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0 0.5 1 1.5 2+ Mortality, RCTs 84% Improvement Relative Risk Mortality, observational 12% ICU admission, observati.. 68% Case, RCTs 60% Case, observational 41% Vitamin D for COVID-19  Sartini et al.  META ANALYSIS Favors vitamin D Favors control

Preventive Vitamin D Supplementation and Risk for COVID-19 Infection: A Systematic Review and Meta-Analysis

Sartini et al., Nutrients, doi:10.3390/nu16050679
Feb 2024  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Systematic review and meta analysis of 7 RCTs and 12 observational studies including over 1.2 million participants showing vitamin D prophylaxis associated with lower COVID-19 cases and lower ICU admission.
12 meta analyses show significant improvements with vitamin D treatment for mortality Argano, Begum, D’Ecclesiis, Hariyanto, Hosseini, Nikniaz, Shah, Xie, mechanical ventilation Hariyanto, Meng, Shah, Xie, ICU admission Hariyanto, Hosseini, Meng, Sartini, Shah, Tentolouris, Xie, hospitalization Argano, severity D’Ecclesiis, Nikniaz, Varikasuvu, Xie, and cases Begum, Sartini, Varikasuvu.
Currently there are 120 vitamin D treatment for COVID-19 studies, showing 36% lower mortality [28‑43%], 16% lower ventilation [-7‑34%], 46% lower ICU admission [28‑60%], 19% lower hospitalization [9‑29%], and 17% fewer cases [9‑24%].
risk of death, 83.7% lower, OR 0.16, p < 0.001, RCTs, RR approximated with OR.
risk of death, 11.8% lower, OR 0.88, p = 0.38, observational, RR approximated with OR.
risk of ICU admission, 68.3% lower, OR 0.32, p = 0.003, observational, RR approximated with OR.
risk of case, 59.7% lower, OR 0.40, p = 0.004, RCTs, RR approximated with OR.
risk of case, 40.8% lower, OR 0.59, p < 0.001, observational, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sartini et al., 28 Feb 2024, peer-reviewed, 8 authors.
This PaperVitamin DAll
Preventive Vitamin D Supplementation and Risk for COVID-19 Infection: A Systematic Review and Meta-Analysis
Marina Sartini, Filippo Del Puente, Martino Oliva, Alessio Carbone, Nicoletta Bobbio, Elisa Schinca, Luana Giribone, Maria Luisa Cristina
Nutrients, doi:10.3390/nu16050679
Over the past few decades, vitamin D has been found to play a crucial role in bone homeostasis, muscle function, oncogenesis, immune response and metabolism. In the context of the COVID-19 pandemic, numerous researchers have tried to determine the role vitamin D might play in the immune response to the virus. The aim of this systematic review and meta-analysis is to demonstrate that preventive vitamin D supplementation can play a protective role in the incidence of COVID-19, mortality and admission to intensive care units (ICUs). A comprehensive search on the PubMed/MEDLINE, Scopus, Cochrane and Google Scholar databases was performed on 15 May 2023, and two of the authors independently screened the literature. As effect measures, we calculated the Odds Ratios with their corresponding 95% confidence intervals (ICs). The assessment of potential bias and the evaluation of study quality will be conducted independently by two researchers. Sixteen publications were selected for inclusion in the meta-analysis. Our findings indicate that vitamin D supplementation has a protective effect against the incidence of COVID-19 in RCT studies (OR 0.403, 95% IC 0.218, 0.747), in the incidence of COVID-19 in analytical studies (OR = 0.592, 95% IC 0.476-0.736) and in ICU admission (OR 0.317, 95% IC 0.147-0.680). Subsequent analyses were conducted by type of subject treated (patient/healthcare workers) and type of supplementation (vitamin D vs. placebo/no treatment or high dose vs. low dose). Our meta-analysis suggests a definitive and significant association between the protective role of vitamin D and COVID-19 incidence and ICU admission.
Conflicts of Interest: The authors declare no conflicts of interest. Abbreviations
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