Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All vitamin D studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchVitamin DVitamin D (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality, RCTs 84% Improvement Relative Risk Mortality, observational 12% ICU admission, observati.. 68% Case, RCTs 60% Case, observational 41% Vitamin D for COVID-19  Sartini et al.  META ANALYSIS c19early.org Favors vitamin D Favors control

Preventive Vitamin D Supplementation and Risk for COVID-19 Infection: A Systematic Review and Meta-Analysis

Sartini et al., Nutrients, doi:10.3390/nu16050679
Feb 2024  
  Post
  Facebook
Share
  Source   PDF   All   Meta
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19early.org
Systematic review and meta analysis of 7 RCTs and 12 observational studies including over 1.2 million participants showing vitamin D prophylaxis associated with lower COVID-19 cases and lower ICU admission.
12 meta analyses show significant improvements with vitamin D treatment for mortality Argano, Begum, D’Ecclesiis, Hariyanto, Hosseini, Nikniaz, Shah, Xie, mechanical ventilation Hariyanto, Meng, Shah, Xie, ICU admission Hariyanto, Hosseini, Meng, Sartini, Shah, Tentolouris, Xie, hospitalization Argano, severity D’Ecclesiis, Nikniaz, Varikasuvu, Xie, and cases Begum, Sartini, Varikasuvu.
Currently there are 120 vitamin D treatment for COVID-19 studies, showing 36% lower mortality [28‑43%], 16% lower ventilation [-7‑34%], 46% lower ICU admission [28‑60%], 19% lower hospitalization [9‑29%], and 17% fewer cases [9‑24%].
risk of death, 83.7% lower, OR 0.16, p < 0.001, RCTs, RR approximated with OR.
risk of death, 11.8% lower, OR 0.88, p = 0.38, observational, RR approximated with OR.
risk of ICU admission, 68.3% lower, OR 0.32, p = 0.003, observational, RR approximated with OR.
risk of case, 59.7% lower, OR 0.40, p = 0.004, RCTs, RR approximated with OR.
risk of case, 40.8% lower, OR 0.59, p < 0.001, observational, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sartini et al., 28 Feb 2024, peer-reviewed, 8 authors.
This PaperVitamin DAll
Preventive Vitamin D Supplementation and Risk for COVID-19 Infection: A Systematic Review and Meta-Analysis
Marina Sartini, Filippo Del Puente, Martino Oliva, Alessio Carbone, Nicoletta Bobbio, Elisa Schinca, Luana Giribone, Maria Luisa Cristina
Nutrients, doi:10.3390/nu16050679
Over the past few decades, vitamin D has been found to play a crucial role in bone homeostasis, muscle function, oncogenesis, immune response and metabolism. In the context of the COVID-19 pandemic, numerous researchers have tried to determine the role vitamin D might play in the immune response to the virus. The aim of this systematic review and meta-analysis is to demonstrate that preventive vitamin D supplementation can play a protective role in the incidence of COVID-19, mortality and admission to intensive care units (ICUs). A comprehensive search on the PubMed/MEDLINE, Scopus, Cochrane and Google Scholar databases was performed on 15 May 2023, and two of the authors independently screened the literature. As effect measures, we calculated the Odds Ratios with their corresponding 95% confidence intervals (ICs). The assessment of potential bias and the evaluation of study quality will be conducted independently by two researchers. Sixteen publications were selected for inclusion in the meta-analysis. Our findings indicate that vitamin D supplementation has a protective effect against the incidence of COVID-19 in RCT studies (OR 0.403, 95% IC 0.218, 0.747), in the incidence of COVID-19 in analytical studies (OR = 0.592, 95% IC 0.476-0.736) and in ICU admission (OR 0.317, 95% IC 0.147-0.680). Subsequent analyses were conducted by type of subject treated (patient/healthcare workers) and type of supplementation (vitamin D vs. placebo/no treatment or high dose vs. low dose). Our meta-analysis suggests a definitive and significant association between the protective role of vitamin D and COVID-19 incidence and ICU admission.
