Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
 
next
study
previous
study
c19early.org COVID-19 treatment researchZincZinc (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

Zinc2+ ion inhibits SARS-CoV-2 main protease and viral replication in vitro

Panchariya et al., Chemical Communications, doi:10.1039/D1CC03563K
Jun 2021  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020, now with p = 0.00000032 from 46 studies, recognized in 17 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 112 treatments. c19early.org
In Silico and In Vitro study showing that ionic zinc inhibits SARS-CoV-2 main protease (Mpro) and inhibits viral replication.
Zinc acetate inhibited viral replication in Vero E6 cells, while zinc glycinate and zinc gluconate did not at non-toxic concentrations. The combination of zinc acetate with zinc ionophore quercetin significantly improved inhibition at low concentrations.
10 preclinical studies support the efficacy of zinc for COVID-19:
Panchariya et al., 15 Jun 2021, peer-reviewed, 18 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
This PaperZincAll
{ 'indexed': {'date-parts': [[2024, 5, 3]], 'date-time': '2024-05-03T08:29:16Z', 'timestamp': 1714724956915}, 'reference-count': 31, 'publisher': 'Royal Society of Chemistry (RSC)', 'issue': '78', 'license': [ { 'start': { 'date-parts': [[2022, 8, 27]], 'date-time': '2022-08-27T00:00:00Z', 'timestamp': 1661558400000}, 'content-version': 'am', 'delay-in-days': 603, 'URL': 'http://rsc.li/journals-terms-of-use'}], 'funder': [ { 'DOI': '10.13039/501100001843', 'name': 'Science and Engineering Research Board', 'doi-asserted-by': 'publisher', 'award': ['IPA/2020/000285']}], 'content-domain': {'domain': ['rsc.org'], 'crossmark-restriction': True}, 'abstract': '<jats:p>Zn<jats:sup>2+</jats:sup>binds to the active site of the SARS-CoV-2 main protease ' '(Mpro), and inhibits enzyme activity and viral replication<jats:italic>in ' 'vitro</jats:italic>.</jats:p>', 'DOI': '10.1039/d1cc03563k', 'type': 'journal-article', 'created': {'date-parts': [[2021, 8, 27]], 'date-time': '2021-08-27T15:41:01Z', 'timestamp': 1630078861000}, 'page': '10083-10086', 'update-policy': 'http://dx.doi.org/10.1039/rsc_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 33, 'title': 'Zinc<sup>2+</sup>ion inhibits SARS-CoV-2 main protease and viral replication<i>in vitro</i>', 'prefix': '10.1039', 'volume': '57', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-2194-1323', 'authenticated-orcid': False, 'given': 'Love', 'family': 'Panchariya', 'sequence': 'first', 'affiliation': [ { 'name': 'Membrane Protein Biology Group, International Centre for Genetic ' 'Engineering and Biotechnology, Aruna Asaf Ali Marg, New ' 'Delhi-110067, India'}]}, { 'ORCID': 'http://orcid.org/0000-0002-0288-3316', 'authenticated-orcid': False, 'given': 'Wajahat Ali', 'family': 'Khan', 'sequence': 'additional', 'affiliation': [ { 'name': 'Membrane Protein Biology Group, International Centre for Genetic ' 'Engineering and Biotechnology, Aruna Asaf Ali Marg, New ' 'Delhi-110067, India'}]}, { 'ORCID': 'http://orcid.org/0000-0001-5679-2105', 'authenticated-orcid': False, 'given': 'Shobhan', 'family': 'Kuila', 'sequence': 'additional', 'affiliation': [ { 'name': 'Membrane Protein Biology Group, International Centre for Genetic ' 'Engineering and Biotechnology, Aruna Asaf Ali Marg, New ' 'Delhi-110067, India'}]}, { 'ORCID': 'http://orcid.org/0000-0002-8382-1140', 'authenticated-orcid': False, 'given': 'Kirtishila', 'family': 'Sonkar', 'sequence': 'additional', 'affiliation': [ { 'name': 'Membrane Protein Biology Group, International Centre for Genetic ' 'Engineering and