The role of cell death in SARS-CoV-2 infection

{ 'indexed': {'date-parts': [[2023, 9, 20]], 'date-time': '2023-09-20T17:12:05Z', 'timestamp': 1695229925442}, 'reference-count': 176, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2023, 9, 20]], 'date-time': '2023-09-20T00:00:00Z', 'timestamp': 1695168000000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2023, 9, 20]], 'date-time': '2023-09-20T00:00:00Z', 'timestamp': 1695168000000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'funder': [ { 'DOI': '10.13039/501100001809', 'name': 'National Natural Science Foundation of China', 'doi-asserted-by': 'publisher', 'award': ['31802164']}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>Severe acute respiratory syndrome coronavirus 2 ' '(SARS-CoV-2), showing high infectiousness, resulted in an ongoing pandemic termed coronavirus ' 'disease 2019 (COVID-19). COVID-19 cases often experience acute respiratory distress syndrome, ' 'which has caused millions of deaths. Apart from triggering inflammatory and immune responses, ' 'many viral infections can cause programmed cell death in infected cells. Cell death ' 'mechanisms have a vital role in maintaining a suitable environment to achieve normal cell ' 'functionality. Nonetheless, these processes are dysregulated, potentially contributing to ' 'disease pathogenesis. Over the past decades, multiple cell death pathways are becoming better ' 'understood. Growing evidence suggests that the induction of cell death by the coronavirus may ' 'significantly contributes to viral infection and pathogenicity. However, the interaction of ' 'SARS-CoV-2 with cell death, together with its associated mechanisms, is yet to be elucidated. ' 'In this review, we summarize the existing evidence concerning the molecular modulation of ' 'cell death in SARS-CoV-2 infection as well as viral-host interactions, which may shed new ' 'light on antiviral therapy against SARS-CoV-2.</jats:p>', 'DOI': '10.1038/s41392-023-01580-8', 'type': 'journal-article', 'created': {'date-parts': [[2023, 9, 20]], 'date-time': '2023-09-20T00:02:11Z', 'timestamp': 1695168131000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'The role of cell death in SARS-CoV-2 infection', 'prefix': '10.1038', 'volume': '8', 'author': [ {'given': 'Cui', 'family': 'Yuan', 'sequence': 'first', 'affiliation': []}, {'given': 'Zhenling', 'family': 'Ma', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jiufeng', 'family': 'Xie', 'sequence': 'additional', 'affiliation': []}, {'given': 'Wenqing', 'family': 'Li', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lijuan', 'family': 'Su', 'sequence': 'additional', 'affiliation': []}, {'given': 'Guozhi', 'family': 'Zhang', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jun', 'family': 'Xu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Yaru', 'family': 'Wu', 'sequence': 'additional', 'affiliation': []}, {'given': 'Min', 'family': 'Zhang', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-0004-2713', 'authenticated-orcid': False, 'given': 'Wei', 'family': 'Liu', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2023, 9, 20]]}, 'reference': [ { 'key': '1580_CR1', 'doi-asserted-by': 'publisher', 'first-page': '355', 'DOI': '10.1038/s41577-020-0331-4', 'volume': '20', 'author': 'M Merad', 'year': '2020', 'unstructured': 'Merad, M. & Martin, J. 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