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The role of cell death in SARS-CoV-2 infection

Yuan et al., Signal Transduction and Targeted Therapy, doi:10.1038/s41392-023-01580-8
Sep 2023  
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Review of cell death pathways in SARS-CoV-2 infection. Authors note that studies show lower selenium levels are associated with higher COVID-19 mortality. Through preserving glutathione peroxidase 4 activity and countering oxidative stress, selenium supplementation is suggested to potentially inhibit ferroptosis, a regulated cell death triggered by oxidative damage. Ferroptosis has been implicated in COVID-19 pathogenesis, and authors propose that selenium may help ameliorate this cell death pathway.
Reviews covering selenium for COVID-19 include Foshati, Maia, Yuan.
Study covers selenium and N-acetylcysteine.
Yuan et al., 20 Sep 2023, peer-reviewed, 10 authors. Contact: liuv@henau.edu.cn.
This PaperSeleniumAll
The role of cell death in SARS-CoV-2 infection
Cui Yuan, Zhenling Ma, Jiufeng Xie, Wenqing Li, Lijuan Su, Guozhi Zhang, Jun Xu, Yaru Wu, Min Zhang, Wei Liu
Signal Transduction and Targeted Therapy, doi:10.1038/s41392-023-01580-8
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), showing high infectiousness, resulted in an ongoing pandemic termed coronavirus disease 2019 (COVID-19). COVID-19 cases often experience acute respiratory distress syndrome, which has caused millions of deaths. Apart from triggering inflammatory and immune responses, many viral infections can cause programmed cell death in infected cells. Cell death mechanisms have a vital role in maintaining a suitable environment to achieve normal cell functionality. Nonetheless, these processes are dysregulated, potentially contributing to disease pathogenesis. Over the past decades, multiple cell death pathways are becoming better understood. Growing evidence suggests that the induction of cell death by the coronavirus may significantly contributes to viral infection and pathogenicity. However, the interaction of SARS-CoV-2 with cell death, together with its associated mechanisms, is yet to be elucidated. In this review, we summarize the existing evidence concerning the molecular modulation of cell death in SARS-CoV-2 infection as well as viral-host interactions, which may shed new light on antiviral therapy against SARS-CoV-2.
AUTHOR CONTRIBUTIONS C.Y. and W.L. wrote the manuscript and created the figures. W.L. and Z.M. revised the manuscript and figures. J.X., W.L., L.S., G.Z., X.J., Y.W., and M.Z. provided conceptual ideas and revised the manuscript. All the authors have read and approved the final manuscript. ADDITIONAL INFORMATION Competing interests: The authors declare no competing interests. Figures were created with biorender.com.
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