Biotechnology, Aruna Asaf Ali Marg, New ' 'Delhi-110067, India'}]}, { 'ORCID': 'http://orcid.org/0000-0002-6998-0911', 'authenticated-orcid': False, 'given': 'Sibasis', 'family': 'Sahoo', 'sequence': 'additional', 'affiliation': [ { 'name': 'Membrane Protein Biology Group, International Centre for Genetic ' 'Engineering and Biotechnology, Aruna Asaf Ali Marg, New ' 'Delhi-110067, India'}]}, { 'given': 'Archita', 'family': 'Ghoshal', 'sequence': 'additional', 'affiliation': [ { 'name': 'Membrane Protein Biology Group, International Centre for Genetic ' 'Engineering and Biotechnology, Aruna Asaf Ali Marg, New ' 'Delhi-110067, India'}]}, { 'given': 'Ankit', 'family': 'Kumar', 'sequence': 'additional', 'affiliation': [ { 'name': 'Vector Borne Diseases Group, International Centre for Genetic ' 'Engineering and Biotechnology, Aruna Asaf Ali Marg, New ' 'Delhi-110067, India'}]}, { 'ORCID': 'http://orcid.org/0000-0002-1806-493X', 'authenticated-orcid': False, 'given': 'Dileep Kumar', 'family': 'Verma', 'sequence': 'additional', 'affiliation': [ { 'name': 'Vector Borne Diseases Group, International Centre for Genetic ' 'Engineering and Biotechnology, Aruna Asaf Ali Marg, New ' 'Delhi-110067, India'}]}, { 'ORCID': 'http://orcid.org/0000-0002-0716-7052', 'authenticated-orcid': False, 'given': 'Abdul', 'family': 'Hasan', 'sequence': 'additional', 'affiliation': [ { 'name': 'Vector Borne Diseases Group, International Centre for Genetic ' 'Engineering and Biotechnology, Aruna Asaf Ali Marg, New ' 'Delhi-110067, India'}]}, { 'ORCID': 'http://orcid.org/0000-0002-0132-8601', 'authenticated-orcid': False, 'given': 'Mohd Azeem', 'family': 'Khan', 'sequence': 'additional', 'affiliation': [ { 'name': 'Membrane Protein Biology Group, International Centre for Genetic ' 'Engineering and Biotechnology, Aruna Asaf Ali Marg, New ' 'Delhi-110067, India'}]}, { 'given': 'Niyati', 'family': 'Jain', 'sequence': 'additional', 'affiliation': [ { 'name': 'CSIR-Institute of Genomics and Integrative Biology, Near Jubilee ' 'Hall, Mall Road, Delhi-110007, India'}]}, { 'given': 'Amit Kumar', 'family': 'Mohapatra', 'sequence': 'additional', 'affiliation': [ { 'name': 'Translational Health Group, International Centre for Genetic ' 'Engineering and Biotechnology, New Delhi-110067, India'}]}, { 'given': 'Shubhashis', 'family': 'Das', 'sequence': 'additional', 'affiliation': [ { 'name': 'Plant Mediator Lab, National Institute of Plant Genome Research, ' 'Aruna Asaf Ali Marg, New Delhi-110 067, India'}]}, { 'given': 'Jitendra K.', 'family': 'Thakur', 'sequence': 'additional', 'affiliation': [ { 'name': 'Plant Mediator Lab, National Institute of Plant Genome Research, ' 'Aruna Asaf Ali Marg, New Delhi-110 067, India'}]}, { 'ORCID': 'http://orcid.org/0000-0001-9897-1419', 'authenticated-orcid': False, 'given': 'Souvik', 'family': 'Maiti', 'sequence': 'additional', 'affiliation': [ { 'name': 'CSIR-Institute of Genomics and Integrative Biology, Mathura ' 'Road, New Delhi, 110025, India'}, { 'name': 'Academy of Scientific and Innovative Research (AcSIR), ' 'Ghaziabad, 201002, India'}]}, { 'given': 'Ranjan Kumar', 'family': 'Nanda', 'sequence': 'additional', 'affiliation': [ { 'name': 'Translational Health Group, International Centre for Genetic ' 'Engineering and Biotechnology, New Delhi-110067, India'}]}, { 'given': 'Rajkumar', 'family': 'Halder', 'sequence': 'additional', 'affiliation': [ { 'name': 'Ruhvenile Biomedical OPC PVT LTD, Plot No-8, OCF Pocket ' 'Institution, Sarita Vihar, New Delhi-110070, India'}]}, { 'given': 'Sujatha', 'family': 'Sunil', 'sequence': 'additional', 'affiliation': [ { 'name': 'Vector Borne Diseases Group, International Centre