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Micronutrient perspective on COVID-19: Umbrella review and reanalysis of meta-analyses

Xie et al., Critical Reviews in Food Science and Nutrition, doi:10.1080/10408398.2023.2174948, PROSPERO CRD42022353953
Feb 2023  
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Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020, now with p = 0.00000032 from 46 studies, recognized in 17 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 109 treatments. c19early.org
Systematic review and meta analysis of micronutrient supplementation, showing zinc supplementation associated with lower mortality. Note that forest plots have OR>1 favoring supplementation.
6 meta analyses show significant improvements with zinc for mortality1-5, severity6, and cases6.
Currently there are 46 zinc treatment for COVID-19 studies, showing 30% lower mortality [12‑44%], 40% lower ventilation [2‑63%], 24% lower ICU admission [-5‑46%], 20% lower hospitalization [4‑34%], and 22% fewer cases [-10‑45%].
Study covers zinc and vitamin D.
Xie et al., 15 Feb 2023, peer-reviewed, 16 authors, trial PROSPERO CRD42022353953.
This PaperZincAll
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