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0 0.5 1 1.5 2+ Mortality -12% Improvement Relative Risk Ventilation 43% ICU admission 44% Hospitalization time 12% Arroyo-Díaz et al. Vitamin D for COVID-19 Prophylaxis Is prophylaxis with vitamin D beneficial for COVID-19? Retrospective 1,267 patients in Spain Lower ICU admission with vitamin D (p=0.035) Arroyo-Díaz et al., Frontiers in Public Health, doi:10.3389/fpubh.2021.758347 Favors vitamin D Favors control
Previous Vitamin D Supplementation and Morbidity and Mortality Outcomes in People Hospitalised for COVID19: A Cross-Sectional Study
Arroyo-Díaz et al., Frontiers in Public Health, doi:10.3389/fpubh.2021.758347
Arroyo-Díaz et al., Previous Vitamin D Supplementation and Morbidity and Mortality Outcomes in People Hospitalised for COVID19: A.., Frontiers in Public Health, doi:10.3389/fpubh.2021.758347
Sep 2021   Source   PDF  
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Retrospective 1,267 hospitalized patients in Spain, 189 on vitamin D supplementation before admission, showing lower ICU admission with supplementation, and no statistically significant difference for mortality or ventilation.
This is the 54th of 111 COVID-19 controlled studies for vitamin D, which collectively show efficacy with p<0.0000000001 (1 in 49 sextillion). 27 studies are RCTs, which show efficacy with p=0.00002.
risk of death, 12.4% higher, RR 1.12, p = 0.59, treatment 50 of 189 (26.5%), control 167 of 1,078 (15.5%), adjusted per study, odds ratio converted to relative risk.
risk of mechanical ventilation, 43.3% lower, RR 0.57, p = 0.22, treatment 11 of 189 (5.8%), control 113 of 1,078 (10.5%), NNT 21, adjusted per study, odds ratio converted to relative risk.
risk of ICU admission, 44.2% lower, RR 0.56, p = 0.03, treatment 13 of 189 (6.9%), control 133 of 1,078 (12.3%), NNT 18, unadjusted.
hospitalization time, 11.8% lower, relative time 0.88, p = 0.20, treatment 189, control 1,078, unadjusted.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Arroyo-Díaz et al., 24 Sep 2021, retrospective, Spain, peer-reviewed, 11 authors, dosage not specified.
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This PaperVitamin DAll
Previous Vitamin D Supplementation and Morbidity and Mortality Outcomes in People Hospitalised for COVID19: A Cross-Sectional Study
Juan Antonio Arroyo-Díaz, Josep Julve, Bogdan Vlacho, Rosa Corcoy, Paola Ponte, Eva Román, Elena Navas-Méndez, Gemma Llauradó, Josep Franch-Nadal, Pere Domingo, Didac Mauricio
Frontiers in Public Health, doi:10.3389/fpubh.2021.758347
Aim: The study aim was to assess the association of vitamin D supplementation before hospital admission and severe outcomes in subjects admitted for COVID-19. Methods: We performed a cross-sectional analysis of pseudonymised medical record data from subjects admitted to the Hospital de la Santa Creu i Sant Pau (Barcelona, Spain) for COVID-19 during March and April 2020. The composite primary study outcome was defined as death and/or invasive mechanical ventilation (IMV). Association between risk factors and study outcomes was evaluated by bivariate analysis, followed by logistic regression analysis. Results: In total, 1,267 persons were hospitalised during the observation period. Overall, 14.9% of the subjects were on active vitamin D supplementation treatment before admission. The subjects in the vitamin D group were significantly older than subjects without vitamin D supplementation. We observed higher rates of the primary outcome (death and/or IMV) among the persons with previous use of vitamin D (30.1 vs. 22.9% in those not receiving treatment). In the bivariate analysis, previous use of vitamin D was positively associated with death and/or IMV [odds ratio (OR): 1.45 95% CI: 1.03; 2.04]; however, after adjustment for other risk factors this association disappeared (OR: 1.09 95%CI: 0.65; 1.81). Arroyo-Díaz et al. Vitamin D Supplementation and Severity of COVID19 Conclusion: We did not find an association between vitamin D supplementation before hospital admission and death and/or IMV in subjects admitted for COVID-19. The age and the burden of age-associated comorbidities were independently associated with the in-hospital events.
DATA AVAILABILITY STATEMENT The data analysed in this study is subject to the following licences/restrictions: The data controller for Hospital de la Santa Creu i Sant Pau does not allow the sharing of raw data. Requests to access these datasets should be directed to Pere Domingo, ETHICS STATEMENT The studies involving human participants were reviewed and approved by the Ethics Committee of the Hospital de la Santa Creu i Sant Pau (Re. Nr. HSCSP-20/117). Written informed consent for participation was not required for this study in accordance with the national legislation and the institutional requirements. AUTHOR CONTRIBUTIONS JA-D, JJ, JF-N, PD, and DM: conceptualisation. EN-M: formal analysis. JA-D, DM, PD, ER, and PP: resources and data curation. BV: writing-original draught preparation. BV, RC, JA-D, GL, JF-N, PD, and DM: writing-review and editing. DM and JF-N: supervision. JA-D: project administration. All authors contributed to the article and approved the submitted version. SUPPLEMENTARY MATERIAL The Supplementary Material for this article can be found online at: 2021.758347/full#supplementary-material Conflict of Interest: RC has received advisory and/or speaking fees from Abbott, Ascensia, Lilly, MSD, Novo and Sanofi. JF-N has received advisory and or speaking fees from Astra-Zeneca, Ascensia, Boehringer Ingelheim, GSK, Lilly, MSD, Novartis, Novo Nordisk, and Sanofi; they received..
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