Vitamin D supplementation to treat SARS-CoV-2 positive patients. Evidence from meta-analysis

Szarpak et al., Cardiology Journal, doi:10.5603/CJ.a2021.0122, Oct 2021
Mortality 44% improvement lower risk ← → higher risk Ventilation 62% ICU admission 81% Vitamin D  Szarpak et al.  META ANALYSIS c19early.org Szarpak et al., Cardiology J., October 2021 0 0.5 1 1.5 2+ RR
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020, now with p < 0.00000000001 from 126 studies, recognized in 18 countries.
Lower risk for mortality, ICU, hospitalization, progression, recovery, cases, and viral clearance.
No treatment is 100% effective. Protocols combine treatments.
6,300+ studies for 210+ treatments. c19early.org
Meta Analysis
Meta analysis of 8 studies with 2,322 patients showing that vitamin D treatment was associated with significantly lower ICU admission and need for mechanical ventilation.
19 meta analyses show significant improvements with vitamin D treatment for mortality1-13, mechanical ventilation1,5,6,11,14-16, ICU admission1,3,5,6,9,11,13-18, hospitalization11, severity2,4,5,10,19, and cases7,18,19.
Currently there are 126 vitamin D treatment for COVID-19 studies, showing 38% lower mortality [31‑45%], 19% lower ventilation [-3‑36%], 45% lower ICU admission [28‑58%], 19% lower hospitalization [9‑29%], and 17% fewer cases [9‑24%].
Important missing comments or errors? Let us know.
risk of death, 44.0% lower, OR 0.56, p = 0.20, RR approximated with OR.
risk of mechanical ventilation, 62.0% lower, OR 0.38, p = 0.02, RR approximated with OR.
risk of ICU admission, 81.0% lower, OR 0.19, p = 0.003, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Szarpak et al., 8 Oct 2021, peer-reviewed, 13 authors. Contact: lukasz.szarpak@gmail.com.
Vitamin D supplementation to treat SARS-CoV-2 positive patients. Evidence from meta-analysis
Luiza Szarpak, Krzysztof J Filipiak, Aleksandra Gasecka, Wladyslaw Gawel, Dorota Koziel, Milosz J Jaguszewski, Jaroslaw Chmielewski, Anatolii Gozhenko, Karol Bielski, Pawel Wroblewski, Ivan Savytskyi, Lukasz Szarpak, Zubaid Rafique
Cardiology Journal, doi:10.5603/cj.a2021.0122
This article has been peer reviewed and published immediately upon acceptance. It is an open access article, which means that it can be
CONCLUSIONS Vitamin D supplementation in SARS-CoV-2 positive patients has the potential to positively impact patients with both mild and severe symptoms. As a number of high-quality randomized control studies have demonstrated a benefit in hospital mortality, vitamin D should be considered a supplemental therapy of strong interest. At the same time, should vitamin D prove to reduce hospitalization rates and symptoms outside of the hospital setting, the cost and benefit to global pandemic mitigation efforts would be substantial. It can be concluded that further multicenter investigation of vitamin D in SARS-CoV-2 positive patients is urgently warranted at this time. Conflict of interest: None declared
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