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All Studies   Meta Analysis    Recent:   

Zinc2+ ion inhibits SARS-CoV-2 main protease and viral replication in vitro

Panchariya et al., Chemical Communications, doi:10.1039/D1CC03563K
Jun 2021  
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Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020
 
*, now known with p = 0.0000013 from 44 studies, recognized in 17 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
In Silico and In Vitro study showing that ionic zinc inhibits SARS-CoV-2 main protease (Mpro) and inhibits viral replication.
Zinc acetate inhibited viral replication in Vero E6 cells, while zinc glycinate and zinc gluconate did not at non-toxic concentrations. The combination of zinc acetate with zinc ionophore quercetin significantly improved inhibition at low concentrations.
10 preclinical studies support the efficacy of zinc for COVID-19:
Panchariya et al., 15 Jun 2021, peer-reviewed, 18 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
This PaperZincAll
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Travel Med.'}, { 'key': 'D1CC03563K/cit4', 'doi-asserted-by': 'crossref', 'first-page': '343', 'DOI': '10.1016/j.ijid.2020.09.014', 'volume': '100', 'author': 'Jothimani', 'year': '2020', 'journal-title': 'Int. J. Infect. Dis.'}, { 'key': 'D1CC03563K/cit5', 'first-page': '13', 'author': 'Vogel-Gonzalez', 'year': '2021', 'journal-title': 'Nutrients'}, { 'key': 'D1CC03563K/cit6', 'doi-asserted-by': 'crossref', 'first-page': '1228', 'DOI': '10.1099/jmm.0.001250', 'volume': '69', 'author': 'Carlucci', 'year': '2020', 'journal-title': 'J. Med. Microbiol.'}, { 'key': 'D1CC03563K/cit7', 'author': 'Frontera', 'year': '2020', 'journal-title': 'Res. Sq.'}, { 'key': 'D1CC03563K/cit8', 'doi-asserted-by': 'crossref', 'first-page': '106214', 'DOI': '10.1016/j.ijantimicag.2020.106214', 'volume': '56', 'author': 'Derwand', 'year': '2020', 'journal-title': 'Int. J. Antimicrob. Agents'}, { 'key': 'D1CC03563K/cit9', 'doi-asserted-by': 'crossref', 'first-page': '244', 'DOI': '10.1039/C4MT00094C', 'volume': '7', 'author': 'Kochanczyk', 'year': '2015', 'journal-title': 'Metallomics'}, { 'key': 'D1CC03563K/cit10', 'doi-asserted-by': 'crossref', 'first-page': '197', 'DOI': '10.1007/s10534-013-9613-7', 'volume': '26', 'author': 'Maret', 'year': '2013', 'journal-title': 'Biometals'}, { 'key': 'D1CC03563K/cit11', 'doi-asserted-by': 'crossref', 'first-page': '7', 'DOI': '10.1016/j.jtemb.2005.02.003', 'volume': '19', 'author': 'Maret', 'year': '2005', 'journal-title': 'J. Trace Elem. Med. Biol.'}, { 'key': 'D1CC03563K/cit12', 'doi-asserted-by': 'crossref', 'first-page': '696', 'DOI': '10.1093/advances/nmz013', 'volume': '10', 'author': 'Read', 'year': '2019', 'journal-title': 'Adv. Nutr.'}, { 'key': 'D1CC03563K/cit13', 'doi-asserted-by': 'crossref', 'first-page': '116', 'DOI': '10.1016/j.febslet.2004.08.015', 'volume': '574', 'author': 'Hsu', 'year': '2004', 'journal-title': 'FEBS Lett.'}, { 'key': 'D1CC03563K/cit14', 'doi-asserted-by': 'crossref', 'first-page': 'e1001176', 'DOI': '10.1371/journal.ppat.1001176', 'volume': '6', 'author': 'te Velthuis', 'year': '2010', 'journal-title': 'PLoS Pathog.'