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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 34% Improvement Relative Risk Zinc for COVID-19  Abuhelwa et al.  META ANALYSIS c19early.org Favors zinc Favors control

Do Zinc Supplements Reduce Mortality in Patients with COVID-19?

Abuhelwa, Z., Translation: The University of Toledo Journal of Medical Sciences, doi:10.46570/utjms.vol11-2023-749
May 2023  
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Zinc for COVID-19
2nd treatment shown to reduce risk in July 2020
 
*, now known with p = 0.0000027 from 43 studies, recognized in 10 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19early.org
Systematic review and meta analysis of 6 studies showing lower mortality with zinc treatment.
6 meta analyses show significant improvements with zinc for mortality Abuhelwa, Olczak-Pruc, Rheingold, Tabatabaeizadeh, Xie, severity Fan, and cases Fan.
Currently there are 43 zinc treatment for COVID-19 studies, showing 29% lower mortality [10‑44%], 44% lower ventilation [4‑68%], 26% lower ICU admission [-7‑49%], 19% lower hospitalization [2‑34%], and 22% fewer cases [-10‑45%].
risk of death, 34.0% lower, RR 0.66, p < 0.001.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Abuhelwa et al., 3 May 2023, peer-reviewed, 1 author. Contact: ziad.abuhelwa@utoledo.edu.
This PaperZincAll
Do Zinc Supplements Reduce Mortality in Patients with COVID-19?
MD Ziad Abuhelwa, PhD Salik Khuder
Translation: The University of Toledo Journal of Medical Sciences, doi:10.46570/utjms.vol11-2023-749
Introduction: Zinc is a trace element that has major role in human immune system. This study aims to assess the clinical benefits of zinc supplements on all-cause mortality in patients with COVID-19. Method: PubMed/MEDLINE, EMBASE, and Cochrane databases were searched for studies that evaluated the clinical efficacy of zinc supplements in patients diagnosed with COVID-19. The outcome was all-cause mortality rate. Pooled relative risk (RR) and corresponding 95% confidence intervals (ICs) were calculated and combined using a random-effects model. Results: A total of 6 studies (3 randomized clinical trials and 3 retrospective observational studies) that included 1,670 patients with COVID-19 (855 received zinc supplements vs. 812 received standard of care without zinc) were included in our systematic review. Our meta-analysis showed that there is statistically significant difference in all-cause mortality rate between the two groups favoring zinc supplements (RR 0.66; 95%CI 0.54 -0.81; P <0.0001) Conclusion: Our study demonstrated that zinc supplements in addition to standard of care can reduce all-cause mortality in patients with COVID-19.
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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