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Micronutrient perspective on COVID-19: Umbrella review and reanalysis of meta-analyses

Xie et al., Critical Reviews in Food Science and Nutrition, doi:10.1080/10408398.2023.2174948, PROSPERO CRD42022353953
Feb 2023  
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Systematic review and meta analysis of micronutrient supplementation, showing zinc supplementation associated with lower mortality. Note that forest plots have OR>1 favoring supplementation.
6 meta analyses show significant improvements with zinc for mortality Abuhelwa, Olczak-Pruc, Rheingold, Tabatabaeizadeh, Xie, severity Fan, and cases Fan.
Currently there are 43 zinc treatment for COVID-19 studies, showing 29% lower mortality [10‑44%], 44% lower ventilation [4‑68%], 26% lower ICU admission [-7‑49%], 29% lower hospitalization [7‑45%], and 22% fewer cases [-10‑45%].
This study includes zinc and vitamin D.
Xie et al., 15 Feb 2023, peer-reviewed, 16 authors, trial PROSPERO CRD42022353953.
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