inhalation of Iodine, and Various Vapours
Osterholm, Kelley, Sommer, Belongia, Efficacy and effectiveness of influenza vaccines: a systematic review and metaanalysis, Lancet Infect Dis, doi:info:doi/10.1016/S1473-3099(11)70295-X
Pasteur, On the germ theory, Science, doi:info:doi/10.1126/science.os-2.62.420
Phillips, Rosenberg, Shopsin, Preventing surgical site infections: a randomized, open-label trial of nasal mupirocin ointment and nasal povidone iodine solution, Infect Control Hosp Epidemiol, doi:info:doi/10.1086/676872
Putri, Muscatello, Stockwell, Newall, Economic burden of seasonal influenza in the United States, Vaccine, doi:info:doi/10.1016/j.vaccine.2018.05.057
Rowe, Meliopoulos, Iverson, Bomme, Schultz-Cherry et al., Direct interactions with influenza promote bacterial adherence during respiratory infections, Nat Microbiol, doi:info:doi/10.1038/s41564-019-0447-0
Sneader, Drug Discovery: A History, doi:info:doi/10.1002/0470015535
Sriwilaijaroen, Wilairat, Hiramatsu, Mechanisms of the action of povidone-iodine against human and avian influenza A viruses: its effects on hemagglutination and sialidase activities, Virol J, doi:info:doi/10.1186/1743-422X-6-124
Stone, Burnet, The action of halogens on influenza virus with special reference to the action of iodine vapour on virus mists, Aust J Exp Biol Med Sci, doi:info:doi/10.1038/icb.1945.32
Suleimani, Ying, Walker, A comprehensive model of allergic rhinitis in guinea pigs, J Pharmacol Toxicol Methods, doi:info:doi/10.1016/j.vascn.2006.05.005
Sun, Tang, Yao, Establishment of a new animal model of allergic rhinitis with biphasic sneezing by intranasal sensitization with Staphylococcal enterotoxin B, Exp Ther Med, doi:info:doi/10.3892/etm.2015.2506
Taylor, The lingual application of iodine as a prophylactic in cerebro-spinal meningitis and influenza, Br Med J, doi:info:doi/10.1136/bmj.1.3152.776
Team, RStudio: Integrated Development for R, Version
Torres, Lindmair-Snell, Langan, Burnikel, Is preoperative nasal povidone-iodine as efficient and cost-effective as standard methicillin-resistant Staphylococcus aureus screening protocol in Total joint arthroplasty?, J Arthroplasty, doi:info:doi/10.1016/j.arth.2015.09.030
Wang, Wu, Wang, Virucidal effect of povidone-iodine against SARS-CoV-2 in vitro, J Int Med Res, doi:info:doi/10.1177/03000605211063695
Yang, Shaff, Shaman, Effectiveness of non-pharmaceutical interventions to contain COVID-19: a case study of the 2020 spring pandemic wave in New York City, J R Soc Interf, doi:info:doi/10.1098/rsif.2020.0822
Young, Yap, Vargas, Strey, Hao et al., National prevalence of influenza diagnoses and vaccination rates among patients presenting to United States physician offices and hospital outpatient departments, 2009 to 2016, Open Forum Infect Dis
Zamora, Chemical and microbiologic characteristics and toxicity of povidone-iodine solutions, Am J Surg, doi:info:doi/10.1016/0002-9610(86)90477-0
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit