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All Studies   Meta Analysis    Recent:   

Previous Vitamin D Supplementation and Morbidity and Mortality Outcomes in People Hospitalised for COVID19: A Cross-Sectional Study

Arroyo-Díaz et al., Frontiers in Public Health, doi:10.3389/fpubh.2021.758347
Sep 2021  
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Mortality -12% Improvement Relative Risk Ventilation 43% ICU admission 44% Hospitalization time 12% Vitamin D  Arroyo-Díaz et al.  Prophylaxis Is prophylaxis with vitamin D beneficial for COVID-19? Retrospective 1,267 patients in Spain Lower ICU admission with vitamin D (p=0.035) c19early.org Arroyo-Díaz et al., Frontiers in Publi.., Sep 2021 Favorsvitamin D Favorscontrol 0 0.5 1 1.5 2+
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 102 treatments. c19early.org
Retrospective 1,267 hospitalized patients in Spain, 189 on vitamin D supplementation before admission, showing lower ICU admission with supplementation, and no statistically significant difference for mortality or ventilation.
This is the 54th of 122 COVID-19 controlled studies for vitamin D, which collectively show efficacy with p<0.0000000001 (1 in 587 sextillion).
30 studies are RCTs, which show efficacy with p=0.0000032.
risk of death, 12.4% higher, RR 1.12, p = 0.59, treatment 50 of 189 (26.5%), control 167 of 1,078 (15.5%), adjusted per study, odds ratio converted to relative risk.
risk of mechanical ventilation, 43.3% lower, RR 0.57, p = 0.22, treatment 11 of 189 (5.8%), control 113 of 1,078 (10.5%), NNT 21, adjusted per study, odds ratio converted to relative risk.
risk of ICU admission, 44.2% lower, RR 0.56, p = 0.03, treatment 13 of 189 (6.9%), control 133 of 1,078 (12.3%), NNT 18, unadjusted.
hospitalization time, 11.8% lower, relative time 0.88, p = 0.20, treatment 189, control 1,078, unadjusted.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Arroyo-Díaz et al., 24 Sep 2021, retrospective, Spain, peer-reviewed, 11 authors, dosage not specified.
This PaperVitamin DAll
Previous Vitamin D Supplementation and Morbidity and Mortality Outcomes in People Hospitalised for COVID19: A Cross-Sectional Study
Juan Antonio Arroyo-Díaz, Josep Julve, Bogdan Vlacho, Rosa Corcoy, Paola Ponte, Eva Román, Elena Navas-Méndez, Gemma Llauradó, Josep Franch-Nadal, Pere Domingo, Didac Mauricio
Frontiers in Public Health, doi:10.3389/fpubh.2021.758347
Aim: The study aim was to assess the association of vitamin D supplementation before hospital admission and severe outcomes in subjects admitted for COVID-19. Methods: We performed a cross-sectional analysis of pseudonymised medical record data from subjects admitted to the Hospital de la Santa Creu i Sant Pau (Barcelona, Spain) for COVID-19 during March and April 2020. The composite primary study outcome was defined as death and/or invasive mechanical ventilation (IMV). Association between risk factors and study outcomes was evaluated by bivariate analysis, followed by logistic regression analysis. Results: In total, 1,267 persons were hospitalised during the observation period. Overall, 14.9% of the subjects were on active vitamin D supplementation treatment before admission. The subjects in the vitamin D group were significantly older than subjects without vitamin D supplementation. We observed higher rates of the primary outcome (death and/or IMV) among the persons with previous use of vitamin D (30.1 vs. 22.9% in those not receiving treatment). In the bivariate analysis, previous use of vitamin D was positively associated with death and/or IMV [odds ratio (OR): 1.45 95% CI: 1.03; 2.04]; however, after adjustment for other risk factors this association disappeared (OR: 1.09 95%CI: 0.65; 1.81). Arroyo-Díaz et al. Vitamin D Supplementation and Severity of COVID19 Conclusion: We did not find an association between vitamin D supplementation before hospital admission and death and/or IMV in subjects admitted for COVID-19. The age and the burden of age-associated comorbidities were independently associated with the in-hospital events.
DATA AVAILABILITY STATEMENT The data analysed in this study is subject to the following licences/restrictions: The data controller for Hospital de la Santa Creu i Sant Pau does not allow the sharing of raw data. Requests to access these datasets should be directed to Pere Domingo, pdomingo@santpau.cat. ETHICS STATEMENT The studies involving human participants were reviewed and approved by the Ethics Committee of the Hospital de la Santa Creu i Sant Pau (Re. Nr. HSCSP-20/117). Written informed consent for participation was not required for this study in accordance with the national legislation and the institutional requirements. AUTHOR CONTRIBUTIONS JA-D, JJ, JF-N, PD, and DM: conceptualisation. EN-M: formal analysis. JA-D, DM, PD, ER, and PP: resources and data curation. BV: writing-original draught preparation. BV, RC, JA-D, GL, JF-N, PD, and DM: writing-review and editing. DM and JF-N: supervision. JA-D: project administration. All authors contributed to the article and approved the submitted version. SUPPLEMENTARY MATERIAL The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fpubh. 2021.758347/full#supplementary-material Conflict of Interest: RC has received advisory and/or speaking fees from Abbott, Ascensia, Lilly, MSD, Novo and Sanofi. JF-N has received advisory and or speaking fees from Astra-Zeneca, Ascensia, Boehringer Ingelheim, GSK, Lilly, MSD, Novartis, Novo Nordisk, and Sanofi; they received..
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Public Health', 'published': {'date-parts': [[2021, 9, 24]]}}
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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