Do Zinc Supplements Reduce Mortality in Patients with COVID-19?
, Z., Translation: The University of Toledo Journal of Medical Sciences, doi:10.46570/utjms.vol11-2023-749, May 2023
Zinc for COVID-19
2nd treatment shown to reduce risk in
July 2020, now with p = 0.00000028 from 47 studies, recognized in 23 countries.
No treatment is 100% effective. Protocols
combine treatments.
6,200+ studies for
200+ treatments. c19early.org
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Systematic review and meta analysis of 6 studies showing lower mortality with zinc treatment.
Currently there are 47 zinc treatment for COVID-19 studies, showing 30% lower mortality [12‑44%], 40% lower ventilation [2‑63%], 24% lower ICU admission [-5‑46%], 20% lower hospitalization [4‑34%], and 22% fewer cases [-10‑45%].
|
risk of death, 34.0% lower, RR 0.66, p < 0.001.
|
| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
1.
Tabatabaeizadeh, S., Zinc supplementation and COVID-19 mortality: a meta-analysis, European Journal of Medical Research, doi:10.1186/s40001-022-00694-z.
2.
Olczak-Pruc et al., The effect of zinc supplementation on the course of COVID-19 – A systematic review and meta-analysis, Annals of Agricultural and Environmental Medicine, doi:10.26444/aaem/155846.
3.
Xie et al., Micronutrient perspective on COVID-19: Umbrella review and reanalysis of meta-analyses, Critical Reviews in Food Science and Nutrition, doi:10.1080/10408398.2023.2174948.
4.
Abuhelwa, Z., Do Zinc Supplements Reduce Mortality in Patients with COVID-19?, Translation: The University of Toledo Journal of Medical Sciences, doi:10.46570/utjms.vol11-2023-749.
Abuhelwa et al., 3 May 2023, peer-reviewed, 1 author.
Contact: ziad.abuhelwa@utoledo.edu.
Do Zinc Supplements Reduce Mortality in Patients with COVID-19?
Translation: The University of Toledo Journal of Medical Sciences, doi:10.46570/utjms.vol11-2023-749
Introduction: Zinc is a trace element that has major role in human immune system. This study aims to assess the clinical benefits of zinc supplements on all-cause mortality in patients with COVID-19. Method: PubMed/MEDLINE, EMBASE, and Cochrane databases were searched for studies that evaluated the clinical efficacy of zinc supplements in patients diagnosed with COVID-19. The outcome was all-cause mortality rate. Pooled relative risk (RR) and corresponding 95% confidence intervals (ICs) were calculated and combined using a random-effects model.
Results: A total of 6 studies (3 randomized clinical trials and 3 retrospective observational studies) that included 1,670 patients with COVID-19 (855 received zinc supplements vs. 812 received standard of care without zinc) were included in our systematic review. Our meta-analysis showed that there is statistically significant difference in all-cause mortality rate between the two groups favoring zinc supplements (RR 0.66; 95%CI 0.54 -0.81; P <0.0001)
Conclusion: Our study demonstrated that zinc supplements in addition to standard of care can reduce all-cause mortality in patients with COVID-19.
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