for Genetic ' 'Engineering and Biotechnology, Aruna Asaf Ali Marg, New ' 'Delhi-110067, India'}]}, { 'ORCID': 'http://orcid.org/0000-0002-4606-8006', 'authenticated-orcid': False, 'given': 'Arulandu', 'family': 'Arockiasamy', 'sequence': 'additional', 'affiliation': [ { 'name': 'Membrane Protein Biology Group, International Centre for Genetic ' 'Engineering and Biotechnology, Aruna Asaf Ali Marg, New ' 'Delhi-110067, India'}]}], 'member': '292', 'published-online': {'date-parts': [[2021]]}, 'reference': [ { 'key': 'D1CC03563K/cit1', 'doi-asserted-by': 'crossref', 'first-page': '265', 'DOI': '10.1038/s41586-020-2008-3', 'volume': '579', 'author': 'Wu', 'year': '2020', 'journal-title': 'Nature'}, { 'key': 'D1CC03563K/cit2', 'doi-asserted-by': 'crossref', 'first-page': 'm4857', 'DOI': '10.1136/bmj.m4857', 'volume': '371', 'author': 'Wise', 'year': '2020', 'journal-title': 'BMJ'}, { 'key': 'D1CC03563K/cit3', 'first-page': '28', 'author': 'Yadav', 'year': '2021', 'journal-title': 'J. Travel Med.'}, { 'key': 'D1CC03563K/cit4', 'doi-asserted-by': 'crossref', 'first-page': '343', 'DOI': '10.1016/j.ijid.2020.09.014', 'volume': '100', 'author': 'Jothimani', 'year': '2020', 'journal-title': 'Int. J. Infect. Dis.'}, { 'key': 'D1CC03563K/cit5', 'first-page': '13', 'author': 'Vogel-Gonzalez', 'year': '2021', 'journal-title': 'Nutrients'}, { 'key': 'D1CC03563K/cit6', 'doi-asserted-by': 'crossref', 'first-page': '1228', 'DOI': '10.1099/jmm.0.001250', 'volume': '69', 'author': 'Carlucci', 'year': '2020', 'journal-title': 'J. Med. Microbiol.'}, { 'key': 'D1CC03563K/cit7', 'author': 'Frontera', 'year': '2020', 'journal-title': 'Res. Sq.'}, { 'key': 'D1CC03563K/cit8', 'doi-asserted-by': 'crossref', 'first-page': '106214', 'DOI': '10.1016/j.ijantimicag.2020.106214', 'volume': '56', 'author': 'Derwand', 'year': '2020', 'journal-title': 'Int. J. Antimicrob. Agents'}, { 'key': 'D1CC03563K/cit9', 'doi-asserted-by': 'crossref', 'first-page': '244', 'DOI': '10.1039/C4MT00094C', 'volume': '7', 'author': 'Kochanczyk', 'year': '2015', 'journal-title': 'Metallomics'}, { 'key': 'D1CC03563K/cit10', 'doi-asserted-by': 'crossref', 'first-page': '197', 'DOI': '10.1007/s10534-013-9613-7', 'volume': '26', 'author': 'Maret', 'year': '2013', 'journal-title': 'Biometals'}, { 'key': 'D1CC03563K/cit11', 'doi-asserted-by': 'crossref', 'first-page': '7', 'DOI': '10.1016/j.jtemb.2005.02.003', 'volume': '19', 'author': 'Maret', 'year': '2005', 'journal-title': 'J. Trace Elem. Med. Biol.'}, { 'key': 'D1CC03563K/cit12', 'doi-asserted-by': 'crossref', 'first-page': '696', 'DOI': '10.1093/advances/nmz013', 'volume': '10', 'author': 'Read', 'year': '2019', 'journal-title': 'Adv. Nutr.'}, { 'key': 'D1CC03563K/cit13', 'doi-asserted-by': 'crossref', 'first-page': '116', 'DOI': '10.1016/j.febslet.2004.08.015', 'volume': '574', 'author': 'Hsu', 'year': '2004', 'journal-title': 'FEBS Lett.'}, { 'key': 'D1CC03563K/cit14', 'doi-asserted-by': 'crossref', 'first-page': 'e1001176', 'DOI': '10.1371/journal.ppat.1001176', 'volume': '6', 'author': 'te Velthuis', 'year': '2010', 'journal-title': 'PLoS Pathog.'}, { 'key': 'D1CC03563K/cit15', 'doi-asserted-by': 'crossref', 'first-page': '279', 'DOI': '10.1038/s41467-020-20542-0', 'volume': '12', 'author': 'Kokic', 'year': '2021', 'journal-title': 'Nat. Commun.'}, { 'key': 'D1CC03563K/cit16', 'doi-asserted-by': 'crossref', 'first-page': '409', 'DOI': '10.1126/science.abb3405', 'volume': '368', 'author': 'Zhang', 'year': '2020', 'journal-title': 'Science'}, { 'key': 'D1CC03563K/cit17', 'doi-asserted-by': 'crossref', 'first-page': 'eabe0751', 'DOI': '10.1126/sciadv.abe0751', 'volume': '6', 'author': 'Sacco', 'year': '2020', 'journal-title': 'Sci. Adv.'