Zinc supplementation and COVID-19 mortality: a meta-analysis

{ 'indexed': {'date-parts': [[2022, 5, 23]], 'date-time': '2022-05-23T04:10:57Z', 'timestamp': 1653279057118}, 'reference-count': 21, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2022, 5, 23]], 'date-time': '2022-05-23T00:00:00Z', 'timestamp': 1653264000000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2022, 5, 23]], 'date-time': '2022-05-23T00:00:00Z', 'timestamp': 1653264000000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2022, 12]]}, 'abstract': '<jats:title>Abstract</jats:title><jats:sec>\n' ' <jats:title>Background and aims</jats:title>\n' ' <jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the ' 'agent of a pneumonia outbreak and was called 2019 novel coronavirus disease (COVID-19). ' 'COVID-19 emerged in December 2019 and now considered a pandemic. Zinc supplementation can ' 'reduce mortality in patients with severe pneumonia. This study aimed at meta-analysis of the ' 'results of related studies and evaluate the effect of zinc supplementation on COVID-19 ' 'mortality.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Methods</jats:title>\n' ' <jats:p>A systematic search has conducted for manuscripts through ' 'PUBMED/Medline and Google Scholar (Cochrane guideline has considered it as the gray ' 'literature) up to September 2021. This meta-analysis followed Preferred Reporting Items for ' 'Systematic Reviews and Meta-analysis (PRISMA) Guideline for evaluation of the effect zinc ' 'supplementation on COVID-19 mortality. Based on the heterogeneity a fixed-effect or ' 'random-effect model, the OR and 95% CI were used to assess the combined risk.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>After assessment, five studies with 1506 participants in case and ' 'control groups were included in meta-analysis. The OR for one study was not estimable, and ' 'the pool OR was estimated for other studies with 1398 participants. The meta-analysis showed ' 'that zinc supplementation in cases led to a significant lower risk of mortality when it was ' 'compared with the control group; pooled OR (95% CI) was 0.57 [0.43, 0.77] ' '(<jats:italic>P</jats:italic>\u2009&lt;\u20090.001).</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Conclusion</jats:title>\n' ' <jats:p>This meta-analysis has suggested that zinc supplementation is ' 'associated with a lower mortality rate in COVID-19 patients. Zinc supplementation could be ' 'considered as a simple way and cost benefit approach for reduction of mortality in COVID-19 ' 'patients.</jats:p>\n' ' </jats:sec>', 'DOI': '10.1186/s40001-022-00694-z', 'type': 'journal-article', 'created': {'date-parts': [[2022, 5, 23]], 'date-time': '2022-05-23T03:44:22Z', 'timestamp': 1653277462000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Zinc supplementation and COVID-19 mortality: a meta-analysis', 'prefix': '10.1186', 'volume': '27', 'author': [{'given': 'Seyed-Amir', 'family': 'Tabatabaeizadeh', 'sequence': 'first', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2022, 5, 23]]}, 'reference': [ { 'issue': '1', 'key': '694_CR1', 'doi-asserted-by': 'publisher', 'first-page': '1', 'DOI': '10.1186/s40001-020-00475-6', 'volume': '26', 'author': 'S-A Tabatabaeizadeh', 'year': '2021', 'unstructured': 'Tabatabaeizadeh S-A. 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