Previous Vitamin D Supplementation and Morbidity and Mortality Outcomes in People Hospitalised for COVID19: A Cross-Sectional Study

DOI record: { "DOI": "10.3389/fpubh.2021.758347", "ISSN": [ "2296-2565" ], "URL": "http://dx.doi.org/10.3389/fpubh.2021.758347", "abstract": "<jats:p><jats:bold>Aim:</jats:bold> The study aim was to assess the association of vitamin D supplementation before hospital admission and severe outcomes in subjects admitted for COVID-19.</jats:p><jats:p><jats:bold>Methods:</jats:bold> We performed a cross-sectional analysis of pseudonymised medical record data from subjects admitted to the Hospital de la Santa Creu i Sant Pau (Barcelona, Spain) for COVID-19 during March and April 2020. The composite primary study outcome was defined as death and/or invasive mechanical ventilation (IMV). Association between risk factors and study outcomes was evaluated by bivariate analysis, followed by logistic regression analysis.</jats:p><jats:p><jats:bold>Results:</jats:bold> In total, 1,267 persons were hospitalised during the observation period. Overall, 14.9% of the subjects were on active vitamin D supplementation treatment before admission. The subjects in the vitamin D group were significantly older than subjects without vitamin D supplementation. We observed higher rates of the primary outcome (death and/or IMV) among the persons with previous use of vitamin D (30.1 vs. 22.9% in those not receiving treatment). In the bivariate analysis, previous use of vitamin D was positively associated with death and/or IMV [odds ratio (OR): 1.45 95% CI: 1.03; 2.04]; however, after adjustment for other risk factors this association disappeared (OR: 1.09 95%CI: 0.65; 1.81).</jats:p><jats:p><jats:bold>Conclusion:</jats:bold> We did not find an association between vitamin D supplementation before hospital admission and death and/or IMV in subjects admitted for COVID-19. The age and the burden of age-associated comorbidities were independently associated with the in-hospital events.</jats:p>", "alternative-id": [ "10.3389/fpubh.2021.758347" ], "author": [ { "affiliation": [], "family": "Arroyo-Díaz", "given": "Juan Antonio", "sequence": "first" }, { "affiliation": [], "family": "Julve", "given": "Josep", "sequence": "additional" }, { "affiliation": [], "family": "Vlacho", "given": "Bogdan", "sequence": "additional" }, { "affiliation": [], "family": "Corcoy", "given": "Rosa", "sequence": "additional" }, { "affiliation": [], "family": "Ponte", "given": "Paola", "sequence": "additional" }, { "affiliation": [], "family": "Román", "given": "Eva", "sequence": "additional" }, { "affiliation": [], "family": "Navas-Méndez", "given": "Elena", "sequence": "additional" }, { "affiliation": [], "family": "Llauradó", "given": "Gemma", "sequence": "additional" }, { "affiliation": [], "family": "Franch-Nadal", "given": "Josep", "sequence": "additional" }, { "affiliation": [], "family": "Domingo", "given": "Pere", "sequence": "additional" }, { "affiliation": [], "family": "Mauricio", "given": "Didac", "sequence": "additional" } ], "container-title": "Frontiers in Public Health", "container-title-short": "Front. Public Health", "content-domain": { "crossmark-restriction": true, "domain": [ "frontiersin.org" ] }, "created": { "date-parts": [ [ 2021, 9, 25 ] ], "date-time": "2021-09-25T00:41:32Z", "timestamp": 1632530492000 }, "deposited": { "date-parts": [ [ 2021, 9, 25 ] ], "date-time": "2021-09-25T00:42:02Z", "timestamp": 1632530522000 }, "indexed": { "date-parts": [ [ 2024, 2, 28 ] ], "date-time": "2024-02-28T15:20:28Z", "timestamp": 1709133628928 }, "is-referenced-by-count": 8, "issued": { "date-parts": [ [ 2021, 9, 24 ] ] }, "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0/", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2021, 9, 24 ] ], "date-time": "2021-09-24T00:00:00Z", "timestamp": 1632441600000 } } ], "link": [ { "URL": "https://www.frontiersin.org/articles/10.3389/fpubh.2021.758347/full", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "1965", "original-title": [], "prefix": "10.3389", "published": { "date-parts": [ [ 2021, 9, 24 ] ] }, "published-online": { "date-parts": [ [ 2021, 9, 24 ] ] }, "publisher": "Frontiers Media SA", "reference": [ { "key": "B1", "unstructured": "2021" }, { "key": "B2", "unstructured": "COVID-19 Weekly Epidemiological Update 222021" }, { "DOI": "10.1056/NEJMoa2023184", "article-title": "Repurposed antiviral drugs for covid-19—interim WHO solidarity trial results", "doi-asserted-by": "crossref", "first-page": "497", "journal-title": "N Engl J Med", "key": "B3", "volume": "384", "year": "2021" }, { "DOI": "10.1056/NEJMoa2021436", "article-title": "Dexamethasone in Hospitalized Patients with Covid-19", "author": "Horby", "doi-asserted-by": "publisher", "first-page": "693", "journal-title": "N Engl J Med", "key": "B4", "volume": "384", "year": "2021" }, { "author": "Caballero", "key": "B5", "volume-title": "Guide to Nutritional Supplements", "year": "2009" }, { "DOI": "10.1038/ejcn.2010.265", "article-title": "Vitamin D deficiency in Spain: a population-based cohort study", "author": "González-Molero", "doi-asserted-by": "publisher", "first-page": "321", "journal-title": "Eur J Clin Nutr.", "key": "B6", "volume": "65", "year": "2011" }, { "DOI": "10.2174/18715281113129990046", "article-title": "The role of vitamin D in prevention and treatment of infection", "author": "Gunville", "doi-asserted-by": "publisher", "first-page": "239", "journal-title": "Inflamm Allergy-Drug Targets", "key": "B7", "volume": "12", "year": "2013" }, { "DOI": "10.1016/j.jsbmb.2020.105751", "article-title": "Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among subjects hospitalised for COVID-19: a pilot randomised clinical study", "author": "Entrenas Castillo", "doi-asserted-by": "publisher", "first-page": "105751", "journal-title": "J Steroid Biochem Mol Biol.", "key": "B8", "volume": "203", "year": "2020" }, { "DOI": "10.3390/nu12113377", "article-title": "Vitamin d supplementation associated to better survival in hospitalised frail elderly covid-19 subjects: the geria-covid quasi-experimental study", "author": "Annweiler", "doi-asserted-by": "publisher", "first-page": "3377", "journal-title": "Nutrients.", "key": "B9", "volume": "12", "year": "2020" }, { "DOI": "10.1001/jamanetworkopen.2020.19722", "article-title": "Association of vitamin D status and other clinical characteristics with COVID-19 test results", "author": "Meltzer", "doi-asserted-by": "publisher", "first-page": "e2019722", "journal-title": "JAMA Netw Open", "key": "B10", "volume": "3", "year": "2020" }, { "DOI": "10.1371/journal.pone.0239252", "article-title": "SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels", "author": "Kaufman", "doi-asserted-by": "publisher", "first-page": "e0239252", "journal-title": "PLoS ONE", "key": "B11", "volume": "15", "year": "2020" }, { "DOI": "10.1371/journal.pone.0255132", "article-title": "Palmer JR. 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