}, { 'key': 'D1CC03563K/cit18', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1038/s41467-019-13993-7', 'volume': '11', 'author': 'Vuong', 'year': '2020', 'journal-title': 'Nat. Commun.'}, { 'key': 'D1CC03563K/cit19', 'doi-asserted-by': 'crossref', 'first-page': '678', 'DOI': '10.1038/s41422-020-0356-z', 'volume': '30', 'author': 'Ma', 'year': '2020', 'journal-title': 'Cell Res.'}, { 'key': 'D1CC03563K/cit20', 'doi-asserted-by': 'publisher', 'author': 'Owen', 'year': '2021', 'journal-title': 'medRxiv', 'DOI': '10.1101/2021.07.28.21261232'}, { 'key': 'D1CC03563K/cit21', 'doi-asserted-by': 'crossref', 'first-page': '289', 'DOI': '10.1038/s41586-020-2223-y', 'volume': '582', 'author': 'Jin', 'year': '2020', 'journal-title': 'Nature'}, { 'key': 'D1CC03563K/cit22', 'doi-asserted-by': 'crossref', 'first-page': '7646', 'DOI': '10.1074/jbc.M807947200', 'volume': '284', 'author': 'Lee', 'year': '2009', 'journal-title': 'J. Biol. Chem.'}, { 'key': 'D1CC03563K/cit23', 'doi-asserted-by': 'crossref', 'first-page': '5454', 'DOI': '10.1016/j.febslet.2007.10.048', 'volume': '581', 'author': 'Lee', 'year': '2007', 'journal-title': 'FEBS Lett.'}, { 'key': 'D1CC03563K/cit24', 'doi-asserted-by': 'crossref', 'first-page': '642', 'DOI': '10.1126/science.abf7945', 'volume': '372', 'author': 'Gunther', 'year': '2021', 'journal-title': 'Science'}, { 'key': 'D1CC03563K/cit25', 'doi-asserted-by': 'crossref', 'first-page': '168', 'DOI': '10.3390/biom9050168', 'volume': '9', 'author': 'Cragnell', 'year': '2019', 'journal-title': 'Biomolecules'}, { 'key': 'D1CC03563K/cit26', 'doi-asserted-by': 'crossref', 'first-page': '483', 'DOI': '10.1093/oxfordjournals.jac.a020864', 'volume': '40', 'author': 'Eby', 'year': '1997', 'journal-title': 'J. Antimicrob. Chemother.'}, { 'key': 'D1CC03563K/cit27', 'doi-asserted-by': 'crossref', 'first-page': '482', 'DOI': '10.1016/j.mehy.2009.10.017', 'volume': '74', 'author': 'Eby III', 'year': '2010', 'journal-title': 'Med. Hypotheses'}, { 'key': 'D1CC03563K/cit28', 'doi-asserted-by': 'crossref', 'first-page': '8085', 'DOI': '10.1021/jf5014633', 'volume': '62', 'author': 'Dabbagh-Bazarbachi', 'year': '2014', 'journal-title': 'J. Agric. Food Chem.'}, { 'key': 'D1CC03563K/cit29', 'first-page': '544', 'volume': '65', 'author': 'Bratu', 'year': '2014', 'journal-title': 'Rev. Chim.'}, { 'key': 'D1CC03563K/cit30', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1038/sigtrans.2017.29', 'volume': '2', 'author': 'Bafaro', 'year': '2017', 'journal-title': 'Signal Transduction Targeted Ther.'}, { 'key': 'D1CC03563K/cit31', 'doi-asserted-by': 'crossref', 'first-page': '2285', 'DOI': '10.3390/ijms18112285', 'volume': '18', 'author': 'Maret', 'year': '2017', 'journal-title': 'Int. J. Mol. Sci.'}], 'container-title': 'Chemical Communications', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'http://pubs.rsc.org/en/content/articlepdf/2021/CC/D1CC03563K', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 4, 18]], 'date-time': '2024-04-18T01:57:29Z', 'timestamp': 1713405449000}, 'score': 1, 'resource': {'primary': {'URL': 'https://xlink.rsc.org/?DOI=D1CC03563K'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021]]}, 'references-count': 31, 'journal-issue': {'issue': '78', 'published-print': {'date-parts': [[2021, 9, 30]]}}, 'URL': 'http://dx.doi.org/10.1039/D1CC03563K', 'relation': { 'has-preprint': [ { 'id-type': 'doi', 'id': '10.1101/2021.06.15.448551', 'asserted-by': 'object'}]}, 'ISSN': ['1359-7345', '1364-548X'], 'subject': [], 'container-title-short': 'Chem. Commun.', 'published': {'date-parts': [[2021]]}}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit