Zinc2+ ion inhibits SARS-CoV-2 main protease and viral replication in vitro

Panchariya et al., Chemical Communications, doi:10.1039/D1CC03563K (In Vitro)

Panchariya et al., Zinc2+ ion inhibits SARS-CoV-2 main protease and viral replication in vitro, Chemical Communications, doi:10.1039/D1CC03563K (In Vitro)

Jun 2021 Source PDF

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In Silico and In Vitro study showing that ionic zinc inhibits SARS-CoV-2 main protease (M^pro) and inhibits viral replication.

Zinc acetate inhibited viral replication in Vero E6 cells, while zinc glycinate and zinc gluconate did not at non-toxic concentrations. The combination of zinc acetate with zinc ionophore quercetin significantly improved inhibition at low concentrations.

2 In Vitro studies support the efficacy of zinc [Hajdrik, Panchariya].

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1. Hajdrik et al., Foods, doi:10.3390/foods11050694, In Vitro Determination of Inhibitory Effects of Humic Substances Complexing Zn and Se on SARS-CoV-2 Virus Replication, https://www.mdpi.com/2304-8158/11/5/694.

2. Panchariya et al., Chemical Communications, doi:10.1039/D1CC03563K, Zinc2+ ion inhibits SARS-CoV-2 main protease and viral replication in vitro, https://pubs.rsc.org/en/content/ar..elanding/2021/cc/d1cc03563k/unauth.

Panchariya et al., 15 Jun 2021, peer-reviewed, 18 authors.

In Vitro studies are an important part of preclinical research, however results may be very different in vivo.

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