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All Studies   Meta Analysis    Recent:   

Do Zinc Supplements Reduce Mortality in Patients with COVID-19?

Abuhelwa, Z., Translation: The University of Toledo Journal of Medical Sciences, doi:10.46570/utjms.vol11-2023-749
May 2023  
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Mortality 34% Improvement Relative Risk Zinc for COVID-19  Abuhelwa et al.  META ANALYSIS c19early.org Favorszinc Favorscontrol 0 0.5 1 1.5 2+
Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020
 
*, now with p = 0.00000064 from 45 studies, recognized in 17 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 81 treatments. c19early.org
Systematic review and meta analysis of 6 studies showing lower mortality with zinc treatment.
6 meta analyses show significant improvements with zinc for mortality1-5, severity6, and cases6.
Currently there are 45 zinc treatment for COVID-19 studies, showing 30% lower mortality [12‑44%], 40% lower ventilation [2‑63%], 24% lower ICU admission [-5‑46%], 20% lower hospitalization [4‑34%], and 22% fewer cases [-10‑45%].
risk of death, 34.0% lower, RR 0.66, p < 0.001.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Abuhelwa et al., 3 May 2023, peer-reviewed, 1 author. Contact: ziad.abuhelwa@utoledo.edu.
This PaperZincAll
Do Zinc Supplements Reduce Mortality in Patients with COVID-19?
MD Ziad Abuhelwa, PhD Salik Khuder
Translation: The University of Toledo Journal of Medical Sciences, doi:10.46570/utjms.vol11-2023-749
Introduction: Zinc is a trace element that has major role in human immune system. This study aims to assess the clinical benefits of zinc supplements on all-cause mortality in patients with COVID-19. Method: PubMed/MEDLINE, EMBASE, and Cochrane databases were searched for studies that evaluated the clinical efficacy of zinc supplements in patients diagnosed with COVID-19. The outcome was all-cause mortality rate. Pooled relative risk (RR) and corresponding 95% confidence intervals (ICs) were calculated and combined using a random-effects model. Results: A total of 6 studies (3 randomized clinical trials and 3 retrospective observational studies) that included 1,670 patients with COVID-19 (855 received zinc supplements vs. 812 received standard of care without zinc) were included in our systematic review. Our meta-analysis showed that there is statistically significant difference in all-cause mortality rate between the two groups favoring zinc supplements (RR 0.66; 95%CI 0.54 -0.81; P <0.0001) Conclusion: Our study demonstrated that zinc supplements in addition to standard of care can reduce all-cause mortality in patients with COVID-19.
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