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Anti-inflammatory and Nutritional Interventions Against SARS-CoV-2: A Comprehensive Review

Mu et al., Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2024.101422
Sep 2024  
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Review of anti-inflammatory and nutritional interventions against SARS-CoV-2. Authors emphasize the importance of a healthy immune response in reducing the severity of COVID-19, especially in high-risk groups like the elderly and those with comorbidities. Inflammation and oxidative stress can exacerbate SARS-CoV-2 infections, and the cytokine storm seen in severe cases can lead to organ damage and death. Early and consistent nutritional interventions are proposed as potentially effective prevention and recovery strategies. Multi-nutrient combinations including vitamin D, zinc, selenium, omega-3 fatty acids, probiotics, flavonoids, and peptides may provide a comprehensive immune boost and reduce inflammation better than isolated nutrients. The antioxidant properties of nutrients like selenium are noted to be especially beneficial in the elderly by reducing viral replication and supporting immune cell function.
Reviews covering selenium for COVID-19 include1-9.
Review covers diet, probiotics, selenium, vitamin C, vitamin D, and zinc.
Mu et al., 16 Sep 2024, peer-reviewed, 4 authors. Contact: liangying498@163.com.
This PaperSeleniumAll
Anti-inflammatory and Nutritional Interventions Against SARS-CoV-2: A Comprehensive Review
Jianfei Mu, Otobong D Akan, Qinlu Lin, Ying Liang
Journal of Agriculture and Food Research, doi:10.1016/j.jafr.2024.101422
Highlights 1. Inflammation and oxidative stress exacerbate the severity of SARS-CoV-2 infections. 2. Timely recovery from infection is attributed to effective immune response (which is absent in risk groups). 3. Elderly individuals and those with health comorbidities are most vulnerable to SARS-CoV-2 infections. 4. Early and consistent nutritional interventions may provide effective prevention and recovery strategies for COVID-19.
Abbreviations Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2; Corona Virus Disease Ethical Approval Not applicable. Consent to participate Not applicable. Consent to publish All authors read and approved the publishing of this article. Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. [ 125, 126] Vitamin B Vitamin B2 (riboflavin) aids the energy metabolism of all cells [127] Treatment with Vitamin B3 inhibits neutrophil infiltration into the lungs and has a strong anti- [128] J o u r n a l P r e -p r o o f inflammatory effect during ventilator-induced lung injury. Vitamin B6 aids many tissue metabolisms, including protein metabolism, and strengthens the body's immune system. [24] Vitamin B12 plays a vital role in metabolic processes, cardiovascular and circulatory systems, and the control and antiviral activity of the immune system. [129] Vitamin C Vitamin C aids collagen synthesis in connective tissues, acts as an antioxidant, supports immune functions, and protects against infection caused by coronaviruses. [130] Vitamin D Vitamin D stimulates the maturation of immune cells and boosts response to acute infections in age-associated inflammatory disorders. [137] Resveratrol aids in the enhancement of NK cell cytotoxicity and has anti-inflammatory effects. [138] J o u r n a l P r e -p r o o f ..
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