}, { 'key': 'D1CC03563K/cit15', 'doi-asserted-by': 'crossref', 'first-page': '279', 'DOI': '10.1038/s41467-020-20542-0', 'volume': '12', 'author': 'Kokic', 'year': '2021', 'journal-title': 'Nat. Commun.'}, { 'key': 'D1CC03563K/cit16', 'doi-asserted-by': 'crossref', 'first-page': '409', 'DOI': '10.1126/science.abb3405', 'volume': '368', 'author': 'Zhang', 'year': '2020', 'journal-title': 'Science'}, { 'key': 'D1CC03563K/cit17', 'doi-asserted-by': 'crossref', 'first-page': 'eabe0751', 'DOI': '10.1126/sciadv.abe0751', 'volume': '6', 'author': 'Sacco', 'year': '2020', 'journal-title': 'Sci. Adv.'}, { 'key': 'D1CC03563K/cit18', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1038/s41467-019-13993-7', 'volume': '11', 'author': 'Vuong', 'year': '2020', 'journal-title': 'Nat. Commun.'}, { 'key': 'D1CC03563K/cit19', 'doi-asserted-by': 'crossref', 'first-page': '678', 'DOI': '10.1038/s41422-020-0356-z', 'volume': '30', 'author': 'Ma', 'year': '2020', 'journal-title': 'Cell Res.'}, { 'key': 'D1CC03563K/cit20', 'doi-asserted-by': 'publisher', 'author': 'Owen', 'year': '2021', 'journal-title': 'medRxiv', 'DOI': '10.1101/2021.07.28.21261232'}, { 'key': 'D1CC03563K/cit21', 'doi-asserted-by': 'crossref', 'first-page': '289', 'DOI': '10.1038/s41586-020-2223-y', 'volume': '582', 'author': 'Jin', 'year': '2020', 'journal-title': 'Nature'}, { 'key': 'D1CC03563K/cit22', 'doi-asserted-by': 'crossref', 'first-page': '7646', 'DOI': '10.1074/jbc.M807947200', 'volume': '284', 'author': 'Lee', 'year': '2009', 'journal-title': 'J. Biol. Chem.'}, { 'key': 'D1CC03563K/cit23', 'doi-asserted-by': 'crossref', 'first-page': '5454', 'DOI': '10.1016/j.febslet.2007.10.048', 'volume': '581', 'author': 'Lee', 'year': '2007', 'journal-title': 'FEBS Lett.'}, { 'key': 'D1CC03563K/cit24', 'doi-asserted-by': 'crossref', 'first-page': '642', 'DOI': '10.1126/science.abf7945', 'volume': '372', 'author': 'Gunther', 'year': '2021', 'journal-title': 'Science'}, { 'key': 'D1CC03563K/cit25', 'doi-asserted-by': 'crossref', 'first-page': '168', 'DOI': '10.3390/biom9050168', 'volume': '9', 'author': 'Cragnell', 'year': '2019', 'journal-title': 'Biomolecules'}, { 'key': 'D1CC03563K/cit26', 'doi-asserted-by': 'crossref', 'first-page': '483', 'DOI': '10.1093/oxfordjournals.jac.a020864', 'volume': '40', 'author': 'Eby', 'year': '1997', 'journal-title': 'J. Antimicrob. Chemother.'}, { 'key': 'D1CC03563K/cit27', 'doi-asserted-by': 'crossref', 'first-page': '482', 'DOI': '10.1016/j.mehy.2009.10.017', 'volume': '74', 'author': 'Eby III', 'year': '2010', 'journal-title': 'Med. Hypotheses'}, { 'key': 'D1CC03563K/cit28', 'doi-asserted-by': 'crossref', 'first-page': '8085', 'DOI': '10.1021/jf5014633', 'volume': '62', 'author': 'Dabbagh-Bazarbachi', 'year': '2014', 'journal-title': 'J. Agric. Food Chem.'}, { 'key': 'D1CC03563K/cit29', 'first-page': '544', 'volume': '65', 'author': 'Bratu', 'year': '2014', 'journal-title': 'Rev. Chim.'}, { 'key': 'D1CC03563K/cit30', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1038/sigtrans.2017.29', 'volume': '2', 'author': 'Bafaro', 'year': '2017', 'journal-title': 'Signal Transduction Targeted Ther.'}, { 'key': 'D1CC03563K/cit31', 'doi-asserted-by': 'crossref', 'first-page': '2285', 'DOI': '10.3390/ijms18112285', 'volume': '18', 'author': 'Maret', 'year': '2017', 'journal-title': 'Int. J. Mol. 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