Conflicts of Interest: The authors declare no conflicts of interest. Abbreviations
References
Ali, Role of vitamin D in preventing of COVID-19 infection, progression and severity, J. Infect. Public Health, doi:10.1016/j.jiph.2020.06.021
Annweiler, Corvaisier, Gautier, Dubée, Legrand et al., Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study, Nutrients, doi:10.3390/nu12113377
Arroyo-Díaz, Julve, Vlacho, Corcoy, Ponte et al., Previous Vitamin D Supplementation and Morbidity and Mortality Outcomes in People Hospitalised for COVID-19: A Cross-Sectional Study, Front. Public Health, doi:10.3389/fpubh.2021.758347
Autier, Gandini, Vitamin D Supplementation and Total Mortality: A Meta-Analysis of Randomized Controlled Trials, Arch. Intern. Med, doi:10.1001/archinte.167.16.1730
Beran, Mhanna, Srour, Ayesh, Stewart et al., Clinical significance of micronutrient supplements in patients with coronavirus disease 2019: A comprehensive systematic review and meta-analysis, Clin. Nutr. ESPEN, doi:10.1016/j.clnesp.2021.12.033
Bikle, Vitamin, Newer Concepts of Its Metabolism and Function at the Basic and Clinical Level, J. Endocr. Soc, doi:10.1210/jendso/bvz038
Bouillon, Marcocci, Carmeliet, Bikle, White et al., Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions, Endocr. Rev, doi:10.1210/er.2018-00126
Bouillon, Quesada-Gomez, Vitamin D Endocrine System and COVID-19, JBMR Plus, doi:10.1002/jbm4.10576
Brown, Cohen, Tabor, Zappalà, Maruvada et al., The vitamin D paradox in Black Americans: A systemsbased approach to investigating clinical practice, research, and public health-Expert panel meeting report, BMC Proc, doi:10.1186/s12919-018-0102-4
Brunvoll, Nygaard, Ellingjord-Dale, Holland, Istre et al., Prevention of COVID-19 and other acute respiratory infections with cod liver oil supplementation, a low dose vitamin D supplement: Quadruple blinded, randomised placebo controlled trial, BMJ, doi:10.1136/bmj-2022-071245
Cangiano, Fatti, Danesi, Gazzano, Croci et al., Mortality in an Italian nursing home during COVID-19 pandemic: Correlation with gender, age, ADL, vitamin D supplementation, and limitations of the diagnostic tests, Aging, doi:10.18632/aging.202307
Cereda, Bogliolo, Lobascio, Barichella, Zecchinelli et al., Vitamin D supplementation and outcomes in coronavirus disease 2019 (COVID-19) patients from the outbreak area of Lombardy, Italy, Nutrition, doi:10.1016/j.nut.2020.111055
Charan, Goyal, Saxena, Yadav, Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis, J. Pharmacol. Pharmacother, doi:10.4103/0976-500X.103685
Charoenngam, Shirvani, Reddy, Vodopivec, Apovian et al., Association of Vitamin D Status with Hospital Morbidity and Mortality in Adult Hospitalized Patients with COVID-19, Endocr. Pract, doi:10.1016/j.eprac.2021.02.013
Dawson-Hughes, Heaney, Holick, Lips, Meunier et al., Estimates of optimal vitamin D status, Osteoporos. Int, doi:10.1007/s00198-005-1867-7
Gibbons, Norton, Mccullough, Meltzer, Lavigne et al., Association between vitamin D supplementation and COVID-19 infection and mortality, Sci. Rep, doi:10.1038/s41598-022-24053-4
Grant, Lahore, Mcdonnell, Baggerly, French et al., Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths, Nutrients, doi:10.3390/nu12040988
Gu, Korteweg, Pathology and Pathogenesis of Severe Acute Respiratory Syndrome, Am. J. Pathol, doi:10.2353/ajpath.2007.061088
Gunville, Mourani, Ginde, The Role of Vitamin D in Prevention and Treatment of Infection, Inflamm. Allergy-Drug Targets, doi:10.2174/18715281113129990046
Hariyanto, Intan, Hananto, Harapan, Kurniawan, Vitamin D supplementation and COVID-19 outcomes: A systematic review, meta-analysis and meta-regression, Rev. Med. Virol, doi:10.1002/rmv.2269
Hastie, Mackay, Ho, Celis-Morales, Katikireddi et al., Vitamin D concentrations and COVID-19 infection in UK Biobank, Diabetes Metab. Syndr. Clin. Res. Rev, doi:10.1016/j.dsx.2020.04.050
Hernández, Nan, Fernandez-Ayala, García-Unzueta, Hernández-Hernández et al., Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection, J. Clin. Endocrinol. Metab, doi:10.1210/clinem/dgaa733
Holick, Vitamin, Deficiency, None, N. Engl. J. Med, doi:10.1056/NEJMra070553
Hu, The Effect of Active Vitamin D on Coronavirus, Highlights Sci. Eng. Technol, doi:10.54097/hset.v30i.5235
Jolliffe, Greenberg, Hooper, Mathyssen, Rafiq et al., Vitamin D to prevent exacerbations of COPD: Systematic review and meta-analysis of individual participant data from randomised controlled trials, Thorax, doi:10.1136/thoraxjnl-2018-212092
Jolliffe, Holt, Greenig, Talaei, Perdek et al., Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and COVID-19: Phase 3 randomised controlled trial (CORONAVIT), BMJ, doi:10.1136/bmj-2022-071230
