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Micronutrient perspective on COVID-19: Umbrella review and reanalysis of meta-analyses

Xie et al., Critical Reviews in Food Science and Nutrition, doi:10.1080/10408398.2023.2174948, PROSPERO CRD42022353953
Feb 2023  
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Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020
 
*, now known with p = 0.0000013 from 44 studies, recognized in 11 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Systematic review and meta analysis of micronutrient supplementation, showing zinc supplementation associated with lower mortality. Note that forest plots have OR>1 favoring supplementation.
6 meta analyses show significant improvements with zinc for mortality Abuhelwa, Olczak-Pruc, Rheingold, Tabatabaeizadeh, Xie, severity Fan, and cases Fan.
Currently there are 44 zinc treatment for COVID-19 studies, showing 29% lower mortality [10‑44%], 44% lower ventilation [4‑68%], 26% lower ICU admission [-7‑49%], 20% lower hospitalization [4‑34%], and 22% fewer cases [-10‑45%].
Study covers zinc and vitamin D.
Xie et al., 15 Feb 2023, peer-reviewed, 16 authors, trial PROSPERO CRD42022353953.
This PaperZincAll
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