All Studies Meta Analysis Recent:

Micronutrient perspective on COVID-19: Umbrella review and reanalysis of meta-analyses

Xie et al., Critical Reviews in Food Science and Nutrition, doi:10.1080/10408398.2023.2174948, PROSPERO CRD42022353953

Feb 2023

Post
Facebook

Source PDF All Studies Meta AnalysisMeta

Vitamin D for COVID-19

8th treatment shown to reduce risk in October 2020

^*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.

Lower risk for mortality, ICU admission, hospitalization, progression, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine complementary and synergistic treatments. ^* >10% efficacy in meta analysis with ≥3 clinical studies.

4,100+ studies for 60+ treatments. c19early.org

Systematic review and meta analysis of micronutrient supplementation, showing vitamin D supplementation associated with lower mortality, mechanical ventilation, ICU admission, and severity. Note that forest plots have OR>1 favoring supplementation. Vitamin D deficiency was also associated with higher mortality, mechanical ventilation, ICU admission, severity, and cases.

12 meta analyses show significant improvements with vitamin D treatment for mortality Argano, Begum, D’Ecclesiis, Hariyanto, Hosseini, Nikniaz, Shah, Xie, mechanical ventilation Hariyanto, Meng, Shah, Xie, ICU admission Hariyanto, Hosseini, Meng, Sartini, Shah, Tentolouris, Xie, hospitalization Argano, severity D’Ecclesiis, Nikniaz, Varikasuvu, Xie, and cases Begum, Sartini, Varikasuvu.

Currently there are 120 vitamin D treatment for COVID-19 studies, showing 36% lower mortality [28‑43%], 16% lower ventilation [-7‑34%], 46% lower ICU admission [28‑60%], 19% lower hospitalization [9‑29%], and 17% fewer cases [9‑24%].

1. Argano et al., Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis, Pharmaceuticals, doi:10.3390/ph16010130.mdpi.com, doi.org.

2. Begum et al., The Role of Vitamin D in COVID-19 Survival and Prevention: A Meta-analysis, Sudan Journal of Medical Sciences, doi:10.18502/sjms.v19i1.15776.knepublishing.com, doi.org.

3. D’Ecclesiis et al., Vitamin D and SARS-CoV2 infection, severity and mortality: A systematic review and meta-analysis, PLOS ONE, doi:10.1371/journal.pone.0268396.plos.org, doi.org.

4. Hariyanto et al., Vitamin D supplementation and Covid‐19 outcomes: A systematic review, meta‐analysis and meta‐regression, Reviews in Medical Virology, doi:10.1002/rmv.2269.wiley.com, doi.org.

5. Hosseini et al., Effects of Vitamin D Supplementation on COVID-19 Related Outcomes: A Systematic Review and Meta-Analysis, Nutrients, doi:10.3390/nu14102134.mdpi.com, doi.org.

6. Meng et al., The role of vitamin D in the prevention and treatment of SARS-CoV-2 infection: A meta-analysis of randomized controlled trials, Clinical Nutrition, doi:10.1016/j.clnu.2023.09.008.sciencedirect.com, doi.org.

7. Nikniaz et al., The impact of vitamin D supplementation on mortality rate and clinical outcomes of COVID-19 patients: A systematic review and meta-analysis, Pharmaceutical Sciences, doi:10.34172/PS.2021.13.ac.ir, doi.org.

8. Sartini et al., Preventive Vitamin D Supplementation and Risk for COVID-19 Infection: A Systematic Review and Meta-Analysis, Nutrients, doi:10.3390/nu16050679.mdpi.com, doi.org.

9. Shah et al., Does vitamin D supplementation reduce COVID-19 severity? - a systematic review, QJM: An International Journal of Medicine, doi:10.1093/qjmed/hcac040.oup.com, doi.org.

10. Tentolouris et al., The effect of vitamin D supplementation on mortality and intensive care unit admission of COVID-19 patients. A systematic review, meta-analysis and meta-regression, Diabetes/Metabolism Research and Reviews, doi:10.1002/dmrr.3517.wiley.com, doi.org.

11. Varikasuvu et al., COVID-19 and Vitamin D (Co-VIVID Study): a systematic review and meta-analysis of randomized controlled trials, Expert Review of Anti-infective Therapy, doi:10.1080/14787210.2022.2035217.tandfonline.com, doi.org.

12. Xie et al., Micronutrient perspective on COVID-19: Umbrella review and reanalysis of meta-analyses, Critical Reviews in Food Science and Nutrition, doi:10.1080/10408398.2023.2174948.tandfonline.com, doi.org.

Important missing comments or errors? Let us know.

Study covers zinc and vitamin D.

Xie et al., 15 Feb 2023, peer-reviewed, 16 authors, trial PROSPERO CRD42022353953.

This Paper Vitamin D All

Download Image

Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

Submit

Post

@CovidAnalysis

FAQ

Public domain CC0 1.0