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All Studies   Meta Analysis    Recent:   

Therapeutic and prognostic role of vitamin D for COVID-19 infection: A systematic review and meta-analysis of 43 observational studies

Petrelli et al., The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2021.105883
Mar 2021  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 121 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19early.org
Meta analysis showing vitamin D deficiency associated with higher risk of COVID-19, worse severity, and higher mortality.
Supplementation with vitamin D reduced the risk of severe cases and mortality.
15 meta analyses show significant improvements with vitamin D treatment for mortality1-10, mechanical ventilation1,6,7,11,12, ICU admission1,3,6,7,10-14, hospitalization5, severity2,4,6,15, and cases8,14,15.
Currently there are 121 vitamin D treatment for COVID-19 studies, showing 36% lower mortality [28‑43%], 19% lower ventilation [-4‑37%], 46% lower ICU admission [29‑60%], 19% lower hospitalization [9‑29%], and 17% fewer cases [9‑24%].
Petrelli et al., 26 Mar 2021, peer-reviewed, 6 authors.
This PaperVitamin DAll
Therapeutic and prognostic role of vitamin D for COVID-19 infection: A systematic review and meta-analysis of 43 observational studies
Fausto Petrelli, Andrea Luciani, Gianluca Perego, Giuseppina Dognini, Paolo Luigi Colombelli, Antonio Ghidini
The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2021.105883
Vitamin D modulates the systemic inflammatory response through interaction with immune system. As such, it has a possible protective role against the risk of respiratory tract infections and other diseases. It may be useful in particular, during COVID-19 pandemic. PubMed, the Cochrane Library, and EMBASE were searched from inception until January 31, 2021, for observational or clinical studies reporting the prognosis (and therapeutic effect) of COVID-19 infection in patients with deficient vitamin D levels. The infection rate, severity, and death from COVID-19 infection were pooled to provide an odds ratio with a 95 % confidence interval (OR 95 % CI). An OR > 1 was associated with the worst outcome in deficient compared with nondeficient patients. We assessed the association between vitamin D and risk, severity, and mortality for COVID-19 infection, through a review of 43 observational studies. Among subjects with deficient vitamin D values, risk of COVID-19 infection was higher compared to those with replete values (OR = 1.26; 95 % CI, 1.19-1.34; P < .01). Vitamin D deficiency was also associated with worse severity and higher mortality than in nondeficient patients (OR = 2.6; 95 % CI, 1.84-3.67; P < .01 and OR = 1.22; 95 % CI, 1.04-1.43; P < .01, respectively). Reduced vitamin D values resulted in a higher infection risk, mortality and severity COVID-19 infection. Supplementation may be considered as preventive and therapeutic measure.
Authors statement Fausto Petrelli: Conceptualization, Methodology, Software Writing-Original draft preparation. Antonio Ghidini, Gianluca Perego: Data curation. Andrea Luciani: Supervision, Visualization, Investigation. Paolo Colombelli: Supervision. Giuseppina Dognini: Writing-Reviewing and Editing. Funding The authors declare no funding.
References
Ahmed, A network-based analysis reveals the mechanism underlying vitamin D in suppressing cytokine storm and virus in SARS-CoV-2 infection, Front. Immunol, doi:10.3389/fimmu.2020.590459
Arboleda, Urcuqui-Inchima, Vitamin D supplementation: a potential approach for COVID-19 therapeutics?, Front. Immunol
Heath, Kim, Hodge, English, Muller, Vitamin D status and mortality: a systematic review of observational studies, Int. J. Environ. Res. Public Health, doi:10.3390/ijerph16030383
Kempker, Martin, Vitamin D and sepsis: from associations to causal connections, Inflamm. Allergy Drug Targets
Zdrenghea, Makrinioti, Bagacean, Vitamin D modulation of innate immune responses to respiratory viral infections, Rev. Med. Virol
Zhang, Fang, Tang, Jia, Feng et al., Association between vitamin D supplementation and mortality: systematic review and meta-analysis, BMJ, doi:10.1136/bmj.l4673
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