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0 0.5 1 1.5 2+ Mortality 63% Improvement Relative Risk Ventilation 66% ICU admission 73% Vitamin D  Hariyanto et al.  META ANALYSIS Favors vitamin D Favors control

Vitamin D supplementation and Covid‐19 outcomes: A systematic review, meta‐analysis and meta‐regression

Hariyanto et al., Reviews in Medical Virology, doi:10.1002/rmv.2269
Jun 2021  
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Meta analysis of 11 COVID-19 studies showing lower mortality, mechanical ventilation, and ICU admission with vitamin D. Authors also perform meta-regression showing greater efficacy with increasing age.
9 meta analyses show significant improvements with vitamin D treatment for mortality Argano, D’Ecclesiis, Hariyanto, Hosseini, Nikniaz, Shah, Xie, mechanical ventilation Hariyanto, Shah, Xie, ICU admission Hariyanto, Hosseini, Shah, Tentolouris, Xie, hospitalization Argano, severity D’Ecclesiis, Nikniaz, Varikasuvu, Xie, and cases Varikasuvu.
Currently there are 116 vitamin D treatment for COVID-19 studies, showing 36% lower mortality [27‑43%], 16% lower ventilation [-8‑35%], 47% lower ICU admission [29‑61%], 20% lower hospitalization [8‑29%], and 16% fewer cases [7‑23%].
risk of death, 63.0% lower, OR 0.37, p < 0.001, RR approximated with OR.
risk of mechanical ventilation, 66.0% lower, OR 0.34, p = 0.005, RR approximated with OR.
risk of ICU admission, 73.0% lower, OR 0.27, p = 0.02, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hariyanto et al., 27 Jun 2021, peer-reviewed, 5 authors.
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This PaperVitamin DAll
Vitamin D supplementation and Covid‐19 outcomes: A systematic review, meta‐analysis and meta‐regression
Timotius Ivan Hariyanto, Denny Intan, Joshua Edward Hananto, Harapan Harapan, Andree Kurniawan
Reviews in Medical Virology, doi:10.1002/rmv.2269
Vitamin D has many protective properties and potential role against acute lung injury. Low serum vitamin D is associated with high risk of pneumonia and development of acute respiratory distress syndrome. This study sought to analyse the efficacy of vitamin D in improving the outcomes of coronavirus disease 2019 (Covid-19) patients. Using specific keywords, we comprehensively searched the potential articles on PubMed, Europe PMC and database until 8th May 2021. All published studies on Covid-19 and vitamin D were retrieved. Statistical analysis was conducted using Review Manager 5.4 software. A total of 11 studies with 22,265 Covid-19 patients were included in the meta-analysis. Our data suggested that vitamin D supplementation was associated with reduction in intensive care unit admission rate (OR 0.27; 95% CI: 0.09-0.76, p = 0.010, I 2 = 70%, random-effect modelling); reduction of the need for mechanical ventilation (OR 0.34; 95% CI: 0.16-0.72, p = 0.005, I 2 = 61%, random-effect modelling) and reduction of mortality from Covid-19 (OR 0.37; 95% CI: 0.21-0.66, p < 0.001, I 2 = 50%, random-effect modelling). Further analysis showed that the associations were influenced by age (p = 0.020). Our study suggests that vitamin D supplementation may offer beneficial effects on Covid-19 outcomes. However, more randomized clinical trials are required to confirm this conclusion. K E Y W O R D S coronavirus disease 2019, Covid-19, vitamin D 1 | INTRODUCTION Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to spread globally causing a pandemic and has become a major medical focus for the last couple of years. The pandemic has involved over 164 million confirmed cases, with more than 3.4 million deaths as of 23 May 2021. 1 While some SARS-CoV-2 infections appear as mild upper respiratory symptoms and may be self-limiting, notable numbers of patients require hospitalizations and intensive treatment following progression into a more severe cases,
CONFLICT OF INTEREST The authors declare that there is no conflict of interest. AUTHOR CONTRIBUTION Conceptualization
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