Jones, Vitamin, Ross, Caballero, Modern Nutrition in Health and Disease
Karonova, Golovatyuk, Kudryavtsev, Chernikova, Mikhaylova et al., Effect of Cholecalciferol Supplementation on the Clinical Features and Inflammatory Markers in Hospitalized COVID-19 Patients: A Randomized, Open-Label, Single-Center Study, Nutrients, doi:10.3390/nu14132602
Kaufman, Niles, Kroll, Bi, Holick, SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels, PLoS ONE, doi:10.1371/journal.pone.0239252
Lamers, Haagmans, SARS-CoV-2 pathogenesis, Nat. Rev. Microbiol, doi:10.1038/s41579-022-00713-0
Liu, Clare, Heilbronner, Dash, Krez et al., Vitamin D and SARS-CoV-2 Infection: SERVE Study (SARS-CoV-2 Exposure and the Role of Vitamin D among Hospital Employees), J. Nutr, doi:10.1016/j.tjnut.2023.03.001
Ma, Wang, Yang, Huang, Weng et al., Methodological quality (risk of bias) assessment tools for primary and secondary medical studies: What are they and which is better?, Mil. Med. Res, doi:10.1186/s40779-020-00238-8
Ma, Zhou, Heianza, Qi, Habitual use of vitamin D supplements and risk of coronavirus disease 2019 (COVID-19) infection: A prospective study in UK Biobank, Am. J. Clin. Nutr, doi:10.1093/ajcn/nqaa381
Martineau, Vitamin D in the prevention or treatment of COVID-19, Proc. Nutr. Soc, doi:10.1017/S0029665122002798
Nnoaham, Clarke, Low serum vitamin D levels and tuberculosis: A systematic review and meta-analysis, Leuk. Res, doi:10.1093/ije/dym247
Oristrell, Oliva, Casado, Subirana, Domínguez et al., Vitamin D supplementation and COVID-19 risk: A population-based, cohort study, J. Endocrinol. Investig, doi:10.1007/s40618-021-01639-9
Oristrell, Oliva, Subirana, Casado, Domínguez et al., Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study, Biomedicines, doi:10.3390/biomedicines9050509
Page, Mckenzie, Bossuyt, Boutron, Hoffmann et al., The PRISMA 2020 statement: An updated guideline for reporting systematic reviews, BMJ, doi:10.1136/bmj.n71
Pal, Banerjee, Bhadada, Shetty, Singh et al., Vitamin D supplementation and clinical outcomes in COVID-19: A systematic review and meta-analysis, J. Endocrinol. Investig, doi:10.1007/s40618-021-01614-4
Parant, Bouloy, Haesebaert, Bendim'red, Goldet et al., Vitamin D and COVID-19 Severity in Hospitalized Older Patients: Potential Benefit of Prehospital Vitamin D Supplementation, Nutrients, doi:10.3390/nu14081641
Parisini, Boni, Vacca, Bobbio, Del Puente et al., Impact of the COVID-19 Pandemic on Epidemiology of Antibiotic Resistance in an Intensive Care Unit (ICU): The Experience of a North-West Italian Center, Antibiotics, doi:10.3390/antibiotics12081278
Petrakis, Panopoulou, Rafailidis, Lemonakis, Lazaridis et al., The Impact of the COVID-19 Pandemic on Antimicrobial Resistance and Management of Bloodstream Infections, Pathogens
Romero-Ibarguengoitia, Gutiérrez-González, Cantú-López, Sanz-Sánchez, González-Cantú, Effect of Vitamin D 3 Supplementation vs. Dietary-Hygienic Measures on SARS-CoV-2 Infection Rates in Hospital Workers with 25-Hydroxyvitamin D 3 [25(OH)D 3 ] Levels ≥20 ng/mL, Microorganisms, doi:10.3390/microorganisms11020282
Sabetta, Depetrillo, Cipriani, Smardin, Burns et al., Serum 25-Hydroxyvitamin D and the Incidence of Acute Viral Respiratory Tract Infections in Healthy Adults, PLoS ONE, doi:10.1371/journal.pone.0011088
Sartini, Del Puente, Carbone, Oliva, Preventive Vitamin D Supplementation and Risk for COVID-19 Infection: A Systematic Review and Meta-Analysis, PROSPERO
Sartini, Del Puente, Oliva, Carbone, Blasi Vacca et al., Riding the COVID Waves: Clinical Trends, Outcomes, and Remaining Pitfalls of the SARS-CoV-2 Pandemic: An Analysis of Two High-Incidence Periods at a Hospital in Northern Italy, J. Clin. Med, doi:10.3390/jcm10225239
Shah, Varna, Sharma, Mavalankar, Does vitamin D supplementation reduce COVID-19 severity? A systematic review, QJM Int. J. Med, doi:10.1093/qjmed/hcac040
Van Helmond, Brobyn, Lariccia, Cafaro, Hunter et al., Vitamin D 3 Supplementation at 5000 IU Daily for the Prevention of Influenza-like Illness in Healthcare Workers: A Pragmatic Randomized Clinical Trial, Nutrients, doi:10.3390/nu15010180
Villasis-Keever, López-Alarcón, Miranda-Novales, Zurita-Cruz, Barrada-Vázquez et al., Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial, Arch. Med. Res, doi:10.1016/j.arcmed.2022.04.003
Wang, Feng, Ying, Zhou, Li, Efficacy and Safety of Vitamin D Supplementation for Pulmonary Tu-berculosis: A Systematic Review and Meta-analysis, Iran. J. Public Health
Ødum, Kongsbak-Wismann, Vitamin D and SARS-CoV-2, Basic Clin. Pharmacol. Toxicol, doi:10.1111/bcpt.13872
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit