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The impact of vitamin D administration on mortality in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials

Kow et al., Inflammopharmacology, doi:10.1007/s10787-024-01564-2
Sep 2024  
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Mortality 28% Improvement Relative Risk Mortality, severe cases 43% Vitamin D for COVID-19  Kow et al.  META ANALYSIS c19early.org Favorsvitamin D Favorscontrol 0 0.5 1 1.5 2+
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020, now with p < 0.00000000001 from 125 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments.
5,300+ studies for 116 treatments. c19early.org
Systematic review and meta analysis of 19 RCTs with 2,495 patients, showing significantly lower mortality with vitamin D treatment.
19 meta analyses show significant improvements with vitamin D treatment for mortality1-14, mechanical ventilation1,6,7,12,15,16, ICU admission1,3,6,7,10,12,14-18, hospitalization5,12, severity2,4,6,11,19, and cases8,18,19.
Currently there are 125 vitamin D treatment for COVID-19 studies, showing 38% lower mortality [30‑45%], 19% lower ventilation [-3‑36%], 45% lower ICU admission [28‑58%], 19% lower hospitalization [9‑29%], and 17% fewer cases [9‑24%].
risk of death, 28.0% lower, OR 0.72, p = 0.04, RR approximated with OR.
risk of death, 43.0% lower, OR 0.57, p = 0.02, severe cases, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kow et al., 3 Sep 2024, peer-reviewed, 5 authors.
This PaperVitamin DAll
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