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0 0.5 1 1.5 2+ Mortality 34% Improvement Relative Risk c19early.org/z Abuhelwa et al. Zinc for COVID-19 META ANALYSIS Favors zinc Favors control

Do Zinc Supplements Reduce Mortality in Patients with COVID-19?

Abuhelwa, Z., Translation: The University of Toledo Journal of Medical Sciences, doi:10.46570/utjms.vol11-2023-749 (meta analysis)
Abuhelwa, Do Zinc Supplements Reduce Mortality in Patients with COVID-19?, , Z., Translation: The University of Toledo Journal of Medical Sciences, doi:10.46570/utjms.vol11-2023-749 (meta analysis)
May 2023   Source   PDF  
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Systematic review and meta analysis of 6 studies showing lower mortality with zinc treatment.
Currently there are 41 zinc studies and meta analysis shows:
OutcomeImprovement
Mortality29% lower [10‑44%]
Ventilation47% lower [4‑71%]
ICU admission26% lower [-9‑49%]
Hospitalization29% lower [7‑45%]
Cases22% fewer [-10‑45%]
risk of death, 34.0% lower, RR 0.66, p < 0.001.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Abuhelwa et al., 3 May 2023, peer-reviewed, 1 author.
Contact: ziad.abuhelwa@utoledo.edu.
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Abstract: The University of Toledo Infectious Diseases Abstract, Department of Medicine Research Symposium Translation Journal of Medical Sciences UTJMS 2023 May 5; 11(1):e1-e1 Do Zinc Supplements Reduce Mortality in Patients with COVID-19? A Systematic Review and Meta-Analysis Ziad Abuhelwa, MD1*, Salik Khuder, PhD 1 Division of Internal Medicine, Department of Medicine, The University of Toledo, Toledo, OH 43614 *Corresponding author: Ziad.Abuhelwa@utoledo.edu Published: 05 May 2023 Introduction: Zinc is a trace element that has major role in human immune system. This study aims to assess the clinical benefits of zinc supplements on all-cause mortality in patients with COVID-19. Method: PubMed/MEDLINE, EMBASE, and Cochrane databases were searched for studies that evaluated the clinical efficacy of zinc supplements in patients diagnosed with COVID-19. The outcome was all-cause mortality rate. Pooled relative risk (RR) and corresponding 95% confidence intervals (ICs) were calculated and combined using a random-effects model. Results: A total of 6 studies (3 randomized clinical trials and 3 retrospective observational studies) that included 1,670 patients with COVID-19 (855 received zinc supplements vs. 812 received standard of care without zinc) were included in our systematic review. Our meta-analysis showed that there is statistically significant difference in all-cause mortality rate between the two groups favoring zinc supplements (RR 0.66; 95%CI 0.54 - 0.81; P <0.0001) Conclusion: Our study demonstrated that zinc supplements in addition to standard of care can reduce all-cause mortality in patients with COVID-19. https://dx.doi.org/10.46570/utjms.vol11-2023-749
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