Previous Vitamin D Supplementation and Morbidity and Mortality Outcomes in People Hospitalised for COVID19: A Cross-Sectional Study
Juan Antonio Arroyo-Díaz, Josep Julve, Bogdan Vlacho, Rosa Corcoy, Paola Ponte, Eva Román, Elena Navas-Méndez, Gemma Llauradó, Josep Franch-Nadal, Pere Domingo, Didac Mauricio
Frontiers in Public Health, doi:10.3389/fpubh.2021.758347
Aim: The study aim was to assess the association of vitamin D supplementation before hospital admission and severe outcomes in subjects admitted for COVID-19. Methods: We performed a cross-sectional analysis of pseudonymised medical record data from subjects admitted to the Hospital de la Santa Creu i Sant Pau (Barcelona, Spain) for COVID-19 during March and April 2020. The composite primary study outcome was defined as death and/or invasive mechanical ventilation (IMV). Association between risk factors and study outcomes was evaluated by bivariate analysis, followed by logistic regression analysis. Results: In total, 1,267 persons were hospitalised during the observation period. Overall, 14.9% of the subjects were on active vitamin D supplementation treatment before admission. The subjects in the vitamin D group were significantly older than subjects without vitamin D supplementation. We observed higher rates of the primary outcome (death and/or IMV) among the persons with previous use of vitamin D (30.1 vs. 22.9% in those not receiving treatment). In the bivariate analysis, previous use of vitamin D was positively associated with death and/or IMV [odds ratio (OR): 1.45 95% CI: 1.03; 2.04]; however, after adjustment for other risk factors this association disappeared (OR: 1.09 95%CI: 0.65; 1.81). Arroyo-Díaz et al. Vitamin D Supplementation and Severity of COVID19 Conclusion: We did not find an association between vitamin D supplementation before hospital admission and death and/or IMV in subjects admitted for COVID-19. The age and the burden of age-associated comorbidities were independently associated with the in-hospital events.
DATA AVAILABILITY STATEMENT The data analysed in this study is subject to the following licences/restrictions: The data controller for Hospital de la Santa Creu i Sant Pau does not allow the sharing of raw data. Requests to access these datasets should be directed to Pere Domingo, pdomingo@santpau.cat.
ETHICS STATEMENT The studies involving human participants were reviewed and approved by the Ethics Committee of the Hospital de la Santa Creu i Sant Pau (Re. Nr. HSCSP-20/117). Written informed consent for participation was not required for this study in accordance with the national legislation and the institutional requirements.
AUTHOR CONTRIBUTIONS JA-D, JJ, JF-N, PD, and DM: conceptualisation. EN-M: formal analysis. JA-D, DM, PD, ER, and PP: resources and data curation. BV: writing-original draught preparation. BV, RC, JA-D, GL, JF-N, PD, and DM: writing-review and editing. DM and JF-N: supervision. JA-D: project administration. All authors contributed to the article and approved the submitted version.
SUPPLEMENTARY MATERIAL The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fpubh. 2021.758347/full#supplementary-material Conflict of Interest: RC has received advisory and/or speaking fees from Abbott, Ascensia, Lilly, MSD, Novo and Sanofi. JF-N has received advisory and or speaking fees from Astra-Zeneca, Ascensia, Boehringer Ingelheim, GSK, Lilly, MSD, Novartis, Novo Nordisk, and Sanofi; they received..
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'abstract': '<jats:p><jats:bold>Aim:</jats:bold> The study aim was to assess the association of vitamin D '
'supplementation before hospital admission and severe outcomes in subjects admitted for '
'COVID-19.</jats:p><jats:p><jats:bold>Methods:</jats:bold> We performed a cross-sectional '
'analysis of pseudonymised medical record data from subjects admitted to the Hospital de la '
'Santa Creu i Sant Pau (Barcelona, Spain) for COVID-19 during March and April 2020. The '
'composite primary study outcome was defined as death and/or invasive mechanical ventilation '
'(IMV). Association between risk factors and study outcomes was evaluated by bivariate '
'analysis, followed by logistic regression '
'analysis.</jats:p><jats:p><jats:bold>Results:</jats:bold> In total, 1,267 persons were '
'hospitalised during the observation period. Overall, 14.9% of the subjects were on active '
'vitamin D supplementation treatment before admission. The subjects in the vitamin D group '
'were significantly older than subjects without vitamin D supplementation. We observed higher '
'rates of the primary outcome (death and/or IMV) among the persons with previous use of '
'vitamin D (30.1 vs. 22.9% in those not receiving treatment). In the bivariate analysis, '
'previous use of vitamin D was positively associated with death and/or IMV [odds ratio (OR): '
'1.45 95% CI: 1.03; 2.04]; however, after adjustment for other risk factors this association '
'disappeared (OR: 1.09 95%CI: 0.65; 1.81).</jats:p><jats:p><jats:bold>Conclusion:</jats:bold> '
'We did not find an association between vitamin D supplementation before hospital admission '
'and death and/or IMV in subjects admitted for COVID-19. The age and the burden of '
'age-associated comorbidities were independently associated with the in-hospital '
'events.</jats:p>',
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